Chemical and pharmacological studies of saponins with a focus on American ginseng

Journal of Ginseng Research

Volumn 34, Issue 3, 2010, Pages 160-167

  Yuan, Chun Su ^a   Wang, Chong Zhi ^a   Wicks, Sheila M ^a   Qi, Lian Wen ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

American ginseng; Asian ginseng; Ginsenoside; Panax ginseng; Panax quinquefolius L.; Pharmacology; Saponins

Indexed keywords

PANAX GINSENG; PANAX QUINQUEFOLIUS;

EID: 79951785879     PISSN: 12268453     EISSN: None     Source Type: Journal    
DOI: 10.5142/jgr.2010.34.3.160     Document Type: Review

References (75)

1. Court WE. Ginseng: the history of an insignificant plant. Pharm Hist (Lond) 2000;30:38-44.
2. Ang-Lee MK, Moss J, Yuan CS. Herbal medicines and perioperative care. JAMA 2001;286:208-216. (Pubitemid 32640852)
3. Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 1999;58:1685-1693. (Pubitemid 29505408)
4. Jia L, Zhao Y. Current evaluation of the millennium phytomedicine-ginseng (I): etymology, pharmacognosy, phytochemistry, market and regulations. Curr Med Chem 2009;16:2475-2484.
5. Christensen LP. Ginsenosides chemistry, biosynthesis, analysis, and potential health effects. Adv Food Nutr Res 2009;55:1-99.
6. Editor Board of Zhong Hua Ben Cao. The Chinese herbal (Zhong Hua Ben Cao). Shanghai: Shanghai Science and Technology Press, 1999.
7. Marie-Victorin F, Rouleau E. Flore laurentienne. 2nd ed. Montreal: Les Presses de l'Université de Montréal, 1964.
8. Ngan F, Shaw P, But P, Wang J. Molecular authentication of Panax species. Phytochemistry 1999;50:787-791. (Pubitemid 29135041)
9. Fuzzati N. Analysis methods of ginsenosides. J Chromatogr B Analyt Technol Biomed Life Sci 2004;812:119-133. (Pubitemid 39535405)
10. Qu CL, Bai YP, Jin XQ, Wang YT, Zhang K, You JY, Zhang HQ. Study on ginsenosides in different parts and ages of Panax quinquefolius L. Food Chem 2009;115:340-346.
11. Wang A, Wang CZ, Wu JA, Osinski J, Yuan CS. Determination of major ginsenosides in Panax quinquefolius (American ginseng) using high-performance liquid chromatography. Phytochem Anal 2005;16:272-277. (Pubitemid 40975415)
12. Wang CZ, Yuan CS. Potential role of ginseng in the treatment of colorectal cancer. Am J Chin Med 2008;36:1019-1028.
13. Yoshikawa M, Murakami T, Yashiro K, Yamahara J, Matsuda H, Saijoh R, Tanaka O. Bioactive saponins and glycosides. XI. Structures of new dammarane-type triterpene oligoglycosides, quinquenosides I, II, III, I V, and V, from American ginseng, the roots of Panax quinquefolium L. Chem Pharm Bull (Tokyo) 1998;46:647-654. (Pubitemid 28216940)
14. Shin YW, Bae EA, Kim DH. Inhibitory effect of ginsenoside Rg5 and its metabolite ginsenoside Rh3 in an oxazolone-induced mouse chronic dermatitis model. Arch Pharm Res 2006;29:685-690.
15. Nakamura S, Sugimoto S, Matsuda H, Yoshikawa M. Medicinal flowers. XVII New dammarane-type triterpene glycosides from flower buds of American ginseng, Panax quinquefolium L. Chem Pharm Bull (Tokyo) 2007;55:1342-1348. (Pubitemid 47414575)
16. Schlag EM, McIntosh MS. Ginsenoside content and variation among and within American ginseng (Panax quinquefolius L.) populations. Phytochemistry 2006;67:1510-1519. (Pubitemid 44092919)
17. Zhang K, Wang X, Ding L, Li J, Qu CL, Chen LG, Jin HY, Zhang HQ. Determination of seven major ginsenosides in different parts of Panax quinquefolius L. (American ginseng) with different ages. Chem Res Chin Univ 2008;24:707-711.
18. Lim W, Mudge KW, Vermeylen F. Effects of population, age, and cultivation methods on ginsenoside content of wild American ginseng (Panax quinquefolium). J Agric Food Chem 2005;53:8498-8505. (Pubitemid 41608905)
19. Lin WN, Lu HY, Lee MS, Yang SY, Chen HJ, Chang YS, Chang WT. Evaluation of the cultivation age of dried ginseng radix and its commercial products by using (1) H-NMR fingerprint analysis. Am J Chin Med 2010;38:205-218.
20. Sengupta S, Toh SA, Sellers LA, Skepper JN, Koolwijk P, Leung HW, Yeung HW, Wong RN, Sasisekharan R, Fan TP. Modulating angiogenesis: the yin and the yang in ginseng. Circulation 2004;110:1219-1225. (Pubitemid 39202336)
21. Wang CZ, Aung HH, Ni M, Wu JA, Tong R, Wicks S, He TC, Yuan CS. Red American ginseng: ginsenoside constituents and antiproliferative activities of heat-processed Panax quinquefolius roots. Planta Med 2007;73:669-674. (Pubitemid 47066161)
22. Lau AJ, Seo BH, Woo SO, Koh HL. High-performance liquid chromatographic method with quantitative comparisons of whole chromatograms of raw and steamed Panax notoginseng. J Chromatogr A 2004;1057:141-149.
23. Kwon SW, Han SB, Park IH, Kim JM, Park MK, Park JH. Liquid chromatographic determination of less polar ginsenosides in processed ginseng. J Chromatogr A 2001;921:335-339. (Pubitemid 32537840)
24. Wang CZ, Zhang B, Song WX, Wang A, Ni M, Luo X, Aung HH, Xie JT, Tong R, He TC, et al. Steamed American ginseng berry: ginsenoside analyses and anticancer activities. J Agric Food Chem 2006;54:9936-9942. (Pubitemid 46158993)
25. Jin Y, Lu Z. Effect of PQS on FFA and LDH in rat myocardium damaged by injuring the left anterior descending coronary artery. Baiqiuen Yike Daxue Xuebao 1992;18:121-122.
26. Li G, Yang S, Lui F. Effect of P. quinquefolius saponin on the platelet aggregation rate and superoxide dismutase activity in the hyperlipidaemic rats. Baiqiuen Yike Daxue Xuebao 1996;22:3.
27. Shao ZH, Xie JT, Vanden Hoek TL, Mehendale S, Aung H, Li CQ, Qin Y, Schumacker PT, Becker LB, Yuan CS. Antioxidant effects of American ginseng berry extract in cardiomyocytes exposed to acute oxidant stress. Biochim Biophys Acta 2004;1670:165-171. (Pubitemid 38229767)
28. Mehendale SR, Wang CZ, Shao ZH, Li CQ, Xie JT, Aung HH, Yuan CS. Chronic pretreatment with American ginseng berry and its polyphenolic constituents attenuate oxidant stress in cardiomyocytes. Eur J Pharmacol 2006;553:209-214. (Pubitemid 44779590)
29. Xie JT, Shao ZH, Vanden Hoek TL, Chang WT, Li J, Mehendale S, Wang CZ, Hsu CW, Becker LB, Yin JJ, et al. Antioxidant effects of ginsenoside Re in cardiomyocytes. Eur J Pharmacol 2006;532:201-207.
30. Wang CL, Shi DZ, Yin HJ. Effect of Panax quinquefolius saponin on angiogenesis and expressions of VEGF and bFGF in myocardium of rats with acute myocardial infarction. Zhongguo Zhong Xi Yi Jie He Za Zhi 2007;27:331-334.
31. Prior RL, Cao G, Prior RL, Cao G. Analysis of botanicals and dietary supplements for antioxidant capacity: a review. J AOAC Int 2000;83:950-956.
32. Wang CZ, Mehendale SR, Yuan CS. Commonly used antioxidant botanicals: active constituents and their potential role in cardiovascular illness. Am J Chin Med 2007;35:543-558. (Pubitemid 47307694)
33. Ng TB, Yeung HW. Hypoglycemic constituents of Panax ginseng. Gen Pharmacol 1985;16:549-552. (Pubitemid 16230748)
34. Attele AS, Zhou YP, Xie JT, Wu JA, Zhang L, Dey L, Pugh W, Rue PA, Polonsky KS, Yuan CS. Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes 2002;51:1851-1858. (Pubitemid 34564298)
35. Dey L, Xie JT, Wang A, Wu J, Maleckar SA, Yuan CS. Anti-hyperglycemic effects of ginseng: comparison between root and berry. Phytomedicine 2003;10:600-605. (Pubitemid 37092688)
36. Xie JT, Wu JA, Mehendale S, Aung HH, Yuan CS. Antihyperglycemic effect of the polysaccharides fraction from American ginseng berry extract in ob/ob mice. Phytomedicine 2004;11:182-187. (Pubitemid 38314060)
37. Xie JT, McHendale S, Yuan CS. Ginseng and diabetes. Am J Chin Med 2005;33:397-404.
38. Xie JT, Mehendale SR, Li X, Quigg R, Wang X, Wang CZ, Wu JA, Aung H H A, Rue P, Bell GI, et al. Anti-diabetic effect of ginsenoside Re in ob/ob mice. Biochim Biophys Acta 2005;1740:319-325. (Pubitemid 40804743)
39. Shang W, Yang Y, Jiang B, Jin H, Zhou L, Liu S, Chen M. Ginsenoside Rb1 promotes adipogenesis in 3T3-L1 cells by enhancing PPARgamma2 and C/EBPalpha gene expression. Life Sci 2007;80:618-625. (Pubitemid 46074052)
40. Shang W, Yang Y, Zhou L, Jiang B, Jin H, Chen M. Ginsenoside Rb1 stimulates glucose uptake through insulinlike signaling pathway in 3T3-L1 adipocytes. J Endocrinol 2008;198:561-569.
41. Park S, Ahn IS, Kwon DY, Ko BS, Jun. WK. Ginsenosides Rb1 and Rg1 suppress triglyceride accumulation in 3T3-L1 adipocytes and enhance beta-cell insulin secretion and viability in Min6 cells via PKA-dependent pathways. Biosci Biotechnol Biochem 2008;72:2815-2823.
42. Stohs SJ. The role of free radicals in toxicity and disease. J Basic Clin Physiol Pharmacol 1995;6:205-228. (Pubitemid 26086168)
43. Cetin A, Kaynar L, Kocyigit I, Hacioglu SK, Saraymen R, Ozturk A, Sari I, Sagdic O. Role of grape seed extract on methotrexate induced oxidative stress in rat liver. Am J Chin Med 2008;36:861-872.
44. Xie JT, Wang CZ, Li XL, Ni M, Fishbein A, Yuan CS. Anti-diabetic effect of American ginseng may not be linked to antioxidant activity: comparison between American ginseng and Scutellaria baicalensis using an ob/ob mice model. Fitoterapia 2009;80:306-311.
45. Nah SY, Kim DH, Rhim H. Ginsenosides: are any of them candidates for drugs acting on the central nervous system? CNS Drug Rev 2007;13:381-404. (Pubitemid 350233470)
46. Chang Y, Huang WJ, Tien LT, Wang SJ. Ginsenosides Rg1 and Rb1 enhance glutamate release through activation of protein kinase A in rat cerebrocortical nerve terminals (synaptosomes). Eur J Pharmacol 2008;578:28-36. (Pubitemid 350179758)
47. Tian J, Fu F, Geng M, Jiang Y, Yang J, Jiang W, Wang C, Liu K. Neuroprotective effect of 20 (S)-ginsenoside Rg3 on cerebral ischemia in rats. Neurosci Lett 2005;374:92-97. (Pubitemid 40092203)
48. Benishin CG, Lee R, Wang LC, Liu HJ. Effects of ginsenoside Rb1 on central cholinergic metabolism. Pharmacology 1991;42:223-239.
49. Lee JH, Jeong SM, Kim JH, Lee BH, Yoon IS, Lee JH, Choi SH, Lee SM, Park YS, Lee JH, et al. Effects of ginsenosides and their metabolites on voltage-dependent Ca (2+) channel subtypes. Mol Cells 2006;21:52-62.
50. Mook-Jung I, Hong HS, Boo JH, Lee KH, Yun SH, Cheong MY, Joo I, Huh K, Jung MW. Ginsenoside Rb1 and Rg1 improve spatial learning and increase hippocampal synaptophysin level in mice. J Neurosci Res 2001;63:509-515. (Pubitemid 32193708)
51. Yuan QL, Yang CX, Xu P, Gao XQ, Deng L, Chen P, Sun ZL, Chen QY. Neuroprotective effects of ginsenoside Rb1 on transient cerebral ischemia in rats. Brain Res 2007;1167:1-12. (Pubitemid 47302431)
52. Chen X, Huang T, Zhang J, Song J, Chen L, Zhu Y. Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1's attenuation of beta-amyloid peptide25-35-induced tau hyperphosphorylation in cortical neurons. Brain Res 2008;1200:99-106.
53. Xue JF, Liu ZJ, Hu JF, Chen H, Zhang JT, Chen NH. Ginsenoside Rb1 promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway. Brain Res 2006;1106:91-98. (Pubitemid 44163324)
54. Zhao H, Li Q, Pei X, Zhang Z, Yang R, Wang J, Li Y. Long-term ginsenoside administration prevents memory impairment in aged C57BL/6J mice by up-regulating the synaptic plasticity-related proteins in hippocampus. Behav Brain Res 2009;201:311-317.
55. Zhao H, Li Q, Zhang Z, Pei X, Wang J, Li Y. Long-term ginsenoside consumption prevents memory loss in aged SAMP8 mice by decreasing oxidative stress and upregulating the plasticity-related proteins in hippocampus. Brain Res 2009;1256:111-122.
56. Corbit R, Ebbs S, King ML, Murphy LL. The influence of lead and arsenite on the inhibition of human breast cancer MCF-7 cell proliferation by American ginseng root (Panax quinquefolius L.). Life Sci 2006;78:1336-1340. (Pubitemid 43204337)
57. Duda RB, Zhong Y, Navas V, Li MZ, Toy BR, Alavarez JG. American ginseng and breast cancer therapeutic agents synergistically inhibit MCF-7 breast cancer cell growth. J Surg Oncol 1999;72:230-239. (Pubitemid 30007793)
58. Xie JT, Wang CZ, Zhang B, Mehendale SR, Li XL, Sun S, Han AH, Du W, He TC, Yuan CS. In vitro and in vivo anticancer effects of American ginseng berry: exploring representative compounds. Biol Pharm Bull 2009;32:1552-1558.
59. Yue PY, Wong DY, Wu PK, Leung PY, Mak NK, Yeung HW, Liu L, Cai Z, Jiang ZH, Fan TP, et al. The angiosuppressive effects of 20 (R)-ginsenoside Rg3. Biochem Pharmacol 2006;72:437-445.
60. Kim SY, Kim DH, Han SJ, Hyun JW, Kim HS. Repression of matrix metalloproteinase gene expression by ginsenoside Rh2 in human astroglioma cells. Biochem Pharmacol 2007;74:1642-1651.
61. Kim SM, Lee SY, Cho JS, Son SM, Choi SS, Yun YP, Yoo HS, Yoon do Y, Oh KW, Han SB, et al. Combination of ginsenoside Rg3 with docetaxel enhances the susceptibility of prostate cancer cells via inhibition of NF-kappaB. Eur J Pharmacol 2010;631:1-9.
62. Duda RB, Kang SS, Archer SY, Meng S, Hodin RA. American ginseng transcriptionally activates p21 mRNA in breast cancer cell lines. J Korean Med Sci 2001;16 Suppl: S54-S60.
63. Park JA, Lee KY, Oh YJ, Kim KW, Lee SK. Activation of caspase-3 protease via a Bcl-2-insensitive pathway during the process of ginsenoside Rh2-induced apoptosis. Cancer Lett 1997;121:73-81. (Pubitemid 27504317)
64. Jia WW, Bu X, Philips D, Yan H, Liu G, Chen X, Bush JA, Li G. Rh2, a compound extracted from ginseng, hypersensitizes multidrug-resistant tumor cells to chemotherapy. Can J Physiol Pharmacol 2004;82:431-437. (Pubitemid 39388382)
65. Luo X, Wang CZ, Chen J, Song WX, Luo J, Tang N, He BC, Kang Q, Wang Y, Du W, et al. Characterization of gene expression regulated by American ginseng and ginsenoside Rg3 in human colorectal cancer cells. Int J Oncol 2008;32:975-983.
66. Aung HH, Mehendale SR, Wang CZ, Xie JT, McEntee E, Yuan CS. Cisplatin's tumoricidal effect on human breast carcinoma MCF-7 cells was not attenuated by American ginseng. Cancer Chemother Pharmacol 2007;59:369-374. (Pubitemid 46025524)
67. Mehendale S, Aung H, Wang A, Yin JJ, Wang CZ, Xie JT, Yuan CS. American ginseng berry extract and ginsenoside Re attenuate cisplatin-induced kaolin intake in rats. Cancer Chemother Pharmacol 2005;56:63-69. (Pubitemid 41201757)
68. Sonnenborn U. Recent investigations of the immunological, pharmacological and endocrinological activities of an old medicinal plant. Deutsch Apoth Zeit 1987;127:433-441.
69. Court W E. Ginseng: the genus panax. Amsterdam: Harwood Academic Press, 2000.
70. Zhang D, Wang S, Chang Y, Han H. Effects of Panax quinquefolia saponins on hematopoietic growth factor in cyclophosphamide depressed mice. Baiqiuen Yike Daxue Xuebao 1992;18:412-414.
71. Zhuang M, Wu Y, Li M, Shu Y. Effects of some medicinal polysaccharides on immune deficiency in animal models induced by cobra anticomplementary factor. J Nat Toxins 1996;5:161-164. (Pubitemid 26309989)
72. Biondo PD, Goruk S, Ruth MR, O'Connell E, Field CJ. Effect of CVT-E002 (COLD-fX) versus a ginsenoside extract on systemic and gut-associated immune function. Int Immunopharmacol 2008;8:1134-1142.
73. Cui JF, Bjorkhem I, Eneroth P. Gas chromatographic-mass spectrometric determination of 20 (S)-protopanaxadiol and 20 (S)-protopanaxatriol for study on human urinary excretion of ginsenosides after ingestion of ginseng preparations. J Chromatogr B Biomed Sci Appl 1997;689:349-355. (Pubitemid 27091361)
74. Tawab MA, Bahr U, Karas M, Wurglics M, Schubert-Zsilavecz M. Degradation of ginsenosides in humans after oral administration. Drug Metab Dispos 2003;31:1065-1071. (Pubitemid 36975678)
75. Hasegawa H. Proof of the mysterious efficacy of ginseng: basic and clinical trials: metabolic activation of ginsenoside: deglycosylation by intestinal bacteria and esterification with fatty acid. J Pharmacol Sci 2004;95:153-157. (Pubitemid 38899683)