Analysis of common and specific mechanisms of liver function affected by nitrotoluene compounds

PLoS ONE

Volumn 6, Issue 2, 2011, Pages

  Deng, Youping ^a   Meyer, Sharon A ^b   Guan, Xin ^c   Escalon, Barbara Lynn ^d   Ai, Junmei ^e   Wilbanks, Mitchell S ^d   Welti, Ruth ^f   Garcia Reyero, Natàlia ^g   Perkins, Edward J ^d  

^a RUSH MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF LOUISIANA AT MONROE   (United States)

^c SpecProc Inc   (United States)

^d US ARMY ENGINEER RESEARCH AND DEVELOPMENT CENTER   (United States)

^e UNIVERSITY OF SOUTHERN MISSISSIPPI   (United States)

^f KANSAS STATE UNIVERSITY   (United States)

^g JACKSON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 4,6 DINITROTOLUENE; 2,4 DINITROTOLUENE; 2,6 DINITROTOLUENE; 4 AMINO 2,6 DINITROTOLUENE; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450; INTERLEUKIN 1; LIPOPOLYSACCHARIDE; NITROBENZENE DERIVATIVE; RETINOID X RECEPTOR; TRANSCRIPTION FACTOR NRF2; TRINITROTOLUENE; UNCLASSIFIED DRUG; TOLUENE; TRANSCRIPTOME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BLOOD TOXICITY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HISTOPATHOLOGY; LIPID METABOLISM; LIPOGENESIS; LIVER FUNCTION; LIVER TOXICITY; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; RAT; SIGNAL TRANSDUCTION; XENOBIOTIC METABOLISM; ANIMAL; DOSE RESPONSE; DRUG EFFECT; GENE REGULATORY NETWORK; LIVER; METABOLISM; METHODOLOGY; PHYSIOLOGY; POLLUTANT; REPRODUCIBILITY; SPRAGUE DAWLEY RAT; TIME; TOXICITY TESTING;

RATTUS;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; FEMALE; GENE REGULATORY NETWORKS; LIPID METABOLISM; LIVER; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; TIME FACTORS; TOLUENE; TOXICITY TESTS; TRANSCRIPTOME;

EID: 79951564930     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014662     Document Type: Article

References (76)

1. Jenkins TF, Hewitt AD, Grant CL, Thiboutot S, Ampleman G, et al. (2006) Identity and distribution of residues of energetic compounds at army live-fire training ranges. Chemosphere 63: 1280-1290.
2. Wintz H, Yoo LJ, Loguinov A, Wu YY, Steevens JA, et al. (2006) Gene expression profiles in fathead minnow exposed to 2,4-DNT: correlation with toxicity in mammals. Toxicol Sci 94: 71-82.
3. Gust KA, Pirooznia M, Quinn MJ Jr, Johnson MS, Escalon L, et al. (2009) Neurotoxicogenomic investigations to assess mechanisms of action of the munitions constituents RDX and 2,6-DNT in Northern bobwhite (Colinus virginianus). Toxicol Sci 110: 168-180.
4. Levine BS, Furedi EM, Gordon DE, Barkley JJ, Lish PM, (1990) Toxic interactions of the munitions compounds TNT and RDX in F344 rats. Fundam Appl Toxicol 15: 373-380.
5. Talmage SS, Opresko DM, Maxwell CJ, Welsh CJ, Cretella FM, et al. (1999) Nitroaromatic munition compounds: environmental effects and screening values. Rev Environ Contam Toxicol 161: 1-156.
6. Sabbioni G, Wei J, Liu YY, (1996) Determination of hemoglobin adducts in workers exposed to 2,4, 6-trinitrotoluene. J Chromatogr B Biomed Appl 682: 243-248.
7. La DK, Froines JR, (1992) 32P-postlabelling analysis of DNA adducts from Fischer-344 rats administered 2,4-diaminotoluene. Chem Biol Interact 83: 121-134.
8. La DK, Froines JR, (1992) Comparison of DNA adduct formation between 2,4 and 2,6-dinitrotoluene by 32P-postlabelling analysis. Arch Toxicol 66: 633-640.
9. Honeycutt ME, Jarvis AS, McFarland VA, (1996) Cytotoxicity and mutagenicity of 2,4,6-trinitrotoluene and its metabolites. Ecotoxicol Environ Saf 35: 282-287.
10. Sabbioni G, Jones CR, Sepai O, Hirvonen A, Norppa H, et al. (2006) Biomarkers of exposure, effect, and susceptibility in workers exposed to nitrotoluenes. Cancer Epidemiol Biomarkers Prev 15: 559-566.
11. Jones CR, Liu YY, Sepai O, Yan H, Sabbioni G, (2005) Hemoglobin adducts in workers exposed to nitrotoluenes. Carcinogenesis 26: 133-143.
12. Gong P, Guan X, Inouye LS, Pirooznia M, Indest KJ, et al. (2007) Toxicogenomic analysis provides new insights into molecular mechanisms of the sublethal toxicity of 2,4,6-trinitrotoluene in Eisenia fetida. Environ Sci Technol 41: 8195-8202.
13. Reddy G, Chandra SAM, Lish JW, Qualls CW, (2000) Toxicity of 2,4,6-trinitrotoluene (TNT) in hispid cotton rats (Sigmodon hispidus): Hematological, biochemical, and pathological effects. International Journal of Toxicology 19: 169-177.
14. Ellis HV III, (1978) Mammalian toxicity of munitions compounds. Phase I. Acute oral toxicity, primary skin and eye irritation, dermal sensitization, disposition and metabolism and Ames tests of additional compounds. Progress report no. 6.
15. Ellis HV III, (1980) Mammalian toxicity of munitions compounds. Summary of toxicity of nitrotoluenes. AD A080146.
16. Travlos GS, Morris RW, Elwell MR, Duke A, Rosenblum S, et al. (1996) Frequency and relationships of clinical chemistry and liver and kidney histopathology findings in 13-week toxicity studies in rats. Toxicology 107: 17-29.
17. Hall RL, Everds NE, (2008) Principles of clinical pathology for toxicological studies. In: Hayes AW, editors. In Principles and methods of toxicology Boca Raton, FL CRC Pres pp. 1317-1358.
18. Popp JA, Cattley RC, (1991) Hepatobiliary system. In: Haschek WM, Rousseaux CG, editors. Handbook of Toxicologic Pathology San Diego Academic Press, Inc. pp. 279-314.
19. Bartz R, Li WH, Venables B, Zehmer JK, Roth MR, et al. (2007) Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic. J Lipid Res 48: 837-847.
20. Welti R, Li W, Li M, Sang Y, Biesiada H, et al. (2002) Profiling membrane lipids in plant stress responses. Role of phospholipase D alpha in freezing-induced lipid changes in Arabidopsis. J Biol Chem 277: 31994-32002.
21. Zhou BB, Elledge SJ, (2000) The DNA damage response: putting checkpoints in perspective. Nature 408: 433-439.
22. Glass KY, Newsome CR, Tchounwou PB, (2005) Cytotoxicity and expression of c-fos, HSP70, and GADD45/153 proteins in human liver carcinoma (HepG2) cells exposed to dinitrotoluenes. Int J Environ Res Public Health 2: 355-361.
23. Homma-Takeda S, Hiraku Y, Ohkuma Y, Oikawa S, et al. (2002) 2,4,6-trinitrotoluene-induced reproductive toxicity via oxidative DNA damage by its metabolite. Free Radic Res 36: 555-566.
24. Ashby J, Burlinson B, Lefevre PA, Topham J, (1985) Non-genotoxicity of 2,4,6-trinitrotoluene (TNT) to the mouse bone marrow and the rat liver: implications for its carcinogenicity. Arch Toxicol 58: 14-19.
25. Tchounwou PB, Wilson BA, Ishaque AB, Schneider J, (2001) Transcriptional activation of stress genes and cytotoxicity in human liver carcinoma cells (HepG2) exposed to 2,4,6-trinitrotoluene, 2,4-dinitrotoluene, and 2,6-dinitrotoluene. Environ Toxicol 16: 209-216.
26. Bermudez E, Tillery D, Butterworth BE, (1979) The effect of 2,4-diaminotoluene and isomers of dinitrotoluene on unscheduled DNA synthesis in primary rat hepatocytes. Environ Mutagen 1: 391-398.
27. Cooke MS, Evans MD, Dizdaroglu M, Lunec J, (2003) Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J 17: 1195-1214.
28. Pusapati RV, Rounbehler RJ, Hong S, Powers JT, Yan M, et al. (2006) ATM promotes apoptosis and suppresses tumorigenesis in response to Myc. Proc Natl Acad Sci U S A 103: 1446-1451.
29. Amundson SA, Bittner M, Meltzer P, Trent J, Fornace AJ Jr, (2001) Physiological function as regulation of large transcriptional programs: the cellular response to genotoxic stress. Comp Biochem Physiol B Biochem Mol Biol 129: 703-710.
30. Vousden KH, Prives C, (2009) Blinded by the Light: The Growing Complexity of p53. Cell 137: 413-431.
31. Yang XH, Sladek TL, Liu X, Butler BR, Froelich CJ, et al. (2001) Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin- and etoposide-induced apoptosis. Cancer Res 61: 348-354.
32. Yu X, Kensler T, (2005) Nrf2 as a target for cancer chemoprevention. Mutat Res 591: 93-102.
33. Tong KI, Katoh Y, Kusunoki H, Itoh K, Tanaka T, et al. (2006) Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model. Mol Cell Biol 26: 2887-2900.
34. Gong P, Cederbaum AI, (2006) Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1. Hepatology 43: 144-153.
35. Rawat A, Gust KA, Deng Y, Garcia-Reyero N, Quinn MJ Jr, et al. (2010) From raw materials to validated system: The construction of a genomic library and microarray to interpret systemic perturbations in Northern bobwhite. Physiol Genomics.
36. Hankinson O, (1995) The aryl hydrocarbon receptor complex. Annu Rev Pharmacol Toxicol 35: 307-340.
37. Miao W, Hu L, Scrivens PJ, Batist G, (2005) Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: direct cross-talk between phase I and II drug-metabolizing enzymes. J Biol Chem 280: 20340-20348.
38. Lassen N, Bateman JB, Estey T, Kuszak JR, Nees DW, et al. (2007) Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(-/-)/Aldh1a1(-/-) knock-out mice. J Biol Chem 282: 25668-25676.
39. Sabbioni G, Liu YY, Yan H, Sepai O, (2005) Hemoglobin adducts, urinary metabolites and health effects in 2,4,6-trinitrotoluene exposed workers. Carcinogenesis 26: 1272-1279.
40. Rushmore TH, Kong AN, (2002) Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes. Curr Drug Metab 3: 481-490.
41. Hollenstein K, Frei DC, Locher KP, (2007) Structure of an ABC transporter in complex with its binding protein. Nature 446: 213-216.
42. De MA, (1999) Heat shock proteins: facts, thoughts, and dreams. Shock 11: 1-12.
43. Santoro MG, (2000) Heat shock factors and the control of the stress response. Biochem Pharmacol 59: 55-63.
44. Ferre P, (2004) The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. Diabetes 53 (Suppl 1): S43-S50.
45. Lee CH, Olson P, Evans RM, (2003) Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology 144: 2201-2207.
46. Beigneux AP, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR, (2000) The acute phase response is associated with retinoid X receptor repression in rodent liver. J Biol Chem 275: 16390-16399.
47. Beigneux AP, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR, (2003) Sick euthyroid syndrome is associated with decreased TR expression and DNA binding in mouse liver. Am J Physiol Endocrinol Metab 284: E228-E236.
48. Kim MS, Sweeney TR, Shigenaga JK, Chui LG, Moser A, et al. (2007) Tumor necrosis factor and interleukin 1 decrease RXRalpha, PPARalpha, PPARgamma, LXRalpha, and the coactivators SRC-1, PGC-1alpha, and PGC-1beta in liver cells. Metabolism 56: 267-279.
49. Mashek DG, McKenzie MA, Van Horn CG, Coleman RA, (2006) Rat long chain acyl-CoA synthetase 5 increases fatty acid uptake and partitioning to cellular triacylglycerol in McArdle-RH7777 cells. J Biol Chem 281: 945-950.
50. Schug TT, Berry DC, Toshkov IA, Cheng L, Nikitin AY, et al. (2008) Overcoming retinoic acid-resistance of mammary carcinomas by diverting retinoic acid from PPARbeta/delta to RAR. Proc Natl Acad Sci U S A 105: 7546-7551.
51. Schug TT, Berry DC, Shaw NS, Travis SN, Noy N, (2007) Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors. Cell 129: 723-733.
52. Luebker DJ, Hansen KJ, Bass NM, Butenhoff JL, Seacat AM, (2002) Interactions of fluorochemicals with rat liver fatty acid-binding protein. Toxicology 176: 175-185.
53. Shipley JM, Waxman DJ, (2004) Simultaneous, bidirectional inhibitory crosstalk between PPAR and STAT5b. Toxicol Appl Pharmacol 199: 275-284.
54. Hickey NJ, Crump D, Jones SP, Kennedy SW, (2009) Effects of 18 perfluoroalkyl compounds on mRNA expression in chicken embryo hepatocyte cultures. Toxicol Sci 111: 311-320.
55. Koller BH, Geraghty DE, Shimizu Y, DeMars R, Orr HT, (1988) HLA-E. A novel HLA class I gene expressed in resting T lymphocytes. J Immunol 141: 897-904.
56. Rotondi M, Chiovato L, Romagnani S, Serio M, Romagnani P, (2007) Role of chemokines in endocrine autoimmune diseases. Endocr Rev 28: 492-520.
57. Rotondi M, Minelli R, Magri F, Leporati P, Romagnani P, et al. (2007) Serum CXCL10 levels and occurrence of thyroid dysfunction in patients treated with interferon-alpha therapy for hepatitis C virus-related hepatitis. Eur J Endocrinol 156: 409-414.
58. Patel AA, Torres DM, Harrison SA, (2009) Effect of weight loss on nonalcoholic fatty liver disease. J Clin Gastroenterol 43: 970-974.
59. Foreman JE, Chang SC, Ehresman DJ, Butenhoff JL, Anderson CR, et al. (2009) Differential hepatic effects of perfluorobutyrate mediated by mouse and human PPAR-alpha. Toxicol Sci 110: 204-211.
60. Morita K, Miyamoto T, Fujita N, Kubota Y, Ito K, et al. (2007) Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification. J Exp Med 204: 1613-1623.
61. Spanggord RJ, Myers CJ, LeValley SE, Green CE, Tyson CA, (1990) Structure-activity relationship for the intrinsic hepatotoxicity of dinitrotoluenes. Chem Res Toxicol 3: 551-558.
62. Giordano FJ, (2005) Oxygen, oxidative stress, hypoxia, and heart failure. J Clin Invest 115: 500-508.
63. National Research Council (1996) Guide for the care and use of laboratory animals. Washington D.C. National Academy Press.
64. Johnson MS, Quinn MJ, Bazar MA, Gust KA, Escalon BL, Perkins EJ, (2007) Subacute toxicity of oral 2,6-dinitrotoluene and 1,3,5-trinitro-1,3,5-triazine (RDX) exposure to the northern bobwhite (Colinus virginianus). Environ Toxicol Chem 26: 1481-1487.
65. Vacca LL, (1985) Laboratory manual of histochemistry. New York Raven Press.
66. Fairbanks V, Klee G, (1986) biochemical aspects of hematology. In: Tietz NW, editors. In Textbook of Clinical Chemistry Philadelphia W.B. Saunders Co. pp. 1532-1534.
67. Sharp PE, LaRegina MC, (1998) The laboratory rat. Boca Raton, FL CRC Press.
68. Assink HA, Blijenberg BG, Boerma GJ, Leijnse B, (1984) The introduction of bromocresol purple for the determination of serum albumin on SMAC and ACA, and the standardization procedure. J Clin Chem Clin Biochem 22: 685-692.
69. Reiner A, Yekutieli D, Benjamini Y, (2003) Identifying differentially expressed genes using false discovery rate controlling procedures. Bioinformatics 19: 368-375.
70. Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, et al. (2000) Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 25: 25-29.
71. Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, et al. (2003) DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 4: 3.
72. Huang dW, Sherman BT, Lempicki RA, (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4: 44-57.
73. Pirooznia M, Habib T, Perkins EJ, Deng Y, (2008) GOfetcher: a database with complex searching facility for gene ontology. Bioinformatics 24: 2561-2563.
74. Bredel M, Bredel C, Juric D, Harsh GR, Vogel H, et al. (2005) Functional network analysis reveals extended gliomagenesis pathway maps and three novel MYC-interacting genes in human gliomas. Cancer Res 65: 8679-8689.
75. Zuo Y, Zhuang DZ, Han R, Isaac G, Tobin JJ, et al. (2008) ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters. J Biol Chem 283: 36624-36635.
76. Devaiah SP, Roth MR, Baughman E, Li M, Tamura P, et al. (2006) Quantitative profiling of polar glycerolipid species from organs of wild-type Arabidopsis and a phospholipase Dalpha1 knockout mutant. Phytochemistry 67: 1907-1924.