Dipeptide vinyl sultams: Synthesis via the Wittig-Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 15, 2006, Pages 4115-4119

  Valente, Cláudia ^a   Guedes, Rita C ^a   Moreira, Rui ^a   Iley, Jim ^b   Gut, Jiri ^c   Rosenthal, Philip J ^c  

^a UNIVERSITY OF LISBON   (Portugal)

^b OPEN UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antimalarials; Cysteine proteases; Falcipain 2; Molecular modelling; Papain; Plasmodium falciparum; Vinyl sultams; Wittig Horner reaction

Indexed keywords

ALDEHYDE DERIVATIVE; FALCIPAIN 2; N TERT BUTYLOXYCARBONYLPHENYLALANINE ALDEHYDE; PAPAIN; UNCLASSIFIED DRUG; VINYL DERIVATIVE;

ARTICLE; DRUG ACTIVITY; DRUG SYNTHESIS; HORNER REACTION; NONHUMAN; PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; CYSTEINE ENDOPEPTIDASES; DIPEPTIDES; MODELS, MOLECULAR; PAPAIN; PLASMODIUM FALCIPARUM;

PLASMODIUM FALCIPARUM;

EID: 33745242354     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.04.079     Document Type: Article

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