Crystal structural analysis of human serum albumin complexed with hemin and fatty acid

BMC Structural Biology

Volumn 3, Issue , 2003, Pages 1-9

  Zunszain, Patricia A ^a   Ghuman, Jamie ^a   Komatsu, Teruyuki ^b   Tsuchida, Eishun ^b   Curry, Stephen ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b WASEDA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; HEMIN; IRON; LIPID BINDING PROTEIN; MYRISTIC ACID; PROPIONIC ACID DERIVATIVE; RECOMBINANT HUMAN SERUM ALBUMIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; STOICHIOMETRY; STRUCTURE ANALYSIS;

EID: 3042673067     PISSN: 14726807     EISSN: None     Source Type: Journal    
DOI: 10.1186/1472-6807-3-1     Document Type: Article

References (35)

1. Jeney V, Balla J, Yachie A, Varga Z, Vercellotti GM, Eaton JW and Balla G: Pro-oxidant and cytotoxic effects of circulating heme Blood 2002, 100:879-887.
2. Tolosano E and Altruda F: Hemopexin: structure, function, and regulation DNA Cell Biol 2002, 21:297-306.
3. Adams PA and Berman MC: Kinetics and mechanism of the interaction between human serum albumin and monomeric haemin Biochem J 1980, 191:95-102.
4. Peters T: All about albumin: biochemistry, genetics and medical applications San Diego, Academic Press; 1995.
5. He XM and Carter DC: Atomic structure and chemistry of human serum albumin Nature 1992, 358:209-215.
6. Sudlow G, Birkett DJ and Wade DN: The characterization of two specific drug binding sites on human serum albumin Mol Pharmacol 1975, 11:824-832.
7. Hamilton JA, Era S, Bhamidipati SP and Reed RG: Locations of the three primary binding sites for long-chain fatty acids on bovine serum albumin Proc Natl Acad Sci USA 1991, 88:2051-2054.
8. Curry S, Mandelkow H, Brick P and Franks N: Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites Nature Structural Biology 1998, 5:827-835.
9. Bhattacharya AA, Grüne T and Curry S: Crystallographic analysis reveals common modes of binding of medium and long-chain fatty acids to human serum albumin J Mol Biol 2000, 303:721-732.
10. Petitpas I, Grüne T, Bhattacharya AA and Curry S: Crystal structures of human serum albumin complexed with monounsaturated and polyunsaturated fatty acids J Mol Biol 2001, 314:955-960.
11. Petitpas I, Petersen CE, Ha CE, Bhattacharya AA, Zunszain PA, Ghu-man J, Bhagavan NV and Curry S: Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia Proc Natl Acad Sci USA 2003, 100:6440-6445.
12. Bhattacharya AA, Curry S and Franks NP: Binding of the general anesthetics propofol and halothane to human serum albumin: high-resolution crystal structures J Biol Chem 2000, 275:38731-38738.
13. Petitpas I, Bhattacharya AA, Twine S, East M and Curry S: Crystal structure analysis of warfarin binding to human serum albumin: anatomy of drug site I J Biol Chem 2001, 276:22804-22809.
14. Dockal M, Carter DC and Ruker F: The three recombinant domains of human serum albumin. Structural characterization and ligand binding properties J Biol Chem 1999, 274:29303-29310.
15. Tsuchida E, Ando K, Maejima H, Kawai N, Komatsu T, Takeoka S and Nishide H: Properties of and oxygen binding by albumin- tetraphenylporphyrinatoiron(II) derivative complexes Bioconjug Chem 1997, 8:534-538.
16. Marden MC, Hazard ES, Leclerc L and Gibson QH: Flash photolysis of the serum albumin-heme-CO complex Biochemistry 1989, 28:4422-4426.
17. Komatsu T, Hamamatsu K, Takeoka S, Nishide H and Tsuchida E: Human serum albumin-bound synthetic hemes as an oxygen carrier: determination of equilibrium constants for heme binding to host albumin Artif Cells Blood Substit Immobil Biotechnol 1998, 26:519-527.
18. Komatsu T, Matsukawa Y and Tsuchida E: Kinetics of CO and O2 binding to human serum albumin-heme hybrid Bioconjug Chem 2000, 11:772-776.
19. Tsuchida E, Komatsu T, Hamamatsu K, Matsukawa Y, Tajima A, Yoshizu A, Izumi Y and Kobayashi K: Exchange transfusion with albumin-heme as an artificial O2-infusion into anesthetized rats: physiological responses, O2-delivery, and reduction of the oxidized hemin sites by red blood cells Bioconjug Chem 2000, 11:46-50.
20. Tsuchida E, Komatsu T, Matsukawa Y, Nakagawa A, Sakai H, Kobayashi K and Suematsu M: Human serum albumin incorporating synthetic heme: Red blood cell substitute without hypertension by nitric oxide scavenging J Biomed Mater Res 2003, 64A:257-261.
21. Tsuchida E, Komatsu T, Matsukawa Y, Hamamatsu K and Wu J: Human serum albumin incorporating Tetrakis(o-pivalamido) phenylporphinatoiron(II) derivative as a totally synthetic O2-carrying hemoprotein Bioconjug Chem 1999, 10:797-802.
22. Wardell M, Wang Z, Ho JX, Robert J, Ruker F, Ruble J and Carter DC: The atomic structure of human methemalbumin at 1.9 Å Biochem Biophys Res Commun 2002, 291:813-819.
23. Sugio S, Kashima A, Mochizuki S, Noda M and Kobayashi K: Crystal structure of human serum albumin at 2.5 Å resolution Protein Eng 1999, 12:439-446.
24. Curry S, Brick P and Franks NP: Fatty acid binding to human serum albumin: new insights from crystallographic studies Biochim Biophys Acta 1999, 1441:131-140.
25. Paoli M, Anderson BF, Baker HM, Morgan WT, Smith A and Baker EN: Crystal structure of hemopexin reveals a novel high-affinity heme site formed between two beta-propeller domains Nat Struct Biol 1999, 6:926-931.
26. Komatsu T, Matsukawa Y and Tsuchida E: Effect of heme structure on O2-binding properties of human serum albumin-heme hybrids: intramolecular histidine coordination provides a stable O2-adduct complex Bioconjug Chem 2002, 13:397-402.
27. Carter DC, Chang B, Ho JX, Keeling K and Krishnasami Z: Preliminary crystallographic studies of four crystal forms of serum albumin Eur J Biochem 1994, 226:1049-1052.
28. Collaborative Computer Project No. 4.: The CCP4 suite: programs for protein crystallography Acta Crystallogr. 1994, D50:760-763.
29. Navaza J: Implementation of molecular replacement in AMoRe Acta Crystallogr. 2001, D57:1367-1372.
30. Brünger AT, Adams PD, Clore GM, DeLano WL, Gros P, Grosse-Kunstleve RW, Jiang JS, Kuszewski J, Nilges M, Pannu NS, Read RJ, Rice LM, Simonson T and Warren GL: Crystallography & NMR system: A new software suite for macromolecular structure determination Acta Crystallogr. 1998, D54:905-921.
31. Jones TA, Zou JY, Cowan SW and Kjeldgaard M: Improved methods for building protein models in electron density maps and the location of errors in these maps Acta Crystallogr. 1991, A47:110-119.
32. Esnouf R: An extensively modified version of Molscript that includes greatly enhanced colouring capabilities J Mol Graphics 1997, 15:133-138.
33. Merrit EA and Bacon DJ: Raster3D - photorealistic molecular graphics Methods in Enzymology 1997, 277:505-524.
34. Kraulis PJ: MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures J App Crystallogr 1991, 24:946-950.
35. Delano WL: The PyMOL molecular graphics system San Carlos, CA, USA, DeLano Scientific; 2002.