Effects of oral dosing paradigms (gavage versus diet) on pharmacokinetics and pharmacodynamics

Chemico-Biological Interactions

Volumn 164, Issue 1-2, 2006, Pages 68-75

  Kapetanovic, I M ^a   Krishnaraj, R ^b   Martin Jimenez, T ^c   Yuan, L ^b   van Breemen, R B ^b   Lyubimov, A ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c UNIVERSITY OF TENNESSEE   (United States)

Author keywords

Diet dosing; Oral gavage; PGE2; Pharmacodynamics; Pharmacokinetics; Sulindac

Indexed keywords

NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN E2; SULINDAC;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BREAST; CANCER PREVENTION; CHEMOPROPHYLAXIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG SAFETY; FEEDING; FEMALE; LINEAR SYSTEM; MAMMARY GLAND; NONHUMAN; PHARMACODYNAMICS; RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS; BIOLOGICAL MARKERS; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; MAMMARY GLANDS, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; RISK FACTORS; SULINDAC; TIME FACTORS;

EID: 33750732304     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2006.08.019     Document Type: Article

References (20)

1. Crowell J.A., and Holmes C.J. Agent identification and preclinical testing. Cancer Treat. Res. 106 (2001) 1-30
2. Keller J.J., and Giardiello F.M. Chemoprevention strategies using NSAIDs and COX-2 inhibitors. Cancer Biol. Ther. 2 4 Suppl. 1 (2003) S140-S149
3. Rao C.V., and Reddy B.S. NSAIDs and chemoprevention. Curr. Cancer Drug Targets 4 1 (2004) 29-42
4. Davies G.L. Cyclooxygenase-2 and chemoprevention of breast cancer. J. Steroid Biochem. Mol. Biol. 86 3-5 (2003) 495-499
5. Han E.K., Arber N., Yamamoto H., Lim J.T., Delohery T., Pamukcu R., Piazza G.A., Xing W.Q., and Weinstein I.B. Effects of sulindac and its metabolites on growth and apoptosis in human mammary epithelial and breast carcinoma cell lines. Breast Cancer Res. Treat. 48 3 (1998) 195-203
6. Thompson H.J., Jiang C., Lu J., Mehta R.G., Piazza G.A., Paranka N.S., Pamukcu R., and Ahnen D.J. Sulfone metabolite of sulindac inhibits mammary carcinogenesis. Cancer Res. 57 2 (1997) 267-271
7. Badawi A.F., and Archer M.C. Effect of hormonal status on the expression of the cyclooxygenase 1 and 2 genes and prostaglandin synthesis in rat mammary glands. Prostaglandins Other Lipid Mediat. 56 2-3 (1998) 167-181
8. Sample D., Wargovich M., Fischer S.M., Inamdar N., Schwartz P., Wang X., Do K.A., and Sinicrope F.A. A dose-finding study of aspirin for chemoprevention utilizing rectal mucosal prostaglandin E(2) levels as a biomarker. Cancer Epidemiol. Biomarkers Prev. 11 3 (2002) 275-279
9. Badawi A.F., Eldeen M.B., Liu Y., Ross E.A., and Badr M.Z. Inhibition of rat mammary gland carcinogenesis by simultaneous targeting of cyclooxygenase-2 and peroxisome proliferator-activated receptor gamma. Cancer Res. 64 3 (2004) 1181-1189
10. Bailer A.J. Testing for the equality of area under the curves when using destructive measurement techniques. J. Pharmacokinet. Biopharm. 16 3 (1988) 303-309
11. Nedelman J.R., and Gibiansky E. The variance of a better AUC estimator for sparse, destructive sampling in toxicokinetics. J. Pharm. Sci. 85 8 (1996) 884-886
12. Nedelman J.R., Gibiansky E., and Lau D.T. Applying Bailer's method for AUC confidence intervals to sparse sampling. Pharm. Res. 12 1 (1995) 124-128
13. Arnold D.L., Bryce F.R., Clegg D.J., Cherry W., Tanner J.R., and Hayward S. Dosing via gavage or diet for reproduction studies: a pilot study using two fat-soluble compounds-hexachlorobenzene and aroclor 1254. Food Chem. Toxicol. 38 8 (2000) 697-706
14. Worden A.N., and Harper K.H. Oral toxicity as influenced by method of administration. Proc. Eur. Soc. Study Drug Toxicol. 2 (1964) 107-110
15. Hebert C.D., Yuan J., and Dieter M.P. Comparison of the toxicity of cinnamaldehyde when administered by microencapsulation in feed or by corn oil gavage. Food Chem. Toxicol. 32 12 (1994) 1107-1115
16. Yuan J.H., Goehl T.J., Murrill E., Moore R., Clark J., Hong H.L., and Irwin R.D. Toxicokinetics of pentachlorophenol in the F344 rat. Gavage and dosed feed studies. Xenobiotica 24 6 (1994) 553-560
17. Cook C.S., Lonien M., and Hribar J. Effect of diet and gavage on the dose- and dose-mode-dependent absorption and metabolism of bidisomide in rat. Xenobiotica 30 5 (2000) 523-533
18. Dain J.G., and Jaffe J.M. Effect of diet and gavage on the absorption and metabolism of fluperlapine in the rat. Drug Metab. Dispos. 16 2 (1988) 238-242
19. Yuan J.H., Goehl T.J., Abdo K., Clark J., Espinosa O., Bugge C., and Garcia D. Effects of gavage versus dosed feed administration on the toxicokinetics of benzyl acetate in rats and mice. Food Chem. Toxicol. 33 2 (1995) 151-158
20. Born S.L., Api A.M., Ford R.A., Lefever F.R., and Hawkins D.R. Comparative metabolism and kinetics of coumarin in mice and rats. Food Chem. Toxicol. 41 2 (2003) 247-258