-
1
-
-
0036852241
-
Cancer immunoediting: From immunosurveillance to tumor escape
-
DOI 10.1038/ni1102-991
-
Dunn GP, Bruce AT, Ikeda H, Old LJ, Schreiber RD: Cancer immunoediting: from immunosurveillance to tumor escap (Pubitemid 35363648)
-
(2002)
Nature Immunology
, vol.3
, Issue.11
, pp. 991-998
-
-
Dunn, G.P.1
Bruce, A.T.2
Ikeda, H.3
Old, L.J.4
Schreiber, R.D.5
-
2
-
-
16844379997
-
Immunosuppressive networks in the tumour environment and their therapeutic relevance
-
DOI 10.1038/nrc1586
-
Zou W: Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat. Rev. Cancer 5(4), 263-274 (2005). (Pubitemid 40488632)
-
(2005)
Nature Reviews Cancer
, vol.5
, Issue.4
, pp. 263-274
-
-
Zou, W.1
-
3
-
-
13244273592
-
Contrasting frequencies of antitumor and anti-vaccine T cells in metastases of a melanoma patient vaccinated with a MAGE tumor antigen
-
DOI 10.1084/jem.20041378
-
Lurquin C, Lethe B, De Plaen E et al.: Contrasting frequencies of antitumor and anti-vaccine T cells in metastases of a melanoma patient vaccinated with a mage tumor antigen. J. Exp. Med. 201(2), 249-257 (2005). (Pubitemid 40189434)
-
(2005)
Journal of Experimental Medicine
, vol.201
, Issue.2
, pp. 249-257
-
-
Lurquin, C.1
Lethe, B.2
De Plaen, E.3
Corbiere, V.4
Theate, I.5
Van Baren, N.6
Coulie, P.G.7
Boon, T.8
-
4
-
-
0037811736
-
Immunization with melan-A peptide-pulsed peripheral blood mononuclear cells plus recombinant human interleukin-12 induces clinical activity and T-cell responses in advanced melanoma
-
DOI 10.1200/JCO.2003.12.144
-
Peterson AC, Harlin H, Gajewski TF: Immunization with Melan-A peptide-pulsed peripheral blood mononuclear cells plus recombinant human interleukin-12 induces clinical activity and T-cell responses in advanced melanoma. J. Clin. Oncol. 21(12), 2342-2348 (2003). (Pubitemid 46628465)
-
(2003)
Journal of Clinical Oncology
, vol.21
, Issue.12
, pp. 2342-2348
-
-
Peterson, A.C.1
Harlin, H.2
Gajewski, T.F.3
-
5
-
-
27144500671
-
+ T cells in patients with melanoma
-
Rosenberg SA, Sherry RM, Morton KE et al.: Tumor progression can occur despite the induction of very high levels of self/tumor antigen-specific CD8+ T cells in patients with melanoma. J. Immunol. 175(9), 6169-6176 (2005). (Pubitemid 41508105)
-
(2005)
Journal of Immunology
, vol.175
, Issue.9
, pp. 6169-6176
-
-
Rosenberg, S.A.1
Sherry, R.M.2
Morton, K.E.3
Scharfman, W.J.4
Yang, J.C.5
Topalian, S.L.6
Royal, R.E.7
Kammula, U.8
Restifo, N.P.9
Hughes, M.S.10
Schwartzentruber, D.11
Berman, D.M.12
Schwarz, S.L.13
Ngo, L.T.14
Mavroukakis, S.A.15
White, D.E.16
Steinberg, S.M.17
-
6
-
-
58149483422
-
CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T-cell responses in metastatic melanoma patients with clinical benefit
-
Yuan J, Gnjatic S, Li H et al.: CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T-cell responses in metastatic melanoma patients with clinical benefit. Proc. Natl Acad. Sci. USA 105(51), 20410-20415 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, Issue.51
, pp. 20410-20415
-
-
Yuan, J.1
Gnjatic, S.2
Li, H.3
-
7
-
-
0033024863
-
High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993
-
Atkins MB, Lotze MT, Dutcher JP et al.: High-dose recombinant IL-2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. J. Clin. Oncol. 17(7), 2105-2116 (1999). (Pubitemid 29318842)
-
(1999)
Journal of Clinical Oncology
, vol.17
, Issue.7
, pp. 2105-2116
-
-
Atkins, M.B.1
Lotze, M.T.2
Dutcher, J.P.3
Fisher, R.I.4
Weiss, G.5
Margolin, K.6
Abrams, J.7
Sznol, M.8
Parkinson, D.9
Hawkins, M.10
Paradise, C.11
Kunkel, L.12
Rosenberg, S.A.13
-
8
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, ODay SJ, McDermott DF et al.: Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363(8), 711-723 (2010).
-
(2010)
N. Engl. J. Med.
, vol.363
, Issue.8
, pp. 711-723
-
-
Hodi, F.S.1
Oday, S.J.2
McDermott, D.F.3
-
9
-
-
70350647412
-
Tumor immunosuppressive environment: Effects on tumor-specific and nontumor antigen immune responses
-
De Souza AP, Bonorino C: Tumor immunosuppressive environment: effects on tumor-specific and nontumor antigen immune responses. Expert Rev. Anticancer Ther. 9(9), 1317-1332 (2009).
-
(2009)
Expert Rev. Anticancer Ther.
, vol.9
, Issue.9
, pp. 1317-1332
-
-
De Souza, A.P.1
Bonorino, C.2
-
10
-
-
77954951446
-
The polarization of immune cells in the tumour environment by TGFb
-
Flavell RA, Sanjabi S, Wrzesinski SH, Licona-Limon P: The polarization of immune cells in the tumour environment by TGFb. Nat. Rev. Immunol. 10, 554-567 (2010).
-
(2010)
Nat. Rev. Immunol.
, vol.10
, pp. 554-567
-
-
Flavell, R.A.1
Sanjabi, S.2
Wrzesinski, S.H.3
Licona-Limon, P.4
-
11
-
-
20144376844
-
Stat3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effects
-
Burdelya L, Kujawski M, Niu G et al.: STAT3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effects. J. Immunol. 174(7), 3925-3931 (2005). (Pubitemid 40395966)
-
(2005)
Journal of Immunology
, vol.174
, Issue.7
, pp. 3925-3931
-
-
Burdelya, L.1
Kujawski, M.2
Niu, G.3
Zhong, B.4
Wang, T.5
Zhang, S.6
Kortylewski, M.7
Shain, K.8
Kay, H.9
Djeu, J.10
Dalton, W.11
Pardoll, D.12
Wei, S.13
Yu, H.14
-
12
-
-
25444444988
-
Activation of dendritic cells via inhibition of Jak2/STAT3 signaling
-
Nefedova Y, Cheng P, Gilkes D et al.: Activation of dendritic cells via inhibition of JAK2/STAT3 signaling. J. Immunol. 175(7), 4338-4346 (2005). (Pubitemid 41361968)
-
(2005)
Journal of Immunology
, vol.175
, Issue.7
, pp. 4338-4346
-
-
Nefedova, Y.1
Cheng, P.2
Gilkes, D.3
Blaskovich, M.4
Beg, A.A.5
Sebti, S.M.6
Gabrilovich, D.I.7
-
13
-
-
0347364683
-
Hyperactivation of STAT3 is Involved in Abnormal Differentiation of Dendritic Cells in Cancer
-
Nefedova Y, Huang M, Kusmartsev S et al.: Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer. J. Immunol. 172(1), 464-474 (2004). (Pubitemid 38020502)
-
(2004)
Journal of Immunology
, vol.172
, Issue.1
, pp. 464-474
-
-
Nefedova, Y.1
Huang, M.2
Kusmartsev, S.3
Bhattacharya, R.4
Cheng, P.5
Salup, R.6
Jove, R.7
Gabrilovich, D.8
-
14
-
-
33745859743
-
The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells
-
DOI 10.1084/jem.20051848
-
Sumimoto H, Imabayashi F, Iwata T, Kawakami Y: The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells. J. Exp. Med. 203(7), 1651-1656 (2006). (Pubitemid 44036269)
-
(2006)
Journal of Experimental Medicine
, vol.203
, Issue.7
, pp. 1651-1656
-
-
Sumimoto, H.1
Imabayashi, F.2
Iwata, T.3
Kawakami, Y.4
-
15
-
-
77954726255
-
Emerging targeted therapies for breast cancer
-
Alvarez RH, Valero V, Hortobagyi GN: Emerging targeted therapies for breast cancer. J. Clin. Oncol. 28(20), 3366-3379 (2010).
-
(2010)
J. Clin. Oncol.
, vol.28
, Issue.20
, pp. 3366-3379
-
-
Alvarez, R.H.1
Valero, V.2
Hortobagyi, G.N.3
-
16
-
-
65649118222
-
Drug targeting of oncogenic pathways in melanoma
-
Fecher LA, Amaravadi RK, Schuchter LM, Flaherty KT: Drug targeting of oncogenic pathways in melanoma. Hematol. Oncol. Clin. North Am. 23(3), 599-618 (2009).
-
(2009)
Hematol. Oncol. Clin. North Am.
, vol.23
, Issue.3
, pp. 599-618
-
-
Fecher, L.A.1
Amaravadi, R.K.2
Schuchter, L.M.3
Flaherty, K.T.4
-
17
-
-
0024976525
-
Rapamycin for immunosuppression in organ allografting
-
Calne RY, Collier DS, Lim S et al.: Rapamycin for immunosuppression in organ allografting. Lancet 2(8656), 227 (1989).
-
(1989)
Lancet
, vol.2
, Issue.8656
, pp. 227
-
-
Calne, R.Y.1
Collier, D.S.2
Lim, S.3
-
19
-
-
0033104824
-
Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation
-
Powell JD, Lerner CG, Schwartz RH: Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation. J. Immunol. 162(5), 2775-2784 (1999). (Pubitemid 29309302)
-
(1999)
Journal of Immunology
, vol.162
, Issue.5
, pp. 2775-2784
-
-
Powell, J.D.1
Lerner, C.G.2
Schwartz, R.H.3
-
20
-
-
0035889885
-
Antagonistic roles for CTLA-4 and the mammalian target of rapamycin in the regulation of clonal anergy: Enhanced cell cycle progression promotes recall antigen responsiveness
-
Vanasek TL, Khoruts A, Zell T, Mueller DL: Antagonistic roles for CTLA-4 and the mammalian target of rapamycin in the regulation of clonal anergy: enhanced cell cycle progression promotes recall antigen responsiveness. J. Immunol. 167(10), 5636-5644 (2001). (Pubitemid 33062753)
-
(2001)
Journal of Immunology
, vol.167
, Issue.10
, pp. 5636-5644
-
-
Vanasek, T.L.1
Khoruts, A.2
Zell, T.3
Mueller, D.L.4
-
21
-
-
33846909503
-
A role for mammalian target of rapamycin in regulating T cell activation versus anergy
-
Zheng Y, Collins SL, Lutz MA et al.: A role for mammalian target of rapamycin in regulating T-cell activation versus anergy. J. Immunol. 178(4), 2163-2170 (2007). (Pubitemid 46233414)
-
(2007)
Journal of Immunology
, vol.178
, Issue.4
, pp. 2163-2170
-
-
Zheng, Y.1
Coffins, S.L.2
Lutz, M.A.3
Allen, A.N.4
Kole, T.P.5
Zarek, P.E.6
Powell, J.D.7
-
22
-
-
66949173728
-
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
-
Delgoffe GM, Kole TP, Zheng Y et al.: The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 30(6), 832-844 (2009).
-
(2009)
Immunity
, vol.30
, Issue.6
, pp. 832-844
-
-
Delgoffe, G.M.1
Kole, T.P.2
Zheng, Y.3
-
23
-
-
46949088630
-
De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR
-
DOI 10.1189/jlb.1207851
-
Kang J, Huddleston SJ, Fraser JM, Khoruts A: De novo induction of antigen-specific CD4+CD25+foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR. J. Leukoc. Biol. 83(5), 1230-1239 (2008). (Pubitemid 351960355)
-
(2008)
Journal of Leukocyte Biology
, vol.83
, Issue.5
, pp. 1230-1239
-
-
Kang, J.1
Huddleston, S.J.2
Fraser, J.M.3
Khoruts, A.4
-
24
-
-
20444373376
-
Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
-
Battaglia M, Stabilini A, Roncarolo MG: Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood 105(12), 4743-4748 (2005).
-
(2005)
Blood
, vol.105
, Issue.12
, pp. 4743-4748
-
-
Battaglia, M.1
Stabilini, A.2
Roncarolo, M.G.3
-
25
-
-
33845915103
-
+ regulatory T cells cultured with rapamycin
-
Strauss L, Whiteside TL, Knights A, Bergmann C, Knuth A, Zippelius A: Selective survival of naturally occurring human CD4+CD25+FoxP3+ regulatory T cells cultured with rapamycin. J. Immunol. 178(1), 320-329 (2007). (Pubitemid 46033615)
-
(2007)
Journal of Immunology
, vol.178
, Issue.1
, pp. 320-329
-
-
Strauss, L.1
Whiteside, T.L.2
Knights, A.3
Bergmann, C.4
Knuth, A.5
Zippelius, A.6
-
27
-
-
34249805413
-
+ T regulatory cells and promote organ transplant tolerance
-
Turnquist HR, Raimondi G, Zahorchak AF, Fischer RT, Wang Z, Thomson AW: Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific FoxP3+ T regulatory cells and promote organ transplant tolerance. J. Immunol. 178(11), 7018-7031 (2007). (Pubitemid 46847428)
-
(2007)
Journal of Immunology
, vol.178
, Issue.11
, pp. 7018-7031
-
-
Turnquist, H.R.1
Raimondi, G.2
Zahorchak, A.F.3
Fischer, R.T.4
Wang, Z.5
Thomson, A.W.6
-
28
-
-
0036682957
-
Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells
-
DOI 10.1182/blood.V100.3.1084
-
Hackstein H, Taner T, Logar AJ, Thomson AW: Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells. Blood 100(3), 1084-1087 (2002). (Pubitemid 34832646)
-
(2002)
Blood
, vol.100
, Issue.3
, pp. 1084-1087
-
-
Hackstein, H.1
Taner, T.2
Logar, A.J.3
Thomson, A.W.4
-
29
-
-
0038036797
-
Rapamycin inhibits IL-4-induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo
-
DOI 10.1182/blood-2002-11-3370
-
Hackstein H, Taner T, Zahorchak AF et al.: Rapamycin inhibits IL-4 induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo. Blood 101(11), 4457-4463 (2003). (Pubitemid 36857814)
-
(2003)
Blood
, vol.101
, Issue.11
, pp. 4457-4463
-
-
Hackstein, H.1
Taner, T.2
Zahorchak, A.F.3
Morelli, A.E.4
Logar, A.J.5
Gessner, A.6
Thomson, A.W.7
-
30
-
-
0037439786
-
Rapamycin impairs antigen uptake of human dendritic cells
-
DOI 10.1097/00007890-200301150-00025
-
Monti P, Mercalli A, Leone BE, Valerio DC, Allavena P, Piemonti L: Rapamycin impairs antigen uptake of human dendritic cells. Transplantation 75(1), 137-145 (2003). (Pubitemid 36139710)
-
(2003)
Transplantation
, vol.75
, Issue.1
, pp. 137-145
-
-
Monti, P.1
Mercalli, A.2
Eugenio Leone, B.3
Valerio, D.C.4
Allavena, P.5
Piemonti, L.6
-
31
-
-
74649086985
-
The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation
-
Gulen MF, Kang Z, Bulek K et al.: The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity 32(1), 54-66 (2010).
-
(2010)
Immunity
, vol.32
, Issue.1
, pp. 54-66
-
-
Gulen, M.F.1
Kang, Z.2
Bulek, K.3
-
32
-
-
35348852627
-
Distinct signaling mechanisms activate the target of rapamycin in response to different B-cell stimuli
-
DOI 10.1002/eji.200737281
-
Donahue AC, Fruman DA: Distinct signaling mechanisms activate the target of rapamycin in response to different B-cell stimuli. Eur. J. Immunol. 37(10), 2923-2936 (2007). (Pubitemid 47578311)
-
(2007)
European Journal of Immunology
, vol.37
, Issue.10
, pp. 2923-2936
-
-
Donahue, A.C.1
Fruman, D.A.2
-
33
-
-
58149143166
-
Effects of immunosuppressive drugs on purified human B cells: Evidence supporting the use of MMF and rapamycin
-
Heidt S, Roelen DL, Eijsink C, Van Kooten C, Claas FH, Mulder A: Effects of immunosuppressive drugs on purified human B cells: evidence supporting the use of MMF and rapamycin. Transplantation 86(9), 1292-1300 (2008).
-
(2008)
Transplantation
, vol.86
, Issue.9
, pp. 1292-1300
-
-
Heidt, S.1
Roelen, D.L.2
Eijsink, C.3
Van Kooten, C.4
Claas, F.H.5
Mulder, A.6
-
34
-
-
38149136619
-
Rapamycin, but not cyclosporine or fk506, alters natural killer cell function
-
Wai LE, Fujiki M, Takeda S, Martinez OM, Krams SM: Rapamycin, but not cyclosporine or fk506, alters natural killer cell function. Transplantation 85(1), 145-149 (2008).
-
(2008)
Transplantation
, vol.85
, Issue.1
, pp. 145-149
-
-
Wai, L.E.1
Fujiki, M.2
Takeda, S.3
Martinez, O.M.4
Krams, S.M.5
-
35
-
-
0026329354
-
Characterization of the anti-inflammatory effect of FK-506 on human mast cells
-
De Paulis A, Cirillo R, Ciccarelli A, De Crescenzo G, Oriente A, Marone G: Characterization of the anti-inflammatory effect of FK-506 on human mast cells. J. Immunol. 147(12), 4278-4285 (1991).
-
(1991)
J. Immunol.
, vol.147
, Issue.12
, pp. 4278-4285
-
-
De Paulis, A.1
Cirillo, R.2
Ciccarelli, A.3
De Crescenzo, G.4
Oriente, A.5
Marone, G.6
-
36
-
-
50949130076
-
Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced IL-12 production in dendritic cells
-
Ohtani M, Nagai S, Kondo S et al.: Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced IL-12 production in dendritic cells. Blood 112(3), 635-643 (2008).
-
(2008)
Blood
, vol.112
, Issue.3
, pp. 635-643
-
-
Ohtani, M.1
Nagai, S.2
Kondo, S.3
-
37
-
-
54949109311
-
The TSC-mTOR signaling pathway regulates the innate inflammatory response
-
Weichhart T, Costantino G, Poglitsch M et al.: The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity 29(4), 565-577 (2008).
-
(2008)
Immunity
, vol.29
, Issue.4
, pp. 565-577
-
-
Weichhart, T.1
Costantino, G.2
Poglitsch, M.3
-
38
-
-
74649085700
-
The mTOR kinase determines effector versus memory CD8+ T-cell fate by regulating the expression of transcription factors T-bet and eomesodermin
-
Rao RR, Li Q, Odunsi K, Shrikant PA: The mTOR kinase determines effector versus memory CD8+ T-cell fate by regulating the expression of transcription factors T-bet and eomesodermin. Immunity 32(1), 67-78 (2010).
-
(2010)
Immunity
, vol.32
, Issue.1
, pp. 67-78
-
-
Rao, R.R.1
Li, Q.2
Odunsi, K.3
Shrikant, P.A.4
-
39
-
-
39549116503
-
PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation
-
DOI 10.1084/jem.20070763
-
Guiducci C, Ghirelli C, Marloie-Provost MA et al.: PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation. J. Exp. Med. 205(2), 315-322 (2008). (Pubitemid 351281597)
-
(2008)
Journal of Experimental Medicine
, vol.205
, Issue.2
, pp. 315-322
-
-
Guiducci, C.1
Ghirelli, C.2
Marloie-Provost, M.-A.3
Matray, T.4
Coffman, R.L.5
Liu, Y.-J.6
Barrat, F.J.7
Soumelis, V.8
-
40
-
-
22544445221
-
Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-κB activation and IFN-β synthesis downstream of Toll-like receptor 3 and 4
-
DOI 10.1002/eji.200425801
-
Aksoy E, Vanden Berghe W, Detienne S et al.: Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kB activation and IFN-b synthesis downstream of Toll-like receptor 3 and 4. Eur. J. Immunol. 35(7), 2200-2209 (2005). (Pubitemid 41015059)
-
(2005)
European Journal of Immunology
, vol.35
, Issue.7
, pp. 2200-2209
-
-
Aksoy, E.1
Berghe, W.V.2
Detienne, S.3
Amraoui, Z.4
Fitzgerald, K.A.5
Haegemann, G.6
Goldman, M.7
Willems, F.8
-
41
-
-
0036707521
-
PI3K-mediated negative feedback regulation of IL-12 production in DCs
-
Fukao T, Tanabe M, Terauchi Y et al.: PI3K-mediated negative feedback regulation of IL-12 production in DCs. Nat. Immunol. 3(9), 875-881 (2002).
-
(2002)
Nat. Immunol.
, vol.3
, Issue.9
, pp. 875-881
-
-
Fukao, T.1
Tanabe, M.2
Terauchi, Y.3
-
42
-
-
0037199972
-
The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells
-
DOI 10.1074/jbc.M203298200
-
Guha M, Mackman N: The phosphatidylinositol 3-kinase-AKT pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J. Biol. Chem. 277(35), 32124-32132 (2002). (Pubitemid 34969025)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.35
, pp. 32124-32132
-
-
Guha, M.1
Mackman, N.2
-
43
-
-
0346103719
-
Modulation of the Phosphoinositide 3-Kinase Pathway Alters Innate Resistance to Polymicrobial Sepsis
-
Williams DL, Li C, Ha T et al.: Modulation of the phosphoinositide 3-kinase pathway alters innate resistance to polymicrobial sepsis. J. Immunol. 172(1), 449-456 (2004). (Pubitemid 38020500)
-
(2004)
Journal of Immunology
, vol.172
, Issue.1
, pp. 449-456
-
-
Williams, D.L.1
Li, C.2
Ha, T.3
Ozment-Skelton, T.4
Kalbfleisch, J.H.5
Preiszner, J.6
Brooks, L.7
Breuel, K.8
Schweitzer, J.B.9
-
44
-
-
34250803183
-
Role of phosphatidylinositol-3 kinase in transcriptional regulation of TLR-induced IL-12 and IL-10 by Fcγ receptor ligation in murine macrophages
-
Polumuri SK, Toshchakov VY, Vogel SN: Role of phosphatidylinositol-3 kinase in transcriptional regulation of TLR-induced IL-12 and IL-10 by Fc g receptor ligation in murine macrophages. J. Immunol. 179(1), 236-246 (2007). (Pubitemid 46986539)
-
(2007)
Journal of Immunology
, vol.179
, Issue.1
, pp. 236-246
-
-
Polumuri, S.K.1
Toshchakov, V.Y.2
Vogel, S.N.3
-
45
-
-
0035869634
-
A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-α, and contact sensitizers
-
Arrighi JF, Rebsamen M, Rousset F, Kindler V, Hauser C: A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-a, and contact sensitizers. J. Immunol. 166(6), 3837-3845 (2001). (Pubitemid 32224909)
-
(2001)
Journal of Immunology
, vol.166
, Issue.6
, pp. 3837-3845
-
-
Arrighi, J.-F.1
Rebsamen, M.2
Rousset, F.3
Kindler, V.4
Hauser, C.5
-
46
-
-
0033118982
-
Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice
-
Lu HT, Yang DD, Wysk M et al.: Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (MKK3)-deficient mice. EMBO J. 18(7), 1845-1857 (1999). (Pubitemid 29158528)
-
(1999)
EMBO Journal
, vol.18
, Issue.7
, pp. 1845-1857
-
-
Lu, H.-T.1
Yang, D.D.2
Wysk, M.3
Gatti, E.4
Mellman, I.5
Davis, R.J.6
Flavell, R.A.7
-
47
-
-
0035022325
-
Effective antigen presentation by dendritic cells is NF-κB dependent: Coordinate regulation of MHC, co-stimulatory molecules and cytokines
-
Yoshimura S, Bondeson J, Foxwell BM, Brennan FM, Feldmann M: Effective antigen presentation by dendritic cells is NF-kB dependent: coordinate regulation of MHC, costimulatory molecules and cytokines. Int. Immunol. 13(5), 675-683 (2001). (Pubitemid 32427870)
-
(2001)
International Immunology
, vol.13
, Issue.5
, pp. 675-683
-
-
Yoshimura, S.1
Bondeson, J.2
Foxwell, B.M.J.3
Brennan, F.M.4
Feldmann, M.5
-
48
-
-
0035496927
-
Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells
-
Puig-Kroger A, Relloso M, Fernandez-Capetillo O et al.: Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells. Blood 98(7), 2175-2182 (2001).
-
(2001)
Blood
, vol.98
, Issue.7
, pp. 2175-2182
-
-
Puig-Kroger, A.1
Relloso, M.2
Fernandez-Capetillo, O.3
-
49
-
-
33646470960
-
Erk1-/- mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis
-
Agrawal A, Dillon S, Denning TL, Pulendran B: Erk1-/- mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis. J. Immunol. 176(10), 5788-5796 (2006).
-
(2006)
J. Immunol.
, vol.176
, Issue.10
, pp. 5788-5796
-
-
Agrawal, A.1
Dillon, S.2
Denning, T.L.3
Pulendran, B.4
-
50
-
-
0033120111
-
Extracellular signal-regulated kinase, stress-activated protein kinase/c-Jun N-terminal kinase, and p38(mapk) are involved in IL-10-mediated selective repression of TNF-α-induced activation and maturation of human peripheral blood monocyte-derived dendritic cells
-
Sato K, Nagayama H, Tadokoro K, Juji T, Takahashi TA: Extracellular signal-regulated kinase, stress-activated protein kinase/c-Jun N-terminal kinase, and p38MAPK are involved in IL-10-mediated selective repression of TNF-a-induced activation and maturation of human peripheral blood monocyte-derived dendritic cells. J. Immunol. 162(7), 3865-3872 (1999). (Pubitemid 29314764)
-
(1999)
Journal of Immunology
, vol.162
, Issue.7
, pp. 3865-3872
-
-
Sato, K.1
Nagayama, H.2
Tadokoro, K.3
Juji, T.4
Takahashi, T.A.5
-
51
-
-
0034254811
-
The PI3 kinase, p38 SAP kinase, and NF-κb signal transduction pathways are involved in the survival and maturation of lipopolysaccharide- stimulated human monocyte-derived dendritic cells
-
Ardeshna KM, Pizzey AR, Devereux S, Khwaja A: The PI3 kinase, p38 sap kinase, and NF-kB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells. Blood 96(3), 1039-1046 (2000). (Pubitemid 30616871)
-
(2000)
Blood
, vol.96
, Issue.3
, pp. 1039-1046
-
-
Ardeshna, K.M.1
Pizzey, A.R.2
Devereux, S.3
Khwaja, A.4
-
52
-
-
42449157639
-
Targeting dendritic cell signaling to regulate the response to immunization
-
Escors D, Lopes L, Lin R et al.: Targeting dendritic cell signaling to regulate the response to immunization. Blood 111(6), 3050-3061 (2008).
-
(2008)
Blood
, vol.111
, Issue.6
, pp. 3050-3061
-
-
Escors, D.1
Lopes, L.2
Lin, R.3
-
54
-
-
0028859281
-
Selective requirement for MAP kinase activation in thymocyte differentiation
-
Alberola-Ila J, Forbush KA, Seger R, Krebs EG, Perlmutter RM: Selective requirement for MAP kinase activation in thymocyte differentiation. Nature 373(6515), 620-623 (1995).
-
(1995)
Nature
, vol.373
, Issue.6515
, pp. 620-623
-
-
Alberola-Ila, J.1
Forbush, K.A.2
Seger, R.3
Krebs, E.G.4
Perlmutter, R.M.5
-
55
-
-
0037338890
-
TCR ligand discrimination is enforced by competing ERK positive and SHP-I negative feedback pathways
-
DOI 10.1038/ni895
-
Stefanova I, Hemmer B, Vergelli M, Martin R, Biddison WE, Germain RN: TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways. Nat. Immunol. 4(3), 248-254 (2003). (Pubitemid 36322134)
-
(2003)
Nature Immunology
, vol.4
, Issue.3
, pp. 248-254
-
-
Stefanova, I.1
Hemmer, B.2
Vergelli, M.3
Martin, R.4
Biddison, W.E.5
Germain, R.N.6
-
56
-
-
77949901838
-
Pharmacologic inhibition of MEK-ERK signaling enhances Th17 differentiation
-
Tan AH, Lam KP: Pharmacologic inhibition of MEK-ERK signaling enhances Th17 differentiation. J. Immunol. 184(4), 1849-1857 (2010).
-
(2010)
J. Immunol.
, vol.184
, Issue.4
, pp. 1849-1857
-
-
Tan, A.H.1
Lam, K.P.2
-
57
-
-
14644440555
-
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
-
DOI 10.1200/JCO.2005.06.081
-
Hicklin DJ, Ellis LM: Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J. Clin. Oncol. 23(5), 1011-1027 (2005). (Pubitemid 46202320)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.5
, pp. 1011-1027
-
-
Hicklin, D.J.1
Ellis, L.M.2
-
58
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
Forsythe JA, Jiang BH, Iyer NV et al.: Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell Biol. 16(9), 4604-4613 (1996). (Pubitemid 26272112)
-
(1996)
Molecular and Cellular Biology
, vol.16
, Issue.9
, pp. 4604-4613
-
-
Forsythe, J.A.1
Jiang, B.-H.2
Iyer, N.V.3
Agani, F.4
Leung, S.W.5
Koos, R.D.6
Semenza, G.L.7
-
59
-
-
34547630698
-
Tumor angiogenesis: Cause or consequence of cancer?
-
DOI 10.1158/0008-5472.CAN-07-2053
-
Shchors K, Evan G: Tumor angiogenesis: cause or consequence of cancer? Cancer Res. 67(15), 7059-7061 (2007). (Pubitemid 47206529)
-
(2007)
Cancer Research
, vol.67
, Issue.15
, pp. 7059-7061
-
-
Shchors, K.1
Evan, G.2
-
60
-
-
7944224442
-
Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
-
DOI 10.1016/j.ccr.2004.09.026, PII S1535610804003022
-
Tang N, Wang L, Esko J et al.: Loss of HIF-1a in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 6(5), 485-495 (2004). (Pubitemid 39469984)
-
(2004)
Cancer Cell
, vol.6
, Issue.5
, pp. 485-495
-
-
Tang, N.1
Wang, L.2
Esko, J.3
Giordano, F.J.4
Huang, Y.5
Gerber, H.-P.6
Ferrara, N.7
Johnson, R.S.8
-
61
-
-
0030498734
-
Angiogenesis and metastasis
-
Ellis LM, Fidler IJ: Angiogenesis and metastasis. Eur. J. Cancer 32A(14), 2451-2460 (1996).
-
(1996)
Eur. J. Cancer
, vol.32 A
, Issue.14
, pp. 2451-2460
-
-
Ellis, L.M.1
Fidler, I.J.2
-
62
-
-
0032400862
-
Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo
-
Gabrilovich D, Ishida T, Oyama T et al.: Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo. Blood 92(11), 4150-4166 (1998). (Pubitemid 28544331)
-
(1998)
Blood
, vol.92
, Issue.11
, pp. 4150-4166
-
-
Gabrilovich, D.1
Ishida, T.2
Oyama, T.3
Ran, S.4
Kravtsov, V.5
Nadaf, S.6
Carbone, D.P.7
-
63
-
-
0029842830
-
Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells
-
DOI 10.1038/nm1096-1096
-
Gabrilovich DI, Chen HL, Girgis KR et al.: Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat. Med. 2(10), 1096-1103 (1996). (Pubitemid 26338628)
-
(1996)
Nature Medicine
, vol.2
, Issue.10
, pp. 1096-1103
-
-
Gabrilovich, D.I.1
Chen, H.L.2
Girgis, K.R.3
Cunningham, H.T.4
Meny, G.M.5
Nadaf, S.6
Kavanaugh, D.7
Carbone, D.P.8
-
64
-
-
61349100687
-
Myeloid-derived suppressor cells as regulators of the immune system
-
Gabrilovich DI, Nagaraj S: Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol. 9(3), 162-174 (2009).
-
(2009)
Nat. Rev. Immunol.
, vol.9
, Issue.3
, pp. 162-174
-
-
Gabrilovich, D.I.1
Nagaraj, S.2
-
65
-
-
0032741283
-
Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function
-
Gabrilovich DI, Ishida T, Nadaf S, Ohm JE, Carbone DP: Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. Clin. Cancer Res. 5(10), 2963-2970 (1999). (Pubitemid 29493976)
-
(1999)
Clinical Cancer Research
, vol.5
, Issue.10
, pp. 2963-2970
-
-
Gabrilovich, D.I.1
Ishida, T.2
Nadaf, S.3
Ohm, J.E.4
Carbone, D.P.5
-
66
-
-
27644590410
-
Tumour-associated macrophage infiltration, neovascularization and aggressiveness in malignant melanoma: Role of monocyte chemotactic protein-1 and vascular endothelial growth factor-A
-
DOI 10.1097/00008390-200510000-00010
-
Varney ML, Johansson SL, Singh RK: Tumour-associated macrophage infiltration, neovascularization and aggressiveness in malignant melanoma: role of monocyte chemotactic protein-1 and vascular endothelial growth factor-a. Melanoma Res. 15(5), 417-425 (2005). (Pubitemid 41558952)
-
(2005)
Melanoma Research
, vol.15
, Issue.5
, pp. 417-425
-
-
Varney, M.L.1
Johansson, S.L.2
Singh, R.K.3
-
67
-
-
0033903714
-
Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer
-
Ueno T, Toi M, Saji H et al.: Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer. Clin. Cancer Res. 6(8), 3282-3289 (2000). (Pubitemid 30637758)
-
(2000)
Clinical Cancer Research
, vol.6
, Issue.8
, pp. 3282-3289
-
-
Ueno, T.1
Toi, M.2
Saji, H.3
Muta, M.4
Bando, H.5
Kuroi, K.6
Koike, M.7
Inadera, H.8
Matsushima, K.9
-
68
-
-
70350728931
-
Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation
-
Solinas G, Germano G, Mantovani A, Allavena P: Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J. Leukoc. Biol. 86(5), 1065-1073 (2009).
-
(2009)
J. Leukoc. Biol.
, vol.86
, Issue.5
, pp. 1065-1073
-
-
Solinas, G.1
Germano, G.2
Mantovani, A.3
Allavena, P.4
-
69
-
-
19944422061
-
A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
-
DOI 10.1056/NEJMoa041588
-
Paik S, Shak S, Tang G et al.: A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N. Engl. J. Med. 351(27), 2817-2826 (2004). (Pubitemid 40051905)
-
(2004)
New England Journal of Medicine
, vol.351
, Issue.27
, pp. 2817-2826
-
-
Paik, S.1
Shak, S.2
Tang, G.3
Kim, C.4
Baker, J.5
Cronin, M.6
Baehner, F.L.7
Walker, M.G.8
Watson, D.9
Park, T.10
Hiller, W.11
Fisher, E.R.12
Wickerham, D.L.13
Bryant, J.14
Wolmark, N.15
-
70
-
-
0037777538
-
VEGF inhibits T-cell development and may contribute to tumor-induced immune suppression
-
Ohm JE, Gabrilovich DI, Sempowski GD et al.: VEGF inhibits T-cell development and may contribute to tumor-induced immune suppression. Blood 101(12), 4878-4886 (2003). (Pubitemid 36857749)
-
(2003)
Blood
, vol.101
, Issue.12
, pp. 4878-4886
-
-
Ohm, J.E.1
Gabrilovich, D.I.2
Sempowski, G.D.3
Kisseleva, E.4
Parman, K.S.5
Nadaf, S.6
Carbone, D.P.7
-
71
-
-
33845343558
-
Vascular endothelial growth factor blockade reduces intratumoral regulatory T cells and enhances the efficacy of a GM-CSF-secreting cancer immunotherapy
-
DOI 10.1158/1078-0432.CCR-06-1558
-
Li B, Lalani AS, Harding TC et al.: Vascular endothelial growth factor blockade reduces intratumoral regulatory T cells and enhances the efficacy of a GM-CSF-secreting cancer immunotherapy. Clin. Cancer Res. 12(22), 6808-6816 (2006). (Pubitemid 44876851)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.22
, pp. 6808-6816
-
-
Li, B.1
Lalani, A.S.2
Harding, T.C.3
Luan, B.4
Koprivnikar, K.5
Guang, H.T.6
Prell, R.7
VanRoey, M.J.8
Simmons, A.D.9
Jooss, K.10
-
72
-
-
34547106845
-
Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF
-
DOI 10.1182/blood-2007-01-065714
-
Huang Y, Chen X, Dikov Mm et al.: Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF. Blood 110(2), 624-631 (2007). (Pubitemid 47105401)
-
(2007)
Blood
, vol.110
, Issue.2
, pp. 624-631
-
-
Huang, Y.1
Chen, X.2
Dikov, M.M.3
Novitskiy, S.V.4
Mosse, C.A.5
Yang, L.6
Carbone, D.P.7
-
73
-
-
34548125294
-
Vascular endothelial growth factor-trap overcomes defects in dendritic cell differentiation but does not improve antigen-specific immune responses
-
DOI 10.1158/1078-0432.CCR-07-0409
-
Fricke I, Mirza N, Dupont J et al.: Vascular endothelial growth factor-TRAP overcomes defects in dendritic cell differentiation but does not improve antigen-specific immune responses. Clin. Cancer Res. 13(16), 4840-4848 (2007). (Pubitemid 47298146)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.16
, pp. 4840-4848
-
-
Fricke, I.1
Mirza, N.2
Dupont, J.3
Lockhart, C.4
Jackson, A.5
Lee, J.-H.6
Sosman, J.A.7
Gabrilovich, D.I.8
-
74
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
DOI 10.1056/NEJMoa060655
-
Escudier B, Eisen T, Stadler WM et al.: Sorafenib in advanced clear-cell renal-cell carcinoma. N. Engl. J. Med. 356(2), 125-134 (2007). (Pubitemid 46089673)
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.2
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
Szczylik, C.4
Oudard, S.5
Siebels, M.6
Negrier, S.7
Chevreau, C.8
Solska, E.9
Desai, A.A.10
Rolland, F.11
Demkow, T.12
Hutson, T.E.13
Gore, M.14
Freeman, S.15
Schwartz, B.16
Shan, M.17
Simantov, R.18
Bukowski, R.M.19
-
75
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet JM, Ricci S, Mazzaferro V et al.: Sorafenib in advanced hepatocellular carcinoma. N. Engl. J. Med. 359(4), 378-390 (2008).
-
(2008)
N. Engl. J. Med.
, vol.359
, Issue.4
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
-
76
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
DOI 10.1056/NEJMoa065044
-
Motzer RJ, Hutson TE, Tomczak P et al.: Sunitinib versus interferon-a in metastatic renal-cell carcinoma. N. Engl. J. Med. 356(2), 115-124 (2007). (Pubitemid 46089672)
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.2
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
Michaelson, D.4
Bukowski, R.M.5
Rixe, O.6
Oudard, S.7
Negrier, S.8
Szczylik, C.9
Kim, S.T.10
Chen, I.11
Bycott, P.W.12
Baum, C.M.13
Figlin, R.A.14
-
77
-
-
77953930730
-
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
-
Maemondo M, Inoue A, Kobayashi K et al.: Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N. Engl. J. Med. 362(25), 2380-2388 (2010).
-
(2010)
N. Engl. J. Med.
, vol.362
, Issue.25
, pp. 2380-2388
-
-
Maemondo, M.1
Inoue, A.2
Kobayashi, K.3
-
78
-
-
42949128595
-
Major response to imatinib mesylate in KIT-mutated melanoma
-
Hodi FS, Friedlander P, Corless CL et al.: Major response to imatinib mesylate in KIT-mutated melanoma. J. Clin. Oncol. 26(12), 2046-2051 (2008).
-
(2008)
J. Clin. Oncol.
, vol.26
, Issue.12
, pp. 2046-2051
-
-
Hodi, F.S.1
Friedlander, P.2
Corless, C.L.3
-
79
-
-
47249099056
-
Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation
-
DOI 10.1111/j.1755-148X.2008.00475.x
-
Lutzky J, Bauer J, Bastian BC: Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation. Pigment Cell Melanoma Res. 21(4), 492-493 (2008). (Pubitemid 351990966)
-
(2008)
Pigment Cell and Melanoma Research
, vol.21
, Issue.4
, pp. 492-493
-
-
Lutzky, J.1
Bauer, J.2
Bastian, B.C.3
-
80
-
-
33746418579
-
+ and normal monocyte-derived dendritic cells but strongly inhibits T cell expansion despite reciprocal dendritic cell-T cell activation
-
DOI 10.1189/jlb.0705419
-
Boissel N, Rousselot P, Raffoux E et al.: Imatinib mesylate minimally affects BCR-ABL+ and normal monocyte-derived dendritic cells but strongly inhibits T-cell expansion despite reciprocal dendritic cell-T cell activation. J. Leukoc. Biol. 79(4), 747-756 (2006). (Pubitemid 44835607)
-
(2006)
Journal of Leukocyte Biology
, vol.79
, Issue.4
, pp. 747-756
-
-
Boissel, N.1
Rousselot, P.2
Raffoux, E.3
Cayuela, J.-M.4
Soulier, J.5
Mooney, N.6
Charron, D.7
Dombret, H.8
Toubert, A.9
Rea, D.10
-
81
-
-
3843119865
-
Imatinib mesylate inhibits T-cell proliferation in vitro and delayed-type hypersensitivity in vivo
-
DOI 10.1182/blood-2003-12-4266
-
Dietz AB, Souan L, Knutson GJ, Bulur PA, Litzow MR, Vuk-Pavlovic S: Imatinib mesylate inhibits T-cell proliferation in vitro and delayed-type hypersensitivity in vivo. Blood 104(4), 1094-1099 (2004). (Pubitemid 39038030)
-
(2004)
Blood
, vol.104
, Issue.4
, pp. 1094-1099
-
-
Dietz, A.B.1
Souan, L.2
Knutson, G.J.3
Bulur, P.A.4
Litzow, M.R.5
Vuk-Pavlovic, S.6
-
82
-
-
4344597828
-
Imatinib inhibits the activation and proliferation of normal T lymphocytes in vitro
-
DOI 10.1038/sj.leu.2403401
-
Cwynarski K, Laylor R, Macchiarulo E et al.: Imatinib inhibits the activation and proliferation of normal T lymphocytes in vitro. Leukemia 18(8), 1332-1339 (2004). (Pubitemid 39136740)
-
(2004)
Leukemia
, vol.18
, Issue.8
, pp. 1332-1339
-
-
Cwynarksi, K.1
Laylor, R.2
Macchiarulo, E.3
Goldman, J.4
Lombardi, G.5
Melo, J.V.6
Dazzi, F.7
-
83
-
-
15244351682
-
Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner
-
DOI 10.1182/blood-2004-07-2527
-
Seggewiss R, Lore K, Greiner E et al.: Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner. Blood 105(6), 2473-2479 (2005). (Pubitemid 40387048)
-
(2005)
Blood
, vol.105
, Issue.6
, pp. 2473-2479
-
-
Seggewiss, R.1
Lore, K.2
Greiner, E.3
Magnusson, M.K.4
Price, D.A.5
Douek, D.C.6
Dunbar, C.E.7
Wiestner, A.8
-
84
-
-
33751167425
-
Imatinib mesylate selectively impairs expansion of memory cytotoxic T cells without affecting the control of primary viral infections
-
Mumprecht S, Matter M, Pavelic V, Ochsenbein AF: Imatinib mesylate selectively impairs expansion of memory cytotoxic T cells without affecting the control of primary viral infections. Blood 108(10), 3406-3413 (2006).
-
(2006)
Blood
, vol.108
, Issue.10
, pp. 3406-3413
-
-
Mumprecht, S.1
Matter, M.2
Pavelic, V.3
Ochsenbein, A.F.4
-
85
-
-
0037341414
-
Development of Varicella-Zoster virus infection in patients with chronic myelogenous leukemia treated with imatinib mesylate
-
Mattiuzzi GN, Cortes JE, Talpaz M et al.: Development of varicella-zoster virus infection in patients with chronic myelogenous leukemia treated with imatinib mesylate. Clin. Cancer Res. 9(3), 976-980 (2003). (Pubitemid 36323700)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.3
, pp. 976-980
-
-
Mattiuzzi, G.N.1
Cortes, J.E.2
Talpaz, M.3
Reuben, J.4
Rios, M.B.5
Shan, J.6
Kontoyiannis, D.7
Giles, F.J.8
Raad, I.9
Verstovsek, S.10
Ferrajoli, A.11
Kantarjian, H.M.12
-
86
-
-
27644449731
-
Imatinib mesylate suppresses cytokine synthesis by activated CD4 T cells of patients with chronic myelogenous leukemia
-
DOI 10.1038/sj.leu.2403933, PII 2403933
-
Gao H, Lee BN, Talpaz M et al.: Imatinib mesylate suppresses cytokine synthesis by activated CD4 T cells of patients with chronic myelogenous leukemia. Leukemia 19(11), 1905-1911 (2005). (Pubitemid 41553998)
-
(2005)
Leukemia
, vol.19
, Issue.11
, pp. 1905-1911
-
-
Gao, H.1
Lee, B.-N.2
Talpaz, M.3
Donato, N.J.4
Cortes, J.E.5
Kantarjian, H.M.6
Reuben, J.M.7
-
87
-
-
3342956520
-
Requirement for Abl kinases in T cell receptor signaling
-
DOI 10.1016/j.cub.2004.07.021, PII S0960982204005196
-
Zipfel PA, Zhang W, Quiroz M, Pendergast AM: Requirement for ABL kinases in T cell receptor signaling. Curr. Biol. 14(14), 1222-1231 (2004). (Pubitemid 38991808)
-
(2004)
Current Biology
, vol.14
, Issue.14
, pp. 1222-1231
-
-
Zipfel, P.A.1
Zhang, W.2
Quiroz, M.3
Pendergast, A.M.4
-
88
-
-
58149187113
-
Imatinib mesylate inhibits CD4+ CD25+ regulatory T-cell activity and enhances active immunotherapy against BCR-ABL-tumors
-
Larmonier N, Janikashvili N, Lacasse CJ et al.: Imatinib mesylate inhibits CD4+ CD25+ regulatory T-cell activity and enhances active immunotherapy against BCR-ABL-tumors. J. Immunol. 181(10), 6955-6963 (2008).
-
(2008)
J. Immunol.
, vol.181
, Issue.10
, pp. 6955-6963
-
-
Larmonier, N.1
Janikashvili, N.2
Lacasse, C.J.3
-
89
-
-
12144288429
-
Critical Role for Kit-mediated Src Kinase but Not PI 3-Kinase Signaling in Pro T and Pro B Cell Development
-
DOI 10.1084/jem.20031983
-
Agosti V, Corbacioglu S, Ehlers I et al.: Critical role for KIT-mediated Src kinase but not PI 3-kinase signaling in pro T- and pro B-cell development. J. Exp. Med. 199(6), 867-878 (2004). (Pubitemid 38375206)
-
(2004)
Journal of Experimental Medicine
, vol.199
, Issue.6
, pp. 867-878
-
-
Agosti, V.1
Corbacioglu, S.2
Ehlers, I.3
Waskow, C.4
Sommer, G.5
Berrozpe, G.6
Kissel, H.7
Tucker, C.M.8
Manova, K.9
Moore, M.A.S.10
Rodewald, H.-R.11
Besmer, P.12
-
90
-
-
45749101780
-
Development and dynamics of robust T-cell responses to CML under imatinib treatment
-
Chen CI, Maecker HT, Lee PP: Development and dynamics of robust T-cell responses to CML under imatinib treatment. Blood 111(11), 5342-5349 (2008).
-
(2008)
Blood
, vol.111
, Issue.11
, pp. 5342-5349
-
-
Chen, C.I.1
Maecker, H.T.2
Lee, P.P.3
-
91
-
-
3042802079
-
+ peripheral blood progenitor cells
-
DOI 10.1182/blood-2003-03-0975
-
Appel S, Boehmler AM, Grunebach F et al.: Imatinib mesylate affects the development and function of dendritic cells generated from CD34+ peripheral blood progenitor cells. Blood 103(2), 538-544 (2004). (Pubitemid 38140084)
-
(2004)
Blood
, vol.103
, Issue.2
, pp. 538-544
-
-
Appel, S.1
Boehmler, A.M.2
Grunebach, F.3
Muller, M.R.4
Rupf, A.5
Weck, M.M.6
Hartmann, U.7
Reichardt, V.L.8
Kanz, L.9
Brummendorf, T.H.10
Brossart, P.11
-
92
-
-
16344368251
-
Effects of imatinib on monocyte-derived dendritic cells are mediated by inhibition of nuclear factor-κB and Akt signaling pathways
-
DOI 10.1158/1078-0432.CCR-04-1713
-
Appel S, Rupf A, Weck Mm et al.: Effects of imatinib on monocyte-derived dendritic cells are mediated by inhibition of nuclear factor-kB and Akt signaling pathways. Clin. Cancer Res. 11(5), 1928-1940 (2005). (Pubitemid 40471859)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.5
, pp. 1928-1940
-
-
Appel, S.1
Rupf, A.2
Weck, M.M.3
Schoor, O.4
Brummendorf, T.H.5
Weinschenk, T.6
Grunebach, F.7
Brossart, P.8
-
93
-
-
2942625414
-
Imatinib and plasmacytoid dendritic cell function in patients with chronic myeloid leukemia
-
DOI 10.1182/blood-2003-09-3220
-
Mohty M, Jourdan E, Mami NB et al.: Imatinib and plasmacytoid dendritic cell function in patients with chronic myeloid leukemia. Blood 103(12), 4666-4668 (2004). (Pubitemid 38746000)
-
(2004)
Blood
, vol.103
, Issue.12
, pp. 4666-4668
-
-
Mohty, M.1
Jourdan, E.2
Mami, N.B.3
Vey, N.4
Damaj, G.5
Blaise, D.6
Isnardon, D.7
Olive, D.8
Gaugler, B.9
-
94
-
-
1442331705
-
Imatinib mesylate impairs Flt3L-mediated dendritic cell expansion and antitumor effects in vivo [2] (multiple letters)
-
DOI 10.1182/blood-2003-10-3475
-
Taieb J, Maruyama K, Borg C, Terme M, Zitvogel L: Imatinib mesylate impairs Flt3L-mediated dendritic cell expansion and antitumor effects in vivo. Blood 103(5), 1966-1967; author reply 1967 (2004). (Pubitemid 38269001)
-
(2004)
Blood
, vol.103
, Issue.5
, pp. 1966-1967
-
-
Taieb, J.1
Maruyama, K.2
Borg, C.3
Terme, M.4
Zitvogel, L.5
Appel, S.6
Brossart, P.7
-
95
-
-
12844265929
-
+ T-cell tolerance
-
DOI 10.1182/blood-2004-01-0027
-
Wang H, Cheng F, Cuenca A et al.: Imatinib mesylate (STI-571) enhances antigen-presenting cell function and overcomes tumor-induced CD4+ T-cell tolerance. Blood 105(3), 1135-1143 (2005). (Pubitemid 40170886)
-
(2005)
Blood
, vol.105
, Issue.3
, pp. 1135-1143
-
-
Wang, H.1
Cheng, F.2
Cuenca, A.3
Horna, P.4
Zheng, Z.5
Bhalla, K.6
Sotomayor, E.M.7
-
96
-
-
33747610930
-
Imatinib mesylate does not impair the immunogenicity of human myeloid blood dendritic cells [7]
-
DOI 10.1038/sj.leu.2404315, PII 2404315
-
Wehner R, Wendisch M, Schakel K et al.: Imatinib mesylate does not impair the immunogenicity of human myeloid blood dendritic cells. Leukemia 20(9), 1629-1632 (2006). (Pubitemid 44264112)
-
(2006)
Leukemia
, vol.20
, Issue.9
, pp. 1629-1632
-
-
Wehner, R.1
Wendisch, M.2
Schakel, K.3
Bornhauser, M.4
Platzbecker, U.5
Mohr, B.6
Temme, A.7
Bachmann, M.8
Rieber, E.P.9
Schmitz, M.10
-
97
-
-
4043134677
-
Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects
-
DOI 10.1172/JCI200421102
-
Borg C, Terme M, Taieb J et al.: Novel mode of action of c-KIT tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects. J. Clin. Invest. 114(3), 379-388 (2004). (Pubitemid 39071610)
-
(2004)
Journal of Clinical Investigation
, vol.114
, Issue.3
, pp. 379-388
-
-
Borg, C.1
Terme, M.2
Taieb, J.3
Menard, C.4
Flament, C.5
Robert, C.6
Maruyama, K.7
Wakasugi, H.8
Angevin, E.9
Thielemans, K.10
Le Cesne, A.11
Chung-Scott, V.12
Lazar, V.13
Tchou, I.14
Crepineau, F.15
Lemoine, F.16
Bernard, J.17
Fletcher, J.A.18
Turhan, A.19
Blay, J.-Y.20
Spatz, A.21
Emile, J.-F.22
Heinrich, M.C.23
Mecheri, S.24
Tursz, T.25
Zitvogel, L.26
more..
-
98
-
-
45549107384
-
The critical role of IL-15 in the antitumor effects mediated by the combination therapy imatinib and IL-2
-
Mignot G, Ullrich E, Bonmort M et al.: The critical role of IL-15 in the antitumor effects mediated by the combination therapy imatinib and IL-2. J. Immunol. 180(10), 6477-6483 (2008).
-
(2008)
J. Immunol.
, vol.180
, Issue.10
, pp. 6477-6483
-
-
Mignot, G.1
Ullrich, E.2
Bonmort, M.3
-
99
-
-
33646858146
-
Imatinib mesylate - Uncovering a fast track to adaptive immunity
-
Smyth MJ: Imatinib mesylate - uncovering a fast track to adaptive immunity. N. Engl. J. Med. 354(21), 2282-2284 (2006).
-
(2006)
N. Engl. J. Med.
, vol.354
, Issue.21
, pp. 2282-2284
-
-
Smyth, M.J.1
-
100
-
-
77954753261
-
Anti-inflammatory M2 type macrophages characterize metastasized and tyrosine kinase inhibitor-treated gastrointestinal stromal tumors
-
Van Dongen M, Savage ND, Jordanova ES et al.: Anti-inflammatory M2 type macrophages characterize metastasized and tyrosine kinase inhibitor-treated gastrointestinal stromal tumors. Int. J. Cancer 127(4), 899-909 (2010).
-
(2010)
Int. J. Cancer
, vol.127
, Issue.4
, pp. 899-909
-
-
Van Dongen, M.1
Savage, N.D.2
Jordanova, E.S.3
-
101
-
-
40949118437
-
Temsirolimus, an inhibitor of mammalian target of rapamycin
-
Rini Bi: Temsirolimus, an inhibitor of mammalian target of rapamycin. Clin. Cancer Res. 14(5), 1286-1290 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, Issue.5
, pp. 1286-1290
-
-
Bi, R.1
-
102
-
-
33644747449
-
BAY 43-9006 inhibition of oncogenic RET mutants
-
DOI 10.1093/jnci/djj069
-
Carlomagno F, Anaganti S, Guida T et al.: Bay 43-9006 inhibition of oncogenic RET mutants. J. Natl Cancer Inst. 98(5), 326-334 (2006). (Pubitemid 43338212)
-
(2006)
Journal of the National Cancer Institute
, vol.98
, Issue.5
, pp. 326-334
-
-
Carlomagno, F.1
Anaganti, S.2
Guida, T.3
Salvatore, G.4
Troncone, G.5
Wilhelm, S.M.6
Santoro, M.7
-
103
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
DOI 10.1158/0008-5472.CAN-04-1443
-
Wilhelm SM, Carter C, Tang L et al.: Bay 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 64(19), 7099-7109 (2004). (Pubitemid 39331023)
-
(2004)
Cancer Research
, vol.64
, Issue.19
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
Wilkie, D.4
McNabola, A.5
Rong, H.6
Chen, C.7
Zhang, X.8
Vincent, P.9
McHugh, M.10
Cao, Y.11
Shujath, J.12
Gawlak, S.13
Eveleigh, D.14
Rowley, B.15
Liu, L.16
Adnane, L.17
Lynch, M.18
Auclair, D.19
Taylor, I.20
Gedrich, R.21
Voznesensky, A.22
Riedl, B.23
Post, L.E.24
Bollag, G.25
Trail, P.A.26
more..
-
104
-
-
47049127786
-
Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses
-
Hipp MM, Hilf N, Walter S et al.: Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses. Blood 111(12), 5610-5620 (2008).
-
(2008)
Blood
, vol.111
, Issue.12
, pp. 5610-5620
-
-
Hipp, M.M.1
Hilf, N.2
Walter, S.3
-
105
-
-
63949087054
-
Influence of bevacizumab, sunitinib and sorafenib as single agents or in combination on the inhibitory effects of VEGF on human dendritic cell differentiation from monocytes
-
Alfaro C, Suarez N, Gonzalez A et al.: Influence of bevacizumab, sunitinib and sorafenib as single agents or in combination on the inhibitory effects of VEGF on human dendritic cell differentiation from monocytes. Br. J. Cancer 100(7), 1111-1119 (2009).
-
(2009)
Br. J. Cancer
, vol.100
, Issue.7
, pp. 1111-1119
-
-
Alfaro, C.1
Suarez, N.2
Gonzalez, A.3
-
106
-
-
63949085355
-
Apoptosis of CD4+CD25high T cells in response to sirolimus requires activation of T cell receptor and is modulated by IL-2
-
Molhoek KR, Mcskimming CC, Olson WC, Brautigan DL, Slingluff CL Jr: Apoptosis of CD4+CD25high T cells in response to sirolimus requires activation of T cell receptor and is modulated by IL-2. Cancer Immunol. Immunother. 58(6), 867-876 (2009).
-
(2009)
Cancer Immunol. Immunother.
, vol.58
, Issue.6
, pp. 867-876
-
-
Molhoek, K.R.1
McSkimming, C.C.2
Olson, W.C.3
Brautigan, D.L.4
Slingluff Jr., C.L.5
-
107
-
-
45149084681
-
Sorafenib inhibits activation of human peripheral blood T cells by targeting LCK phosphorylation
-
DOI 10.1038/leu.2008.58, PII LEU200858
-
Zhao W, Gu YH, Song R, Qu BQ, Xu Q: Sorafenib inhibits activation of human peripheral blood T cells by targeting LCK phosphorylation. Leukemia 22(6), 1226-1233 (2008). (Pubitemid 351833791)
-
(2008)
Leukemia
, vol.22
, Issue.6
, pp. 1226-1233
-
-
Zhao, W.1
Gu, Y.H.2
Song, R.3
Qu, B.Q.4
Xu, Q.5
-
108
-
-
60849088576
-
MAPK-independent impairment of T-cell responses by the multikinase inhibitor sorafenib
-
Houben R, Voigt H, Noelke C, Hofmeister V, Becker JC, Schrama D: MAPK-independent impairment of T-cell responses by the multikinase inhibitor sorafenib. Mol. Cancer Ther. 8(2), 433-440 (2009).
-
(2009)
Mol. Cancer Ther.
, vol.8
, Issue.2
, pp. 433-440
-
-
Houben, R.1
Voigt, H.2
Noelke, C.3
Hofmeister, V.4
Becker, J.C.5
Schrama, D.6
-
109
-
-
33744954585
-
Sunitinib in patients with metastatic renal cell carcinoma
-
DOI 10.1001/jama.295.21.2516
-
Motzer RJ, Rini BI, Bukowski RM et al.: Sunitinib in patients with metastatic renal cell carcinoma. JAMA 295(21), 2516-2524 (2006). (Pubitemid 43854967)
-
(2006)
Journal of the American Medical Association
, vol.295
, Issue.21
, pp. 2516-2524
-
-
Motzer, R.J.1
Rini, B.I.2
Bukowski, R.M.3
Curti, B.D.4
George, D.J.5
Hudes, G.R.6
Redman, B.G.7
Margolin, K.A.8
Merchan, J.R.9
Wilding, G.10
Ginsberg, M.S.11
Bacik, J.12
Kim, S.T.13
Baum, C.M.14
Michaelson, M.D.15
-
110
-
-
58149179532
-
Sunitinib reverses type-1 immune suppression and decreases T-regulatory cells in renal cell carcinoma patients
-
Finke JH, Rini B, Ireland J et al.: Sunitinib reverses type-1 immune suppression and decreases T-regulatory cells in renal cell carcinoma patients. Clin. Cancer Res. 14(20), 6674-6682 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, Issue.20
, pp. 6674-6682
-
-
Finke, J.H.1
Rini, B.2
Ireland, J.3
-
111
-
-
63549105681
-
Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients
-
Ko JS, Zea AH, Rini BI et al.: Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients. Clin. Cancer Res. 15(6), 2148-2157 (2009).
-
(2009)
Clin. Cancer Res.
, vol.15
, Issue.6
, pp. 2148-2157
-
-
Ko, J.S.1
Zea, A.H.2
Rini, B.I.3
-
112
-
-
77951754469
-
Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained
-
Ko JS, Rayman P, Ireland J et al.: Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained. Cancer Res. 70(9), 3526-3536 (2010).
-
(2010)
Cancer Res.
, vol.70
, Issue.9
, pp. 3526-3536
-
-
Ko, J.S.1
Rayman, P.2
Ireland, J.3
-
113
-
-
53249111806
-
Sunitinib-induced myeloid lineage redistribution in renal cell cancer patients: CD1c+ dendritic cell frequency predicts progression-free survival
-
Van Cruijsen H, Van Der Veldt AA, Vroling L et al.: Sunitinib-induced myeloid lineage redistribution in renal cell cancer patients: CD1c+ dendritic cell frequency predicts progression-free survival. Clin. Cancer Res. 14(18), 5884-5892 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, Issue.18
, pp. 5884-5892
-
-
Van Cruijsen, H.1
Van Der Veldt, A.A.2
Vroling, L.3
-
114
-
-
65549141834
-
The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies
-
Ozao-Choy J, Ma G, Kao J et al.: The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies. Cancer Res. 69(6), 2514-2522 (2009).
-
(2009)
Cancer Res.
, vol.69
, Issue.6
, pp. 2514-2522
-
-
Ozao-Choy, J.1
Ma, G.2
Kao, J.3
-
115
-
-
65549129226
-
Sunitinib inhibition of STAT3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells
-
Xin H, Zhang C, Herrmann A, Du Y, Figlin R, Yu H: Sunitinib inhibition of STAT3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells. Cancer Res. 69(6), 2506-2513 (2009).
-
(2009)
Cancer Res.
, vol.69
, Issue.6
, pp. 2506-2513
-
-
Xin, H.1
Zhang, C.2
Herrmann, A.3
Du, Y.4
Figlin, R.5
Yu, H.6
-
116
-
-
33846927750
-
Imatinib mesylate inhibits antigen-specific memory CD8 T cell responses in vivo
-
Sinai P, Berg RE, Haynie JM, Egorin MJ, Ilaria RL Jr, Forman J: Imatinib mesylate inhibits antigen-specific memory CD8 T-cell responses in vivo. J. Immunol. 178(4), 2028-2037 (2007). (Pubitemid 46233399)
-
(2007)
Journal of Immunology
, vol.178
, Issue.4
, pp. 2028-2037
-
-
Sinai, P.1
Berg, R.E.2
Haynie, J.M.3
Egorin, M.J.4
Ilaria Jr., R.L.5
Forman, J.6
-
117
-
-
76149102749
-
Early efficacy signal demonstrated in advanced melanoma in a Phase i trial of the oncogenic BRAF-selective inhibitor PLX4032
-
Chapman P Pi, Sosman J et al.: Early efficacy signal demonstrated in advanced melanoma in a Phase I trial of the oncogenic BRAF-selective inhibitor PLX4032. Eur. J. Cancer 7(3), 5 (2009).
-
(2009)
Eur. J. Cancer
, vol.7
, Issue.3
, pp. 5
-
-
Chapman, P.Pi.1
Sosman, J.2
-
118
-
-
67651246671
-
Phase i study of PLX4032: Proof of concept for V600E BRAF mutation as a therapeutic target in human cancer
-
Abstract 9000
-
Flaherty K, Puzanov I, Sosman J et al.: Phase I study of PLX4032: proof of concept for V600E BRAF mutation as a therapeutic target in human cancer. J. Clin. Oncol. 27(Suppl. 15), Abstract 9000 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, Issue.SUPPL. 15
-
-
Flaherty, K.1
Puzanov, I.2
Sosman, J.3
-
119
-
-
77950519079
-
Antitumour and immune-adjuvant activities of protein-tyrosine kinase inhibitors
-
Seliger B, Massa C, Rini B, Ko J, Finke J: Antitumour and immune-adjuvant activities of protein-tyrosine kinase inhibitors. Trends Mol. Med. 16(4), 184-192 (2010).
-
(2010)
Trends Mol. Med.
, vol.16
, Issue.4
, pp. 184-192
-
-
Seliger, B.1
Massa, C.2
Rini, B.3
Ko, J.4
Finke, J.5
-
120
-
-
77954373338
-
Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function
-
Boni A, Cogdill AP, Dang P et al.: Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function. Cancer Res. 70(13), 5213-5219 (2010).
-
(2010)
Cancer Res.
, vol.70
, Issue.13
, pp. 5213-5219
-
-
Boni, A.1
Cogdill, A.P.2
Dang, P.3
|