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Volumn 25, Issue 2, 2006, Pages 99-105

Does dioxin exert toxic effects in humans at or near current background body levels?: An evidence-based conclusion

Author keywords

Cytochrome P450 IA2; Dioxin; Evidence based toxicology

Indexed keywords

CYTOCHROME P450 1A2; DIOXIN;

EID: 33644780910     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/0960327106ht594oa     Document Type: Article
Times cited : (13)

References (43)
  • 2
    • 1542317591 scopus 로고    scopus 로고
    • Authority-based explanation
    • Guzelian PS, Guzelian CP. Authority-based explanation. Science 2004; 303: 1468-69.
    • (2004) Science , vol.303 , pp. 1468-1469
    • Guzelian, P.S.1    Guzelian, C.P.2
  • 3
    • 24044495237 scopus 로고    scopus 로고
    • Issues in risk assessment for developmental effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds
    • Aylward LL, Lamb JC, Lewis SC. Issues in risk assessment for developmental effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Toxicol Sci 2005; 87: 3-10.
    • (2005) Toxicol Sci , vol.87 , pp. 3-10
    • Aylward, L.L.1    Lamb, J.C.2    Lewis, S.C.3
  • 4
    • 3242661636 scopus 로고    scopus 로고
    • An evaluation of benchmark dose methodology for non-cancer continuous-data health effects in animals due to exposures to dioxin (TCDD)
    • Gaylor DW, Aylward LL. An evaluation of benchmark dose methodology for non-cancer continuous-data health effects in animals due to exposures to dioxin (TCDD). Regul Toxicol Pharmacol 2004; 40: 9-17.
    • (2004) Regul Toxicol Pharmacol , vol.40 , pp. 9-17
    • Gaylor, D.W.1    Aylward, L.L.2
  • 5
    • 0024445437 scopus 로고
    • Human CYP1A2 sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression
    • Ikeya K, Jaiswal AK, Owens RA, Jones JE, Nebert DW, Kimura S. Human CYP1A2 sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression. Mol Endocrinol 1989; 3: 1399-408.
    • (1989) Mol Endocrinol , vol.3 , pp. 1399-1408
    • Ikeya, K.1    Jaiswal, A.K.2    Owens, R.A.3    Jones, J.E.4    Nebert, D.W.5    Kimura, S.6
  • 6
    • 0345732258 scopus 로고    scopus 로고
    • A combination of tea (Camellia senensis) catechins is required for optimal inhibition of induced CYP1A expression by green tea extract
    • Williams SN, Pickwell GV, Quattrochi LC. A combination of tea (Camellia senensis) catechins is required for optimal inhibition of induced CYP1A expression by green tea extract. J Agric Food Chem 2003; 51: 6627-23.
    • (2003) J Agric Food Chem , vol.51 , pp. 6627-6723
    • Williams, S.N.1    Pickwell, G.V.2    Quattrochi, L.C.3
  • 7
    • 0033971846 scopus 로고    scopus 로고
    • 2,3,7,8 Tetrachlorodibenzo-p-dioxin induction of cytochrome P4501A in cultured rat and human hepatocytes
    • Xu L, Li AP, Kaminski DL, Ruh MF. 2,3,7,8 Tetrachlorodibenzo-p-dioxin induction of cytochrome P4501A in cultured rat and human hepatocytes. Chem Biol Interact 2000; 124: 173-89.
    • (2000) Chem Biol Interact , vol.124 , pp. 173-189
    • Xu, L.1    Li, A.P.2    Kaminski, D.L.3    Ruh, M.F.4
  • 8
    • 0027406963 scopus 로고
    • Activation of cyp1a1 and cyp1a2 genes in adult mouse hepatocytes in primary culture
    • Nemoto N, Sakurai J. Activation of cyp1a1 and cyp1a2 genes in adult mouse hepatocytes in primary culture. Jpn J Cancer Res 1993; 84: 272-78.
    • (1993) Jpn J Cancer Res , vol.84 , pp. 272-278
    • Nemoto, N.1    Sakurai, J.2
  • 9
    • 0029118476 scopus 로고
    • Xenobiotic-inducible transcription of cytochrome P450 genes
    • Denison MS, Whitlock JP Jr. Xenobiotic-inducible transcription of cytochrome P450 genes. J Biol Chem 1995; 270: 18175-78.
    • (1995) J Biol Chem , vol.270 , pp. 18175-18178
    • Denison, M.S.1    Whitlock Jr., J.P.2
  • 10
    • 0029000839 scopus 로고
    • Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor
    • Fernandez-Salguero P, Pineau T, Hilbert DM, McPhail T, Lee SST, Kimura S et al. Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science 1995; 268: 722-26.
    • (1995) Science , vol.268 , pp. 722-726
    • Fernandez-Salguero, P.1    Pineau, T.2    Hilbert, D.M.3    McPhail, T.4    Lee, S.S.T.5    Kimura, S.6
  • 11
    • 0030015421 scopus 로고    scopus 로고
    • Characterization of a murine Ahr null allele: Involvement of the Ah receptor in hepatic growth and development
    • Schmidt JV, Su GH-T, Reddy JK, Simon MC, Bradfield CA. Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development. Proc Natl Acad Sci USA 1996; 93: 6731-36.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 6731-6736
    • Schmidt, J.V.1    Su, G.H.-T.2    Reddy, J.K.3    Simon, M.C.4    Bradfield, C.A.5
  • 12
    • 0028318179 scopus 로고
    • The human CYP1A2 gene and induction by 3-methylcholanthrene: A region of DNA that supports Ah-receptor binding and promoter-specific induction
    • Quattrochi LC, Vu T, Tukey RH. The human CYP1A2 gene and induction by 3-methylcholanthrene: a region of DNA that supports Ah-receptor binding and promoter-specific induction. J Biol Chem 1994; 269: 6949-54.
    • (1994) J Biol Chem , vol.269 , pp. 6949-6954
    • Quattrochi, L.C.1    Vu, T.2    Tukey, R.H.3
  • 13
    • 2442711488 scopus 로고    scopus 로고
    • Molecular cloning of the guinea pig CYP1A2 gene 5′-flanking region: Identification of functional AHRE and characterization of CYP1A2 expression in GPC16 cells
    • Black VH, Quattrochi LC. Molecular cloning of the guinea pig CYP1A2 gene 5′-flanking region: identification of functional AHRE and characterization of CYP1A2 expression in GPC16 cells. Drug Metab Dispos 2004; 32: 595-602.
    • (2004) Drug Metab Dispos , vol.32 , pp. 595-602
    • Black, V.H.1    Quattrochi, L.C.2
  • 15
    • 0030896578 scopus 로고    scopus 로고
    • Lifestyle and nutritional correlates of cytochrome CYP1A2 activity: Inverse associations with plasma lutein and alpha-tocopherol
    • Le Marchand L, Franke AA, Custer L, Wilkens LR, Cooney RV. Lifestyle and nutritional correlates of cytochrome CYP1A2 activity: inverse associations with plasma lutein and alpha-tocopherol. Pharmacogenetics 1997; 7: 11-19.
    • (1997) Pharmacogenetics , vol.7 , pp. 11-19
    • Le Marchand, L.1    Franke, A.A.2    Custer, L.3    Wilkens, L.R.4    Cooney, R.V.5
  • 16
    • 0032929010 scopus 로고    scopus 로고
    • Genetic polymorphism in the 5′-flanking region of human CYP1A2 gene: Effect on the CYP1A2 inducibility in humans
    • Nakajima M, Yokoi T, Mizutani M, Kinoshita M, Funayama M, Kamataki T. Genetic polymorphism in the 5′-flanking region of human CYP1A2 gene: effect on the CYP1A2 inducibility in humans. J Biochem 1999; 125: 803.
    • (1999) J Biochem , vol.125 , pp. 803
    • Nakajima, M.1    Yokoi, T.2    Mizutani, M.3    Kinoshita, M.4    Funayama, M.5    Kamataki, T.6
  • 17
    • 3543019165 scopus 로고    scopus 로고
    • Time response of cytochrome P450 1A2 activity on cessation of heavy smoking
    • Faber MS, Fuhr U. Time response of cytochrome P450 1A2 activity on cessation of heavy smoking. Clin Pharmacol Therapeut 2004; 76: 178-84.
    • (2004) Clin Pharmacol Therapeut , vol.76 , pp. 178-184
    • Faber, M.S.1    Fuhr, U.2
  • 18
    • 0026699994 scopus 로고
    • Increase of cytochrome P450IA2 activity by omeprazole: Evidence by the 13C-[N-3-methyl]-caffeine breath test in poor and extensive metabolizers of S-mephenytoin
    • Rost KL, Brosicke H, Brockmoller J, Scheffler M, Helge H, Roots I. Increase of cytochrome P450IA2 activity by omeprazole: evidence by the 13C-[N-3-methyl]-caffeine breath test in poor and extensive metabolizers of S-mephenytoin. Clin Pharmacol Therapeut 1992; 52: 170-80.
    • (1992) Clin Pharmacol Therapeut , vol.52 , pp. 170-180
    • Rost, K.L.1    Brosicke, H.2    Brockmoller, J.3    Scheffler, M.4    Helge, H.5    Roots, I.6
  • 19
    • 0027960793 scopus 로고
    • Panfried meat containing high levels of heterocyclic aromatic amines but low levels of polycyclic aromatic hydrocarbons induces cytochrome P4501A2 activity in humans
    • Sinha R, Rothman N, Brown ED, Mark SD, Hoover RN, Caporaso NE et al. Panfried meat containing high levels of heterocyclic aromatic amines but low levels of polycyclic aromatic hydrocarbons induces cytochrome P4501A2 activity in humans. Cancer Res 1994; 54: 6154-59.
    • (1994) Cancer Res , vol.54 , pp. 6154-6159
    • Sinha, R.1    Rothman, N.2    Brown, E.D.3    Mark, S.D.4    Hoover, R.N.5    Caporaso, N.E.6
  • 20
    • 0029875494 scopus 로고    scopus 로고
    • Effects of dietary broccoli on human in vivo drug metabolizing enzymes: Evaluation of caffeine, oestrone and chlorzoxazone metabolism
    • Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human in vivo drug metabolizing enzymes: evaluation of caffeine, oestrone and chlorzoxazone metabolism. Carcinogenesis 1996; 17: 793-99.
    • (1996) Carcinogenesis , vol.17 , pp. 793-799
    • Kall, M.A.1    Vang, O.2    Clausen, J.3
  • 21
    • 22544453632 scopus 로고    scopus 로고
    • Theophylline pharmacokinetics: Comparison of Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice
    • Derkenne S, Curran CP, Shertzer HG, Dalton TP, Nadine Dragin N, Nebert DW. Theophylline pharmacokinetics: comparison of Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice. Pharmacogen Genom 2005; 15: 503-11.
    • (2005) Pharmacogen Genom , vol.15 , pp. 503-511
    • Derkenne, S.1    Curran, C.P.2    Shertzer, H.G.3    Dalton, T.P.4    Nadine Dragin, N.5    Nebert, D.W.6
  • 22
    • 0028850903 scopus 로고
    • Induction of P-450 in workers exposed to dioxin
    • Halperin W et al. Induction of P-450 in workers exposed to dioxin. Occup Environ Med 1995; 52: 86 91.
    • (1995) Occup Environ Med , vol.52 , pp. 8691
    • Halperin, W.1
  • 23
    • 0036694279 scopus 로고    scopus 로고
    • Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: Insights into the measurement of hepatic cytochrome P450 1A2 induction
    • Abraham K, Geusau A, Yalcin T, Helge H, Steffen Bauer S, Brockmöller J. Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: insights into the measurement of hepatic cytochrome P450 1A2 induction. Clin Pharmacol Therapeut 2002; 72: 163-74.
    • (2002) Clin Pharmacol Therapeut , vol.72 , pp. 163-174
    • Abraham, K.1    Geusau, A.2    Yalcin, T.3    Helge, H.4    Steffen Bauer, S.5    Brockmöller, J.6
  • 24
    • 0010333228 scopus 로고
    • The dose response relationship between the serum levels of polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs) and cytochrome P4501A2 activity as determined by the caffeine breath test
    • Lambert GH, Hsu CC, Guo L, Ryan JJ, Schoeller DA. The dose response relationship between the serum levels of polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs) and cytochrome P4501A2 activity as determined by the caffeine breath test. Organohal Comp 1994; 21: 485-88.
    • (1994) Organohal Comp , vol.21 , pp. 485-488
    • Lambert, G.H.1    Hsu, C.C.2    Guo, L.3    Ryan, J.J.4    Schoeller, D.A.5
  • 25
    • 33644759611 scopus 로고    scopus 로고
    • Human response to dioxin: Aryl hydrocarbon receptor (AhR) molecular structure, function, and dose-response data for enzyme induction indicate an impaired human AhR
    • in press
    • Connor KT, Aylward LL. Human response to dioxin: aryl hydrocarbon receptor (AhR) molecular structure, function, and dose-response data for enzyme induction indicate an impaired human AhR. J Toxicol Environ Health Crit Rev Part B (in press).
    • J Toxicol Environ Health Crit Rev Part B
    • Connor, K.T.1    Aylward, L.L.2
  • 27
    • 0000165007 scopus 로고
    • Cytochrome P4501A2 activity in dioxin exposed Seveso subjects as compared topolychlorinated biphenyl and polychorinated dibenzofuran exposed yucheng subjects
    • Lambert GH, Mocarelli P, Hsu CC, Needham LL, Ryan JJ, Guo L et al. Cytochrome P4501A2 activity in dioxin exposed Seveso subjects as compared topolychlorinated biphenyl and polychorinated dibenzofuran exposed yucheng subjects. Organohal Comp 1993; 14: 253-56.
    • (1993) Organohal Comp , vol.14 , pp. 253-256
    • Lambert, G.H.1    Mocarelli, P.2    Hsu, C.C.3    Needham, L.L.4    Ryan, J.J.5    Guo, L.6
  • 28
    • 0041103338 scopus 로고
    • Contextualism and knowledge attributions
    • DeRose K. Contextualism and knowledge attributions. Philos Phenomenal Res 1992; 52: 913-29.
    • (1992) Philos Phenomenal Res , vol.52 , pp. 913-929
    • DeRose, K.1
  • 29
    • 17444397464 scopus 로고    scopus 로고
    • Inhibition of human and rat CYP1A2 by TCDD and dioxin-like chemicals
    • Staskal DF, Diliberto JJ, DeVito MJ, Birnbaum LS. Inhibition of human and rat CYP1A2 by TCDD and dioxin-like chemicals. Toxicol Sci 2005; 84: 225-31.
    • (2005) Toxicol Sci , vol.84 , pp. 225-231
    • Staskal, D.F.1    Diliberto, J.J.2    DeVito, M.J.3    Birnbaum, L.S.4
  • 30
    • 0037494678 scopus 로고    scopus 로고
    • Inhibition of CYP 1A2-dependent MROD activity in rat liver microsomes: An explanation of the hepatic sequestration of a limited subset of halogenated aromatic hydrocarbons
    • Chen JJ, Chen GS, Bunce NJ. Inhibition of CYP 1A2-dependent MROD activity in rat liver microsomes: an explanation of the hepatic sequestration of a limited subset of halogenated aromatic hydrocarbons. Environ Toxicol 2003; 18: 115-19.
    • (2003) Environ Toxicol , vol.18 , pp. 115-119
    • Chen, J.J.1    Chen, G.S.2    Bunce, N.J.3
  • 32
    • 0031913632 scopus 로고    scopus 로고
    • Interaction between iron metabolism and 2,3,7,8-tetrachlorodibenzo-p- dioxin in mice with variants of the Ahr gene: A hepatic oxidative mechanism
    • Andrew G, Smith BC, Robinson S, Scullion MJ, Carthew P, Edwards R et al. Interaction between iron metabolism and 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice with variants of the Ahr gene: a hepatic oxidative mechanism. Mol Pharmacol 1998; 53: 52-61.
    • (1998) Mol Pharmacol , vol.53 , pp. 52-61
    • Andrew, G.1    Smith, B.C.2    Robinson, S.3    Scullion, M.J.4    Carthew, P.5    Edwards, R.6
  • 33
    • 0028607522 scopus 로고
    • The effect of 1,2,3,4-tetrachlorodibenzo-p-dioxin on drug-metabolizing enzymes in the rat liver
    • Hanioka N, Jinno HT, Ando M. The effect of 1,2,3,4-tetrachlorodibenzo-p- dioxin on drug-metabolizing enzymes in the rat liver. Chemosphere 1994; 29: 2477-91.
    • (1994) Chemosphere , vol.29 , pp. 2477-2491
    • Hanioka, N.1    Jinno, H.T.2    Ando, M.3
  • 34
    • 0030273433 scopus 로고    scopus 로고
    • Validation of precision-cut liver slices in dynamic organ culture as an in vitro model for studying CYP1A1 and CYP1A2 induction
    • Drahushuk AT, McGarrigle BP, Tai HL, Kitareewan S, Goldstein JA, Olson JR. Validation of precision-cut liver slices in dynamic organ culture as an in vitro model for studying CYP1A1 and CYP1A2 induction. Toxicol Appl Pharmacol 1996; 140: 393-403.
    • (1996) Toxicol Appl Pharmacol , vol.140 , pp. 393-403
    • Drahushuk, A.T.1    McGarrigle, B.P.2    Tai, H.L.3    Kitareewan, S.4    Goldstein, J.A.5    Olson, J.R.6
  • 35
    • 1942439666 scopus 로고    scopus 로고
    • Cyp1a1(-/-) male mice: Protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria
    • Uno S, Dalton TP, Sinclair PR, Gorman N, Wang B, Smith AG et al. Cyp1a1(-/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria. Toxicol Appl Pharmacol 2004; 196: 410-21.
    • (2004) Toxicol Appl Pharmacol , vol.196 , pp. 410-421
    • Uno, S.1    Dalton, T.P.2    Sinclair, P.R.3    Gorman, N.4    Wang, B.5    Smith, A.G.6
  • 36
    • 0025141568 scopus 로고
    • Relative distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in human hepatic and adipose tissues
    • Leung HW, Wendung JM, Orth R, Hileman F, Paustenbach DJ. Relative distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in human hepatic and adipose tissues. Toxicol Letts 1990; 50: 275-82.
    • (1990) Toxicol Letts , vol.50 , pp. 275-282
    • Leung, H.W.1    Wendung, J.M.2    Orth, R.3    Hileman, F.4    Paustenbach, D.J.5
  • 37
    • 0034035423 scopus 로고    scopus 로고
    • Effect of transforming growth factor-beta1 on cytochrome P450 expression: Inhibition of CYP1 mRNA and protein expression in primary rat hepatocytes
    • Muller GF, Dohr O, El-Bahay C, Kahl R, Abel J. Effect of transforming growth factor-beta1 on cytochrome P450 expression: inhibition of CYP1 mRNA and protein expression in primary rat hepatocytes. Arch Toxicol 2000; 74: 145-52.
    • (2000) Arch Toxicol , vol.74 , pp. 145-152
    • Muller, G.F.1    Dohr, O.2    El-Bahay, C.3    Kahl, R.4    Abel, J.5
  • 38
    • 1642498324 scopus 로고    scopus 로고
    • The olivacine derivative S 16020 (9-hydroxy-5,6-dimethyl-N-[2- (dimethylamino)ethyl)-6h-pyrido(4,3-B)-carbazole-1-carboxamide induces cyp1a and its own metabolism in human hepatocytes in primary culture
    • Pichard-Garcia L, Weaver RJ, Eckett N, Scarfe G, Fabre JM, Lucas C et al. The olivacine derivative S 16020 (9-hydroxy-5,6-dimethyl-N-[2-(dimethylamino) ethyl)-6h-pyrido(4,3-B)-carbazole-1-carboxamide) induces cyp1a and its own metabolism in human hepatocytes in primary culture. Drug Metab Dispos 2004; 32: 80-88.
    • (2004) Drug Metab Dispos , vol.32 , pp. 80-88
    • Pichard-Garcia, L.1    Weaver, R.J.2    Eckett, N.3    Scarfe, G.4    Fabre, J.M.5    Lucas, C.6
  • 39
    • 4344590127 scopus 로고    scopus 로고
    • Comparative analysis of dioxin response elements in human, mouse and rat genomic sequences
    • Sun YV, Boverhof DR, Burgoon LD, Fielden MR, Zacharewski TR. Comparative analysis of dioxin response elements in human, mouse and rat genomic sequences. Nucl Acids Res 2004; 32: 4512-23.
    • (2004) Nucl Acids Res , vol.32 , pp. 4512-4523
    • Sun, Y.V.1    Boverhof, D.R.2    Burgoon, L.D.3    Fielden, M.R.4    Zacharewski, T.R.5
  • 41
    • 0030024574 scopus 로고    scopus 로고
    • Concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans in human placental and fetal tissues from the U.S. and in placentas from Yu-Cheng exposed mothers
    • Schecter A, Startin J, Wright C, Papke Ball O, Lis MA. Concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans in human placental and fetal tissues from the U.S. and in placentas from Yu-Cheng exposed mothers. Chemosphere 1996; 32: 551-57.
    • (1996) Chemosphere , vol.32 , pp. 551-557
    • Schecter, A.1    Startin, J.2    Wright, C.3    Papke Ball, O.4    Lis, M.A.5
  • 42
    • 0036072289 scopus 로고    scopus 로고
    • Environmental exposure to polychlorinated biphenyls and placental CYP1A1 activity in Inuit women from northern Quebec
    • Pereg D, Dewailly E, Poirier GG, Ayotte P. Environmental exposure to polychlorinated biphenyls and placental CYP1A1 activity in Inuit women from northern Quebec. Environ Health Perspect 2002; 110: 607-12.
    • (2002) Environ Health Perspect , vol.110 , pp. 607-612
    • Pereg, D.1    Dewailly, E.2    Poirier, G.G.3    Ayotte, P.4
  • 43
    • 0030895432 scopus 로고    scopus 로고
    • PCBs and dioxin-like compounds in plasma of adult Inuit living in Nunavik (Arctic Quebec)
    • Ayotte P, Dewailly Ryan E, Bruneau S, Lebel G. PCBs and dioxin-like compounds in plasma of adult Inuit living in Nunavik (Arctic Quebec). Chemosphere 1997; 34: 1459-68.
    • (1997) Chemosphere , vol.34 , pp. 1459-1468
    • Ayotte, P.1    Dewailly Ryan, E.2    Bruneau, S.3    Lebel, G.4


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