Importance of the GLUT2 glucose transporter for pancreatic beta cell toxicity of alloxan

Diabetologia

Volumn 45, Issue 11, 2002, Pages 1542-1549

  Elsner, M ^a,b   Tiedge, M ^a,b   Guldbakke, B ^a,b   Munday, R ^a,b   Lenzen, S ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b RUAKURA RESEARCH CENTRE   (New Zealand)

Author keywords

Alloxan; Butylalloxan; Diabetes; GLUT2 glucose transporter; RINm5F cells

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ALLOXAN; BUTYLALLOXAN; COMPLEMENTARY DNA; FREE RADICAL; GLUCOSE; GLUCOSE TRANSPORTER 2; GLUTATHIONE; OXYGEN RADICAL; UNCLASSIFIED DRUG; 3 METHYLGLUCOSE; DRUG DERIVATIVE; GLUCOSE TRANSPORTER; RECOMBINANT PROTEIN;

ALLOXAN DIABETES MELLITUS; ANIMAL CELL; ARTICLE; CELL DEATH; CELL PROTECTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETOGENESIS; DNA VECTOR; DRUG CYTOTOXICITY; DRUG EFFECT; GENETIC TRANSFECTION; INSULIN DEPENDENT DIABETES MELLITUS; LIPOPHILICITY; MICROTITER PLATE ASSAY; NONHUMAN; OXIDATION REDUCTION REACTION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RAT; ANIMAL; CELL CULTURE; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; GENETICS; KINETICS; METABOLISM; MICROSOME; PANCREAS ISLET; PATHOLOGY; PHYSIOLOGY;

3-O-METHYLGLUCOSE; ALLOXAN; ANIMALS; CELLS, CULTURED; GENE EXPRESSION REGULATION; GLUCOSE; GLUCOSE TRANSPORTER TYPE 2; ISLETS OF LANGERHANS; KINETICS; MICROSOMES; MONOSACCHARIDE TRANSPORT PROTEINS; RATS; RECOMBINANT PROTEINS;

EID: 0036434465     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-002-0955-x     Document Type: Article

References (44)

1. Dunn JS, Sheehan HL, McLetchie NGB (1943) Necrosis of islets of Langerhans produced experimentally. Lancet 1: 484-487
2. Dunn JS (1943) An experimental lesion of the pancreatic islets. Surgo 9: 32-34
3. Rerup CC (1970) Drugs producing diabetes through damage of the insulin secreting cells. Pharmacol Rev 22: 485-518
4. Malaisse WJ (1982) Alloxan toxicity to the pancreatic B-cell. A new hypothesis. Biochem Pharmacol 31: 3527-3534
5. McLetchie NGB (1982) Alloxan Diabetes: The scorer and his apprentice. Diabetologia 23: 72-75
6. Lenzen S, Panten U (1988) Alloxan: History and mechanism of action. Diabetologia 31: 337-342
7. Lenzen S, Tiedge M, Jörns A, Munday R (1996) Alloxan derivatives as a tool for the elucidation of the mechanism of the diabetogenic action of alloxan. In: Shafrir E (ed) Lessons from Animal Diabetes,Birkhäuser, Boston, pp 113-122
8. Okamoto H (1996) Okamoto model for B-cell damage: recent advances. In: Shafrir E (ed) Lessons from Animal Diabetes, Birkhäuser, Boston, pp 97-111
9. Szkudelski T (2001) The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res 50: 537-546
10. Lenzen S, Munday R (1991) Thiol-group reactivity, hydrophilicity and stability of alloxan, its reduction products and its N-methyl derivatives and a comparison with ninhydrin. Biochem Pharmacol 42: 1385-1391
11. Munday R (1988) Dialuric acid autoxidation. Effects of transition metals on the reaction rate and on the generation of "active oxygen" species. Biochem Pharmacol 37: 409-413
12. Munday R, Ludwig K, Lenzen S (1993) The relationship between the physicochemical properties and the biological effects of alloxan and several N-alkyl substituted alloxan derivatives. J Endocrinol 139: 153-163
13. Brückmann G, Wertheimer E (1947) Alloxan studies: The action of alloxan homologues and related compounds. J Biol Chem 168: 241-256
14. Jörns A, Munday R, Tiedge M, Lenzen S (1997) Comparative toxicity of alloxan, N-alkylalloxans and ninhydrin to isolated pancreatic islets in vitro. J Endocrinol 155: 283-293
15. McDaniel ML, Bry CG, Fink CJ, Homer RW, Lacy PE (1979) Studies on the site of interaction for ninhydrin, al-loxan, and D- glucose in insulin secretion by isolated islets in vitro. Endocrinology 105: 1446-1451
16. Flatt PR, Swanston-Flatt SK, Tan KS, Marks V (1987) Effects of cytotoxic drugs and inhibitors of insulin secretion on a serially transplantable rat insulinoma and cultured rat insulinoma cells. Gen Pharmacol 18: 293-297
17. Tiedge M, Richter T, Lenzen S (2000) Importance of cysteine residues for the stability and catalytic activity of human pancreatic beta cell glucokinase. Arch Biochem Biophys 375: 251-260
18. Elsner M, Guldbakke B, Tiedge M, Munday R, Lenzen S (2000) Relative importance of transport and alkylation for pancreatic beta- cell toxicity of streptozotocin. Diabetologia 43: 1528-1533
19. Korting HC, Schindler S, Hartinger A, Kerscher M, Angerpointner T, Maibach HI (1994) MTT-assay and neutral red release (NRR)-assay: relative role in the prediction of the irritancy potential of surfactants. Life Sci 55: 533-540
20. Lenzen S (1979) Insulin secretion by isolated perfused rat and mouse pancreas. Am J Physiol 236: E391-E400
21. Thorens B, Sarkar HK, Kaback HR, Lodish HF (1988) Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and beta-pancreatic islet cells. Cell 55: 281-290
22. Tiedge M, Lortz S, Drinkgern J, Lenzen S (1997) Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes 46: 1733-1742
23. Tiedge M, Elsner M, McClenaghan NH et al. (2000) Engineering of a glucose-responsive surrogate cell for insulin replacement therapy of experimental insulin-dependent diabetes. Hum Gene Ther 11: 403-414
24. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate- phenolchloroform extraction. Anal Biochem 162: 156-169
25. Weiser MM (1973) Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. J Biol Chem 248: 2536-2541
26. Rago R, Mitchen J, Wilding G (1990) DNA fluorometric assay in 96-well tissue culture plates using Hoechst 33258 after cell lysis by freezing in distilled water. Anal Biochem 191: 31-34
27. Weaver DC, McDaniel ML, Lacy PE (1978) Alloxan uptake by isolated rat islets of Langerhans. Endocrinology 102: 1847-1855
28. Malaisse WJ, Doherty M, Ladriere L, Malaisse-Lagae F (2001) Pancreatic uptake of [2-(14)C]alloxan. Int J Mol Med 7: 311-315
29. Malaisse-Lagae F, Sener A, Malaisse WJ (1983) Contrasting modes of action of D-glucose and 3-O-methyl-D-glucose as protectors of the rat pancreatic B-cell against alloxan. Biochim Biophys Acta 762: 36-43
30. De Vos A, Heimberg H, Quartier E, Huypens P, Bouwens L, Pipeleers D, Schuit F (1995) Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression. J Clin Invest 96: 2489-2495
31. Tiedge M, Hohne M, Lenzen S (1993) Insulin secretion,insulin content and glucose phosphorylation in RINm5F insulinoma cells after transfection with human GLUT2 glucose- transporter cDNA. Biochem J 296: 113-118
32. Meglasson MD, Matschinsky FM (1986) Pancreatic islet glucose metabolism and regulation of insulin secretion. Diabetes Metab Rev 2: 163-214
33. Lenzen S, Panten U (1988) Signal recognition by pancreatic B-cells. Biochem Pharmacol 37: 371-378
34. Matschinsky FM (1990) Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes. Diabetes 39: 647-652
35. Matschinsky FM (1996) Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm. Diabetes 45: 223-241
36. Miwa I, Hara H, Matsunaga H, Okuda J (1984) Inhibition of glucokinase in hepatocytes by alloxan. Biochem Int 9: 595-602
37. Meglasson MD, Burch PT, Berner DK, Najafi H, Matschinsky FM (1986) Identification of glucokinase as an alloxan-sensitive glucose sensor of the pancreatic beta-cell. Diabetes 35: 1163-1173
38. Lenzen S, Tiedge M, Panten U (1987) Glucokinase in pancreatic B-cells and its inhibition by alloxan. Acta Endocrinol (Copenh) 115: 21-29
39. Bromme HJ, Weinandy R, Peschke D, Peschke E (2001) Simultaneous quantitative determination of alloxan, GSH and GSSG by HPlc. Estimation of the frequency of redox cycling between alloxan and dialuric acid. Horm Metab Res 33: 106-109
40. Jörns A, Tiedge M, Lenzen S, Munday R (1999) Effect of superoxide dismutase, catalase, chelating agents, and free radical scavengers on the toxicity of alloxan to isolated pancreatic islets in vitro. Free Radic Biol Med 26: 1300-1304
41. Bloch KO, Zemel R, Bloch OV, Grief H, Vardi P (2000) Streptozotocin and alloxan-based selection improves toxin resistance of insulin-producing RINm cells. Int J Exp Diabetes Res 1: 211-219
42. Schnedl WJ, Ferber S, Johnson JH, Newgard CB (1994) STZ transport and cytotoxicity. Specific enhancement in GLUT2- expressing cells. Diabetes 43: 1326-1333
43. Mathews CE, Leiter EH (1999) Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait. Diabetes 48: 2189-2196
44. Mathews CE, Leiter EH (1999) Constitutive differences in antioxidant defense status distinguish alloxan-resistant and alloxan-susceptible mice. Free Radic Biol Med 27: 449-455