MinK subdomains that mediate modulation of and association with KvLQT1

Journal of General Physiology

Volumn 116, Issue 3, 2000, Pages 379-389

  Tapper, Andrew R ^a   George Jr , Alfred L ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Heart; KCNE1; KCNQ1; Long QT syndrome; Potassium channel

Indexed keywords

ION CHANNEL; POTASSIUM CHANNEL; POTASSIUM ION;

ANIMAL CELL; ARTICLE; CHIMERA; DELETION MUTANT; GENE EXPRESSION; LONG QT SYNDROME; NONHUMAN; OOCYTE; POLYMERASE CHAIN REACTION; XENOPUS;

ANIMALS; BASE SEQUENCE; DNA PRIMERS; FEMALE; HUMANS; ION CHANNEL GATING; KCNQ POTASSIUM CHANNELS; KCNQ1 POTASSIUM CHANNEL; KINETICS; OOCYTES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN STRUCTURE, TERTIARY; RATS; RECOMBINANT FUSION PROTEINS; SEQUENCE DELETION; XENOPUS LAEVIS;

EID: 0033811345     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.116.3.379     Document Type: Article

References (23)

1. MiRP1 forms I(Kr) potassium channels with HERG and is associated with cardiac arrhythmia
2. Stilbenes and fenamates rescue the loss of I(Ks) channel function induced by an LQT5 mutation and other IsK mutants
3. KvLQT1 and IsK (MinK) proteins associate to form the I(Ks) cardiac potassium current
4. - in Xenopus oocytes: Evidence for regulatory function
5. Cellular dysfunction of LQT5-MinK mutants: Abnormalities of I(Ks), I(Kr) and trafficking in long QT syndrome
6. Mutations of the gene for IsK associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long QT syndrome
7. + channels
8. The extracellular domain of the β1 subunit is both necessary and sufficient for β1-like modulation of sodium channel gating
9. Activation and inactivation of homomeric KvLQT1 potassium channels
10. Molecular mechanism and functional significance of the MinK control of the KvLQT1 channel activity
11. Coassembly of KvLQT1 and MinK (IsK) proteins to form cardiac I(Ks) potassium channel
12. + current. Differential sensitivity to block by class III antiarrhythmic agents
13. A constitutively open potassium channel formed by KCNQ1 and KCNE3
14. KCNE1 mutations cause Jervell and Lange-Nielsen syndrome
15. Dominant-negative KvLQT1 mutations underlie the LQT1 form of long QT syndrome
16. Mutations in the hminK gene cause long QT syndrome and suppress I(Ks) function
17. The conduction pore of a cardiac potassium channel
18. Alteration of channel activities and gating by mutations of slow I(SK) potassium channel
19. Cloning of a membrane protein that induces a slow voltage-gated potassium current
20. + channel (MinK) subunits
21. IsK and KvLQT1: Mutation in either of the two subunits of the slow component of the delayed rectifier potassium channel can cause Jervell and Lange-Nielsen syndrome
22. Positional cloning of a novel potassium channel gene: KvLQT1 mutations cause cardiac arrythmias
23. KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias