Cell reprogramming: A new chemical approach to stem cell biology and tissue regeneration

Current Pharmaceutical Biotechnology

Volumn 12, Issue 2, 2011, Pages 146-150

  Anastasia, L ^a,b   Piccoli, M ^a,b   Garatti, A ^b   Conforti, E ^b   Scaringi, R ^a,b   Bergante, S ^a,b   Castelvecchio, S ^b   Venerando, B ^a,b   Menicanti, L ^b   Tettamanti, G ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b IRCCS POLICLINICO SAN DONATO   (Italy)

Author keywords

Chemical molecules reprogramming stem cell; Stem cell; Tissue regeneration

Indexed keywords

ADULT; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TYPE; CYTOLOGY; FIBROBLAST; HUMAN; NONHUMAN; PHENOTYPE; PLURIPOTENT STEM CELL; RISK ASSESSMENT; TISSUE REGENERATION;

EID: 79551626698     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920111794295828     Document Type: Article

References (65)

1. Takahashi, K.; Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 2006, 126 (4), 663-676.
2. Wilmut, I.; Schnieke, A. E.; McWhir, J.; Kind, A. J.; Campbell, K. H. Viable offspring derived from fetal and adult mammalian cells. Nature, 1997, 385 (6619), 810-813.
3. McLaren, A. Cloning: pathways to a pluripotent future. Science, 2000, 288 (5472), 1775-1780.
4. Hochedlinger, K.; Jaenisch, R. Nuclear reprogramming and pluripotency. Nature, 2006, 441 (7097), 1061-1067.
5. Blelloch, R.; Wang, Z.; Meissner, A.; Pollard, S.; Smith, A.; Jaenisch, R. Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus. Stem Cells, 2006, 24 (9), 2007-2013.
6. Kennedy, D. Editorial retraction. Science, 2006, 311 (5759), 335.
7. Do, J. T.; Scholer, H. R. Nuclei of embryonic stem cells reprogram somatic cells. Stem Cells, 2004, 22 (6), 941-949.
8. Ying, Q. L.; Nichols, J.; Evans, E. P.; Smith, A. G. Changing potency by spontaneous fusion. Nature, 2002, 416 (6880), 545-548.
9. Cowan, C. A.; Atienza, J.; Melton, D. A.; Eggan, K. Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science, 2005, 309 (5739), 1369-1373.
10. Lowry, W. E.; Richter, L.; Yachechko, R.; Pyle, A. D.; Tchieu, J.; Sridharan, R.; Clark, A. T.; Plath, K. Generation of human induced pluripotent stem cells from dermal fibroblasts. Proc. Natl. Acad. Sci. USA, 2008, 105 (8), 2883-2888.
11. Park, I. H.; Zhao, R.; West, J. A.; Yabuuchi, A.; Huo, H.; Ince, T. A.; Lerou, P. H.; Lensch, M. W.; Daley, G. Q. Reprogramming of human somatic cells to pluripotency with defined factors. Nature, 2008, 451 (7175), 141-146.
12. Takahashi, K.; Tanabe, K.; Ohnuki, M.; Narita, M.; Ichisaka, T.; Tomoda, K.; Yamanaka, S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 2007, 131 (5), 861-872.
13. Okita, K.; Ichisaka, T.; Yamanaka, S. Generation of germlinecompetent induced pluripotent stem cells. Nature, 2007, 448 (7151), 313-317.
14. Yu, J.; Vodyanik, M. A.; Smuga-Otto, K.; Antosiewicz-Bourget, J.; Frane, J. L.; Tian, S.; Nie, J.; Jonsdottir, G. A.; Ruotti, V.; Stewart, R.; Slukvin, II; Thomson, J.A. Induced pluripotent stem cell lines derived from human somatic cells. Science, 2007, 318 (5858), 1917-1920.
15. Lin, T.; Ambasudhan, R.; Yuan, X.; Li, W.; Hilcove, S.; Abujarour, R.; Lin, X.; Hahm, H. S.; Hao, E.; Hayek, A.; Ding, S. A chemical platform for improved induction of human iPSCs. Nat. Methods, 2009, 6 (11), 805-808.
16. Miura, K.; Okada, Y.; Aoi, T.; Okada, A.; Takahashi, K.; Okita, K.; Nakagawa, M.; Koyanagi, M.; Tanabe, K.; Ohnuki, M.; Ogawa, D.; Ikeda, E.; Okano, H.; Yamanaka, S. Variation in the safety of induced pluripotent stem cell lines. Nat. Biotechnol., 2009, 27 (8), 743-745.
17. Gonzalez, F.; Barragan Monasterio, M.; Tiscornia, G.; Montserrat Pulido, N.; Vassena, R.; Batlle Morera, L.; Rodriguez Piza, I.; Izpisua Belmonte, J. C. Generation of mouse-induced pluripotent stem cells by transient expression of a single nonviral polycistronic vector. Proc. Natl. Acad. Sci. USA, 2009, 106 (22), 8918-8922.
18. Chang, C. W.; Lai, Y. S.; Pawlik, K. M.; Liu, K.; Sun, C. W.; Li, C.; Schoeb, T. R.; Townes, T. M. Polycistronic lentiviral vector for hit and run reprogramming of adult skin fibroblasts to induced pluripotent stem cells. Stem Cells, 2009, 27 (5), 1042-1049.
19. Soldner, F.; Hockemeyer, D.; Beard, C.; Gao, Q.; Bell, G. W.; Cook, E. G.; Hargus, G.; Blak, A.; Cooper, O.; Mitalipova, M.; Isacson, O.; Jaenisch, R. Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell, 2009, 136 (5), 964-977.
20. Woltjen, K.; Michael, I. P.; Mohseni, P.; Desai, R.; Mileikovsky, M.; Hamalainen, R.; Cowling, R.; Wang, W.; Liu, P.; Gertsenstein, M.; Kaji, K.; Sung, H. K.; Nagy, A. PiggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature, 2009, 458 (7239), 766-770.
21. Kaji, K.; Norrby, K.; Paca, A.; Mileikovsky, M.; Mohseni, P.; Woltjen, K. Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature, 2009, 458 (7239), 771-775.
22. Yu, J.; Hu, K.; Smuga-Otto, K.; Tian, S.; Stewart, R.; Slukvin, II; Thomson, J.A. Human induced pluripotent stem cells free of vector and transgene sequences. Science, 2009, 324 (5928), 797-801.
23. Zhou, H.; Wu, S.; Joo, J.Y.; Zhu, S.; Han, D.W.; Lin, T.; Trauger, S.; Bien, G.; Yao, S.; Zhu, Y.; Siuzdak, G.; Scholer, H.R.; Duan, L.; Ding, S. Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell, 2009, 4 (5), 381-384.
24. Ding, S.; Schultz, P.G. A role for chemistry in stem cell biology. Nat. Biotechnol., 2004, 22 (7), 833-840.
25. Yamanaka, S. A fresh look at iPS cells. Cell, 2009, 137 (1), 13-17.
26. Anastasia, L.; Pelissero, G.; Venerando, B.; Tettamanti, G. Cell reprogramming: expectations and challenges for chemistry in stem cell biology and regenerative medicine. Cell Death Differ., 2010, 17(8), 1230-1237.
27. Li, W.; Wei, W.; Zhu, S.; Zhu, J.; Shi, Y.; Lin, T.; Hao, E.; Hayek, A.; Deng, H.; Ding, S. Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell, 2008, 4(1),16-19.
28. Shi, Y.; Desponts, C.; Do, J. T.; Hahm, H. S.; Scholer, H. R.; Ding, S. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell, 2008, 3 (5), 568-574.
29. Lyssiotis, C. A.; Foreman, R. K.; Staerk, J.; Garcia, M.; Mathur, D.; Markoulaki, S.; Hanna, J.; Lairson, L. L.; Charette, B. D.; Bouchez, L. C.; Bollong, M.; Kunick, C.; Brinker, A.; Cho, C. Y.; Schultz, P. G.; Jaenisch, R. Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proc. Natl. Acad. Sci. USA, 2009, 106 (22), 8912-8917.
30. Kubicek, S.; O'Sullivan, R. J.; August, E. M.; Hickey, E. R.; Zhang, Q.; Teodoro, M. L.; Rea, S.; Mechtler, K.; Kowalski, J. A.; Homon, C. A.; Kelly, T. A.; Jenuwein, T. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol. Cell, 2007, 25 (3), 473-481.
31. Shi, Y.; Do, J. T.; Desponts, C.; Hahm, H. S.; Scholer, H. R.; Ding, S. A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell, 2008, 2 (6), 525-528.
32. Schramm, M.; Thomas, G.; Towart, R.; Franckowiak, G. Novel dihydropyridines with positive inotropic action through activation of Ca2+ channels. Nature, 1983, 303 (5917), 535-537.
33. Huangfu, D.; Maehr, R.; Guo, W.; Eijkelenboom, A.; Snitow, M.; Chen, A. E.; Melton, D. A. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat. Biotechnol., 2008, 26 (7), 795-7.
34. Mikkelsen, T. S.; Hanna, J.; Zhang, X.; Ku, M.; Wernig, M.; Schorderet, P.; Bernstein, B. E.; Jaenisch, R.; Lander, E. S.; Meissner, A. Dissecting direct reprogramming through integrative genomic analysis. Nature, 2008, 454 (7200), 49-55.
35. Liao, J.; Cui, C.; Chen, S.; Ren, J.; Chen, J.; Gao, Y.; Li, H.; Jia, N.; Cheng, L.; Xiao, H.; Xiao, L. Generation of induced pluripotent stem cell lines from adult rat cells. Cell Stem Cell, 2009, 4 (1), 11-5.
36. Demers, S. P.; Yoo, J. G.; Lian, L.; Therrien, J.; Smith, L. C. Rat embryonic stem-like (ES-like) cells can contribute to extraembryonic tissues in vivo. Cloning Stem Cells, 2007, 9 (4), 512-522.
37. Ruhnke, M.; Ungefroren, H.; Zehle, G.; Bader, M.; Kremer, B.; Fandrich, F. Long-term culture and differentiation of rat embryonic stem cell-like cells into neuronal, glial, endothelial, and hepatic lineages. Stem Cells, 2003, 21 (4), 428-436.
38. Schulze, M.; Ungefroren, H.; Bader, M.; Fandrich, F. Derivation, maintenance, and characterization of rat embryonic stem cells in vitro. Methods Mol. Biol., 2006, 329, 45-58.
39. Ueda, S.; Kawamata, M.; Teratani, T.; Shimizu, T.; Tamai, Y.; Ogawa, H.; Hayashi, K.; Tsuda, H.; Ochiya, T. Establishment of rat embryonic stem cells and making of chimera rats. PLoS ONE, 2008, 3 (7), e2800.
40. Buehr, M.; Meek, S.; Blair, K.; Yang, J.; Ure, J.; Silva, J.; McLay, R.; Hall, J.; Ying, Q. L.; Smith, A. Capture of authentic embryonic stem cells from rat blastocysts. Cell, 2008, 135 (7), 1287-1298.
41. Bain, G.; Kitchens, D.; Yao, M.; Huettner, J. E.; Gottlieb, D. I. Embryonic stem cells express neuronal properties in vitro. Dev. Biol., 1995, 168 (2), 342-357.
42. Sorm, F.; Piskala, A.; Cihak, A.; Vesely, J. 5-Azacytidine, a new, highly effective cancerostatic. Experientia, 1964, 20 (4), 202-203.
43. Christman, J.K. 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene, 2002, 21 (35), 5483-5495.
44. Brockes, J.P. Amphibian limb regeneration: rebuilding a complex structure. Science, 1997, 276 (5309), 81-87.
45. Gurdon, J.B.; Melton, D.A. Nuclear reprogramming in cells. Science, 2008, 322 (5909), 1811-1815.
46. McGann, C. J.; Odelberg, S. J.; Keating, M. T. Mammalian myotube dedifferentiation induced by newt regeneration extract. Proc. Natl. Acad. Sci. USA, 2001, 98 (24), 13699-13704.
47. Shen, C. N.; Slack, J. M.; Tosh, D. Molecular basis of transdifferentiation of pancreas to liver. Nat. Cell. Biol., 2000, 2(12), 879-887.
48. Kondo, T.; Raff, M. Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science, 2000, 289 (5485), 1754-1757.
49. Chen, S.; Zhang, Q.; Wu, X.; Schultz, P. G.; Ding, S. Dedifferentiation of lineage-committed cells by a small molecule. J. Am. Chem. Soc., 2004, 126 (2), 410-411.
50. Chen, S.; Do, J. T.; Zhang, Q.; Yao, S.; Yan, F.; Peters, E. C.; Scholer, H. R.; Schultz, P. G.; Ding, S. Self-renewal of embryonic stem cells by a small molecule. Proc. Natl. Acad. Sci. USA, 2006, 103 (46), 17266-17271.
51. Rosania, G. R.; Chang, Y. T.; Perez, O.; Sutherlin, D.; Dong, H.; Lockhart, D. J.; Schultz, P. G. Myoseverin, a microtubule-binding molecule with novel cellular effects. Nat. Biotechnol., 2000, 18 (3), 304-308.
52. Anastasia, L.; Sampaolesi, M.; Papini, N.; Oleari, D.; Lamorte, G.; Tringali, C.; Monti, E.; Galli, D.; Tettamanti, G.; Cossu, G.; Venerando, B. Reversine-treated fibroblasts acquire myogenic competence in vitro and in regenerating skeletal muscle. Cell Death Differ., 2006, 13 (12), 2042-2051.
53. Lee, E. K.; Bae, G. U.; You, J. S.; Lee, J. C.; Jeon, Y. J.; Park, J. W.; Park, J. H.; Ahn, S. H.; Kim, Y. K.; Choi, W. S.; Kang, J. S.; Han, G.; Han, J. W. Reversine increases the plasticity of lineagecommitted cells toward neuroectodermal lineage. J. Biol. Chem., 2009, 284 (5), 2891-2901.
54. Fania, C.; Anastasia, L.; Vasso, M.; Papini, N.; Capitanio, D.; Venerando, B.; Gelfi, C. Proteomic signature of reversine-treated murine fibroblasts by 2-D difference gel electrophoresis and MS: Possible associations with cell signalling networks. Electrophoresis, 2009, 30 (12), 2193-2206.
55. Miyoshi, K.; Mori, H.; Mizobe, Y.; Himaki, T.; Yoshida, M.; Sato, M. Beneficial effects of reversine on in vitro development of miniature pig somatic cell nuclear transfer embryos. J. Reprod. Dev., 2010, 56 (2), 291-296.
56. Chen, S.; Takanashi, S.; Zhang, Q.; Xiong, W.; Zhu, S.; Peters, E.C.; Ding, S.; Schultz, P.G. Reversine increases the plasticity of lineage-committed mammalian cells. Proc. Natl. Acad. Sci. USA, 2007, 104 (25), 10482-10487.
57. Shan, S. W.; Tang, M. K.; Chow, P. H.; Maroto, M.; Cai, D. Q.; Lee, K. K. Induction of growth arrest and polycomb gene expression by reversine allows C2C12 cells to be reprogrammed to various differentiated cell types. Proteomics, 2007, 7 (23), 4303-4316.
58. Amabile, G.; D'Alise, A. M.; Iovino, M.; Jones, P.; Santaguida, S.; Musacchio, A.; Taylor, S.; Cortese, R. The Aurora B kinase activity is required for the maintenance of the differentiated state of murine myoblasts. Cell Death Differ., 2009, 16 (2), 321-330.
59. Hsieh, T. C.; Traganos, F.; Darzynkiewicz, Z.; Wu, J. M. The 2,6- disubstituted purine reversine induces growth arrest and polyploidy in human cancer cells. Int. J. Oncol., 2007, 31 (6), 1293-1300.
60. D'Alise, A. M.; Amabile, G.; Iovino, M.; Di Giorgio, F. P.; Bartiromo, M.; Sessa, F.; Villa, F.; Musacchio, A.; Cortese, R. Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells. Mol. Cancer Ther., 2008, 7 (5), 1140-1149.
61. McMillin, D. W.; Delmore, J.; Weisberg, E.; Negri, J. M.; Geer, D. C.; Klippel, S.; Mitsiades, N.; Schlossman, R. L.; Munshi, N. C.; Kung, A. L.; Griffin, J. D.; Richardson, P. G.; Anderson, K. C.; Mitsiades, C. S. Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity. Nat. Med., 2010, 16 (4), 483-489.
62. Wichterle, H.; Lieberam, I.; Porter, J. A.; Jessell, T.M. Directed differentiation of embryonic stem cells into motor neurons. Cell, 2002, 110 (3), 385-397.
63. Wu, X.; Ding, S.; Ding, Q.; Gray, N. S.; Schultz, P. G. Small molecules that induce cardiomyogenesis in embryonic stem cells. J. Am. Chem. Soc., 2004, 126(6), 1590-1591.
64. Yan, P.; Nagasawa, A.; Uosaki, H.; Sugimoto, A.; Yamamizu, K.; Teranishi, M.; Matsuda, H.; Matsuoka, S.; Ikeda, T.; Komeda, M.; Sakata, R.; Yamashita, J. K. Cyclosporin-A potently induces highly cardiogenic progenitors from embryonic stem cells. Biochem. Biophys. Res. Commun., 2009, 379 (1), 115-120.
65. 3rd.; Smith, H. O.; Venter, J. C. Creation of a bacterial cell controlled by a chemically synthesized genome. Science, 2010, 329(5987), 52-56.