Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing male Wistar(Han) rat. I: No decrease in epididymal sperm count after a single acute dose

Toxicological Sciences

Volumn 99, Issue 1, 2007, Pages 214-223

  Bell, David R ^a   Clode, Sally ^b   Fan, Ming Qi ^a   Fernandes, Alwyn ^e   Foster, Paul M D ^c   Jiang, Tao ^a   Loizou, George ^d   MacNicoll, Alan ^e   Miller, Brian G ^f   Rose, Martin ^e   Tran, Lang ^f   White, Shaun ^e  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UK   (United Kingdom)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d HEALTH AND SAFETY LABORATORY   (United Kingdom)

^e CENTRAL SCIENCE LABORATORY   (United Kingdom)

^f INSTITUTE OF OCCUPATIONAL MEDICINE   (United Kingdom)

Author keywords

Developmental; Dioxin; Sperm; Toxicity

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BRAIN WEIGHT; CONTROLLED STUDY; DOSE RESPONSE; EPIDIDYMIS; FEMALE; GESTATIONAL AGE; INFLAMMATORY CELL; LIVER WEIGHT; MALE; MALE GENITAL SYSTEM DISEASE; NEWBORN DEATH; NONHUMAN; PRENATAL EXPOSURE; PROGENY; RAT; REPRODUCTIVE TOXICITY; SPERMATOZOON COUNT; STATISTICAL SIGNIFICANCE; TESTIS WEIGHT; TOXICITY TESTING; WEIGHT REDUCTION; WISTAR RAT;

ACUTE TOXICITY TESTS; ADMINISTRATION, ORAL; ANIMALS; ANIMALS, NEWBORN; BEHAVIOR, ANIMAL; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; EPIDIDYMIS; FEMALE; FERTILITY; MALE; MATERNAL EXPOSURE; MOTOR ACTIVITY; ORGAN SIZE; PERINEUM; PREGNANCY; RATS; RATS, WISTAR; SEXUAL MATURATION; SPERM COUNT; SPERMATOZOA; TESTIS; TETRACHLORODIBENZODIOXIN;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 34547914534     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm140     Document Type: Article

References (43)

1. Ambidge, P. F., Cox, E. A., Creaser, C. S., Greenberg, M., Gem, M. G. D., Gilbert, J., Jones, P. W., Kibblewhite, M. G., Levey, J., Lisseter, S. G., et al. (1990). Acceptance criteria for analytical data on polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans. Chemosphere 21, 999-1006.
2. Ashby, J., Tinwell, H., Lefevre, P. A., Joiner, R., and Haseman, J. (2003). The effect on sperm production in adult Sprague-Dawley rats exposed by gavage to bisphenol a between postnatal days 91-97. Toxicol. Sci. 74, 129-138.
3. Bell, D. R., Clode, S., Fan, M. Q., Fernandes, A., Foster, P. M. D., Jiang, T., Loizou, G., MacNicoll, A., Miller, B., Rose, M., et al. (2007). Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the developing male Wistar(Han) rat II: Chronic dosing causes developmental delay. Toxicol. Sci. 99(1), 234-243.
4. Bjerke, D. L., and Peterson, R. E. (1994). Reproductive toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male-rats - different effects of in-utero versus lactational exposure. Toxicol. Appl. Pharmacol. 127, 241-249.
5. Bjerke, D. L., Sommer, R. J., Moore, R. W., and Peterson, R. E. (1994). Effects of in-utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on responsiveness of the male-rat reproductive-system To testosterone stimulation in adulthood. Toxicol. Appl. Pharmacol. 127, 250-257.
6. Carney, E. W., Zablotny, C. L., Marty, M. S., Crissman, J. W., Anderson, P., Woolhiser, M., and Holsapple, M. (2004). The effects of feed restriction during in utero and postnatal development in rats. Toxicol. Sci. 82, 237-249.
7. Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (COT). (2001). COT Statement on the Tolerable Daily Intake for Dioxins and Dioxin-Like Polychlorinated Biphenyls. Available at: http://www.food.gov.uk/science/ouradvisors/toxicity/ statements/cotstatements2001/dioxinsstate.
8. Creasy, D. M. (2003). Evaluation of testicular toxicology: A synopsis and discussion of the recommendations proposed by the society of toxicologic pathology. Birth Defects Res. B Dev. Reprod. Toxicol. 68, 408-415.
9. Faqi, A. S., Dalsenter, P. R., Merker, H. J., and Chahoud, I. (1998). Reproductive toxicity and tissue concentrations of low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male offspring rats exposed throughout pregnancy and lactation. Toxicol. Appl. Pharmacol. 150, 383-392.
10. Fernandes, A., DSilva, K., and Rose, M. (2004). Simultaneous determination of PCDDs, PCDFs, PCBs and PBDEs in food. Talanta 63, 1147-1155.
11. Gray, L. E., Kelce, W. R., Monosson, E., Ostby, J. S., and Birnbaum, L. S. (1995). Exposure to TCDD during development permanently alters reproductive function in male Long-Evans rats and hamsters - reduced ejaculated and epididymal sperm numbers and sex accesory-gland weights in offspring with normal androgenic status. Toxicol. Appl. Pharmacol. 131, 108-118.
12. Gray, L. E., Ostby, J. S., and Kelce, W. R. (1997a). A dose-response analysis of the reproductive effects of a single gestational dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male Long Evans Hooded rat offspring. Toxicol. Appl. Pharmacol. 146, 11-20.
13. Gray, L. E., Wolf, C., Mann, P., and Ostby, J. S. (1997b). In utero exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin alters reproductive development of female long evans hooded rat offspring. Toxicol. Appl. Pharmacol. 146, 237-244.
14. Haws, L. C., Su, S. H., Harris, M., DeVito, M. J., Walker, N. J., Farland, W. H., Finley, B., and Birnbaum, L. S. (2006). Development of a refined database of mammalian relative potency estimates for dioxin-like compounds. Toxicol. Sci. 89, 4-30.
15. Ikeda, M., Tamura, M., Yamashita, J., Suzuki, C., and Tomita, T. (2005). Repeated in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure affects male gonads in offspring, leading to sex ratio changes in F-2 progeny. Toxicol. Appl. Pharmacol. 206, 351-355.
16. Ioannidis, J. P. A. (2005a). Contradicted and initially stronger effects in highly cited clinical research. JAMA 294, 218-228.
17. Ioannidis, J. P. A. (2005b). Why most published research findings are false. PLoS Med. 2, 696-701.
18. JECFA. (2001). Joint FAO/WHO Expert Committee on Food Additives, Fifty-seventh meeting, Rome, 5-14 June 2001. Summary and Conclusions Vol. 909. Joint FAO/WHO Expert Committee on Food Additives, Rome.
19. Korte, M., Thiel, R., Koch, E., Stahlmann, R., and Neubert, D. (1992). Tissue concentrations of 2,3,7,8-TCDD in rats and offspring after continuous exposure during the late fetal and postnatal-period. Chemosphere 25, 1183-1188.
20. Lanning, L. L., Creasy, D. M., Chapin, R. E., Mann, P. C., Barlow, N. J., Regan, K. S., and Goodman, D. G. (2002). Recommended approaches for the evaluation of testicular and epididymal toxicity. Toxicol. Pathol. 30, 507-520.
21. Lee, Y., Nelder, J. A., and Pawitan, Y. (2006). Generalized Linear Models with Random Effects: Unified Analysis via H-likelihood. Chapman & Hall/CRC, Boca Raton, FL.
22. Mably, T. A., Bjerke, D. L., Moore, R. W., Gendronfitzpatrick, A., and Peterson, R. E. (1992a). Inutero and lactational exposure of male-rats to 2,3,7,8-tetrachlorodibenzo-para-dioxin.3. Effects On spermatogenesis and reproductive capability. Toxicol. Appl. Pharmacol. 114, 118-126.
23. Mably, T. A., Moore, R. W., Goy, R. W., and Peterson, R. E. (1992b). Inutero and lactational exposure Of male-rats to 2,3,7,8-tetrachlorodibenzo-para-dioxin.2. Effects on sexual-behavior and the regulation of luteinizing-hormone secretion in adulthood. Toxicol. Appl. Pharmacol. 114, 108-117.
24. Mably, T. A., Moore, R. W., and Peterson, R. E. (1992c). Inutero and lactational exposure of male-rats to 2,3,7,8-tetrachlorodibenzo-para-dioxin. 1. Effects on androgenic status. Toxicol. Appl. Pharmacol. 114, 97-107.
25. Maier, E. A., Vancleuvenbergen, R., Kramer, G. N., Tuinstra, L., and Pauwels, J. (1995). Bcr (non-certified) reference materials for dioxins and furans in milk powder. Fresenius J. Anal. Chem. 352, 179-183.
26. Mylchreest, E., Cattley, R. C., and Foster, P. M. D. (1998). Male reproductive tract malformations in rats following gestational and lactational exposure to di(n-butyl) phthalate: An antiandrogenic mechanism? Toxicol. Sci. 43, 47-60.
27. Ohsako, S., Miyabara, Y., Nishimura, N., Kurosawa, S., Sakaue, M., Ishimura, R., Sato, M., Takeda, K., Aoki, Y., Sone, H., et al. (2001). Maternal exposure to a low dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suppressed the development of reproductive organs of male rats: Dose-dependent increase of mRNA levels of 5 alpha-reductase type 2 in contrast to decrease of androgen receptor in the pubertal ventral prostate. Toxicol. Sci. 60, 132-143.
28. Ohsako, S., Miyabara, Y., Sakaue, M., Ishimura, R., Kakeyama, M., Izumi, H., Yonemoto, J., and Tohyama, C. (2002). Developmental stage-specific effects of perinatal 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on reproductive organs of male rat offspring. Toxicol. Sci. 66, 283-292.
29. Payne, R. (2004). The Guide to GenStat Release 8. Part 2: Statistics Lawes Agricultural Trust, Rothamsted, UK.
30. Pohjanvirta, R., and Tuomisto, J. (1990). Letter to the editor. Toxicol. Appl. Pharmacol. 105, 508-509.
31. Pohjanvirta, R., and Tuomisto, J. (1994). Short-term toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory-animals - effects, mechanisms, and animal-models. Pharmacol. Rev. 46, 483-549.
32. Pohjanvirta, R., Tuomisto, J., Vartiainen, T., and Rozman, K. (1987). Han/Wistar rats are exceptionally resistant to TCDD-I. Pharmacol. Toxicol. 60, 145-150.
33. Poland, A., and Knutson, J. C. (1982). 2,3,7,8-Tetrachlorodibenzo-para-dioxin and related halogenated aromatic-hydrocarbons - examination of the mechanism of toxicity. Annu. Rev. Pharmacol. Toxicol. 22, 517-554.
34. Roman, B. L., Sommer, R. J., Shinomiya, K., and Peterson, R. E. (1995). In-utero and lactational exposure of the male-rat to 2,3,7,8-tetrachlorodibenzo-p-dioxin - impaired prostate growth and development without inhibited androgen production. Toxicol. Appl. Pharmacol. 134, 241-250.
35. Roman, B. L., Timms, B. G., Prins, G. S., and Peterson, R. E. (1998). In utero and lactational exposure of the male rat to 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs prostate developmeent - 2. Effects on growth and cytodifferentiation. Toxicol. Appl. Pharmacol. 150, 254-270.
36. SCF (2001). Opinion of the Scientific Committee on Food on the Risk Assessment of Dioxins and Dioxin-like PCBs in Food. Available at: http://europa.eu.int/comm/food/fs/sc/scf/outcome_en.html. Accessed May 3, 2001.
37. Simanainen, U., Haavisto, T., Tuomisto, J. T., Paranko, J., Toppari, J., Tuomisto, J., Peterson, R. E., and Viluksela, M. (2004). Pattern of male reproductive system effects after in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure in three defferentially TCDD-sensitive rat lines. Toxicol. Sci. 80, 101-108.
38. Sommer, R. J., Ippolito, D. L., and Peterson, R. E. (1996). In utero and lactational exposure of the male Holtzman rat to 2,3,7,8-tetrachlorodibenzo-p-dioxin: Decreased epididymal and ejaculated sperm numbers without alterations in sperm transit rate. Toxicol. Appl. Pharmacol. 140, 146-153.
39. Theobald, H. M., and Peterson, R. E. (1997). In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-rho-dioxin: Effects on development of the male and female reproductive system of the mouse. Toxicol. Appl. Pharmacol. 145, 124-135.
40. Van den Berg, M., Birnbaum, L., Bosveld, A. T. C., Brunstrom, B., Cook, P., Feeley, M., Giesy, J. P., Hanberg, A., Hasegawa, R., Kennedy, S. W., et al. (1998). Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ. Health Perspect. 106 775-792.
41. Wilker, C., Johnson, L., and Safe, S. (1996). Effects of developmental exposure to indole-3-carbinol or 2,3,7,8-tetrachlorodibenzo-p-dioxin on reproductive potential of male rat offspring. Toxicol. Appl. Pharmacol. 141, 68-75.
42. Williams, D. A. (1972). Comparison of several dose levels with a zero dose control. Biometrics 28, 519-531.
43. Yonemoto, J., Ichiki, T., Takei, T., and Tohyama, C. (2005). Maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and the body burden in offspring of Long-Evans rats. Environ. Health Prev. Med. 10, 21-32.