Relationships between tissue levels of 2,3,7,8-Tetrachlorodibenzo- p-dioxin (TCDD), RNAs, and toxicity in the developing male wistar(Han) Rat

Toxicological Sciences

Volumn 99, Issue 2, 2007, Pages 591-604

  Bell, David R ^a   Clode, Sally ^b   Fan, Ming Qi ^a   Fernandes, Alwyn ^e   Foster, Paul M D ^c   Jiang, Tao ^a   Loizou, George ^d   Macnicoll, Alan ^e   Miller, Brian G ^f   Rose, Martin ^e   Tran, Lang ^f   White, Shaun ^e  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b Department of Genetic and Molecular Toxicology   (United Kingdom)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d HEALTH AND SAFETY LABORATORY   (United Kingdom)

^e CENTRAL SCIENCE LABORATORY   (United Kingdom)

^f INSTITUTE OF OCCUPATIONAL MEDICINE   (United Kingdom)

Author keywords

Balanopreputial separation; Developmental; Dioxin; Puberty; Sperm; Toxicity

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; MESSENGER RNA; CYP1A2 PROTEIN, RAT; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY BURDEN; CHRONIC TOXICITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DISEASE PREDISPOSITION; DOSE RESPONSE; DRUG ABSORPTION; DRUG TISSUE LEVEL; EMBRYO DEVELOPMENT; EMBRYOTOXICITY; FEMALE; FETUS; GESTATIONAL AGE; LACTATION; LONG TERM EXPOSURE; MALE; MALE GENITAL SYSTEM; MARE; NONHUMAN; NUCLEOTIDE SEQUENCE; PERINATAL PERIOD; PLACENTAL TRANSFER; PRENATAL DRUG EXPOSURE; PROTEIN INDUCTION; RAT; TISSUE INDUCTION; TOXICITY TESTING; TOXICOKINETICS; ANIMAL; DRUG EFFECT; GENETICS; METABOLISM; PREGNANCY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WISTAR RAT;

RATTUS NORVEGICUS;

ANIMALS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; FEMALE; FETUS; MALE; PREGNANCY; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TETRACHLORODIBENZODIOXIN;

EID: 38449109625     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm179     Document Type: Article

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