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Volumn 17, Issue 5, 2008, Pages 741-748

Axitinib for renal cell carcinoma

Author keywords

Axitinib; Multitargeted tyrosine kinase inhbitor; Renal cell carcinoma

Indexed keywords

ALPHA INTERFERON; ANTIHYPERTENSIVE AGENT; AUTOLOGOUS HEAT SHOCK PROTEIN PEPTIDE COMPLEX VACCINE; AXITINIB; BEVACIZUMAB; CANCER VACCINE; CD135 ANTIGEN; CYTOKINE; DOCETAXEL; EVEROLIMUS; GEMCITABINE; INTERFERON; INTERLEUKIN 2; MONOCLONAL ANTIBODY G250; PAZOPANIB; PLACEBO; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN RET; RAF PROTEIN; SORAFENIB; STEM CELL FACTOR; SUNITINIB; TEMSIROLIMUS; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3; ANGIOGENESIS INHIBITOR; IMIDAZOLE DERIVATIVE; INDAZOLE DERIVATIVE;

EID: 44449152184     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.17.5.741     Document Type: Article
Times cited : (69)

References (42)
  • 1
    • 28844484134 scopus 로고    scopus 로고
    • Medical progress: Renal-cell carcinoma
    • Cohen HT, McGovern FJ. Medical progress: renal-cell carcinoma. N Engl J Med 2005;353:2477-90
    • (2005) N Engl J Med , vol.353 , pp. 2477-2490
    • Cohen, H.T.1    McGovern, F.J.2
  • 2
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005;23:1011-27
    • (2005) J Clin Oncol , vol.23 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 3
    • 0036983115 scopus 로고    scopus 로고
    • The Ras-Raf-MEK-ERK pathway in the treatment of cancer
    • Hilger RA, Scheullen ME, Strumberg D. The Ras-Raf-MEK-ERK pathway in the treatment of cancer. Onkologie 2002;25:511-8
    • (2002) Onkologie , vol.25 , pp. 511-518
    • Hilger, R.A.1    Scheullen, M.E.2    Strumberg, D.3
  • 4
    • 0034944380 scopus 로고    scopus 로고
    • Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism
    • Chen J, Fujii K, Zhang L, et al. Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism. Proc Natl Acad Sci USA 2001;98:7783-8
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 7783-7788
    • Chen, J.1    Fujii, K.2    Zhang, L.3
  • 5
    • 0038724937 scopus 로고    scopus 로고
    • Role of Raf in vascular protection from distinct apoptotic stimuli
    • Alavi A, Hood JD, Frausto R, et al. Role of Raf in vascular protection from distinct apoptotic stimuli. Science 2003;301:94-6
    • (2003) Science , vol.301 , pp. 94-96
    • Alavi, A.1    Hood, J.D.2    Frausto, R.3
  • 6
    • 0034944380 scopus 로고    scopus 로고
    • Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism
    • Chen J, Fujii K, Zhang L, et al. Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism. Proc Natl Acad Sci USA 2001;98:7783-8
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 7783-7788
    • Chen, J.1    Fujii, K.2    Zhang, L.3
  • 7
    • 0036789574 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
    • Hudson CC, Liu M, Chiang GG, et al. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. mol Cell Biol 2002;22:7004-14
    • (2002) mol Cell Biol , vol.22 , pp. 7004-7014
    • Hudson, C.C.1    Liu, M.2    Chiang, G.G.3
  • 8
    • 1542751639 scopus 로고    scopus 로고
    • The molecular target of rapamycin (mTOR) as a therapeutic target against cancer
    • Mita MM, Mita A, Rowinsky EK. The molecular target of rapamycin (mTOR) as a therapeutic target against cancer. Cancer Biol Ther 2003;2:S169-77
    • (2003) Cancer Biol Ther , vol.2
    • Mita, M.M.1    Mita, A.2    Rowinsky, E.K.3
  • 9
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007;356(2):115-24
    • (2007) N Engl J Med , vol.356 , Issue.2 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 10
    • 33744954585 scopus 로고    scopus 로고
    • Sunitinib in patients with metastatic renal cell carcinoma
    • Motzer RJ, Rini BI, Bukowski RM, et al. Sunitinib in patients with metastatic renal cell carcinoma. JAMA 2006;295(21):2516-24
    • (2006) JAMA , vol.295 , Issue.21 , pp. 2516-2524
    • Motzer, R.J.1    Rini, B.I.2    Bukowski, R.M.3
  • 11
    • 33644833910 scopus 로고    scopus 로고
    • Motzer RJ, Michaelson MD, Redman BG, et al. Activity of SU 11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 2066;24(1):16-24
    • Motzer RJ, Michaelson MD, Redman BG, et al. Activity of SU 11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 2066;24(1):16-24
  • 12
    • 33750631676 scopus 로고    scopus 로고
    • Efficacy and safety of sunitinib malate (SU1 1248) in bevacizumab-refractory metastatic renal cell carcinoma [abstract 4522]
    • 222s
    • Rini BI, George DJ, Michaelson MD, et al. Efficacy and safety of sunitinib malate (SU1 1248) in bevacizumab-refractory metastatic renal cell carcinoma [abstract 4522]. Proc Am Soc Clin Oncol 2006;24:222s
    • (2006) Proc Am Soc Clin Oncol , vol.24
    • Rini, B.I.1    George, D.J.2    Michaelson, M.D.3
  • 13
    • 33846148701 scopus 로고    scopus 로고
    • Treatment Approaches in Renal cancer Global Evaluation Trial (TARGETs): A Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Sorafenib, an Oral Multi-Kinase Inhibitor in Advanced Renal Cell Carcinoma
    • Escudier B, Eisen T, Stadler WM, et al. Treatment Approaches in Renal cancer Global Evaluation Trial (TARGETs): A Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Sorafenib, an Oral Multi-Kinase Inhibitor in Advanced Renal Cell Carcinoma. N Engl J Med 2007;356(2):125-34
    • (2007) N Engl J Med , vol.356 , Issue.2 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 14
    • 45349086611 scopus 로고    scopus 로고
    • Bukowski RM, Eisen T, Szczylik C, et al. Final results of the randomized phase III trial of sorafenib in advanced renal cell carcinoma: survival and biomarker analysis. 2007 ASCO Annual Meeting Proceedings Part I. J Clin Oncol 2007;25(18S Suppl):5023
    • Bukowski RM, Eisen T, Szczylik C, et al. Final results of the randomized phase III trial of sorafenib in advanced renal cell carcinoma: survival and biomarker analysis. 2007 ASCO Annual Meeting Proceedings Part I. J Clin Oncol 2007;25(18S Suppl):5023
  • 15
    • 45349100660 scopus 로고    scopus 로고
    • Szczylik C, Demkow, T. Staehler M, et al. Randomized phase II trial of first-line treatment with sorafenib versus interferon in patients with advanced renal cell carcinoma: final results. 2007 ASCO Annual Meeting Proceedings Part I. J Clin Oncol 2007;25(18S Suppl):5025
    • Szczylik C, Demkow, T. Staehler M, et al. Randomized phase II trial of first-line treatment with sorafenib versus interferon in patients with advanced renal cell carcinoma: final results. 2007 ASCO Annual Meeting Proceedings Part I. J Clin Oncol 2007;25(18S Suppl):5025
  • 16
    • 37349080670 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial
    • Escudier B, Pluzanska A, Koralewski P, et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet 2007;370(9605):2103-11
    • (2007) Lancet , vol.370 , Issue.9605 , pp. 2103-2111
    • Escudier, B.1    Pluzanska, A.2    Koralewski, P.3
  • 17
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    • Hudes G, Carducci M, Tomczak P, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007;356(22):2271-81
    • (2007) N Engl J Med , vol.356 , Issue.22 , pp. 2271-2281
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3
  • 18
    • 0142180734 scopus 로고    scopus 로고
    • Histologic predictors of renal cell carcinoma (RCC) response to interleukin-2 based therapy
    • Upton MP, Parker RA, Youmans A, et al. Histologic predictors of renal cell carcinoma (RCC) response to interleukin-2 based therapy. Proc Am Soc Clin Oncol 2003;22:851
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 851
    • Upton, M.P.1    Parker, R.A.2    Youmans, A.3
  • 19
    • 17844400135 scopus 로고    scopus 로고
    • Carbonic anhydrase IX (CAIX) expression predicts for renal cell cancer (RCC) patient response and survival to IL-2 therapy
    • Atkins M, McDermott D, Regan M, et al. Carbonic anhydrase IX (CAIX) expression predicts for renal cell cancer (RCC) patient response and survival to IL-2 therapy. Proc Am Soc Clin Oncol 2004;22(14S Suppl):4512
    • (2004) Proc Am Soc Clin Oncol , vol.22 , Issue.14S SUPPL. , pp. 4512
    • Atkins, M.1    McDermott, D.2    Regan, M.3
  • 20
    • 36749064602 scopus 로고    scopus 로고
    • Antitumor effects of sunitinib or sorafenib in patients with metastatic renal cell carcinoma who received prior antiangiogenic therapy
    • Tamaskar I, Garcia JA, Elson P, et al. Antitumor effects of sunitinib or sorafenib in patients with metastatic renal cell carcinoma who received prior antiangiogenic therapy. J Urol 2008;179(1):81-6
    • (2008) J Urol , vol.179 , Issue.1 , pp. 81-86
    • Tamaskar, I.1    Garcia, J.A.2    Elson, P.3
  • 23
    • 42549089912 scopus 로고    scopus 로고
    • A multicenter, randomized, phase 3 trial of a novel autologous therapeutic vaccine (Vitespen) versus observation as adjuvant therapy in patients at high risk of recurrence after nephrecromy for renal cell carcinoma
    • abstract 633, Anaheim, CA, USA
    • Wood CG, Escudier B, Lacombe L, et al. A multicenter, randomized, phase 3 trial of a novel autologous therapeutic vaccine (Vitespen) versus observation as adjuvant therapy in patients at high risk of recurrence after nephrecromy for renal cell carcinoma [abstract 633]. Proc AUA Annual Meeting; 2007; Anaheim, CA, USA
    • (2007) Proc AUA Annual Meeting
    • Wood, C.G.1    Escudier, B.2    Lacombe, L.3
  • 24
    • 35548997095 scopus 로고    scopus 로고
    • Pazopanib (GW786034) is active in metastatic renal cell carcinoma (RCC): Interim results of a phase II randomized discontinuation trial (RDT)
    • Hurson TE, Davis ID, Machiels JP, et al. Pazopanib (GW786034) is active in metastatic renal cell carcinoma (RCC): interim results of a phase II randomized discontinuation trial (RDT). J Clin Oncol 2007;25(18S Suppl):5031
    • (2007) J Clin Oncol , vol.25 , Issue.18S SUPPL. , pp. 5031
    • Hurson, T.E.1    Davis, I.D.2    Machiels, J.P.3
  • 25
    • 0242370888 scopus 로고    scopus 로고
    • Further characterization of the potent VEGF/PDGF receptor tyrosine kinase inhibitor, AG013736, in preclinical tumor models for its antiangiogenesis and antitumor activity
    • Wickman G, Hallin M. Further characterization of the potent VEGF/PDGF receptor tyrosine kinase inhibitor, AG013736, in preclinical tumor models for its antiangiogenesis and antitumor activity. Proc Am Assoc Clin Cancer Res 2003;44:A3780
    • (2003) Proc Am Assoc Clin Cancer Res , vol.44
    • Wickman, G.1    Hallin, M.2
  • 26
    • 45349087462 scopus 로고    scopus 로고
    • Axitinib Investigators Brochure, December 2002, Pfizer, Inc.
    • Axitinib Investigators Brochure, December 2002, Pfizer, Inc.
  • 27
    • 33749441325 scopus 로고    scopus 로고
    • Rapid vascular regrowth in tumors after reversal of VEGF inhibition
    • Mancuso MR, Davis I. Norberg SM, et al. Rapid vascular regrowth in tumors after reversal of VEGF inhibition. J Clin Invest 2006;116:2610-21
    • (2006) J Clin Invest , vol.116 , pp. 2610-2621
    • Mancuso, M.R.1    Davis, I.2    Norberg, S.M.3
  • 28
    • 33947144750 scopus 로고    scopus 로고
    • AG-013736, a novel inhibitor of VEGF receptor tyrosine kinases, inhibits breast cancer growth and decreases vascular permeability as detected by dynamic contrast-enhanced magnetic resonance imaging
    • Wilmes LJ, Pallavicini MG, Fleming LM, et al. AG-013736, a novel inhibitor of VEGF receptor tyrosine kinases, inhibits breast cancer growth and decreases vascular permeability as detected by dynamic contrast-enhanced magnetic resonance imaging. Magn Reson Imaging 2007;25(3):319-27
    • (2007) Magn Reson Imaging , vol.25 , Issue.3 , pp. 319-327
    • Wilmes, L.J.1    Pallavicini, M.G.2    Fleming, L.M.3
  • 29
    • 24944453855 scopus 로고    scopus 로고
    • Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: Pharmacokinetic and clinical results
    • Rugo HS, Herbst RS, Liu G, et al. Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results. J Clin Oncol 2005;23(24):5474-83
    • (2005) J Clin Oncol , vol.23 , Issue.24 , pp. 5474-5483
    • Rugo, H.S.1    Herbst, R.S.2    Liu, G.3
  • 30
    • 24944515034 scopus 로고    scopus 로고
    • Dynamic contrast-enhanced magnetic resonance imaging as a pharmacodynamic measure of response after acute dosing of AG-013736, an oral angiogenesis inhibitor, in patients with advanced solid tumors: Results from a phase I study
    • Liu G, Rugo HS, Wilding G, et al. Dynamic contrast-enhanced magnetic resonance imaging as a pharmacodynamic measure of response after acute dosing of AG-013736, an oral angiogenesis inhibitor, in patients with advanced solid tumors: results from a phase I study. J Clin Oncol 2005;23(24):5464-73
    • (2005) J Clin Oncol , vol.23 , Issue.24 , pp. 5464-5473
    • Liu, G.1    Rugo, H.S.2    Wilding, G.3
  • 31
    • 35448934762 scopus 로고    scopus 로고
    • Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: A phase II study
    • Rixe O, Bukowski RM, Michaelson MD, et al. Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study. Lancet Oncol 2007;8(11):975-84
    • (2007) Lancet Oncol , vol.8 , Issue.11 , pp. 975-984
    • Rixe, O.1    Bukowski, R.M.2    Michaelson, M.D.3
  • 32
    • 45349090582 scopus 로고    scopus 로고
    • Rixe O, Meric, J, Bloch J, et al. Surrogate markets of activity of AG-013736, a muld-target tyrosine kinase receptor inhibitor, in metastatic renal cell cancer (RCC). Proc Am Soc Clin Oncol 2005;23(16S):3003
    • Rixe O, Meric, J, Bloch J, et al. Surrogate markets of activity of AG-013736, a muld-target tyrosine kinase receptor inhibitor, in metastatic renal cell cancer (RCC). Proc Am Soc Clin Oncol 2005;23(16S):3003
  • 33
    • 35549007093 scopus 로고    scopus 로고
    • Axitinib in patients with metastatic renal cell cancer refractory to sorafenib
    • Rini BI, Wilding GT, Hudes GR, et al. Axitinib in patients with metastatic renal cell cancer refractory to sorafenib. J Clin Oncol 2007;25 (18S):5032
    • (2007) J Clin Oncol , vol.25 , Issue.18 S , pp. 5032
    • Rini, B.I.1    Wilding, G.T.2    Hudes, G.R.3
  • 34
    • 67649651994 scopus 로고    scopus 로고
    • A randomized, double-blind phase II study of the oral tyrosine kinase inhibitor (TKI) axitinib (AG-013736) in combination with docetaxel (DOC) compared to DOC plus placebo (PL) in metastatic breast cancer (MBC)
    • Rugo HS, Stopeck A, Joy AA, et al. A randomized, double-blind phase II study of the oral tyrosine kinase inhibitor (TKI) axitinib (AG-013736) in combination with docetaxel (DOC) compared to DOC plus placebo (PL) in metastatic breast cancer (MBC). 2007 ASCO Annual Meeting Proceedings Part I. J Clin Oncol 2007;25 (18S Suppl):1003
    • (2007) ASCO Annual Meeting Proceedings Part I. J Clin Oncol 2007;25 (18S Suppl):1003
    • Rugo, H.S.1    Stopeck, A.2    Joy, A.A.3
  • 35
    • 45349092132 scopus 로고    scopus 로고
    • Schiller JH, Larson T, Ou SI, et al. Efficacy and safety of axitinib (AG-013736; AG) in patients (pts) with advanced non-small cell lung cancer (NSCLC): a phase II trial. 2007 ASCO Annual Meeting Proceedings Part I. J Clin Oncol 2007;25(18S Suppl):7507
    • Schiller JH, Larson T, Ou SI, et al. Efficacy and safety of axitinib (AG-013736; AG) in patients (pts) with advanced non-small cell lung cancer (NSCLC): a phase II trial. 2007 ASCO Annual Meeting Proceedings Part I. J Clin Oncol 2007;25(18S Suppl):7507
  • 36
    • 45349097131 scopus 로고    scopus 로고
    • Cohen EE, Vokes EE, Rosen LS, et al. A phase II study of axitinib (AG-013736 [AG]) in patients (pts) with advanced thyroid cancers. 2007 ASCO Annual Meeting Proceedings Part I. J Clin Oncol 2007;25(18S Suppl):6008
    • Cohen EE, Vokes EE, Rosen LS, et al. A phase II study of axitinib (AG-013736 [AG]) in patients (pts) with advanced thyroid cancers. 2007 ASCO Annual Meeting Proceedings Part I. J Clin Oncol 2007;25(18S Suppl):6008
  • 37
    • 45349096576 scopus 로고    scopus 로고
    • Spano J, Chodkiewicz C, Maurel J, et al. A randomized phase Il study of axitinib (AG-013736) and gemcitabine versus gemcitabine in advanced pancreatic cancer preceded by a phase 1 component. 2007 ASCO Annual Meeting Proceedings Part I. J Clin Oncol 2007;25(18S Suppl);4551
    • Spano J, Chodkiewicz C, Maurel J, et al. A randomized phase Il study of axitinib (AG-013736) and gemcitabine versus gemcitabine in advanced pancreatic cancer preceded by a phase 1 component. 2007 ASCO Annual Meeting Proceedings Part I. J Clin Oncol 2007;25(18S Suppl);4551
  • 39
    • 35148820611 scopus 로고    scopus 로고
    • Molecular and cellular biomarkers for angiogenesis in clinical oncology
    • Bertolini F, Mancuso P, Shaked Y, Kerbel RS. Molecular and cellular biomarkers for angiogenesis in clinical oncology. Drug Discov Today 2007;12(19-20):806-12
    • (2007) Drug Discov Today , vol.12 , Issue.19-20 , pp. 806-812
    • Bertolini, F.1    Mancuso, P.2    Shaked, Y.3    Kerbel, R.S.4
  • 40
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
    • Mendel DB, Laird AD, Xin X, et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 2003;9(1):327-37
    • (2003) Clin Cancer Res , vol.9 , Issue.1 , pp. 327-337
    • Mendel, D.B.1    Laird, A.D.2    Xin, X.3
  • 41
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004;64:7099-109
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 42
    • 34447322566 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity
    • Kumar R, Knick VB, Rudolph SK, et al. Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity. Mol Cancer Ther 2007;6(7):2012-21
    • (2007) Mol Cancer Ther , vol.6 , Issue.7 , pp. 2012-2021
    • Kumar, R.1    Knick, V.B.2    Rudolph, S.K.3


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