Derivation of soil Clean-Up levels for 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD) toxicity equivalence (TEQD/F) in soil through deterministic and probabilistic risk assessment of exposure and Toxicity

Human and Ecological Risk Assessment

Volumn 17, Issue 1, 2011, Pages 125-158

  Kirman, Chris ^a   Budinsky, Robert A ^b   Yost, Lisa ^c   Baker, Ben F ^d   Zabik, Jack M ^b   Rowlands, J Craig ^b   Long, Tom F ^e   Simon, Ted ^f  

^a LLP   (United States)

^b DOW CHEMICAL COMPANY   (United States)

^c EXPONENT INC   (United States)

^d Sugar River Consulting   (United States)

^e The Sapphire Group   (United States)

^f Ted Simon LLC   (United States)

Author keywords

Clean up; Dioxin; Monte carlo; Risk; Soil; Toxicity values

Indexed keywords

EID: 79951572337     PISSN: 10807039     EISSN: 15497860     Source Type: Journal    
DOI: 10.1080/10807039.2011.538629     Document Type: Article

References (97)

1. Abraham K, Geusau A, Tosun Y, et al. 2002. Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: Insights into the measurement of hepatic cytochrome P450 1A2 induction. Clin Pharmacol Ther 72(2):163-74
2. Arias E. 2007. United States Life Tables, 2003. National Vital Statistics Report 54:14. US National Center for Health Statistics. Available at http://www.cdc.gov/nchs/data/nvsr/nvsr54/nvsr5414.pdf
3. ATSDR (Agency for Toxic Substances and Disease Registry). 1998. Toxicological Profile for Chlorinated Dibenzo-p-dioxins. US Department of Health and Human Services, Atlanta, GA, USA
4. Aylward LL, Goodman JE, Charnley G, et al. 2008. A margin-of-exposure approach to assessment of noncancer risks of dioxins based on human exposure and response data. Environ Health Perspect 116:1344-51
5. Baccarelli A, Giacomini SM, Corbetta C, et al. 2008. Neonatal thyroid function in Seveso 25 years after maternal exposure to dioxin. PLoS Med 5:1133-1142
6. Bell DR, Clode S, Fan MQ, et al. 2007a. Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing male Wistar(Han) rat. I: No decrease in epididymal sperm count after a single acute dose. Toxicol Sci 99(1):214-23
7. Bell, DR, Clode S, Fan MQ, et al. 2007b. Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing male Wistar(Han) rat. II: Chronic dosing causes developmental delay. Toxicol Sci 99(1):224-33
8. Bell DR, Clode S, Fan MQ, et al. 2007c. Relationships between tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mRNAs, and toxicity in the developing male Wistar(Han) rat. Toxicol Sci 99(2):591-604
9. Bonaccorsi A, di Domenico A, Fanelli R, et al. 1984. The influence of soil particle adsorption on 2,3,7,8-tetrachlorodibenzo-p-dioxin biological uptake in the rabbit. Arch Toxicol Suppl 8:431-4
10. Book SA and LK Bustad. 1974. The fetal and neonatal pig in biomedical research. J Animal Sci 38:997-1002
11. Bowman RE, Schantz SL, Weerasinghe NCA, et al. 1989. Chronic dietary intake of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at 5 or 25 parts per trillion in the monkey: TCDD kinetics and dose-effect estimate of reproductive toxicity. Chemosphere 18(1-6):243-52
12. Budinsky RA, Rowlands JC, Casteel S, et al. 2008. A pilot study of oral bioavailability of dioxins and furans from contaminated soils: Impact of differential hepatic enzyme activity and species differences. Chemosphere 70:1774-86
13. Carney EW, Zablotny CL, Marty MS, et al. 2004. The effects of feed restriction during in utero and postnatal development in rats. Toxicol Sci 82(1):237-49
14. Casteel S.W,Weis C.P, Henningsen G.M, et al. 2006. Estimation of relative bioavailability of lead in soil and soil-like materials using young swine. Environ Health Perspect 114:1162-71
15. CH2M Hill. 2007. Data Evaluation Report in Support of Bioavailability Study, Midland Area Soils. CH2M Hill, Midland, MI, USA
16. Cheng H, Aylward L, Beall C, et al. 2006. TCDD exposure-response analysis and risk assessment. Risk Anal 26:1059-1071
17. Connor KT and LL Aylward. 2006. Human response to dioxin: aryl hydrocarbon receptor (AhR) molecular structure, function, and dose-response data for enzyme induction indicate an impaired human AhR. J Toxicol Environ Health B Crit Rev 9:147-71
18. Costeff H. 1966. A simple empirical formula for calculating surface area in children. Arch Dis Child 41:681-3
19. Della Porta G, Dragani AD, and Sozzi G. 1987. Carcinogenic effects of infantile and long-term 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment in the mouse. Tumori 73:99-107
20. Demond A, Adriaens P, Towey T, et al. 2008. Statistical comparison of residential soil concentrations of PCDDs, PCDFs and PCBs from two communities in Michigan. Environ Sci Technol 42(15):5441-8
21. ECSCF (European Commission Scientific Committee on Foods). 2001. Opinion of the Scientific Committee on Food on the Risk Assessment of Dioxins and Dioxin-like PCBs in Food. CS/CNTM/DIOXIN/20 final. Brussels, Belgium: European Commission. Available at http://europa.eu.int/comm/food/fs/sc/scf/out90en.pdf
22. Eklund G, Tallkvist J, and Oskarsson A. 2004. A piglet model for studies of gastrointestinal uptake of cadmium in neonates. Toxicol Lett 146:237-47
23. Finley B and Paustenbach D. 1994. The benefits of probabilistic exposure assessment: Three case studies involving contaminated air, water, and soil. Risk Anal 14(1):53-73
24. Franzblau A, Hedgeman E, Chen Q, et al. 2008a. Case report: Human exposure to dioxins from clay. Environ Health Perspect 116(2):238-42
25. Franzblau A, Hedgeman E, Knutson K, et al. 2008b. The University of Michigan Dioxin Exposure Study: A follow-up investigation of cases with high serum concentrations of 2,3,4,7,8-PentaCDF. Epidemiology 16(5):S236
26. Franzblau A, Zwica L, Knutson K, et al. 2009a. An investigation of homes with high concentrations of PCDDs, PCDFs, and/or dioxin-like PCBs in house dust. J Occup Environ Hyg 6(3):188-99
27. Franzblau A, Demond A, Towey T, et al. 2009b. Residences with anomalous soil concentrations of dioxin-like compounds in two communities in Michigan, USA: A case study. Chemosphere 74(3):395-403
28. Garabrant DH, Franzblau A, Lepkowski J, et al. 2008a. The University of Michigan Dioxin Exposure Study:Methods for an environmental exposure study of polychlorinated dioxins, furans and biphenyls. Environ Health Perspect doi:10.1289/ehp.11777 [OnlineDecember 22, 2008]
29. Garabrant DH, Franzblau A, Lepkowski J, et al. 2008b. The University of Michigan Dioxin Exposure Study: Predictors of human serum dioxin concentrations in Midland and Saginaw, Michigan. Environ Health Perspect doi:10.1289/ehp.11779 [Online December 22, 2008]
30. Gray LE, Ostby JS, and Kelce WR. 1997. A dose-response analysis of the reproductive effects of a single gestational dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male Long Evans Hooded rat offspring. Toxicol Appl Pharmacol 146(1):11-20
31. Gray MN, Aylward LL, and Keenan RE. 2006. Relative cancer potencies of selected dioxinlike compounds on a body-burden basis: Comparison to current toxic equivalency factors (TEFs). J Toxicol Environ Health Part A 69:907-17
32. Guzelian P, Quattrochi L, Karch N, et al. 2006. Does dioxin exert toxic effects in humans at or near current background body levels?: An evidence-based conclusion. Hum Exp Toxicol 25:99-105
33. Hailey J.R, Walker N.J, Sells D.M, et al. 2005 Classification of proliferative hepatocellular lesions in Harlan Sprague-Dawley rats chronically exposed to dioxin-like compounds. Toxicol Pathol 33:165-74
34. Haws LC, Su SH, Harris M, et al. 2006. Development of a refined database of mammalian relative potency estimates for dioxin-like compounds. Toxicol Sci 89(1):4-30
35. Hedgeman E, Chen Q, Hong B, et al. 2008. TheUniversity ofMichiganDioxin Exposure Study: Population survey results and serum concentrations for polychlorinated dioxins, furans and biphenyls. Environ Health Perspect. doi:10.1289/ehp.11780 [Online December 22, 2008]
36. Iida M, Anna CH, Gaskin ND, et al. 2007. The putative tumor suppressor Tsc-22 is downregulated early in chemically induced hepatocarcinogenesis and may be a suppressor of Gadd45b. Toxicol Sci 99:43-50
37. JECFA (Joint Expert Committee on Food Additives). 2001. Summary and Conclusions. Joint FAO/WHO Expert Committee on Food Additives, World Health Organization. Fiftyseventh meeting, June 5-14, 2001, Rome. Available at http:///www.who.int/ipcs/food/jecfa/summaries/en/summary57.pdf (accessed June 24, 2009)
38. Johnson FE. 1998. Population variation in growth patterns. Section 2.5. In: Cambridge Encyclopedia of Human Growth and Development. Cambridge University Press, Cambridge, UK
39. Johnson T and Capel J. 1992. A Monte Carlo Approach to Simulating Residential Occupancy Periods and its Application to the General U.S. Population. EPA-450/3-92-011. US Environmental Protection Agency, Research Triangle Park, NC, USA
40. Kissel. 2009. The Kissel Laboratory Website. University of Washington, Department of Environmental and Occupational Health Sciences, Seattle, WA, USA. Available at http://depts.washington.edu/jkspage
41. Kociba RJ, Keyes DG, Beyer JE, et al. 1978. Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats. Toxicol Appl Pharmacol 46(2):279-303
42. Krishnan TR, Abraham I, and Craig S. 1994. Use of the domestic pig as a model for oral bioavailability and pharmacokinetic studies. Biopharm Drug Dispos 15:341-6
43. Lambert GH, Needham LL, Turner W, et al. 2006. Induced CYP1A2 activity as a phenotypic biomarker in humans highly exposed to certain PCBs/PCDFs. Environ Sci Technol 40:6176-80
44. Lucier GW, Rumbaugh RC, McCoy Z, et al. 1986. Ingestion of soil contaminated with 2,37,8-tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic enzyme activities in rats. Fund Appl Toxicol 6:364-371
45. Maruyama W and Aoki Y. 2006. Estimated cancer risk of dioxins to humans using a bioassay and physiologically based pharmacokinetic model. Toxicol Appl Pharmacol 214(2): 188-98
46. Maruyama W, Yoshida K, Tanaka T, et al. 2002. Possible range of dioxin concentration in human tissues: Simulation with a physiologically based model. J Toxicol Environ Health A 265:2053-73
47. Maruyama W, Yoshida K, Tanaka T, et al. 2003. Simulation of dioxin accumulation in human tissues and analysis of reproductive risk. Chemosphere 53:301-13
48. McConnell EE, Lucier GW, Rumbaugh RC, et al. 1984. Dioxin in soil: Bioavailability after ingestion by rats and guinea pigs. Science 223:1077-9
49. McHale CM, Zhang L, Hubbard AE, et al. 2006. Microarray analysis of gene expression in peripheral blood mononuclear cells from dioxin-exposed human subjects. Toxicology 229:101-13
50. MDEQ (Michigan Department of Environmental Quality). 2001. Attachment A: PART 201 Generic Soil Direct Contact Criteria Technical Support Document. January 5, 2001. [Rescinded except for Attachment A.] Environmental Response Division, Lansing, MI, USA. Available at http://www.deq.state.mi.us/documents/deq-erd-tsd2.pdf
51. MDEQ. 2005. RRD Operational Memorandum No. 1. Technical Support Document-Attachment 6. Part 201: Soil Direct Contact Criteria. Remediation and Redevelopment Division, Lansing,MI, USA. Available at http://www.deq.state.mi.us/documents/deq-rrd-OpMemo1-Attachment6.pdf
52. Miller ER and Ullrey DE. 1987. The pig as a model for human nutrition. Ann Rev Nutri 7:361-82
53. Mocarelli P, Gerthoux PM, Patterson DG Jr, et al. 2008. Environ Health Perspect 116:70-77 (2008). doi:10.1289/ehp.10399 available via http://dx.doi.org/ [Online October 29, 2007]
54. NAS (National Academy of Sciences). 2006. Health Risks from Dioxin and Related Compounds: Evaluation of the EPA Reassessment. Committee on EPA's Exposure and Human Health. The National Academies Press. Washington, DC, USA
55. NAS. 2008. Science and Decisions: Advancing Risk Assessment Committee on Improving Risk Analysis Approaches used by the U.S. EPA. The National Academies Press, Washington, DC, USA. Available at http://www.nap.edu/catalog/12209.html
56. NCDC(National Climatic DataCenter). 2007. Climate Data for MidlandMI. National Oceanic and Atmospheric Administration, US Dept of Commerce. Washington, DC, USA
57. NTP (National Toxicology Program). 1982. Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Osborne-Mendel Rats and B6C3F1 Mice. Technical Report Series No. 209. National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
58. NTP. 2006. NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CAS No. 1746-01-6) in Female Harlan Sprague-Dawley Rats (Gavage Studies). Technical Report Series (521):4-232. National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
59. OEHHA (Office of Environmental Health Hazard Assessment). 2007. Draft for Public Review. Public Health Goal for TCDD in Drinking Water. California Environmental Protection Agency, Pesticide and Environmental Toxicology Branch. Sacramento, CA
60. Paustenbach DJ, Jernigan JD, Bass R, et al. 1992a. A proposed approach to regulating contaminated soil: Identify safe concentrations for seven of the most frequently encountered exposure scenarios. Regul Toxicol Pharmacol 16(1):21-56
61. Paustenbach DJ, Wenning RJ, Lau V, et al. 1992b. Recent developments on the hazards posed by 2,3,7,8-tetrachlorodibenzo-p-dioxin in soil: Implications for setting risk-based cleanup levels at residential and industrial sites. J Toxicol Environ Health 36(2):103-49
62. Paustenbach DJ, Fehling K, Scott P, et al. 2006. Identifying soil cleanup criteria for dioxins in urban residential soils: How have 20 years of research and risk assessment experience affected the analysis? J Toxicol Environ Health B Crit Rev 9(2):87-145
63. Poiger H and Schlatter CH. 1980. Influence of solvents and adsorbents on dermal and intestinal absorption of TCDD. Food Cosmet Toxicol 18:477-81
64. Rao MS, Subbarao V, Prasad JD, et al. 1988. Carcinogenicity of 2,3,7,8-tetrachlorodibenzo-pdioxin in the Syrian golden hamster. Carcinogenesis 9:1677-9
65. Rier SE, Turner WE, Martin DC, et al. 2001. Serum levels of TCDD and dioxin-like chemicals in Rhesus monkeys chronically exposed to dioxin: Correlation of increased serum PCB levels with endometriosis. Toxicol Sci 59(1):147-59
66. Rowlands JC, Budinsky RA, Gollapudi B, et al. 2008. The human AhR: Identification of single nucleotide polymorphisms from six ethnic populations. Organhal Comp 70:2107-10
67. Roy T.A, Hammerstrom K, and Schaum J. 2008. 'Percutaneous absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) from soil. J Toxicol Environ Health, Part A, 71(23):1509-15 Available at http://dx.doi.org/10.1080/15287390802349875
68. Ruby MV, Fehling KA, Paustenbach DJ, et al. 2002. Oral bioaccessibility of dioxins/furans at low concentrations (50-350 ppt toxicity equivalent) in soil. Environ Sci Technol 36:4905-11
69. Schantz SL, Ferguson SA, and Bowman RE. 1992. Effects of 2,3,7,8-tetrachlorodibenzo-pdioxin on behavior of monkeys in peer groups. Neurotoxicol Teratol 14:433-46
70. Shu H, Teitelbaum P, Webb AS, et al. 1988. Bioavailability of soil-bound TCDD: Dermal bioavailability in the rat. Fundam Appl Toxicol 10:335-43
71. Simon T, Aylward LL, Kirman CR, et al. 2009. Estimates of cancer potency of 2,3,7,8-tetrachlorodibenzo(p)dioxin using linear and nonlinear dose-response modeling and toxicokinetics. Toxicol Sci 112(2):490-506
72. Stanek EJ, Calabrese EJ, Barnes R, et al. 1997. Soil ingestion in adults-Results of a second pilot study. Ecotoxicol Environ Safety 36:249-75
73. Stanek EJ, Calabrese EJ, and Zorn M. 2001. Soil ingestion distributions for Monte Carlo risk assessment in children. Hum Ecol Risk Assess 7(2):357-68
74. Toth K, Somfai-Relle S, Sugar J, et al. 1979. Carcinogenicity testing of herbicide 2,4,5-trichlorophenoxyethanol containing dioxin and of pure dioxin in Swiss mice. Nature 278(5704):548-9
75. US Census Bureau. 2007a. Geographical Mobility: 2000-2005, Detailed Tables. Available at http://www.census.gov/population/www/socdemo/migrate/cps2005--5yr.html. Population Division, Journey-To-Work & Migration Statistics Branch, Washington, DC, USA
76. US Census Bureau. 2007b. Table 1. General Mobility, by Region, Sex, and Age: 2000-2005. Available at http://www.census.gov/population/socdemo/migration/cps2005-5yr/tab01-3.xls. Last updated October 16, 2007. Population Division, Journey-To-Work & Migration Statistics Branch, Washington, DC, USA
77. USEPA (US Environmental Protection Agency). 1989. Risk Assessment Guidance for Superfund. Volume 1: Human Health Evaluation Manual (Part A). Interim Final Report. EPA 540/1-89/002. Office of Emergency and Remedial Response, Washington, DC, USA
78. USEPA. 1990. National Oil and Hazardous Substances Pollution Contingency Plan. 40 CFR Part 300, revisedMarch 1990. Office of SolidWaste and Emergency Response.Washington, DC, USA
79. USEPA. 1991. Standard Default Exposure Factors. OSWER Directive: 9285.6-03. Office of Solid Waste and Emergency Response, Washington, DC, USA
80. USEPA. 1992. Dermal Exposure Assessment: Principles and Applications. Interim Report. EPA/600/8-91/011B. Washington, DC, USA
81. USEPA. 1997. Exposure Factors Handbook. EPA/600/P-95/002F. Office of Research and Development, Washington, DC, USA
82. USEPA. 1998. Approach for Addressing Dioxin in Soil at CERCLA and RCRA Sites. OSWER Directive 9200.4-26. Office of Solid Waste and Emergency Response, Washington, DC, USA
83. USEPA. 2001. Risk assessment guidance for Superfund: Volume III, Part A: Process for conducting probabilistic risk assessment. EPA 540-R-02-002. December 2001. Office of Emergency and Remedial Response, Washington, DC, USA
84. USEPA. 2003. Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzop-dioxin and Related Compounds. NAS Review Draft. EPA/600/P-00/001Cb. Office of Research and Development, Washington, DC, USA. Available at http://www.epa.gov/ncea/pdfs/dioxin/nas-review/
85. USEPA. 2004. Risk Assessment Guidance for Superfund. Volume I: Part E. EPA/540/R/99/005, OSWER 9285.7-02EP. Office of Solid Waste and Emergency Response, Washington, DC, USA
86. USEPA. 2005. Guidelines for Carcinogen Risk Assessment. EPA/630/P-03/001B. Risk Assessment Forum Washington, DC, USA
87. USEPA. 2006. Estimation of Relative Bioavailability of Lead in Soil and Soil-like Materials Using In Vivo and In Vitro Methods. OSWER 9285.7-77. Office of Solid Waste and Emergency Response, Washington, DC, USA
88. USEPA. 2009a. Exposure Factors Handbook 2009 Update. EPA/600/R-09/052A. Office of Research and Development, Washington, DC, USA
89. USEPA. 2009b. Draft Recommended Interim Preliminary Remediation Goals for Dioxin in Soil at CERCLA And RCRA Sites. OSWER 9200.3-56. Office of Superfund Remediation and Technology Innovation, Washington, DC.
90. USEPA. 2001. Draft EPA's Reanalysis of Key Issues Related toDioxin Toxicity and Response to NAS Comments. EPA/600/R-10/038A. Available at www.epa.gov/iris. Office of Research and Development Cincinnati, OH.
91. Umbreit TH, Hesse EJ, and Gallo MA. 1986. Bioavailability of dioxin in soil from a 2,3,5-Tmanufacturing site. Science 232:497-99
92. Van den Berg M, Birnbaum LS, Denison M, et al. 2006. The World Health Organization reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicological Sci 93(2):223-41 (doi:10.1093/toxsci/kfl055).
93. van Miller JP, Lalich JJ, and Allen JR. 1977. Increased incidence of neoplasms in rats exposed to low levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chemosphere 9:537-44
94. Walker NJ and J.H Yang. 2006. Complexities in understanding the nature of the dose-response for dioxins and related compounds. Dose Response 3(3):267-72
95. Weis CP and LaVelle JM. 1991. Characteristics to consider when choosing an animal model for the study of lead bioavailability. Chem Spec Bioavail 3:113-20
96. Wendling J, Hileman F, Orth R, et al. 1989. An analytical assessment of the bioavailability of dioxin contaminated soils to animals. Chemosphere 18:929-32
97. Wittsiepe J, Erlenkämper B., Welge P, et al. 2007. Bioavailability of PCDD/F from contaminated soil in young Goettingen minipigs. Chemosphere 67(9):S355-64