Myoseverin, a microtubule-binding molecule with novel cellular effects

Nature Biotechnology

Volumn 18, Issue 3, 2000, Pages 304-308

  Rosania, Gustavo R ^a,b   Chang, Young Tae ^a   Perez, Omar ^a   Sutherlin, Daniel ^a,c   Dong, Helin ^d,e   Lockhart, David J ^d   Schultz, Peter G ^a,d  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Cellomics Inc   (United States)

^c GENENTECH INC   (United States)

^d GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^e Thermo Fisher Scientific   (United States)

Author keywords

Microtubule binding molecule; Morphological screen; Purine library

Indexed keywords

MYOSEVERIN; PURINE DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CONTROLLED STUDY; DNA SYNTHESIS; EXTRACELLULAR MATRIX; IMMUNOMODULATION; MICROTUBULE ASSEMBLY; MOLECULAR BIOLOGY; MUSCLE FIBRIL; PRIORITY JOURNAL; TISSUE REGENERATION; UNINDEXED SEQUENCE; WOUND HEALING;

ACTINS; ANIMALS; BIOTINYLATION; CELL CYCLE; CELL DIVISION; CELL LINE; CYTOSKELETON; FLOW CYTOMETRY; GENE LIBRARY; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MICE; MICROSCOPY, PHASE-CONTRAST; MICROTUBULES; PEPTIDE LIBRARY; PROTEIN BINDING; PURINES; REGENERATION; TRANSCRIPTION, GENETIC; TUBULIN; WOUND HEALING;

EID: 0034016816     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/73753     Document Type: Article

References (28)

1. Black, B.L. & Olson, E.N. Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins. Annu. Rev. Cell Dev. Biol. 14, 167-196 (1998).
2. Shimokawa, T., Kato, M., Ezaki, O. & Hashimoto, S. Transcriptional regulation of muscle-specific genes during myoblast differentiation. Biochem. Biophys. Res. Commun. 246, 287-292 (1998).
3. Guo, K. & Walsh, K. Inhibition of myogenesis by multiple cyclin-Cdk complexes. Coordinate regulation of myogenesis and cell cycle activity at the level of E2F. J. Biol. Chem. 272, 791-797 (1997).
4. Walsh, K. & Perlman, H. Cell cycle exit upon myogenic differentiation. Curr. Opin. Genet. Dev. 1, 597-602 (1997).
5. Brackes, J.P. Amphibian limb regeneration: rebuilding a complex structure. Science 276, 81-87 (1997).
6. Lo, D.C., Allen, F. & Brockes, J.P. Reversal of muscle differentiation during urodele limb regeneration. Proc. Natl. Acad. Sci. USA 90, 7230-7234 (1993).
7. Dorfman, J. et al. Myocardial tissue engineering with autologous myoblast implantation J. Thoracic Cardiovasc. Surg. 116, 744-751 (1998).
8. Taylor, D.A. et al. Regenerating functional myocardium: improved performance after skeletal myoblast transplantation. Nat. Med. 8, 929-933 (1998).
9. Chang, Y.-T. et al. Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors. Chem. Biol. 6, 361-357 (1999).
10. Bains, W., Ponte, R, Blau, H. & Kedes, L. Cardiac actin is the major actin gene product in skeletal muscle cell differentiation in vitro. Mol. Cell Biol. 4, 1449-1453 (1984).
11. Rosania, G.R. & Swanson, J.A. Microtubules modulate pseudopod activity at-a-distance of the cell edge. Cell. Motil. Cytoskeleton 34, 230-245 (1996).
12. Saitoh, O., Arai, T. & Obinata, T. Distribution of microtubules and other cytoskeletal filaments during myotube elongation as revealed by fluorescence microscopy. Cell Tiss. Res. 252, 263-273 (1988).
13. Bischoff, R. & Holtzer, H. The effect of mitotic inhibitors on myogenesis in vitro. J. Cell Biol. 36, 111-127 (1968).
14. Ohuchi, H. et al. An additional limb can be induced from the flank of the chick embryo by FGF4. Biochem. Biophys. Res. Commun. 209, 809-816 (1995).
15. Iyer, V.R. et al. The transcriptional program in the response of human fibroblasts to serum. Science 283, 83-87 (1999).
16. Broxmeyer, J.E. et al. Effects of CC, CXC, C, and CX3C chemokines on proliferation of myeloid progenitor cells, and insights into SDF-1-induced chemotaxis of progenitors. Ann. NY Acad. Sci. 872, 142-162 (1999).
17. Haelens, A. et al. Leukocyte migration and activation of murine chemokines. Immunobiology 195, 499-521 (1996).
18. Takekawa, M. & Saito, H. A family of stress-inducible GADD45-like proteins mediate activation of the stress responsive MTK1/MEKK4/MAPKKK. Cell 95, 521-530 (1998).
19. Albano, R.M., Arkell, R., Beddington, R.S. & Smith, U.C. Expression of inhibin subunits and follistatin during postimplantation mouse development: decidual expression of activin and expression of follistatin in primitive streak, somites and hindbrain. Development 120, 803-813 (1994).
20. Robson, L.G. & Hughes, S.M. The distal limb environment regulates MyoD accumulation and muscle differentiation is mouse-chick chimaeric limbs. Development 122, 3899-3910 (1996).
21. Itoh, N., Mima, T. & Mikawa, T. Loss of fibroblast growth factor receptor is necessary for terminal differentiation of embryonic limb muscle. Development 122, 291-300 (1996).
22. Groskopf, J.C., Syu, L.J., Saltiel, A.R. & Linzer, D.I. Proliferin induces endothelial cell chemotaxis through a G protein-coupled, mitogen-activated protein kinase dependent pathway. Endocrinology 138, 2835-2840 (1997).
23. Tanaka, E.M. & Brockes, J.P. A target of thrombin activation promotes cell cycle re-entry by urodele muscle cells. Wound Repair Regen. 6, 301-391 (1998).
24. Hung, D.T., Jamison, T.F. & Schreiber, S.L. Understanding and controlling the cell cycle with natural products. Chem. Biol. 3, 623-639 (1996).
25. Hansen, M.B., Nielsen, S.E. & Berg, K. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Methods 119, 203-210 (1989).
26. Belmont, L.D. & Mitchison, T.J. Identification of a protein that interacts with tubulin dimmers and increases the catastrophe rate of microtubules. Cell 84, 623-631 (1996).
27. Lockhart, D.J. et al. Expression monitoring by hybridization to high-density oligonucleotide arrays. Nat. Biotechnol. 14, 1675-1680 (1996).
28. Wodicka, L., Dong, H., Mittmann, M., Ho, M.H. & Lockhart, D.J. Genome-wide expression monitoring in Saccharomyces cerevisiae. Nat. Biotechnol. 15, 1359-1367 (1997).