The role of CD14 in neutrophil recruitment within the liver microcirculation during endotoxemia

Journal of Immunology

Volumn 186, Issue 4, 2011, Pages 2592-2601

  McAvoy, Erin F ^a   McDonald, Braedon ^a   Parsons, Sean A ^a   Wong, Connie H ^a   Landmann, Regine ^b   Kubes, Paul ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; HYALURONIC ACID; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIGEN FUNCTION; ARTICLE; CELL ADHESION; CONTROLLED STUDY; ENDOTOXEMIA; HEMATOPOIETIC CELL; INFLAMMATION; KNOCKOUT MOUSE; LEUKOCYTE ACTIVATION; LEUKOPENIA; LIVER CIRCULATION; LIVER SINUSOID; MICROCIRCULATION; MOLECULAR MECHANICS; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; SERUM; VENULE; WILD TYPE;

ANIMALS; ANTIGENS, CD14; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; ENDOTOXEMIA; FEMALE; HEMATOPOIETIC STEM CELLS; IMMUNITY, INNATE; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; LIVER CIRCULATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROCIRCULATION; NEUTROPHIL INFILTRATION; RECEPTORS, CHEMOKINE; SIGNAL TRANSDUCTION;

EID: 79951824994     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1002248     Document Type: Article

References (34)

1. Poltorak, A., X. He, I. Smirnova, M. Y. Liu, C. Van Huffel, X. Du, D. Birdwell, E. Alejos, M. Silva, C. Galanos, et al. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282: 2085-2088. (Pubitemid 29001265)
2. Roger, T., C. Froidevaux, D. Le Roy, M. K. Reymond, A. L. Chanson, D. Mauri, K. Burns, B. M. Riederer, S. Akira, and T. Calandra. 2009. Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4. Proc. Natl. Acad. Sci. USA 106: 2348-2352.
3. Brown, K. A., S. D. Brain, J. D. Pearson, J. D. Edgeworth, S. M. Lewis, and D. F. Treacher. 2006. Neutrophils in development of multiple organ failure in sepsis. Lancet 368: 157-169.
4. Dhainaut, J. F., N. Marin, A. Mignon, and C. Vinsonneau. 2001. Hepatic response to sepsis: interaction between coagulation and inflammatory processes. Crit. Care Med. 29(7 Suppl): S42-S47.
5. Park, B. S., D. H. Song, H. M. Kim, B. S. Choi, H. Lee, and J. O. Lee. 2009. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 458: 1191-1195.
6. Wright, S. D., R. A. Ramos, P. S. Tobias, R. J. Ulevitch, and J. C. Mathison. 1990. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249: 1431-1433.
7. Lloyd, K. L., and P. Kubes. 2006. GPI-linked endothelial CD14 contributes to the detection of LPS. Am. J. Physiol. Heart Circ. Physiol. 291: H473-H481.
8. Jerala, R. 2007. Structural biology of the LPS recognition. Int. J. Med. Microbiol. 297: 353-363.
9. Haziot, A., E. Ferrero, F. Köntgen, N. Hijiya, S. Yamamoto, J. Silver, C. L. Stewart, and S. M. Goyert. 1996. Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice. Immunity 4: 407-414.
10. Andonegui, G., S. M. Goyert, and P. Kubes. 2002. Lipopolysaccharide- induced leukocyte-endothelial cell interactions: a role for CD14 versus toll-like receptor 4 within microvessels. J. Immunol. 169: 2111-2119. (Pubitemid 34857677)
11. Andonegui, G., C. S. Bonder, F. Green, S. C. Mullaly, L. Zbytnuik, E. Raharjo, and P. Kubes. 2003. Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs. J. Clin. Invest. 111: 1011-1020.
12. Carvalho-Tavares, J., M. J. Hickey, J. Hutchison, J. Michaud, I. T. Sutcliffe, and P. Kubes. 2000. A role for platelets and endothelial selectins in tumor necrosis factor-alpha-induced leukocyte recruitment in the brain microvasculature. Circ. Res. 87: 1141-1148.
13. Hickey, M. J., E. Sihota, A. Amrani, P. Santamaria, L. D. Zbytnuik, E. S. Ng, W. Ho, K. A. Sharkey, and P. Kubes. 2002. Inducible nitric oxide synthase (iNOS) in endotoxemia: chimeric mice reveal different cellular sources in various tissues. FASEB J. 16: 1141-1143.
14. Wong, J., B. Johnston, S. S. Lee, D. C. Bullard, C. W. Smith, A. L. Beaudet, and P. Kubes. 1997. A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature. J. Clin. Invest. 99: 2782-2790.
15. Turhan, A., L. A. Weiss, N. Mohandas, B. S. Coller, and P. S. Frenette. 2002. Primary role for adherent leukocytes in sickle cell vascular occlusion: a new paradigm. Proc. Natl. Acad. Sci. USA 99: 3047-3051.
16. McDonald, B., E. F. McAvoy, F. Lam, V. Gill, C. de la Motte, R. C. Savani, and P. Kubes. 2008. Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids. J. Exp. Med. 205: 915-927.
17. Cauwels, A., K. Frei, S. Sansano, C. Fearns, R. Ulevitch, W. Zimmerli, and R. Landmann. 1999. The origin and function of soluble CD14 in experimental bacterial meningitis. J. Immunol. 162: 4762-4772. (Pubitemid 29314878)
18. Khan, A. I., S. M. Kerfoot, B. Heit, L. Liu, G. Andonegui, B. Ruffell, P. Johnson, and P. Kubes. 2004. Role of CD44 and hyaluronan in neutrophil recruitment. J. Immunol. 173: 7594-7601. (Pubitemid 39628201)
19. Schaff, U. Y., I. Yamayoshi, T. Tse, D. Griffin, L. Kibathi, and S. I. Simon. 2008. Calcium flux in neutrophils synchronizes beta2 integrin adhesive and signaling events that guide inflammatory recruitment. Ann. Biomed. Eng. 36: 632-646.
20. Clark, S. R., A. C. Ma, S. A. Tavener, B. McDonald, Z. Goodarzi, M. M. Kelly, K. D. Patel, S. Chakrabarti, E. McAvoy, G. D. Sinclair, et al. 2007. Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat. Med. 13: 463-469.
21. Racanelli, V., and B. Rehermann. 2006. The liver as an immunological organ. Hepatology 43(Suppl 1): S54-S62.
22. Jung, U., K. E. Norman, K. Scharffetter-Kochanek, A. L. Beaudet, and K. Ley. 1998. Transit time of leukocytes rolling through venules controls cytokine-induced inflammatory cell recruitment in vivo. J. Clin. Invest. 102: 1526-1533.
23. Bas, S., B. R. Gauthier, U. Spenato, S. Stingelin, and C. Gabay. 2004. CD14 is an acute-phase protein. J. Immunol. 172: 4470-4479. (Pubitemid 38375263)
24. Fearns, C., V. V. Kravchenko, R. J. Ulevitch, and D. J. Loskutoff. 1995. Murine CD14 gene expression in vivo: extramyeloid synthesis and regulation by lipopolysaccharide. J. Exp. Med. 181: 857-866.
25. Zhuo, L., A. Kanamori, R. Kannagi, N. Itano, J.Wu, M. Hamaguchi, N. Ishiguro, and K. Kimata. 2006. SHAP potentiates the CD44-mediated leukocyte adhesion to the hyaluronan substratum. J. Biol. Chem. 281: 20303-20314.
26. Wiersinga, W. J., A. F. de Vos, C. W. Wieland, M. Leendertse, J. J. Roelofs, and T. van der Poll. 2008. CD14 impairs host defense against gram-negative sepsis caused by Burkholderia pseudomallei in mice. J. Infect. Dis. 198: 1388-1397.
27. Gregory, S. H., and E. J. Wing. 2002. Neutrophil-Kupffer cell interaction: a critical component of host defenses to systemic bacterial infections. J. Leukoc. Biol. 72: 239-248.
28. Martin, G. S., D. M. Mannino, S. Eaton, and M. Moss. 2003. The epidemiology of sepsis in the United States from 1979 through 2000. N. Engl. J. Med. 348: 1546-1554.
29. Beutler, B., Z. Jiang, P. Georgel, K. Crozat, B. Croker, S. Rutschmann, X. Du, and K. Hoebe. 2006. Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu. Rev. Immunol. 24: 353-389.
30. Ziegler, E. J., J. A. McCutchan, J. Fierer, M. P. Glauser, J. C. Sadoff, H. Douglas, and A. I. Braude. 1982. Treatment of gram-negative bacteremia and shock with human antiserum to a mutant Escherichia coli. N. Engl. J. Med. 307: 1225-1230.
31. Butcher, E. C. 1991. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 67: 1033-1036. (Pubitemid 121001517)
32. Welbourn, C. R., and Y. Young. 1992. Endotoxin, septic shock and acute lung injury: neutrophils, macrophages and inflammatory mediators. Br. J. Surg. 79: 998-1003.
33. Andonegui, G., H. Zhou, D. Bullard, M. M. Kelly, S. C. Mullaly, B. McDonald, E. M. Long, S. M. Robbins, and P. Kubes. 2009. Mice that exclusively express TLR4 on endothelial cells can efficiently clear a lethal systemic Gram-negative bacterial infection. J. Clin. Invest. 119: 1921-1930.
34. Zhou, H., G. Andonegui, C. H. Wong, and P. Kubes. 2009. Role of endothelial TLR4 for neutrophil recruitment into central nervous system microvessels in systemic inflammation. J. Immunol. 183: 5244-5250.