Ibuprofen binding to secondary sites allosterically modulates the spectroscopic and catalytic properties of human serum heme-albumin

FEBS Journal

Volumn 278, Issue 4, 2011, Pages 654-662

  Di Masi, Alessandra ^a   Gullotta, Francesca ^b,c   Bolli, Alessandro ^a   Fanali, Gabriella ^d   Fasano, Mauro ^d   Ascenzi, Paolo ^a  

^a ROMA TRE UNIVERSITY   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c Interuniversity Consortium for the Research on the Chemistry of Metals in Biological Systems   (Italy)

^d UNIVERSITY OF INSUBRIA   (Italy)

Author keywords

allostery; human serum heme albumin; ibuprofen binding; modulation of reactivity and spectroscopic properties; recombinant truncated human serum heme albumin (Asp1 Glu382)

Indexed keywords

ASPARTIC ACID; FATTY ACID; FATTY ACID 2; FATTY ACID 3; FATTY ACID 4; FATTY ACID 6; GLUTAMINE; HEME; HUMAN SERUM ALBUMIN; IBUPROFEN; PEROXYNITRITE; RECOMBINANT PROTEIN; TRUNCATED HUMAN SERUM ALBUMIN; UNCLASSIFIED DRUG;

ALBUMIN BLOOD LEVEL; ALLOSTERISM; ARTICLE; CATALYSIS; DRUG PROTEIN BINDING; HUMAN; ISOMERIZATION; KINETICS; LIGAND BINDING; NITROSYLATION; PRIORITY JOURNAL; PROTEIN DOMAIN; SPECTROSCOPY;

ALLOSTERIC SITE; BIOCATALYSIS; HEME; HUMANS; IBUPROFEN; ISOMERISM; MODELS, MOLECULAR; PEROXYNITROUS ACID; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SERUM ALBUMIN; SPECTROPHOTOMETRY;

EID: 79751502747     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2010.07986.x     Document Type: Article

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