The NSAID sulindac is chemopreventive in the mouse distal colon but carcinogenic in the proximal colon

Gut

Volumn 60, Issue 3, 2011, Pages 350-360

  Mladenova, Dessislava ^a   Daniel, Joseph J ^a   Dahlstrom, Jane E ^b   Bean, Elaine ^b   Gupta, Ruta ^b   Pickford, Russell ^c   Currey, Nicola ^a   Musgrove, Elizabeth A ^a,d   Kohonen Corish, Maija R J ^a,d  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b CANBERRA HOSPITAL   (Australia)

^c University of NSW Analytical Centre   (Australia)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 2; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN MSH2; PROTEIN P53; SULINDAC;

ADENOCARCINOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMOPROPHYLAXIS; COLORECTAL CANCER; GENETIC DISORDER; HISTOPATHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADENOCARCINOMA; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTICARCINOGENIC AGENTS; APOPTOSIS; AZOXYMETHANE; CARCINOGENS; CELL TRANSFORMATION, NEOPLASTIC; COLON; COLONIC NEOPLASMS; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INFLAMMATION MEDIATORS; INTESTINAL MUCOSA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTS HOMOLOG 2 PROTEIN; PRECANCEROUS CONDITIONS; SULINDAC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79851512690     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gut.2010.208314     Document Type: Article

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