Complete inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone- induced rat lung tumorigenesis and favorable modification of biomarkers by phenethyl isothiocyanate

Cancer Epidemiology Biomarkers and Prevention

Volumn 5, Issue 8, 1996, Pages 645-652

  Hecht, Stephen S ^a,b   Trushin, Neil ^a   Rigotty, Jeffrey ^a   Carmella, Steven G ^a   Borukhova, Anna ^a   Akerkar, Shobha ^a   Rivenson, Abraham ^a  

^a AMERICAN HEALTH FOUNDATION   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; BIOLOGICAL MARKER; ISOTHIOCYANIC ACID DERIVATIVE; PHENETHYL ISOTHIOCYANATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOASSAY; CANCER INHIBITION; CONTROLLED STUDY; LUNG ADENOCARCINOMA; LUNG ADENOMA; LUNG CARCINOGENESIS; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PANCREAS CANCER; PRIORITY JOURNAL; RAT; VEGETABLE;

ANIMALS; ANTICARCINOGENIC AGENTS; BIOLOGICAL MARKERS; CARCINOGENS; DNA ADDUCTS; ISOTHIOCYANATES; LUNG NEOPLASMS; MALE; NEOPLASMS, EXPERIMENTAL; NITROSAMINES; RATS; RATS, INBRED F344;

EID: 0029812570     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Tookey, H. L., VanEtten, C. H., and Daxenblehler, M. E. Glucosinolates. In: I. E. Liener (ed.), Toxic Constituents of Plant Stuffs, pp. 103-142, New York: Academie Press, 1980.
2. Hecht, S. S., Chung, F-L., Richie, J. P., Jr., Akerkar, S. A., Borukhova; A., Skowronski, L., and Carmella, S. G. Effects of watercress consumption on metabolism of a tobacco-specific lung carcinogen in smokers. Cancer Epidemiol., Biomarkers & Prev., 4: 877-834, 1995.
3. Stoner, G. D., Morrissey; D.; Heur, Y-H., Daniel; E., Galati, A:, and Wagner, S. A. Inhibitory effects of phenethyl isothiocyanate on N-nitrosobenzylmethylamine earcinogenesis in the rat esophagus. Cancer Res., 51: 2063-2068; 1991.
4. Nishikawa, A., Chung, F. L., Furukawa, F., Imagawa, T., Ikezaki, S., Takahashi, M., and Hayashi, Y. Chemopreventive effects of phenethyl and 3-phenylpropyl isothiocyanates en lung and pancreatic carelnogenesis initiated with W-nitroso-bis(2-oxopfopyl)amine in hamsters. Proc. Am. Assoc. Cancer Res., 36:126, 1995.
5. Wattenberg, L. W. Inhibition of carcinogenic effects of polycyclic hydrocarbons by benzyl isothiocyanate and related compounds. J. Natl. Cancer Inst., 58: 395-398, 1977.
6. 6-methylguanine formation, and m̃êtabollom of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung. Cancer Res., 49: 2894-2897, 1989.
7. Morse, M. A., Ekllnd, K. I., Amin, S. G., Hecht, S. S.; and Chung, F-L. Effects of alkyl chain length on the inhibition of NNK-induced lung neoplàśia in A/J mice by arylalkyl isothiocyanates. Carcinogenesis (Lond.), 10: 1757-1759, 1989.
8. Morse, M. A., Eklind, K. I., Hecht, S. S., Jordan, K. G., Choi, C-I., Desai, D. H., Amin, S. G., and Chung, F-L. Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-l-butanone lung tumorigenesis by arylalkyl isothiocyanates in A/J mice. Cancer Res., 51: 1846-1850, 1991.
9. Morse, M. A., Wang, C-X., Stoner, G. D., Mandai, S., Conran, P. B., Amin, S. G., Hecht, S. S., and Chung, F-L. Inhibition of 4-(methylmtrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation and tumorigenicity in lung of F344 rats by dietary phenethyl isothiocyanate. Cancer Res., 49: 549-553, 1989.
10. Chung, F-L., Kelloff, G., Steele, V., Pittman, B., Zang, E., Jiao, D., Rigotty, J., Choi, C-I., and Rivenson, A. Chemopreventive efficacy of arylalkyl isothiocyanates and N-acetylcysteine for lung tumorigenesis in Fischer rats. Cancer Res., 56: 772-778. 1996.
11. Hoffmann, D., and Hecht, S. S. Advances in tobacco carcinogenesis. In: C. S. Cooper and P. L. Grover (eds.), Handbook of Experimental Pharmacology, pp. 63-102. Heldelberg: Springer-Verlag, 1990.
12. Hecht, S. S., Young, R., and Chen, C. B. Metabolism in the F344 rat of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco specific carcinogen. Cancer Res., 40: 4144-4150, 1980.
13. Staretz, M. E., and Hecht, S. S. Effects of phenithl isothiocyanate on the tissue distribution of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and metabolites In F344 rats. Cancer Res., 55: 5580-5588, 1995.
14. Castonguay, A., Lin, D., Stoner, G. D., Radok, P., Furuya, K., Hecht, S. S., Schut, H. A. J., and Klaunig, J. E. Comparative carcinogenicity in A/J mice and metabolism by cultured mouse peripheral lung of N′-nitrosonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and their analogues. Cancer Res., 43: 1223-1229, 1983.
15. Rlvenson, A., Hoffmann, D., Prokopczyk, B., Amin, S., and Hecht, S. S. Induction of lung and exocrine pancreas tumors in F344 rats by tobacco-specific and Areca-derived N-nitrosamines. Cancer Res., 48: 6912-6917, 1988.
16. Carmella, S. G., Akerkar, S., and Hecht, S. S. Metabolites of the tobaccospecific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers' urine. Cancer Res., 53: 721-724, 1993.
17. Carmella, S. G., Akerkar, S., Richie, J. P., Jr., and Hecht, S. S. Intraindividual and interindivldual differences in metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers' urine. Cancer Epidemiol., Biomarkers & Prev., 4: 635-642, 1995.
18. Hecht, S. S. Metabolic activation and detoxification of tobacco-specific nitrosamines - a model for cancer prevention strategies. Drug Metab. Rev., 26: 373-390, 1994.
19. Hecht, S. S. Recent studies on mechanisms of bioactivation and detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen. CRC Crit. Rev. Toxicol., 26: 163-181, 1996.
20. Smith, T. J., Guo, Z., Thomas, P. E., Chung, F-L., Morse, M. A., Eklind, K., and Yang, C. S. Metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone in mouse lung microsomes and its inhibition by isothiocyanates. Cancer Res., 50: 6817-6822, 1990.
21. Smith, T. J., Guo, Z., Li, C, Ning, S. M., Thomas, P. E., and Yang, C. S. Mechanisms of inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation in mouse by dietary pheneihyl isothiocyanate. Cancer Res., 53: 3276-3282, 1993.
22. Guo, Z., Smith, T. J., Wang, E., Eklind, K. I., Chung, F-L., and Yang, C. S. Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice. Carcinogenesis (Lond.), 14: 1167-1173, 1993.
23. Yang, C. S., Smith, T. J., and Hong, J-Y. Cytochrome P-450 enzymes as targets for chemoprevention against chemical carcinogenesis and toxicity: opportunities and limitations. Cancer Res., 54: 1982s-1986s, 1994.
24. Hoffmann, D., Rivenson, A., Abbi, R., and Wynder, E. A study of tobacco carcinogenesis: effect of the fat content of the diet on the carcinogenic activity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats. Cancer Res., 53: 2758-2761, 1993.
25. Hecht, S. S., Carmella, S. G., and Murphy, S. E. Tobacco-specific nitrosamine hemoglobin adducts. Methods Enzymol., 231: 657-667, 1994.
26. Fleiss, J. L. The Design and Analysis of Clinical Experiments, pp. 220-240. New York: John Wiley & Sons, 1986.
27. Hoffmann, D., Rivenson, A., Amin, S., and Hecht, S. S. Dose-response study of the carcinogenicity of tobacco-specific N-nitrosamines in F344 rats. J. Cancer Res. Clin. Oncol., 108: 81-86, 1984.
28. 6-methylguanine formation in Clara cells and induction of pulmonary neoplasia in the rat by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res., 50: 3772-3780, 1990.
29. Kassie, F., Sonntag, G., Lamprecht, G., Sanyal, R., and Knasmüller, S. Genotoxic effects of naturally occurring isothiocyanates and crude extracts of cruciferous vegetables. Environmental Mutagen Society Abstracts, p. 29, 1994.
30. Musk, S. R. R., and Johnson, I. T. The clastogenic effects of isothiocyanates. Mutat. Res., 100: 111-117, 1993.