Self-antigen presentation by dendritic cells and lymphoid stroma and its implications for autoimmunity

Current Opinion in Immunology

Volumn 23, Issue 1, 2011, Pages 138-145

  Lukacs Kornek, Veronika ^a   Turley, Shannon J ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1; DENDRITIC CELL IMMUNORECEPTOR; FATTY ACID BINDING PROTEIN 2; GLYCOPROTEIN P 15095; LECTIN RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; UNCLASSIFIED DRUG;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CROSS PRESENTATION; DENDRITIC CELL; EFFECTOR CELL; HEMATOPOIETIC STROMA CELL; HOMEOSTASIS; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE MIGRATION; LYMPHOCYTE PROLIFERATION; LYMPHOID ORGAN; MEMORY T LYMPHOCYTE; NONHUMAN; REGULATORY T LYMPHOCYTE; REVIEW; STROMA CELL; T LYMPHOCYTE; UPREGULATION;

ANIMALS; ANTIGEN PRESENTATION; AUTOIMMUNITY; DENDRITIC CELLS; HUMANS; LYMPHOID TISSUE; STROMAL CELLS;

EID: 79951674014     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2010.11.012     Document Type: Review

References (57)

1. Kyewski B., Klein L. A central role for central tolerance. Annu Rev Immunol 2006, 24:571-606.
2. Steinman R.M., Banchereau J. Taking dendritic cells into medicine. Nature 2007, 449(7161):419-426.
3. Jung S., Unutmaz D., Wong P., Sano G., De los Santos K., Sparwasser T., Wu S., Vuthoori S., Ko K., Zavala F., et al. In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity 2002, 17(2):211-220.
4. Probst H.C., van den Broek M. Priming of CTLs by lymphocytic choriomeningitis virus depends on dendritic cells. J Immunol 2005, 174(7):3920-3924.
5. Sapoznikov A., Fischer J.A., Zaft T., Krauthgamer R., Dzionek A., Jung S. Organ-dependent in vivo priming of naive CD4+, but not CD8+, T cells by plasmacytoid dendritic cells. J Exp Med 2007, 204(8):1923-1933.
6. Shortman K., Naik S.H. Steady-state and inflammatory dendritic-cell development. Nat Rev Immunol 2007, 7(1):19-30.
7. Steinman R.M., Idoyaga J. Features of the dendritic cell lineage. Immunol Rev 2010, 234(1):5-17.
8. Pulendran B., Tang H., Denning T.L. Division of labor, plasticity, and crosstalk between dendritic cell subsets. Curr Opin Immunol 2008, 20(1):61-67.
9. Shortman K., Heath W.R. The CD8+ dendritic cell subset. Immunol Rev 2010, 234(1):18-31.
10. Kurts C., Kosaka H., Carbone F.R., Miller J.F., Heath W.R. Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells. J Exp Med 1997, 186(2):239-245.
11. Redmond W.L., Marincek B.C., Sherman L.A. Distinct requirements for deletion versus anergy during CD8 T cell peripheral tolerance in vivo. J Immunol 2005, 174(4):2046-2053.
12. Probst H.C., McCoy K., Okazaki T., Honjo T., van den Broek M. Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4. Nat Immunol 2005, 6(3):280-286.
13. Hawiger D., Inaba K., Dorsett Y., Guo M., Mahnke K., Rivera M., Ravetch J.V., Steinman R.M., Nussenzweig M.C. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med 2001, 194(6):769-779.
14. Belz G.T., Behrens G.M., Smith C.M., Miller J.F., Jones C., Lejon K., Fathman C.G., Mueller S.N., Shortman K., Carbone F.R., et al. The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens. J Exp Med 2002, 196(8):1099-1104.
15. Benke D., Kruger T., Lang A., Hamilton-Williams E.E., Kurts C. Inclusion of Brefeldin A during dendritic cell isolation allows in vitro detection of cross-presented self-antigens. J Immunol Methods 2006, 310(1-2):12-19.
16. Heath W.R., Carbone F.R. Cross-presentation in viral immunity and self-tolerance. Nat Rev 2001, 1(2):126-134.
17. Hildner K., Edelson B.T., Purtha W.E., Diamond M., Matsushita H., Kohyama M., Calderon B., Schraml B.U., Unanue E.R., Diamond M.S., Schreiber R.D., et al. Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. Science 2008, 322(5904):1097-1100.
18. Luckashenak N., Schroeder S., Endt K., Schmidt D., Mahnke K., Bachmann M.F., Marconi P., Deeg C.A., Brocker T. Constitutive crosspresentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo. Immunity 2008, 28(4):521-532.
19. Coombes J.L., Siddiqui K.R., Arancibia-Carcamo C.V., Hall J., Sun C.M., Belkaid Y., Powrie F. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 2007, 204(8):1757-1764.
20. Yamazaki S., Bonito A.J., Spisek R., Dhodapkar M., Inaba K., Steinman R.M. Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors. Blood 2007, 110(13):4293-4302.
21. Yamazaki S., Dudziak D., Heidkamp G.F., Fiorese C., Bonito A.J., Inaba K., Nussenzweig M.C., Steinman R.M. CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells. J Immunol 2008, 181(10):6923-6933.
22. Irla M., Kupfer N., Suter T., Lissilaa R., Benkhoucha M., Skupsky J., Lalive P.H., Fontana A., Reith W., Hugues S. MHC class II-restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell-mediated autoimmunity. J Exp Med 2010, 207(9):1891-1905.
23. Darrasse-Jeze G., Deroubaix S., Mouquet H., Victora G.D., Eisenreich T., Yao K.H., Masilamani R.F., Dustin M.L., Rudensky A., Liu K., et al. Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. J Exp Med 2009, 206(9):1853-1862.
24. Bennett C.L., Clausen B.E. DC ablation in mice: promises, pitfalls, and challenges. Trends Immunol 2007, 28(12):525-531.
25. Bar-On L., Jung S. Defining dendritic cells by conditional and constitutive cell ablation. Immunol Rev 2010, 234(1):76-89.
26. Fields M.L., Sokol C.L., Eaton-Bassiri A., Seo S., Madaio M.P., Erikson J. Fas/Fas ligand deficiency results in altered localization of anti-double-stranded DNA B cells and dendritic cells. J Immunol 2001, 167(4):2370-2378.
27. Chen M., Wang Y.H., Wang Y., Huang L., Sandoval H., Liu Y.J., Wang J. Dendritic cell apoptosis in the maintenance of immune tolerance. Science 2006, 311(5764):1160-1164.
28. Stranges P.B., Watson J., Cooper C.J., Choisy-Rossi C.M., Stonebraker A.C., Beighton R.A., Hartig H., Sundberg J.P., Servick S., Kaufmann G., et al. Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity. Immunity 2007, 26(5):629-641.
29. Fujikado N., Saijo S., Yonezawa T., Shimamori K., Ishii A., Sugai S., Kotaki H., Sudo K., Nose M., Iwakura Y. Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells. Nat Med 2008, 14(2):176-180.
30. Jongbloed S.L., Benson R.A., Nickdel M.B., Garside P., McInnes I.B., Brewer J.M. Plasmacytoid dendritic cells regulate breach of self-tolerance in autoimmune arthritis. J Immunol 2009, 182(2):963-968.
31. Caton M.L., Smith-Raska M.R., Reizis B. Notch-RBP-J signaling controls the homeostasis of CD8-dendritic cells in the spleen. J Exp Med 2007, 204(7):1653-1664.
32. Brockschnieder D., Pechmann Y., Sonnenberg-Riethmacher E., Riethmacher D. An improved mouse line for Cre-induced cell ablation due to diphtheria toxin A, expressed from the Rosa26 locus. Genesis 2006, 44(7):322-327.
33. Birnberg T., Bar-On L., Sapoznikov A., Caton M.L., Cervantes-Barragan L., Makia D., Krauthgamer R., Brenner O., Ludewig B., Brockschnieder D., et al. Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome. Immunity 2008, 29(6):986-997.
34. Ohnmacht C., Pullner A., King S.B., Drexler I., Meier S., Brocker T., Voehringer D. Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J Exp Med 2009, 206(3):549-559.
35. Villadangos J.A., Young L. Antigen-presentation properties of plasmacytoid dendritic cells. Immunity 2008, 29(3):352-361.
36. Katz J.D., Ondr J.K., Opoka R.J., Garcia Z., Janssen E.M. Cutting edge: merocytic dendritic cells break T cell tolerance to beta cell antigens in nonobese diabetic mouse diabetes. J Immunol 2010, 185(4):1999-2003.
37. Hamilton-Williams E.E., Martinez X., Clark J., Howlett S., Hunter K.M., Rainbow D.B., Wen L., Shlomchik M.J., Katz J.D., Beilhack G.F., et al. Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic mice. J Immunol 2009, 183(3):1533-1541.
38. Mueller S.N., Germain R.N. Stromal cell contributions to the homeostasis and functionality of the immune system. Nat Rev 2009, 9(9):618-629.
39. Link A., Vogt T.K., Favre S., Britschgi M.R., Acha-Orbea H., Hinz B., Cyster J.G., Luther S.A. Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat Immunol 2007, 8(11):1255-1265.
40. Katakai T., Suto H., Sugai M., Gonda H., Togawa A., Suematsu S., Ebisuno Y., Katagiri K., Kinashi T., Shimizu A. Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs. J Immunol 2008, 181(9):6189-6200.
41. Gardner J.M., Devoss J.J., Friedman R.S., Wong D.J., Tan Y.X., Zhou X., Johannes K.P., Su M.A., Chang H.Y., Krummel M.F., et al. Deletional tolerance mediated by extrathymic Aire-expressing cells. Science 2008, 321(5890):843-847.
42. Fletcher A.L., Lukacs-Kornek V., Reynoso E.D., Pinner S.E., Bellemare-Pelletier A., Curry M.S., Collier A.R., Boyd R.L., Turley S.J. Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions. J Exp Med 2010, 207(4):689-697.
43. Katakai T., Hara T., Sugai M., Gonda H., Shimizu A. Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. J Exp Med 2004, 200(6):783-795.
44. Sixt M., Kanazawa N., Selg M., Samson T., Roos G., Reinhardt D.P., Pabst R., Lutz M.B., Sorokin L. The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node. Immunity 2005, 22(1):19-29.
45. Randolph G.J., Angeli V., Swartz M.A. Dendritic-cell trafficking to lymph nodes through lymphatic vessels. Nat Rev Immunol 2005, 5(8):617-628.
46. Pham T.H., Baluk P., Xu Y., Grigorova I., Bankovich A.J., Pappu R., Coughlin S.R., McDonald D.M., Schwab S.R., Cyster J.G. Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. J Exp Med 2010, 207(1):17-27.
47. Lee J.W., Epardaud M., Sun J., Becker J.E., Cheng A.C., Yonekura A.R., Heath J.K., Turley S.J. Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self. Nat Immunol 2007, 8(2):181-190.
48. Magnusson F.C., Liblau R.S., von Boehmer H., Pittet M.J., Lee J.W., Turley S.J., Khazaie K. Direct presentation of antigen by lymph node stromal cells protects against CD8 T-cell-mediated intestinal autoimmunity. Gastroenterology 2008, 134(4):1028-1037.
49. Nichols L.A., Chen Y., Colella T.A., Bennett C.L., Clausen B.E., Engelhard V.H. Deletional self-tolerance to a melanocyte/melanoma antigen derived from tyrosinase is mediated by a radio-resistant cell in peripheral and mesenteric lymph nodes. J Immunol 2007, 179(2):993-1003.
50. Yip L., Su L., Sheng D., Chang P., Atkinson M., Czesak M., Albert P.R., Collier A.R., Turley S.J., Fathman C.G., et al. Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes. Nat Immunol 2009, 10(9):1026-1033.
51. Tokuda N., Adachi T., Adachi Y., Higashi M., Sharifi K., Tuerxun T., Sawada T., Kondo H., Owada Y. Identification of FABP7 in fibroblastic reticular cells of mouse lymph nodes. Histochem Cell Biol 2010, 134(5):445-452.
52. Cohen J.N., Guidi C.J., Tewalt E.F., Qiao H., Rouhani S.J., Ruddell A., Farr A.G., Tung K.S., Engelhard V.H. Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation. J Exp Med 2010, 207(4):681-688.
53. Hamilton-Williams E.E., Lang A., Benke D., Davey G.M., Wiesmuller K.H., Kurts C. Cutting edge: TLR ligands are not sufficient to break cross-tolerance to self-antigens. J Immunol 2005, 174(3):1159-1163.
54. Reynoso E.D., Elpek K.G., Francisco L., Bronson R., Bellemare-Pelletier A., Sharpe A.H., Freeman G.J., Turley S.J. Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade. J Immunol 2009, 182(4):2102-2112.
55. Keir M.E., Butte M.J., Freeman G.J., Sharpe A.H. PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol 2008, 26:677-704.
56. Vezys V., Lefrancois L. Cutting edge: inflammatory signals drive organ-specific autoimmunity to normally cross-tolerizing endogenous antigen. J Immunol 2002, 169(12):6677-6680.
57. Vezys V., Olson S., Lefrancois L. Expression of intestine-specific antigen reveals novel pathways of CD8 T cell tolerance induction. Immunity 2000, 12(5):505-514.