메뉴 건너뛰기




Volumn 3, Issue 2, 2011, Pages 213-227

Small-molecule protein kinase inhibitors and their effects on the immune system: Implications for cancer treatment

Author keywords

cancer; immunotherapy; MAPK; PI3K AKT mTOR; VEGF VEGFR tyrosine kinase inhibitor

Indexed keywords

ANTINEOPLASTIC AGENT; IMATINIB; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; SORAFENIB; SUNITINIB; TEMSIROLIMUS; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

EID: 79951754050     PISSN: 1750743X     EISSN: None     Source Type: Journal    
DOI: 10.2217/imt.10.99     Document Type: Review
Times cited : (55)

References (120)
  • 2
    • 16844379997 scopus 로고    scopus 로고
    • Immunosuppressive networks in the tumour environment and their therapeutic relevance
    • DOI 10.1038/nrc1586
    • Zou W: Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat. Rev. Cancer 5(4), 263-274 (2005). (Pubitemid 40488632)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.4 , pp. 263-274
    • Zou, W.1
  • 4
    • 0037811736 scopus 로고    scopus 로고
    • Immunization with melan-A peptide-pulsed peripheral blood mononuclear cells plus recombinant human interleukin-12 induces clinical activity and T-cell responses in advanced melanoma
    • DOI 10.1200/JCO.2003.12.144
    • Peterson AC, Harlin H, Gajewski TF: Immunization with Melan-A peptide-pulsed peripheral blood mononuclear cells plus recombinant human interleukin-12 induces clinical activity and T-cell responses in advanced melanoma. J. Clin. Oncol. 21(12), 2342-2348 (2003). (Pubitemid 46628465)
    • (2003) Journal of Clinical Oncology , vol.21 , Issue.12 , pp. 2342-2348
    • Peterson, A.C.1    Harlin, H.2    Gajewski, T.F.3
  • 6
    • 58149483422 scopus 로고    scopus 로고
    • CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T-cell responses in metastatic melanoma patients with clinical benefit
    • Yuan J, Gnjatic S, Li H et al.: CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T-cell responses in metastatic melanoma patients with clinical benefit. Proc. Natl Acad. Sci. USA 105(51), 20410-20415 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.51 , pp. 20410-20415
    • Yuan, J.1    Gnjatic, S.2    Li, H.3
  • 8
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, ODay SJ, McDermott DF et al.: Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363(8), 711-723 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1    Oday, S.J.2    McDermott, D.F.3
  • 9
    • 70350647412 scopus 로고    scopus 로고
    • Tumor immunosuppressive environment: Effects on tumor-specific and nontumor antigen immune responses
    • De Souza AP, Bonorino C: Tumor immunosuppressive environment: effects on tumor-specific and nontumor antigen immune responses. Expert Rev. Anticancer Ther. 9(9), 1317-1332 (2009).
    • (2009) Expert Rev. Anticancer Ther. , vol.9 , Issue.9 , pp. 1317-1332
    • De Souza, A.P.1    Bonorino, C.2
  • 14
    • 33745859743 scopus 로고    scopus 로고
    • The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells
    • DOI 10.1084/jem.20051848
    • Sumimoto H, Imabayashi F, Iwata T, Kawakami Y: The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells. J. Exp. Med. 203(7), 1651-1656 (2006). (Pubitemid 44036269)
    • (2006) Journal of Experimental Medicine , vol.203 , Issue.7 , pp. 1651-1656
    • Sumimoto, H.1    Imabayashi, F.2    Iwata, T.3    Kawakami, Y.4
  • 15
    • 77954726255 scopus 로고    scopus 로고
    • Emerging targeted therapies for breast cancer
    • Alvarez RH, Valero V, Hortobagyi GN: Emerging targeted therapies for breast cancer. J. Clin. Oncol. 28(20), 3366-3379 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.20 , pp. 3366-3379
    • Alvarez, R.H.1    Valero, V.2    Hortobagyi, G.N.3
  • 17
    • 0024976525 scopus 로고
    • Rapamycin for immunosuppression in organ allografting
    • Calne RY, Collier DS, Lim S et al.: Rapamycin for immunosuppression in organ allografting. Lancet 2(8656), 227 (1989).
    • (1989) Lancet , vol.2 , Issue.8656 , pp. 227
    • Calne, R.Y.1    Collier, D.S.2    Lim, S.3
  • 18
    • 0034969478 scopus 로고    scopus 로고
    • MTOR inhibitors: An overview
    • DOI 10.1053/jlts.2001.24645
    • Neuhaus P, Klupp J, Langrehr JM: mTOR inhibitors: an overview. Liver Transpl. 7(6), 473-484 (2001). (Pubitemid 32547260)
    • (2001) Liver Transplantation , vol.7 , Issue.6 , pp. 473-484
    • Neuhaus, P.1    Klupp, J.2    Langrehr, J.M.3
  • 19
    • 0033104824 scopus 로고    scopus 로고
    • Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation
    • Powell JD, Lerner CG, Schwartz RH: Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation. J. Immunol. 162(5), 2775-2784 (1999). (Pubitemid 29309302)
    • (1999) Journal of Immunology , vol.162 , Issue.5 , pp. 2775-2784
    • Powell, J.D.1    Lerner, C.G.2    Schwartz, R.H.3
  • 20
    • 0035889885 scopus 로고    scopus 로고
    • Antagonistic roles for CTLA-4 and the mammalian target of rapamycin in the regulation of clonal anergy: Enhanced cell cycle progression promotes recall antigen responsiveness
    • Vanasek TL, Khoruts A, Zell T, Mueller DL: Antagonistic roles for CTLA-4 and the mammalian target of rapamycin in the regulation of clonal anergy: enhanced cell cycle progression promotes recall antigen responsiveness. J. Immunol. 167(10), 5636-5644 (2001). (Pubitemid 33062753)
    • (2001) Journal of Immunology , vol.167 , Issue.10 , pp. 5636-5644
    • Vanasek, T.L.1    Khoruts, A.2    Zell, T.3    Mueller, D.L.4
  • 22
    • 66949173728 scopus 로고    scopus 로고
    • The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
    • Delgoffe GM, Kole TP, Zheng Y et al.: The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 30(6), 832-844 (2009).
    • (2009) Immunity , vol.30 , Issue.6 , pp. 832-844
    • Delgoffe, G.M.1    Kole, T.P.2    Zheng, Y.3
  • 23
    • 46949088630 scopus 로고    scopus 로고
    • De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR
    • DOI 10.1189/jlb.1207851
    • Kang J, Huddleston SJ, Fraser JM, Khoruts A: De novo induction of antigen-specific CD4+CD25+foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR. J. Leukoc. Biol. 83(5), 1230-1239 (2008). (Pubitemid 351960355)
    • (2008) Journal of Leukocyte Biology , vol.83 , Issue.5 , pp. 1230-1239
    • Kang, J.1    Huddleston, S.J.2    Fraser, J.M.3    Khoruts, A.4
  • 24
    • 20444373376 scopus 로고    scopus 로고
    • Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    • Battaglia M, Stabilini A, Roncarolo MG: Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood 105(12), 4743-4748 (2005).
    • (2005) Blood , vol.105 , Issue.12 , pp. 4743-4748
    • Battaglia, M.1    Stabilini, A.2    Roncarolo, M.G.3
  • 27
    • 34249805413 scopus 로고    scopus 로고
    • + T regulatory cells and promote organ transplant tolerance
    • Turnquist HR, Raimondi G, Zahorchak AF, Fischer RT, Wang Z, Thomson AW: Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific FoxP3+ T regulatory cells and promote organ transplant tolerance. J. Immunol. 178(11), 7018-7031 (2007). (Pubitemid 46847428)
    • (2007) Journal of Immunology , vol.178 , Issue.11 , pp. 7018-7031
    • Turnquist, H.R.1    Raimondi, G.2    Zahorchak, A.F.3    Fischer, R.T.4    Wang, Z.5    Thomson, A.W.6
  • 28
    • 0036682957 scopus 로고    scopus 로고
    • Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells
    • DOI 10.1182/blood.V100.3.1084
    • Hackstein H, Taner T, Logar AJ, Thomson AW: Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells. Blood 100(3), 1084-1087 (2002). (Pubitemid 34832646)
    • (2002) Blood , vol.100 , Issue.3 , pp. 1084-1087
    • Hackstein, H.1    Taner, T.2    Logar, A.J.3    Thomson, A.W.4
  • 29
    • 0038036797 scopus 로고    scopus 로고
    • Rapamycin inhibits IL-4-induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo
    • DOI 10.1182/blood-2002-11-3370
    • Hackstein H, Taner T, Zahorchak AF et al.: Rapamycin inhibits IL-4 induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo. Blood 101(11), 4457-4463 (2003). (Pubitemid 36857814)
    • (2003) Blood , vol.101 , Issue.11 , pp. 4457-4463
    • Hackstein, H.1    Taner, T.2    Zahorchak, A.F.3    Morelli, A.E.4    Logar, A.J.5    Gessner, A.6    Thomson, A.W.7
  • 31
    • 74649086985 scopus 로고    scopus 로고
    • The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation
    • Gulen MF, Kang Z, Bulek K et al.: The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity 32(1), 54-66 (2010).
    • (2010) Immunity , vol.32 , Issue.1 , pp. 54-66
    • Gulen, M.F.1    Kang, Z.2    Bulek, K.3
  • 32
    • 35348852627 scopus 로고    scopus 로고
    • Distinct signaling mechanisms activate the target of rapamycin in response to different B-cell stimuli
    • DOI 10.1002/eji.200737281
    • Donahue AC, Fruman DA: Distinct signaling mechanisms activate the target of rapamycin in response to different B-cell stimuli. Eur. J. Immunol. 37(10), 2923-2936 (2007). (Pubitemid 47578311)
    • (2007) European Journal of Immunology , vol.37 , Issue.10 , pp. 2923-2936
    • Donahue, A.C.1    Fruman, D.A.2
  • 33
    • 58149143166 scopus 로고    scopus 로고
    • Effects of immunosuppressive drugs on purified human B cells: Evidence supporting the use of MMF and rapamycin
    • Heidt S, Roelen DL, Eijsink C, Van Kooten C, Claas FH, Mulder A: Effects of immunosuppressive drugs on purified human B cells: evidence supporting the use of MMF and rapamycin. Transplantation 86(9), 1292-1300 (2008).
    • (2008) Transplantation , vol.86 , Issue.9 , pp. 1292-1300
    • Heidt, S.1    Roelen, D.L.2    Eijsink, C.3    Van Kooten, C.4    Claas, F.H.5    Mulder, A.6
  • 34
    • 38149136619 scopus 로고    scopus 로고
    • Rapamycin, but not cyclosporine or fk506, alters natural killer cell function
    • Wai LE, Fujiki M, Takeda S, Martinez OM, Krams SM: Rapamycin, but not cyclosporine or fk506, alters natural killer cell function. Transplantation 85(1), 145-149 (2008).
    • (2008) Transplantation , vol.85 , Issue.1 , pp. 145-149
    • Wai, L.E.1    Fujiki, M.2    Takeda, S.3    Martinez, O.M.4    Krams, S.M.5
  • 36
    • 50949130076 scopus 로고    scopus 로고
    • Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced IL-12 production in dendritic cells
    • Ohtani M, Nagai S, Kondo S et al.: Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced IL-12 production in dendritic cells. Blood 112(3), 635-643 (2008).
    • (2008) Blood , vol.112 , Issue.3 , pp. 635-643
    • Ohtani, M.1    Nagai, S.2    Kondo, S.3
  • 37
    • 54949109311 scopus 로고    scopus 로고
    • The TSC-mTOR signaling pathway regulates the innate inflammatory response
    • Weichhart T, Costantino G, Poglitsch M et al.: The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity 29(4), 565-577 (2008).
    • (2008) Immunity , vol.29 , Issue.4 , pp. 565-577
    • Weichhart, T.1    Costantino, G.2    Poglitsch, M.3
  • 38
    • 74649085700 scopus 로고    scopus 로고
    • The mTOR kinase determines effector versus memory CD8+ T-cell fate by regulating the expression of transcription factors T-bet and eomesodermin
    • Rao RR, Li Q, Odunsi K, Shrikant PA: The mTOR kinase determines effector versus memory CD8+ T-cell fate by regulating the expression of transcription factors T-bet and eomesodermin. Immunity 32(1), 67-78 (2010).
    • (2010) Immunity , vol.32 , Issue.1 , pp. 67-78
    • Rao, R.R.1    Li, Q.2    Odunsi, K.3    Shrikant, P.A.4
  • 41
    • 0036707521 scopus 로고    scopus 로고
    • PI3K-mediated negative feedback regulation of IL-12 production in DCs
    • Fukao T, Tanabe M, Terauchi Y et al.: PI3K-mediated negative feedback regulation of IL-12 production in DCs. Nat. Immunol. 3(9), 875-881 (2002).
    • (2002) Nat. Immunol. , vol.3 , Issue.9 , pp. 875-881
    • Fukao, T.1    Tanabe, M.2    Terauchi, Y.3
  • 42
    • 0037199972 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells
    • DOI 10.1074/jbc.M203298200
    • Guha M, Mackman N: The phosphatidylinositol 3-kinase-AKT pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J. Biol. Chem. 277(35), 32124-32132 (2002). (Pubitemid 34969025)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.35 , pp. 32124-32132
    • Guha, M.1    Mackman, N.2
  • 44
    • 34250803183 scopus 로고    scopus 로고
    • Role of phosphatidylinositol-3 kinase in transcriptional regulation of TLR-induced IL-12 and IL-10 by Fcγ receptor ligation in murine macrophages
    • Polumuri SK, Toshchakov VY, Vogel SN: Role of phosphatidylinositol-3 kinase in transcriptional regulation of TLR-induced IL-12 and IL-10 by Fc g receptor ligation in murine macrophages. J. Immunol. 179(1), 236-246 (2007). (Pubitemid 46986539)
    • (2007) Journal of Immunology , vol.179 , Issue.1 , pp. 236-246
    • Polumuri, S.K.1    Toshchakov, V.Y.2    Vogel, S.N.3
  • 45
    • 0035869634 scopus 로고    scopus 로고
    • A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-α, and contact sensitizers
    • Arrighi JF, Rebsamen M, Rousset F, Kindler V, Hauser C: A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-a, and contact sensitizers. J. Immunol. 166(6), 3837-3845 (2001). (Pubitemid 32224909)
    • (2001) Journal of Immunology , vol.166 , Issue.6 , pp. 3837-3845
    • Arrighi, J.-F.1    Rebsamen, M.2    Rousset, F.3    Kindler, V.4    Hauser, C.5
  • 46
    • 0033118982 scopus 로고    scopus 로고
    • Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice
    • Lu HT, Yang DD, Wysk M et al.: Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (MKK3)-deficient mice. EMBO J. 18(7), 1845-1857 (1999). (Pubitemid 29158528)
    • (1999) EMBO Journal , vol.18 , Issue.7 , pp. 1845-1857
    • Lu, H.-T.1    Yang, D.D.2    Wysk, M.3    Gatti, E.4    Mellman, I.5    Davis, R.J.6    Flavell, R.A.7
  • 47
    • 0035022325 scopus 로고    scopus 로고
    • Effective antigen presentation by dendritic cells is NF-κB dependent: Coordinate regulation of MHC, co-stimulatory molecules and cytokines
    • Yoshimura S, Bondeson J, Foxwell BM, Brennan FM, Feldmann M: Effective antigen presentation by dendritic cells is NF-kB dependent: coordinate regulation of MHC, costimulatory molecules and cytokines. Int. Immunol. 13(5), 675-683 (2001). (Pubitemid 32427870)
    • (2001) International Immunology , vol.13 , Issue.5 , pp. 675-683
    • Yoshimura, S.1    Bondeson, J.2    Foxwell, B.M.J.3    Brennan, F.M.4    Feldmann, M.5
  • 48
    • 0035496927 scopus 로고    scopus 로고
    • Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells
    • Puig-Kroger A, Relloso M, Fernandez-Capetillo O et al.: Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells. Blood 98(7), 2175-2182 (2001).
    • (2001) Blood , vol.98 , Issue.7 , pp. 2175-2182
    • Puig-Kroger, A.1    Relloso, M.2    Fernandez-Capetillo, O.3
  • 49
    • 33646470960 scopus 로고    scopus 로고
    • Erk1-/- mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis
    • Agrawal A, Dillon S, Denning TL, Pulendran B: Erk1-/- mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis. J. Immunol. 176(10), 5788-5796 (2006).
    • (2006) J. Immunol. , vol.176 , Issue.10 , pp. 5788-5796
    • Agrawal, A.1    Dillon, S.2    Denning, T.L.3    Pulendran, B.4
  • 50
    • 0033120111 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase, stress-activated protein kinase/c-Jun N-terminal kinase, and p38(mapk) are involved in IL-10-mediated selective repression of TNF-α-induced activation and maturation of human peripheral blood monocyte-derived dendritic cells
    • Sato K, Nagayama H, Tadokoro K, Juji T, Takahashi TA: Extracellular signal-regulated kinase, stress-activated protein kinase/c-Jun N-terminal kinase, and p38MAPK are involved in IL-10-mediated selective repression of TNF-a-induced activation and maturation of human peripheral blood monocyte-derived dendritic cells. J. Immunol. 162(7), 3865-3872 (1999). (Pubitemid 29314764)
    • (1999) Journal of Immunology , vol.162 , Issue.7 , pp. 3865-3872
    • Sato, K.1    Nagayama, H.2    Tadokoro, K.3    Juji, T.4    Takahashi, T.A.5
  • 51
    • 0034254811 scopus 로고    scopus 로고
    • The PI3 kinase, p38 SAP kinase, and NF-κb signal transduction pathways are involved in the survival and maturation of lipopolysaccharide- stimulated human monocyte-derived dendritic cells
    • Ardeshna KM, Pizzey AR, Devereux S, Khwaja A: The PI3 kinase, p38 sap kinase, and NF-kB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells. Blood 96(3), 1039-1046 (2000). (Pubitemid 30616871)
    • (2000) Blood , vol.96 , Issue.3 , pp. 1039-1046
    • Ardeshna, K.M.1    Pizzey, A.R.2    Devereux, S.3    Khwaja, A.4
  • 52
    • 42449157639 scopus 로고    scopus 로고
    • Targeting dendritic cell signaling to regulate the response to immunization
    • Escors D, Lopes L, Lin R et al.: Targeting dendritic cell signaling to regulate the response to immunization. Blood 111(6), 3050-3061 (2008).
    • (2008) Blood , vol.111 , Issue.6 , pp. 3050-3061
    • Escors, D.1    Lopes, L.2    Lin, R.3
  • 53
    • 0036221384 scopus 로고    scopus 로고
    • MAP kinases in the immune response
    • DOI 10.1146/annurev.immunol.20.091301.131133
    • Dong C, Davis Rj, Flavell RA: MAP kinases in the immune response. Annu. Rev. Immunol. 20, 55-72 (2002). (Pubitemid 34293420)
    • (2002) Annual Review of Immunology , vol.20 , pp. 55-72
    • Dong, C.1    Davis, R.J.2    Flavell, R.A.3
  • 54
    • 0028859281 scopus 로고
    • Selective requirement for MAP kinase activation in thymocyte differentiation
    • Alberola-Ila J, Forbush KA, Seger R, Krebs EG, Perlmutter RM: Selective requirement for MAP kinase activation in thymocyte differentiation. Nature 373(6515), 620-623 (1995).
    • (1995) Nature , vol.373 , Issue.6515 , pp. 620-623
    • Alberola-Ila, J.1    Forbush, K.A.2    Seger, R.3    Krebs, E.G.4    Perlmutter, R.M.5
  • 55
    • 0037338890 scopus 로고    scopus 로고
    • TCR ligand discrimination is enforced by competing ERK positive and SHP-I negative feedback pathways
    • DOI 10.1038/ni895
    • Stefanova I, Hemmer B, Vergelli M, Martin R, Biddison WE, Germain RN: TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways. Nat. Immunol. 4(3), 248-254 (2003). (Pubitemid 36322134)
    • (2003) Nature Immunology , vol.4 , Issue.3 , pp. 248-254
    • Stefanova, I.1    Hemmer, B.2    Vergelli, M.3    Martin, R.4    Biddison, W.E.5    Germain, R.N.6
  • 56
    • 77949901838 scopus 로고    scopus 로고
    • Pharmacologic inhibition of MEK-ERK signaling enhances Th17 differentiation
    • Tan AH, Lam KP: Pharmacologic inhibition of MEK-ERK signaling enhances Th17 differentiation. J. Immunol. 184(4), 1849-1857 (2010).
    • (2010) J. Immunol. , vol.184 , Issue.4 , pp. 1849-1857
    • Tan, A.H.1    Lam, K.P.2
  • 57
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • DOI 10.1200/JCO.2005.06.081
    • Hicklin DJ, Ellis LM: Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J. Clin. Oncol. 23(5), 1011-1027 (2005). (Pubitemid 46202320)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.5 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 59
    • 34547630698 scopus 로고    scopus 로고
    • Tumor angiogenesis: Cause or consequence of cancer?
    • DOI 10.1158/0008-5472.CAN-07-2053
    • Shchors K, Evan G: Tumor angiogenesis: cause or consequence of cancer? Cancer Res. 67(15), 7059-7061 (2007). (Pubitemid 47206529)
    • (2007) Cancer Research , vol.67 , Issue.15 , pp. 7059-7061
    • Shchors, K.1    Evan, G.2
  • 60
    • 7944224442 scopus 로고    scopus 로고
    • Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
    • DOI 10.1016/j.ccr.2004.09.026, PII S1535610804003022
    • Tang N, Wang L, Esko J et al.: Loss of HIF-1a in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 6(5), 485-495 (2004). (Pubitemid 39469984)
    • (2004) Cancer Cell , vol.6 , Issue.5 , pp. 485-495
    • Tang, N.1    Wang, L.2    Esko, J.3    Giordano, F.J.4    Huang, Y.5    Gerber, H.-P.6    Ferrara, N.7    Johnson, R.S.8
  • 61
    • 0030498734 scopus 로고    scopus 로고
    • Angiogenesis and metastasis
    • Ellis LM, Fidler IJ: Angiogenesis and metastasis. Eur. J. Cancer 32A(14), 2451-2460 (1996).
    • (1996) Eur. J. Cancer , vol.32 A , Issue.14 , pp. 2451-2460
    • Ellis, L.M.1    Fidler, I.J.2
  • 62
    • 0032400862 scopus 로고    scopus 로고
    • Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo
    • Gabrilovich D, Ishida T, Oyama T et al.: Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo. Blood 92(11), 4150-4166 (1998). (Pubitemid 28544331)
    • (1998) Blood , vol.92 , Issue.11 , pp. 4150-4166
    • Gabrilovich, D.1    Ishida, T.2    Oyama, T.3    Ran, S.4    Kravtsov, V.5    Nadaf, S.6    Carbone, D.P.7
  • 64
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich DI, Nagaraj S: Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol. 9(3), 162-174 (2009).
    • (2009) Nat. Rev. Immunol. , vol.9 , Issue.3 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 65
    • 0032741283 scopus 로고    scopus 로고
    • Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function
    • Gabrilovich DI, Ishida T, Nadaf S, Ohm JE, Carbone DP: Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. Clin. Cancer Res. 5(10), 2963-2970 (1999). (Pubitemid 29493976)
    • (1999) Clinical Cancer Research , vol.5 , Issue.10 , pp. 2963-2970
    • Gabrilovich, D.I.1    Ishida, T.2    Nadaf, S.3    Ohm, J.E.4    Carbone, D.P.5
  • 66
    • 27644590410 scopus 로고    scopus 로고
    • Tumour-associated macrophage infiltration, neovascularization and aggressiveness in malignant melanoma: Role of monocyte chemotactic protein-1 and vascular endothelial growth factor-A
    • DOI 10.1097/00008390-200510000-00010
    • Varney ML, Johansson SL, Singh RK: Tumour-associated macrophage infiltration, neovascularization and aggressiveness in malignant melanoma: role of monocyte chemotactic protein-1 and vascular endothelial growth factor-a. Melanoma Res. 15(5), 417-425 (2005). (Pubitemid 41558952)
    • (2005) Melanoma Research , vol.15 , Issue.5 , pp. 417-425
    • Varney, M.L.1    Johansson, S.L.2    Singh, R.K.3
  • 68
    • 70350728931 scopus 로고    scopus 로고
    • Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation
    • Solinas G, Germano G, Mantovani A, Allavena P: Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J. Leukoc. Biol. 86(5), 1065-1073 (2009).
    • (2009) J. Leukoc. Biol. , vol.86 , Issue.5 , pp. 1065-1073
    • Solinas, G.1    Germano, G.2    Mantovani, A.3    Allavena, P.4
  • 72
    • 34547106845 scopus 로고    scopus 로고
    • Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF
    • DOI 10.1182/blood-2007-01-065714
    • Huang Y, Chen X, Dikov Mm et al.: Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF. Blood 110(2), 624-631 (2007). (Pubitemid 47105401)
    • (2007) Blood , vol.110 , Issue.2 , pp. 624-631
    • Huang, Y.1    Chen, X.2    Dikov, M.M.3    Novitskiy, S.V.4    Mosse, C.A.5    Yang, L.6    Carbone, D.P.7
  • 73
    • 34548125294 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-trap overcomes defects in dendritic cell differentiation but does not improve antigen-specific immune responses
    • DOI 10.1158/1078-0432.CCR-07-0409
    • Fricke I, Mirza N, Dupont J et al.: Vascular endothelial growth factor-TRAP overcomes defects in dendritic cell differentiation but does not improve antigen-specific immune responses. Clin. Cancer Res. 13(16), 4840-4848 (2007). (Pubitemid 47298146)
    • (2007) Clinical Cancer Research , vol.13 , Issue.16 , pp. 4840-4848
    • Fricke, I.1    Mirza, N.2    Dupont, J.3    Lockhart, C.4    Jackson, A.5    Lee, J.-H.6    Sosman, J.A.7    Gabrilovich, D.I.8
  • 75
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet JM, Ricci S, Mazzaferro V et al.: Sorafenib in advanced hepatocellular carcinoma. N. Engl. J. Med. 359(4), 378-390 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , Issue.4 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 77
    • 77953930730 scopus 로고    scopus 로고
    • Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
    • Maemondo M, Inoue A, Kobayashi K et al.: Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N. Engl. J. Med. 362(25), 2380-2388 (2010).
    • (2010) N. Engl. J. Med. , vol.362 , Issue.25 , pp. 2380-2388
    • Maemondo, M.1    Inoue, A.2    Kobayashi, K.3
  • 78
    • 42949128595 scopus 로고    scopus 로고
    • Major response to imatinib mesylate in KIT-mutated melanoma
    • Hodi FS, Friedlander P, Corless CL et al.: Major response to imatinib mesylate in KIT-mutated melanoma. J. Clin. Oncol. 26(12), 2046-2051 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.12 , pp. 2046-2051
    • Hodi, F.S.1    Friedlander, P.2    Corless, C.L.3
  • 79
    • 47249099056 scopus 로고    scopus 로고
    • Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation
    • DOI 10.1111/j.1755-148X.2008.00475.x
    • Lutzky J, Bauer J, Bastian BC: Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation. Pigment Cell Melanoma Res. 21(4), 492-493 (2008). (Pubitemid 351990966)
    • (2008) Pigment Cell and Melanoma Research , vol.21 , Issue.4 , pp. 492-493
    • Lutzky, J.1    Bauer, J.2    Bastian, B.C.3
  • 81
    • 3843119865 scopus 로고    scopus 로고
    • Imatinib mesylate inhibits T-cell proliferation in vitro and delayed-type hypersensitivity in vivo
    • DOI 10.1182/blood-2003-12-4266
    • Dietz AB, Souan L, Knutson GJ, Bulur PA, Litzow MR, Vuk-Pavlovic S: Imatinib mesylate inhibits T-cell proliferation in vitro and delayed-type hypersensitivity in vivo. Blood 104(4), 1094-1099 (2004). (Pubitemid 39038030)
    • (2004) Blood , vol.104 , Issue.4 , pp. 1094-1099
    • Dietz, A.B.1    Souan, L.2    Knutson, G.J.3    Bulur, P.A.4    Litzow, M.R.5    Vuk-Pavlovic, S.6
  • 82
    • 4344597828 scopus 로고    scopus 로고
    • Imatinib inhibits the activation and proliferation of normal T lymphocytes in vitro
    • DOI 10.1038/sj.leu.2403401
    • Cwynarski K, Laylor R, Macchiarulo E et al.: Imatinib inhibits the activation and proliferation of normal T lymphocytes in vitro. Leukemia 18(8), 1332-1339 (2004). (Pubitemid 39136740)
    • (2004) Leukemia , vol.18 , Issue.8 , pp. 1332-1339
    • Cwynarksi, K.1    Laylor, R.2    Macchiarulo, E.3    Goldman, J.4    Lombardi, G.5    Melo, J.V.6    Dazzi, F.7
  • 83
    • 15244351682 scopus 로고    scopus 로고
    • Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner
    • DOI 10.1182/blood-2004-07-2527
    • Seggewiss R, Lore K, Greiner E et al.: Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner. Blood 105(6), 2473-2479 (2005). (Pubitemid 40387048)
    • (2005) Blood , vol.105 , Issue.6 , pp. 2473-2479
    • Seggewiss, R.1    Lore, K.2    Greiner, E.3    Magnusson, M.K.4    Price, D.A.5    Douek, D.C.6    Dunbar, C.E.7    Wiestner, A.8
  • 84
    • 33751167425 scopus 로고    scopus 로고
    • Imatinib mesylate selectively impairs expansion of memory cytotoxic T cells without affecting the control of primary viral infections
    • Mumprecht S, Matter M, Pavelic V, Ochsenbein AF: Imatinib mesylate selectively impairs expansion of memory cytotoxic T cells without affecting the control of primary viral infections. Blood 108(10), 3406-3413 (2006).
    • (2006) Blood , vol.108 , Issue.10 , pp. 3406-3413
    • Mumprecht, S.1    Matter, M.2    Pavelic, V.3    Ochsenbein, A.F.4
  • 86
    • 27644449731 scopus 로고    scopus 로고
    • Imatinib mesylate suppresses cytokine synthesis by activated CD4 T cells of patients with chronic myelogenous leukemia
    • DOI 10.1038/sj.leu.2403933, PII 2403933
    • Gao H, Lee BN, Talpaz M et al.: Imatinib mesylate suppresses cytokine synthesis by activated CD4 T cells of patients with chronic myelogenous leukemia. Leukemia 19(11), 1905-1911 (2005). (Pubitemid 41553998)
    • (2005) Leukemia , vol.19 , Issue.11 , pp. 1905-1911
    • Gao, H.1    Lee, B.-N.2    Talpaz, M.3    Donato, N.J.4    Cortes, J.E.5    Kantarjian, H.M.6    Reuben, J.M.7
  • 87
    • 3342956520 scopus 로고    scopus 로고
    • Requirement for Abl kinases in T cell receptor signaling
    • DOI 10.1016/j.cub.2004.07.021, PII S0960982204005196
    • Zipfel PA, Zhang W, Quiroz M, Pendergast AM: Requirement for ABL kinases in T cell receptor signaling. Curr. Biol. 14(14), 1222-1231 (2004). (Pubitemid 38991808)
    • (2004) Current Biology , vol.14 , Issue.14 , pp. 1222-1231
    • Zipfel, P.A.1    Zhang, W.2    Quiroz, M.3    Pendergast, A.M.4
  • 88
    • 58149187113 scopus 로고    scopus 로고
    • Imatinib mesylate inhibits CD4+ CD25+ regulatory T-cell activity and enhances active immunotherapy against BCR-ABL-tumors
    • Larmonier N, Janikashvili N, Lacasse CJ et al.: Imatinib mesylate inhibits CD4+ CD25+ regulatory T-cell activity and enhances active immunotherapy against BCR-ABL-tumors. J. Immunol. 181(10), 6955-6963 (2008).
    • (2008) J. Immunol. , vol.181 , Issue.10 , pp. 6955-6963
    • Larmonier, N.1    Janikashvili, N.2    Lacasse, C.J.3
  • 90
    • 45749101780 scopus 로고    scopus 로고
    • Development and dynamics of robust T-cell responses to CML under imatinib treatment
    • Chen CI, Maecker HT, Lee PP: Development and dynamics of robust T-cell responses to CML under imatinib treatment. Blood 111(11), 5342-5349 (2008).
    • (2008) Blood , vol.111 , Issue.11 , pp. 5342-5349
    • Chen, C.I.1    Maecker, H.T.2    Lee, P.P.3
  • 93
    • 2942625414 scopus 로고    scopus 로고
    • Imatinib and plasmacytoid dendritic cell function in patients with chronic myeloid leukemia
    • DOI 10.1182/blood-2003-09-3220
    • Mohty M, Jourdan E, Mami NB et al.: Imatinib and plasmacytoid dendritic cell function in patients with chronic myeloid leukemia. Blood 103(12), 4666-4668 (2004). (Pubitemid 38746000)
    • (2004) Blood , vol.103 , Issue.12 , pp. 4666-4668
    • Mohty, M.1    Jourdan, E.2    Mami, N.B.3    Vey, N.4    Damaj, G.5    Blaise, D.6    Isnardon, D.7    Olive, D.8    Gaugler, B.9
  • 94
    • 1442331705 scopus 로고    scopus 로고
    • Imatinib mesylate impairs Flt3L-mediated dendritic cell expansion and antitumor effects in vivo [2] (multiple letters)
    • DOI 10.1182/blood-2003-10-3475
    • Taieb J, Maruyama K, Borg C, Terme M, Zitvogel L: Imatinib mesylate impairs Flt3L-mediated dendritic cell expansion and antitumor effects in vivo. Blood 103(5), 1966-1967; author reply 1967 (2004). (Pubitemid 38269001)
    • (2004) Blood , vol.103 , Issue.5 , pp. 1966-1967
    • Taieb, J.1    Maruyama, K.2    Borg, C.3    Terme, M.4    Zitvogel, L.5    Appel, S.6    Brossart, P.7
  • 95
    • 12844265929 scopus 로고    scopus 로고
    • + T-cell tolerance
    • DOI 10.1182/blood-2004-01-0027
    • Wang H, Cheng F, Cuenca A et al.: Imatinib mesylate (STI-571) enhances antigen-presenting cell function and overcomes tumor-induced CD4+ T-cell tolerance. Blood 105(3), 1135-1143 (2005). (Pubitemid 40170886)
    • (2005) Blood , vol.105 , Issue.3 , pp. 1135-1143
    • Wang, H.1    Cheng, F.2    Cuenca, A.3    Horna, P.4    Zheng, Z.5    Bhalla, K.6    Sotomayor, E.M.7
  • 98
    • 45549107384 scopus 로고    scopus 로고
    • The critical role of IL-15 in the antitumor effects mediated by the combination therapy imatinib and IL-2
    • Mignot G, Ullrich E, Bonmort M et al.: The critical role of IL-15 in the antitumor effects mediated by the combination therapy imatinib and IL-2. J. Immunol. 180(10), 6477-6483 (2008).
    • (2008) J. Immunol. , vol.180 , Issue.10 , pp. 6477-6483
    • Mignot, G.1    Ullrich, E.2    Bonmort, M.3
  • 99
    • 33646858146 scopus 로고    scopus 로고
    • Imatinib mesylate - Uncovering a fast track to adaptive immunity
    • Smyth MJ: Imatinib mesylate - uncovering a fast track to adaptive immunity. N. Engl. J. Med. 354(21), 2282-2284 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , Issue.21 , pp. 2282-2284
    • Smyth, M.J.1
  • 100
    • 77954753261 scopus 로고    scopus 로고
    • Anti-inflammatory M2 type macrophages characterize metastasized and tyrosine kinase inhibitor-treated gastrointestinal stromal tumors
    • Van Dongen M, Savage ND, Jordanova ES et al.: Anti-inflammatory M2 type macrophages characterize metastasized and tyrosine kinase inhibitor-treated gastrointestinal stromal tumors. Int. J. Cancer 127(4), 899-909 (2010).
    • (2010) Int. J. Cancer , vol.127 , Issue.4 , pp. 899-909
    • Van Dongen, M.1    Savage, N.D.2    Jordanova, E.S.3
  • 101
    • 40949118437 scopus 로고    scopus 로고
    • Temsirolimus, an inhibitor of mammalian target of rapamycin
    • Rini Bi: Temsirolimus, an inhibitor of mammalian target of rapamycin. Clin. Cancer Res. 14(5), 1286-1290 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.5 , pp. 1286-1290
    • Bi, R.1
  • 104
    • 47049127786 scopus 로고    scopus 로고
    • Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses
    • Hipp MM, Hilf N, Walter S et al.: Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses. Blood 111(12), 5610-5620 (2008).
    • (2008) Blood , vol.111 , Issue.12 , pp. 5610-5620
    • Hipp, M.M.1    Hilf, N.2    Walter, S.3
  • 105
    • 63949087054 scopus 로고    scopus 로고
    • Influence of bevacizumab, sunitinib and sorafenib as single agents or in combination on the inhibitory effects of VEGF on human dendritic cell differentiation from monocytes
    • Alfaro C, Suarez N, Gonzalez A et al.: Influence of bevacizumab, sunitinib and sorafenib as single agents or in combination on the inhibitory effects of VEGF on human dendritic cell differentiation from monocytes. Br. J. Cancer 100(7), 1111-1119 (2009).
    • (2009) Br. J. Cancer , vol.100 , Issue.7 , pp. 1111-1119
    • Alfaro, C.1    Suarez, N.2    Gonzalez, A.3
  • 106
    • 63949085355 scopus 로고    scopus 로고
    • Apoptosis of CD4+CD25high T cells in response to sirolimus requires activation of T cell receptor and is modulated by IL-2
    • Molhoek KR, Mcskimming CC, Olson WC, Brautigan DL, Slingluff CL Jr: Apoptosis of CD4+CD25high T cells in response to sirolimus requires activation of T cell receptor and is modulated by IL-2. Cancer Immunol. Immunother. 58(6), 867-876 (2009).
    • (2009) Cancer Immunol. Immunother. , vol.58 , Issue.6 , pp. 867-876
    • Molhoek, K.R.1    McSkimming, C.C.2    Olson, W.C.3    Brautigan, D.L.4    Slingluff Jr., C.L.5
  • 107
    • 45149084681 scopus 로고    scopus 로고
    • Sorafenib inhibits activation of human peripheral blood T cells by targeting LCK phosphorylation
    • DOI 10.1038/leu.2008.58, PII LEU200858
    • Zhao W, Gu YH, Song R, Qu BQ, Xu Q: Sorafenib inhibits activation of human peripheral blood T cells by targeting LCK phosphorylation. Leukemia 22(6), 1226-1233 (2008). (Pubitemid 351833791)
    • (2008) Leukemia , vol.22 , Issue.6 , pp. 1226-1233
    • Zhao, W.1    Gu, Y.H.2    Song, R.3    Qu, B.Q.4    Xu, Q.5
  • 108
    • 60849088576 scopus 로고    scopus 로고
    • MAPK-independent impairment of T-cell responses by the multikinase inhibitor sorafenib
    • Houben R, Voigt H, Noelke C, Hofmeister V, Becker JC, Schrama D: MAPK-independent impairment of T-cell responses by the multikinase inhibitor sorafenib. Mol. Cancer Ther. 8(2), 433-440 (2009).
    • (2009) Mol. Cancer Ther. , vol.8 , Issue.2 , pp. 433-440
    • Houben, R.1    Voigt, H.2    Noelke, C.3    Hofmeister, V.4    Becker, J.C.5    Schrama, D.6
  • 110
    • 58149179532 scopus 로고    scopus 로고
    • Sunitinib reverses type-1 immune suppression and decreases T-regulatory cells in renal cell carcinoma patients
    • Finke JH, Rini B, Ireland J et al.: Sunitinib reverses type-1 immune suppression and decreases T-regulatory cells in renal cell carcinoma patients. Clin. Cancer Res. 14(20), 6674-6682 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.20 , pp. 6674-6682
    • Finke, J.H.1    Rini, B.2    Ireland, J.3
  • 111
    • 63549105681 scopus 로고    scopus 로고
    • Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients
    • Ko JS, Zea AH, Rini BI et al.: Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients. Clin. Cancer Res. 15(6), 2148-2157 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.6 , pp. 2148-2157
    • Ko, J.S.1    Zea, A.H.2    Rini, B.I.3
  • 112
    • 77951754469 scopus 로고    scopus 로고
    • Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained
    • Ko JS, Rayman P, Ireland J et al.: Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained. Cancer Res. 70(9), 3526-3536 (2010).
    • (2010) Cancer Res. , vol.70 , Issue.9 , pp. 3526-3536
    • Ko, J.S.1    Rayman, P.2    Ireland, J.3
  • 113
    • 53249111806 scopus 로고    scopus 로고
    • Sunitinib-induced myeloid lineage redistribution in renal cell cancer patients: CD1c+ dendritic cell frequency predicts progression-free survival
    • Van Cruijsen H, Van Der Veldt AA, Vroling L et al.: Sunitinib-induced myeloid lineage redistribution in renal cell cancer patients: CD1c+ dendritic cell frequency predicts progression-free survival. Clin. Cancer Res. 14(18), 5884-5892 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.18 , pp. 5884-5892
    • Van Cruijsen, H.1    Van Der Veldt, A.A.2    Vroling, L.3
  • 114
    • 65549141834 scopus 로고    scopus 로고
    • The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies
    • Ozao-Choy J, Ma G, Kao J et al.: The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies. Cancer Res. 69(6), 2514-2522 (2009).
    • (2009) Cancer Res. , vol.69 , Issue.6 , pp. 2514-2522
    • Ozao-Choy, J.1    Ma, G.2    Kao, J.3
  • 115
    • 65549129226 scopus 로고    scopus 로고
    • Sunitinib inhibition of STAT3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells
    • Xin H, Zhang C, Herrmann A, Du Y, Figlin R, Yu H: Sunitinib inhibition of STAT3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells. Cancer Res. 69(6), 2506-2513 (2009).
    • (2009) Cancer Res. , vol.69 , Issue.6 , pp. 2506-2513
    • Xin, H.1    Zhang, C.2    Herrmann, A.3    Du, Y.4    Figlin, R.5    Yu, H.6
  • 117
    • 76149102749 scopus 로고    scopus 로고
    • Early efficacy signal demonstrated in advanced melanoma in a Phase i trial of the oncogenic BRAF-selective inhibitor PLX4032
    • Chapman P Pi, Sosman J et al.: Early efficacy signal demonstrated in advanced melanoma in a Phase I trial of the oncogenic BRAF-selective inhibitor PLX4032. Eur. J. Cancer 7(3), 5 (2009).
    • (2009) Eur. J. Cancer , vol.7 , Issue.3 , pp. 5
    • Chapman, P.Pi.1    Sosman, J.2
  • 118
    • 67651246671 scopus 로고    scopus 로고
    • Phase i study of PLX4032: Proof of concept for V600E BRAF mutation as a therapeutic target in human cancer
    • Abstract 9000
    • Flaherty K, Puzanov I, Sosman J et al.: Phase I study of PLX4032: proof of concept for V600E BRAF mutation as a therapeutic target in human cancer. J. Clin. Oncol. 27(Suppl. 15), Abstract 9000 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.SUPPL. 15
    • Flaherty, K.1    Puzanov, I.2    Sosman, J.3
  • 119
    • 77950519079 scopus 로고    scopus 로고
    • Antitumour and immune-adjuvant activities of protein-tyrosine kinase inhibitors
    • Seliger B, Massa C, Rini B, Ko J, Finke J: Antitumour and immune-adjuvant activities of protein-tyrosine kinase inhibitors. Trends Mol. Med. 16(4), 184-192 (2010).
    • (2010) Trends Mol. Med. , vol.16 , Issue.4 , pp. 184-192
    • Seliger, B.1    Massa, C.2    Rini, B.3    Ko, J.4    Finke, J.5
  • 120
    • 77954373338 scopus 로고    scopus 로고
    • Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function
    • Boni A, Cogdill AP, Dang P et al.: Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function. Cancer Res. 70(13), 5213-5219 (2010).
    • (2010) Cancer Res. , vol.70 , Issue.13 , pp. 5213-5219
    • Boni, A.1    Cogdill, A.P.2    Dang, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.