Cutting edge: Inflammatory signals drive organ-specific autoimmunity to normally cross-tolerizing endogenous antigen

Journal of Immunology

Volumn 169, Issue 12, 2002, Pages 6677-6680

  Vezys, Vaiva ^a   Lefrançois, Leo ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD40 ANTIGEN; CD8 ANTIGEN; CHOLERA TOXIN; CYTOKINE; OVALBUMIN; AUTOANTIGEN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; CROSS TOLERANCE; CYTOKINE RELEASE; ENTEROPATHY; INFLAMMATION; INTESTINE LYMPHATIC TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; VESICULAR STOMATITIS VIRUS; VIRUS INFECTION; ANIMAL; ANTIBODY SPECIFICITY; AUTOIMMUNE DISEASE; C57BL MOUSE; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; INTESTINE MUCOSA; JEJUNUM; LYMPHOCYTE TRANSFUSION; PATHOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ADOPTIVE TRANSFER; ANIMALS; AUTOANTIGENS; AUTOIMMUNE DISEASES; CHOLERA TOXIN; IMMUNE TOLERANCE; INFLAMMATION; INTESTINAL MUCOSA; JEJUNUM; LYMPHOCYTE TRANSFUSION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; ORGAN SPECIFICITY; OVALBUMIN; SIGNAL TRANSDUCTION; VESICULAR STOMATITIS-INDIANA VIRUS;

EID: 0037114135     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.12.6677     Document Type: Article

References (29)

1. + T cell-mediated pathology. J. Immunol. 156:4050.
2. Strober, W., I. J. Fuss, and R. S. Blumberg. 2002. The immunology of mucosal models of inflammation. Annu. Rev. Immunol. 20:495.
3. Swanborg, R. H. 2001. Experimental autoimmune encephalomyelitis in the rat: lessons in T-cell immunology and autoreactivity. Immunol. Rev. 184:129.
4. ++ mice and induces partial tolerance against coxsackieviral myocarditis. J. Immunol. 156:3528.
5. Gross, D. M., T. Forsthuber, M. Tary-Lehmann, C. Etling, K. Ito, Z. A. Nagy, J. A. Field, A. C. Steere, and B. T. Huber. 1998. Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science 281:703.
6. Tompkins, S. M., K. G. Fuller, and S. D. Miller. 2002. Theiler's virus-mediated autoimmunity: local presentation of CNS antigens and epitope spreading. Ann. NY Acad. Sci. 958:26.
7. Horwitz, M. S., A. Ilic, C. Fine, E. Rodriguez, and N. Sarvetnick. 2002. Presented antigen from damaged pancreatic β cells activates autoreactive T cells in virus-mediated autoimmune diabetes. J. Clin. Invest. 109:79.
8. Wucherpfennig, K. W. 2001. Mechanisms for the induction of autoimmunity by infectious agents. J. Clin. Invest. 108:1097.
9. Jun, H. S., and J. W. Yoon. 2001. The role of viruses in type I diabetes: two distinct cellular and molecular pathogenic mechanisms of virus-induced diabetes in animals. Diabetologia 44:271.
10. Ehl, S., J. Hombach, P. Aichele, H. Hengartner, and R. M. Zinkemagel. 1997. Bystander activation of cytotoxic T cells: studies on the mechanism and evaluation of in vivo significance in a transgenic mouse model. J. Exp. Med. 185:1241.
11. Tough, D. F., P. Borrow, and J. Sprent. 1996. Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science 272:1947.
12. Walker, L. S., and A. K. Abbas. 2002. The enemy within: keeping self-reactive T cells at bay in the periphery. Nat. Rev. Immunol. 2:11.
13. Heath, W. R., and F. R. Carbone. 2001. Cross-presentation, dendritic cells, tolerance and immunity. Annu. Rev. Immunol. 19:47.
14. + T cells to cause immunopathology. J. Exp. Med. 187:763.
15. Roth, E., J. Schwartzkopff, and H. Pircher. 2002. CD40 ligation in the presence of self-reactive CD8 T cells leads to severe immunopathology. J. Immunol. 168:5124.
16. + T cells. J. Exp. Med. 186:239.
17. Vezys, V., S. Olson, and L. Lefrancois. 2000. Expression of intestine-specific antigen reveals novel pathways of CD8 T cell tolerance induction. Immunity 12:505.
18. von Herrath, M. G., J. Dockter, and M. B. Oldstone. 1994. How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model. Immunity 1:231.
19. Evans, C. F., M. S. Horwitz, M. V. Hobbs, and M. B. Oldstone. 1996. Viral infection of transgenic mice expressing a viral protein in oligodendrocytes leads to chronic central nervous system autoimmune disease. J. Exp. Med. 184:2371.
20. + T cell tolerance to peripherally expressed antigens. J. Immunol. 163:723.
21. Ohashi, P. S., S. Oehen, K. Buerki, H. Pircher, C. T. Ohashi, B. Odermatt, B. Malissen, R. M. Zinkernagel, and H. Hengartner. 1991. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 65:305.
22. + lymphocytes and its blocking prevents chronic rejection of heart transplants. J. Immunol. 165:7316.
23. Laky, K., L. Lefrancois, and L. Puddington. 1997. Age-dependent intestinal lymphoproliferative disorder due to stem cell factor receptor deficiency: parameters in small and large intestine. J. Immunol. 158:1417.
24. Huang, F. P., N. Platt, M. Wykes, J. R. Major, T. J. Powell, C. D. Jenkins, and G. G. MacPherson. 2000. A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J. Exp. Med. 191:435.
25. Kim, S-K., D. S. Reed, S. Olson, M. J. Schnell, J. K. Rose, P. A. Morton, and L. Lefranecois. 1998. Generation of mucosal cytotoxic T cells against soluble protein by tissue-specific environmental and costimulatory signals. Proc. Natl. Acad. Sci. USA 95:10814.
26. Matzinger, P. 2002. The danger model: a renewed sense of self. Science 296:301.
27. Teixeira, M. M., I. C. Almeida, and R. T. Gazzinelli. 2002. Introduction: innate recognition of bacteria and protozoan parasites. Microbes. Infect. 4:883.
28. Ohashi, P. S., S. Oehen, P. Aichele, H. Pircher, B. Odermatt, P. Herrera, Y. Higuchi, K. Buerki, H. Hengartner, and R. M. Zinkernagel. 1993. Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-α. J. Immunol. 150:5185.
29. Engelmayer, J., M. Larsson, M. Subklewe, A. Chahroudi, W. I. Cox, R. M. Steinman, and N. Bhardwaj. 1999. Vaccinia virus inhibits the maturation of human dendritic cells: a novel mechanism of immune evasion. J. Immunol. 163:6762.