Merocytic dendritic cells break T cell tolerance to β cell antigens in nonobese diabetic mouse diabetes

Journal of Immunology

Volumn 185, Issue 4, 2010, Pages 1999-2003

  Katz, Jonathan D ^a   Ondr, Jennifer K ^a   Opoka, Robert J ^a   Garcia, Zacharias ^b   Janssen, Edith M ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ANTIGEN; PANCREAS ISLET BETA CELL ANTIGEN; UNCLASSIFIED DRUG; ANTIGEN; CD11B ANTIGEN; CD8 ANTIGEN; FLT3 LIGAND PROTEIN; INTERFERON; MEMBRANE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL SUBPOPULATION; CLONAL ANERGY; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; LYMPH NODE; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; ANIMAL; BAGG ALBINO MOUSE; CROSS PRESENTATION; FLOW CYTOMETRY; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; MALE; METABOLISM; MOUSE STRAIN; PATHOLOGY; T LYMPHOCYTE; TRANSGENIC MOUSE; TRANSPLANTATION;

ANIMALS; ANTIGENS; ANTIGENS, CD11B; ANTIGENS, CD8; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CROSS-PRIMING; DENDRITIC CELLS; DIABETES MELLITUS, TYPE 1; FEMALE; FLOW CYTOMETRY; IMMUNE TOLERANCE; INSULIN-SECRETING CELLS; INTERFERON TYPE I; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; MICE, INBRED STRAINS; MICE, TRANSGENIC; T-LYMPHOCYTES;

EID: 77956936559     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1001398     Document Type: Article

References (27)

1. Anderson, M. S., and J. A. Bluestone. 2005. The NOD mouse: a model of immune dysregulation. Annu. Rev. Immunol. 23: 447-485.
2. André, I., A. Gonzalez, B. Wang, J. Katz, C. Benoist, and D. Mathis. 1996. Checkpoints in the progression of autoimmune disease: lessons from diabetes models. Proc. Natl. Acad. Sci. USA 93: 2260-2263.
3. Mathis, D., L. Vence, and C. Benoist. 2001. beta-Cell death during progression to diabetes. Nature 414: 792-798.
4. Katz, J., C. Benoist, and D. Mathis. 1993. Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice. Eur. J. Immunol. 23: 3358-3360.
5. Serreze, D. V., E. H. Leiter, G. J. Christianson, D. Greiner, and D. C. Roopenian. 1994. Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant. Diabetes 43: 505-509.
6. Wicker, L. S., E. H. Leiter, J. A. Todd, R. J. Renjilian, E. Peterson, P. A. Fischer, P. L. Podolin, M. Zijlstra, R. Jaenisch, and L. B. Peterson. 1994. Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes. Diabetes 43: 500-504.
7. Höglund, P., J. Mintern, C. Waltzinger, W. Heath, C. Benoist, and D. Mathis. 1999. Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes. J. Exp. Med. 189: 331-339.
8. Turley, S., L. Poirot, M. Hattori, C. Benoist, and D. Mathis. 2003. Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model. J. Exp. Med. 198: 1527-1537.
9. Belz, G. T., K. Shortman, M. J. Bevan, and W. R. Heath. 2005. CD8alpha+ dendritic cells selectively present MHC class I-restricted noncytolytic viral and intracellular bacterial antigens in vivo. J. Immunol. 175: 196-200.
10. Roos, A., W. Xu, G. Castellano, A. J. Nauta, P. Garred, M. R. Daha, and C. van Kooten. 2004. Mini-review: A pivotal role for innate immunity in the clearance of apoptotic cells. Eur. J. Immunol. 34: 921-929.
11. Janssen, E., K. Tabeta, M. J. Barnes, S. Rutschmann, S. McBride, K. S. Bahjat S. P. Schoenberger, A. N. Theofilopoulos, B. Beutler, and K. Hoebe. 2006. Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway. Immunity 24: 787-799.
12. Saxena, V., J. K. Ondr, A. F. Magnusen, D. H. Munn, and J. D. Katz. 2007. The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes in the nonobese diabetic mouse. J. Immunol. 179: 5041-5053.
13. Katz, J. D., B. Wang, K. Haskins, C. Benoist, and D. Mathis. 1993. Following a diabetogenic T cell from genesis through pathogenesis. Cell 74: 1089-1100.
14. Kurts, C., W. R. Heath, H. Kosaka, J. F. Miller, and F. R. Carbone. 1998. The peripheral deletion of autoreactive CD8+ T cells induced by cross-presentation of self-antigens involves signaling through CD95 (Fas, Apo-1). J. Exp. Med. 188: 415-420.
15. Ehst, B. D., E. Ingulli, and M. K. Jenkins. 2003. Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection. Am. J. Transplant. 3: 1355-1362.
16. Dranoff, G., E. Jaffee, A. Lazenby, P. Golumbek, H. Levitsky, K. Brose, V. Jackson, H. Hamada, D. Pardoll, and R. C. Mulligan. 1993. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc. Natl. Acad. Sci. USA 90: 3539-3543.
17. Lacy, P. E., and M. Kostianovsky. 1967. Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes 16: 35-39.
18. Lyons, A. B. 2000. Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution. J. Immunol. Methods 243: 147-154.
19. Jiang, Z., P. Georgel, X. Du, L. Shamel, S. Sovath, S. Mudd, M. Huber, C. Kalis S. Keck, C. Galanos, et al. 2005. CD14 is required for MyD88-independent LPS signaling. Nat. Immunol. 6: 565-570.
20. Kurrer, M. O., S. V. Pakala, H. L. Hanson, and J. D. Katz. 1997. Beta cell apoptosis in T cell-mediated autoimmune diabetes. Proc. Natl. Acad. Sci. USA 94: 213-218.
21. Steptoe, R. J., J. M. Ritchie, and L. C. Harrison. 2002. Increased generation of dendritic cells from myeloid progenitors in autoimmune-prone nonobese diabetic mice. J. Immunol. 168: 5032-5041.
22. Suri, A., and J. D. Katz. 1999. Dissecting the role of CD4+ T cells in autoimmune diabetes through the use of TCR transgenic mice. Immunol. Rev. 169: 55-65.
23. Morel, P. A., A. C. Vasquez, and M. Feili-Hariri. 1999. Immunobiology of DC in NOD mice. J. Leukoc. Biol. 66: 276-280.
24. Prasad, S. J., and C. C. Goodnow. 2002. Cell-intrinsic effects of non-MHC NOD genes on dendritic cell generation in vivo. Int. Immunol. 14: 677-684.
25. Li, Q., B. Xu, S. A. Michie, K. H. Rubins, R. D. Schreriber, and H. O. McDevitt. 2008. Interferon-alpha initiates type 1 diabetes in nonobese diabetic mice. Proc. Natl. Acad. Sci. USA 105: 12439-12444.
26. Martin-Orozco, N., Y. Chung, S. H. Chang, Y. H. Wang, and C. Dong. 2009. Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells. Eur. J. Immunol. 39: 216-224.
27. Belz, G. T., G. M. N. Behrens, C. M. Smith, J. F. A. P. Miller, C. Jones, K. Lejon, C. G. Fathman, S. N. Mueller, K. Shortman, F. R. Carbone, and W. R. Heath. 2002. The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens. J. Exp. Med. 196: 1099-1104.