Ibuprofen induces an allosteric conformational transition in the heme complex of human serum albumin with significant effects on heme ligation

Journal of the American Chemical Society

Volumn 130, Issue 35, 2008, Pages 11677-11688

  Nicoletti, Francesco P ^a   Howes, Barry D ^a   Fittipaldi, Maria ^a   Fanali, Gabriella ^b   Fasano, Mauro ^b   Ascenzi, Paolo ^c,d   Smulevich, Giulietta ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF INSUBRIA   (Italy)

^c ROMA TRE UNIVERSITY   (Italy)

^d NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION; ABSORPTION SPECTROSCOPY; AMINO ACIDS; ANIMAL CELL CULTURE; ARSENIC COMPOUNDS; BLOOD; BODY FLUIDS; COORDINATION REACTIONS; DYES; ELECTRON RESONANCE; ELECTRON SPIN RESONANCE SPECTROSCOPY; HEMOGLOBIN; PARAMAGNETIC RESONANCE; PARAMAGNETISM; PLASMAS; RESONANCE;

IBUPROFEN;

PORPHYRINS;

HEME DERIVATIVE; HUMAN SERUM ALBUMIN; IBUPROFEN;

ABSORPTION SPECTROSCOPY; ARTICLE; CONFORMATIONAL TRANSITION; DRUG PROTEIN BINDING; ELECTRON SPIN RESONANCE; PROTEIN ANALYSIS; PROTEIN STRUCTURE; RAMAN SPECTROMETRY; STRUCTURE ANALYSIS;

ELECTRON SPIN RESONANCE SPECTROSCOPY; FERRIC COMPOUNDS; FERROUS COMPOUNDS; HEME; HUMANS; IBUPROFEN; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SERUM ALBUMIN; SPECTROPHOTOMETRY, ULTRAVIOLET; SPECTRUM ANALYSIS, RAMAN;

EID: 51349131362     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja800966t     Document Type: Article

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