Preventive effect of pumpkin (Cucurbita pepo L.) on diabetic index and histopathology of pancreas in alloxan-induced diabetes in rats

Journal of Isfahan Medical School

Volumn 28, Issue 117, 2011, Pages 872-881

  Kazemi, Somayeh ^a   Asgari, Sedigheh ^b   Moshtaghian, Seyed Jamal ^a   Rafieian, Mahmoud ^c   Mahzooni, Parvin ^d  

^a UNIVERSITY OF ISFAHAN   (Iran)

^b ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Alloxan monohydrate; Cucurbita pepo; Diabetes; Histopathology; Pancreas

Indexed keywords

ALLOXAN; CUCURBITA PEPO POWDER; INSULIN; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DOSE RESPONSE; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; MALE; MEDICINAL PLANT; NONHUMAN; PANCREAS; PUMPKIN; RAT;

EID: 79851479236     PISSN: 10277595     EISSN: 1735854X     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Tripathi BK, Srivastava AK. Diabetes mellitus: complications and therapeutics. Med Sci Monit 2006; 12(7): RA130-47.
2. Wändell PE. Quality of life of patients with diabetes mellitus. An overview of research in primary health care in the Nordic countries. Scand J Prim Health Care 2005; 23(2): 68-74. (Pubitemid 40904660)
3. Grover JK, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol 2002; 81(1): 81-100. (Pubitemid 34518472)
4. Khan A, Anderson RA. Insulin Potentiating Factor (IPF) Present in Foods, Species and Natural Products. Pakistan Journal of Nutrition 2003; 2(4): 254-7.
5. Yuspa SH. Overview of carcinogenesis: past present and future. Carcinogenesis 2000; 21(3): 341-4. (Pubitemid 30137918)
6. Kasetti RB, Rajasekhar MD, Kondeti VK, Fatima SS, Kumar EG, Swapna S, et al. Antihyperglycemic and antihyperlipidemic activities of methanol: water (4:1) fraction isolated from aqueous extract of Syzygium alternifolium seeds in streptozotocin induced diabetic rats. Food Chem Toxicol 2010; 48(4): 1078-84.
7. Park KH, Kim JR, Lee JS, Lee H, Cho KH. Ethanol and water extract of purple sweet potato exhibits anti-atherosclerotic activity and inhibits protein glycation. J Med Food 2010; 13(1): 91-8.
8. Mohamed RA, Ramadan RS, Ahmed LA. Effect of substituting pumpkin seed protein isolate for casein on serum liver enzymes, lipid profile and antioxidant enzymes in CCl4-intoxicated rats. Advances in Biological Research 2009; 3(1-2): 9-15.
9. Ghasemi dehkordi N, Sajjadi SE, Ghannadi A, Amanzadeh Y, Azadbakht M, Asghari GR, et al. Iranian herbal pharmacopoeia (IHP). Hakim Research Journal 2003. 6(3): 63-9. [in Persian].
10. Xia T, Wang Q. Antihyperglycemic effect of Cucurbita ficifolia fruit extract in streptozotocin-induced diabetic rats. Fitoterapia 2006; 77(7-8): 530-3. (Pubitemid 44738272)
11. Acosta-Patiño JL, Jiménez-Balderas E, Juárez-Oropeza MA, Díaz-Zagoya JC. Hypoglycemic action of Cucurbita ficifolia on Type 2 diabetic patients with moderately high blood glucose levels. Journal of Ethnopharmacology 2001; 77(1): 99-101. (Pubitemid 32727751)
12. Quanhong L, Caili F, Yukui R, Guanghui H, Tongyi C. Effects of protein-bound polysaccharide isolated from pumpkin on insulin in diabetic rats. Plant Foods for Human Nutrition 2005; 60(1): 13-6. (Pubitemid 40772033)
13. Murkovic M, Mülleder U, Neunteufl H. Carotenoid content in different varieties of pumpkins. Journal of Food Composition and Analysis 2002; 15(6): 633-8. (Pubitemid 35446539)
14. Zuhair HA, Abd El-Fattah AA, El-Sayed MI. Pumpkin-seed oil modulates the effect of felodipine and captopril in spontaneously hypertensive rats. Pharmacol Res 2000; 41(5): 555-63.
15. Venkatesh S, Madhava Reddy B, Dayanand Reddy G, Mullangi R, Lakshman M. Antihyperglycemic and hypolipidemic effects of Helicteres isora roots in alloxan-induced diabetic rats: a possible mechanism of action. J Nat Med 2010; 64(3): 295-304.
16. Madhavan V, Nagar JC, Murali A, Mythreyi R, Yoganarasimhan SN. Antihyperglycemic activity of alcohol and aqueous extracts of Pandanus fascicularis Lam. roots in alloxan induced diabetic rats. Pharmacologyonline 2008; 3: 529-36.
17. Ragavan B, Krishnakumari S. Antidiabetic effect of T.arjuna bark extract in alloxan induced diabetic rats. Indian Journal of Clinical Biochemistry 2006; 21(2): 123-8. (Pubitemid 44756937)
18. Rajagopal K, Sasikala K. Antihyperglycaemic and antihyperlipidaemic effects of Nymphaea stellata in alloxan-induced diabetic rats. Singapore Med J 2008; 49(2): 137-41. (Pubitemid 351488549)
19. Sharma U, Sahu R, Roy A, Golwala D. In vivo antidiabetic and antioxidant potential of Stephania hernandifolia in streptozotocin-induced-diabetic rats. J Young Pharm 2010; 2(3): 255-60.
20. Asgary S, Parkhideh S, Solhpour A, Madani H, Mahzouni P, Rahimi P. Effect of ethanolic extract of Juglans regia L. on blood sugar in diabetes-induced Rats. J Med Food 2008; 11(3): 533-8.
21. Alarcon-Aguilar FJ, Hernandez-Galicia E, Campos-Sepulveda AE, Xolalpa-Molina S, Rivas-Vilchis JF, Vazquez-Carrillo LI, et al. Evaluation of the hypoglycemic effect of Cucurbita ficifolia Bouché (Cucurbitaceae) in different experimental models. J Ethnopharmacol 2002; 82(2-3): 185-9. (Pubitemid 35292045)
22. Mohajeri D, Ghafour M, Doustar Y. Antihyperglycemic and pancreas- protective effects of Crocus sativus L. (Saffron) stigma ethanolic extract on rat with alloxan-induced diabetes. Journal of Biological Sciences 2009; 9(4): 1-9.
23. Hii CS, Howell SL. Effects of epicatechin on rat islets of langerhans. Diabetes 1984; 33(3): 291-6. (Pubitemid 14196222)
24. Elsner M, Gurgul-Convey E, Lenzen S. Relative importance of cellular uptake and reactive oxygen species for the toxicity of alloxan and dialuric acid to insulin- producing cells. Free Radic Biol Med 2006; 41(5): 825-34. (Pubitemid 44163416)
25. Elsner M, Tiedge M, Guldbakke B, Munday R, Lenzen S. Importance of the GLUT2 glucose transporter for pancreatic beta-cell toxicity of alloxan. Diabetologia 2002; 45(11): 1542-9. (Pubitemid 35352048)
26. Lenzen S. The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia 2008; 51(2): 216-26.
27. Potapovich AI, Kostyuk VA. Comparative study of antioxidant properties and cytoprotective activity of flavonoids. Biochemistry 2003; 68(5): 514-9.
28. Ratnam DV, Ankola DD, Bhardwaj V, Sahana DK, Kumar MN. Role of antioxidants in prophylaxis and therapy: A pharmacological perspective. J Control Release 2006; 113(3): 189-207. (Pubitemid 43983041)
29. Vaya J, Aviram M. Nutritional antioxidants: mechanism of action, analyses of activities and medical applications. Current Medicinal Chemistry- Immunology, Endocrine & Metabolic Agents 2001; 1(1): 99-117.
30. Bombardelli E, Morazzoni P. Curcubita pepo L. Fitoterapia 1997; 68(4): 291-302.
31. Lazos ES. Nutritional, Fatty acids and oil characteristics of pumpkin and melon seeds. J Food Sci 1986; 51(5): 1382-3.
32. Fissore EN, Matkovic L, Wider E, Rojas AM, Gerschenson LN. Rheological properties of pectin-enriched products isolated from butternut (Cucurbita moschata Duch ex Poiret). LWT-Food Science and Technology 2009; 42(8): 1413-21.
33. Xanthopoulou MN, Nomikos T, Fragopoulou E, Antonopoulou S. Antioxidant and lipoxygenase inhibitory activities of pumpkin seed extracts. Food Research International 2009; 42(5-6): 641-6.
34. Abdel-Hassan IA, Abdel-Barry JA, Tariq Mohammeda S. The hypoglycemic and antihyperglycaemic effect of Citrullus colocynthis fruit aqueous extract in normal and alloxan diabetic rabbits. J Ethnopharmacol 2000; 71(1-2): 325-30. (Pubitemid 30440686)
35. Vessal M, Hemmati M, Vasei M. Antidiabetic effects of quercetin in streptozocin-induced diabetic rats. Comp Biochem Physiol C Toxicol Pharmacol 2003; 135C(3): 357-64. (Pubitemid 36962949)
36. Gourgue CMP, Champ MMJ, Lozano Y, Delort-Laval J. Dietary fiber from mango byproducts: Characterization and hypoglycemic effects determined by in vitro methods. J Agric Food Chem 1992; 40(10): 1864-8.