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Volumn 27, Issue 2, 2011, Pages 113-119

Gut-brain signalling: How lipids can trigger the gut

Author keywords

Brain; Cholecystokinin; Food intake; Glucose production; Gut brain; Intestine; Lipid sensing mechanisms

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACYLGLYCEROL PALMITOYLTRANSFERASE; CARNITINE PALMITOYLTRANSFERASE I; CHOLECYSTOKININ A RECEPTOR; LONG CHAIN FATTY ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

EID: 79551586857     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.1160     Document Type: Review
Times cited : (17)

References (80)
  • 1
    • 33846032275 scopus 로고    scopus 로고
    • Gastrointestinal regulation of food intake
    • Cummings DE, Overduin J. Gastrointestinal regulation of food intake. J Clin Invest 2007; 117: 13-23.
    • (2007) J Clin Invest , vol.117 , pp. 13-23
    • Cummings, D.E.1    Overduin, J.2
  • 2
    • 42549118500 scopus 로고    scopus 로고
    • Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production
    • Wang PY, Caspi L, Lam CK, et al. Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production. Nature 2008; 452: 1012-1016.
    • (2008) Nature , vol.452 , pp. 1012-1016
    • Wang, P.Y.1    Caspi, L.2    Lam, C.K.3
  • 4
    • 34547492947 scopus 로고    scopus 로고
    • A balance of lipid-sensing mechanisms in the brain and liver
    • Caspi L, Wang PY, Lam TK. A balance of lipid-sensing mechanisms in the brain and liver. Cell Metab 2007; 6: 99-104.
    • (2007) Cell Metab , vol.6 , pp. 99-104
    • Caspi, L.1    Wang, P.Y.2    Lam, T.K.3
  • 5
    • 0034063725 scopus 로고    scopus 로고
    • The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans
    • Matzinger D, Degen L, Drewe J, et al. The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans. Gut 2000; 46: 688-693.
    • (2000) Gut , vol.46 , pp. 688-693
    • Matzinger, D.1    Degen, L.2    Drewe, J.3
  • 6
    • 0037403765 scopus 로고    scopus 로고
    • Effects of fat digestion on appetite, APD motility, and gut hormones in response to duodenal fat infusion in humans
    • Feinle C, O'Donovan D, Doran S, et al. Effects of fat digestion on appetite, APD motility, and gut hormones in response to duodenal fat infusion in humans. Am J Physiol Gastrointest Liver Physiol 2003; 284: G798-G807.
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.284
    • Feinle, C.1    O'Donovan, D.2    Doran, S.3
  • 7
    • 0025111324 scopus 로고
    • Intraduodenal infusions of fats elicit satiety in sham-feeding rats
    • Greenberg D, Smith GP, Gibbs J. Intraduodenal infusions of fats elicit satiety in sham-feeding rats. Am J Physiol 1990; 259: R110-R118.
    • (1990) Am J Physiol , vol.259
    • Greenberg, D.1    Smith, G.P.2    Gibbs, J.3
  • 8
    • 0028289119 scopus 로고
    • Effect of a low dose of intraduodenal fat on satiety in humans: studies using the type A cholecystokinin receptor antagonist loxiglumide
    • Lieverse RJ, Jansen JB, Masclee AA, Rovati LC, Lamers CB. Effect of a low dose of intraduodenal fat on satiety in humans: studies using the type A cholecystokinin receptor antagonist loxiglumide. Gut 1994; 35: 501-505.
    • (1994) Gut , vol.35 , pp. 501-505
    • Lieverse, R.J.1    Jansen, J.B.2    Masclee, A.A.3    Rovati, L.C.4    Lamers, C.B.5
  • 9
    • 0033378595 scopus 로고    scopus 로고
    • Inhibition of food intake in response to intestinal lipid is mediated by cholecystokinin in humans
    • Matzinger D, Gutzwiller JP, Drewe J, et al. Inhibition of food intake in response to intestinal lipid is mediated by cholecystokinin in humans. Am J Physiol 1999; 277: R1718-R1724.
    • (1999) Am J Physiol , vol.277
    • Matzinger, D.1    Gutzwiller, J.P.2    Drewe, J.3
  • 10
    • 63749108094 scopus 로고    scopus 로고
    • Cellular fatty acid uptake: a pathway under construction
    • Su X, Abumrad NA. Cellular fatty acid uptake: a pathway under construction. Trends Endocrinol Metab 2009; 20: 72-77.
    • (2009) Trends Endocrinol Metab , vol.20 , pp. 72-77
    • Su, X.1    Abumrad, N.A.2
  • 11
    • 34547124866 scopus 로고    scopus 로고
    • CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine
    • Nassir F, Wilson B, Han X, Gross RW, Abumrad NA. CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine. J Biol Chem 2007; 282: 19493-19501.
    • (2007) J Biol Chem , vol.282 , pp. 19493-19501
    • Nassir, F.1    Wilson, B.2    Han, X.3    Gross, R.W.4    Abumrad, N.A.5
  • 12
    • 0036092239 scopus 로고    scopus 로고
    • Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
    • McGarry JD. Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 2002; 51: 7-18.
    • (2002) Diabetes , vol.51 , pp. 7-18
    • McGarry, J.D.1
  • 13
    • 31544465941 scopus 로고    scopus 로고
    • Molecular disruption of hypothalamic nutrient sensing induces obesity
    • He W, Lam TK, Obici S, Rossetti L. Molecular disruption of hypothalamic nutrient sensing induces obesity. Nat Neurosci 2006; 9: 227-233.
    • (2006) Nat Neurosci , vol.9 , pp. 227-233
    • He, W.1    Lam, T.K.2    Obici, S.3    Rossetti, L.4
  • 14
    • 0038037734 scopus 로고    scopus 로고
    • Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production
    • Obici S, Feng Z, Arduini A, Conti R, Rossetti L. Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production. Nat Med 2003; 9: 756-761.
    • (2003) Nat Med , vol.9 , pp. 756-761
    • Obici, S.1    Feng, Z.2    Arduini, A.3    Conti, R.4    Rossetti, L.5
  • 15
    • 28844433549 scopus 로고    scopus 로고
    • A role for hypothalamic malonyl-CoA in the control of food intake
    • Hu Z, Dai Y, Prentki M, Chohnan S, Lane MD. A role for hypothalamic malonyl-CoA in the control of food intake. J Biol Chem 2005; 280: 39681-39683.
    • (2005) J Biol Chem , vol.280 , pp. 39681-39683
    • Hu, Z.1    Dai, Y.2    Prentki, M.3    Chohnan, S.4    Lane, M.D.5
  • 16
    • 0034901237 scopus 로고    scopus 로고
    • Attenuated satiation response to intestinal nutrients in rats that do not express CCK-A receptors
    • Covasa M, Ritter RC. Attenuated satiation response to intestinal nutrients in rats that do not express CCK-A receptors. Peptides 2001; 22: 1339-1348.
    • (2001) Peptides , vol.22 , pp. 1339-1348
    • Covasa, M.1    Ritter, R.C.2
  • 17
    • 34249713296 scopus 로고    scopus 로고
    • Effects of lauric acid on upper gut motility, plasma cholecystokinin and peptide YY, and energy intake are load, but not concentration, dependent in humans
    • Feltrin KL, Little TJ, Meyer JH, et al. Effects of lauric acid on upper gut motility, plasma cholecystokinin and peptide YY, and energy intake are load, but not concentration, dependent in humans. J Physiol 2007; 581: 767-777.
    • (2007) J Physiol , vol.581 , pp. 767-777
    • Feltrin, K.L.1    Little, T.J.2    Meyer, J.H.3
  • 18
    • 0032725628 scopus 로고    scopus 로고
    • Decreased responsiveness to dietary fat in Otsuka Long-Evans Tokushima fatty rats lacking CCK-A receptors
    • Schwartz GJ, Whitney A, Skoglund C, Castonguay TW, Moran TH. Decreased responsiveness to dietary fat in Otsuka Long-Evans Tokushima fatty rats lacking CCK-A receptors. Am J Physiol 1999; 277: R1144-R1151.
    • (1999) Am J Physiol , vol.277
    • Schwartz, G.J.1    Whitney, A.2    Skoglund, C.3    Castonguay, T.W.4    Moran, T.H.5
  • 19
    • 4143060169 scopus 로고    scopus 로고
    • Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length
    • Feltrin KL, Little TJ, Meyer JH, et al. Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length. Am J Physiol Regul Integr Comp Physiol 2004; 287: R524-R533.
    • (2004) Am J Physiol Regul Integr Comp Physiol , vol.287
    • Feltrin, K.L.1    Little, T.J.2    Meyer, J.H.3
  • 23
    • 0345687863 scopus 로고    scopus 로고
    • Localization of cholecystokinin receptor subtypes in the endocine pancreas
    • Morisset J, Julien S, Laine J. Localization of cholecystokinin receptor subtypes in the endocine pancreas. J Histochem Cytochem 2003; 51: 1501-1513.
    • (2003) J Histochem Cytochem , vol.51 , pp. 1501-1513
    • Morisset, J.1    Julien, S.2    Laine, J.3
  • 25
    • 0023279231 scopus 로고
    • Physiological concentrations of cholecystokinin stimulate amino acid-induced insulin release in humans
    • Rushakoff RJ, Goldfine ID, Carter JD, Liddle RA. Physiological concentrations of cholecystokinin stimulate amino acid-induced insulin release in humans. J Clin Endocrinol Metab 1987; 65: 395-401.
    • (1987) J Clin Endocrinol Metab , vol.65 , pp. 395-401
    • Rushakoff, R.J.1    Goldfine, I.D.2    Carter, J.D.3    Liddle, R.A.4
  • 26
    • 0030249712 scopus 로고    scopus 로고
    • Effect of pyloric cuffs on cholecystokinin satiety
    • Cox JE. Effect of pyloric cuffs on cholecystokinin satiety. Physiol Behav 1996; 60: 1023-1026.
    • (1996) Physiol Behav , vol.60 , pp. 1023-1026
    • Cox, J.E.1
  • 27
    • 0015856224 scopus 로고
    • Cholecystokinin elicits satiety in rats with open gastric fistulas
    • Gibbs J, Young RC, Smith GP. Cholecystokinin elicits satiety in rats with open gastric fistulas. Nature 1973; 245: 323-325.
    • (1973) Nature , vol.245 , pp. 323-325
    • Gibbs, J.1    Young, R.C.2    Smith, G.P.3
  • 28
    • 0017288955 scopus 로고
    • Cholecystokinin-decreased food intake in rhesus monkeys
    • Gibbs J, Falasco JD, McHugh PR. Cholecystokinin-decreased food intake in rhesus monkeys. Am J Physiol 1976; 230: 15-18.
    • (1976) Am J Physiol , vol.230 , pp. 15-18
    • Gibbs, J.1    Falasco, J.D.2    McHugh, P.R.3
  • 29
    • 0019381381 scopus 로고
    • C-terminal octapeptide of cholecystokinin decreases food intake in man
    • Kissileff HR, Pi-Sunyer FX, Thornton J, Smith GP. C-terminal octapeptide of cholecystokinin decreases food intake in man. Am J Clin Nutr 1981; 34: 154-160.
    • (1981) Am J Clin Nutr , vol.34 , pp. 154-160
    • Kissileff, H.R.1    Pi-Sunyer, F.X.2    Thornton, J.3    Smith, G.P.4
  • 30
    • 0018079212 scopus 로고
    • Effect of cholecystokinin on meal size and intermeal interval in the sham-feeding rat
    • Kraly FS, Carty WJ, Resnick S, Smith GP. Effect of cholecystokinin on meal size and intermeal interval in the sham-feeding rat. J Comp Physiol Psychol 1978; 92: 697-707.
    • (1978) J Comp Physiol Psychol , vol.92 , pp. 697-707
    • Kraly, F.S.1    Carty, W.J.2    Resnick, S.3    Smith, G.P.4
  • 31
    • 0026522625 scopus 로고
    • Blockade of type A, not type B, CCK receptors attenuates satiety actions of exogenous and endogenous CCK
    • Moran TH, Ameglio PJ, Schwartz GJ, McHugh PR. Blockade of type A, not type B, CCK receptors attenuates satiety actions of exogenous and endogenous CCK. Am J Physiol 1992; 262: R46-R50.
    • (1992) Am J Physiol , vol.262
    • Moran, T.H.1    Ameglio, P.J.2    Schwartz, G.J.3    McHugh, P.R.4
  • 32
    • 0030985882 scopus 로고    scopus 로고
    • Vagal afferent and efferent contributions to the inhibition of food intake by cholecystokinin
    • Moran TH, Baldessarini AR, Salorio CF, Lowery T, Schwartz GJ. Vagal afferent and efferent contributions to the inhibition of food intake by cholecystokinin. Am J Physiol 1997; 272: R1245-R1251.
    • (1997) Am J Physiol , vol.272
    • Moran, T.H.1    Baldessarini, A.R.2    Salorio, C.F.3    Lowery, T.4    Schwartz, G.J.5
  • 33
    • 0026593574 scopus 로고
    • Satiety induced by endogenous and exogenous cholecystokinin is mediated by CCK-A receptors in mice
    • Weatherford SC, Chiruzzo FY, Laughton WB. Satiety induced by endogenous and exogenous cholecystokinin is mediated by CCK-A receptors in mice. Am J Physiol 1992; 262: R574-R578.
    • (1992) Am J Physiol , vol.262
    • Weatherford, S.C.1    Chiruzzo, F.Y.2    Laughton, W.B.3
  • 34
    • 0029608744 scopus 로고
    • Role of cholecystokinin in the anorexia produced by duodenal delivery of oleic acid in rats
    • Woltman T, Castellanos D, Reidelberger R. Role of cholecystokinin in the anorexia produced by duodenal delivery of oleic acid in rats. Am J Physiol 1995; 269: R1420-R1433.
    • (1995) Am J Physiol , vol.269
    • Woltman, T.1    Castellanos, D.2    Reidelberger, R.3
  • 36
    • 0036721157 scopus 로고    scopus 로고
    • Plasma cholecystokinin is associated with subjective measures of satiety in women
    • Burton-Freeman B, Davis PA, Schneeman BO. Plasma cholecystokinin is associated with subjective measures of satiety in women. Am J Clin Nutr 2002; 76: 659-667.
    • (2002) Am J Clin Nutr , vol.76 , pp. 659-667
    • Burton-Freeman, B.1    Davis, P.A.2    Schneeman, B.O.3
  • 38
    • 0028358122 scopus 로고
    • L-phenylalanine releases cholecystokinin (CCK) and is associated with reduced food intake in humans: evidence for a physiological role of CCK in control of eating
    • Ballinger AB, Clark ML. L-phenylalanine releases cholecystokinin (CCK) and is associated with reduced food intake in humans: evidence for a physiological role of CCK in control of eating. Metabolism 1994; 43: 735-738.
    • (1994) Metabolism , vol.43 , pp. 735-738
    • Ballinger, A.B.1    Clark, M.L.2
  • 39
    • 0031414267 scopus 로고    scopus 로고
    • Pathways of Fos expression in locus ceruleus, dorsal vagal complex, and PVN in response to intestinal lipid
    • Monnikes H, Lauer G, Bauer C, Tebbe J, Zittel TT, Arnold R. Pathways of Fos expression in locus ceruleus, dorsal vagal complex, and PVN in response to intestinal lipid. Am J Physiol 1997; 273: R2059-R2071.
    • (1997) Am J Physiol , vol.273
    • Monnikes, H.1    Lauer, G.2    Bauer, C.3    Tebbe, J.4    Zittel, T.T.5    Arnold, R.6
  • 40
    • 77954934605 scopus 로고    scopus 로고
    • EGR1 is a target for cooperative interactions between cholecystokinin and leptin, and inhibition by ghrelin, in vagal afferent neurons
    • de LG, Lur G, Dimaline R, Varro A, Raybould H, Dockray GJ. EGR1 is a target for cooperative interactions between cholecystokinin and leptin, and inhibition by ghrelin, in vagal afferent neurons. Endocrinology 2010; 151: 3589-3599.
    • (2010) Endocrinology , vol.151 , pp. 3589-3599
    • de, L.G.1    Lur, G.2    Dimaline, R.3    Varro, A.4    Raybould, H.5    Dockray, G.J.6
  • 41
    • 14644429670 scopus 로고    scopus 로고
    • Leptin action in the forebrain regulates the hindbrain response to satiety signals
    • Morton GJ, Blevins JE, Williams DL, et al. Leptin action in the forebrain regulates the hindbrain response to satiety signals. J Clin Invest 2005; 115: 703-710.
    • (2005) J Clin Invest , vol.115 , pp. 703-710
    • Morton, G.J.1    Blevins, J.E.2    Williams, D.L.3
  • 42
    • 67349205060 scopus 로고    scopus 로고
    • Cholecystokinin and gut-brain signalling
    • Dockray GJ. Cholecystokinin and gut-brain signalling. Regul Pept 2009; 155: 6-10.
    • (2009) Regul Pept , vol.155 , pp. 6-10
    • Dockray, G.J.1
  • 43
    • 0021433344 scopus 로고
    • Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats
    • West DB, Fey D, Woods SC. Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats. Am J Physiol 1984; 246: R776-R787.
    • (1984) Am J Physiol , vol.246
    • West, D.B.1    Fey, D.2    Woods, S.C.3
  • 44
    • 67849124833 scopus 로고    scopus 로고
    • Intestinal cholecystokinin controls glucose production through a neuronal network
    • Cheung GW, Kokorovic A, Lam CK, Chari M, Lam TK. Intestinal cholecystokinin controls glucose production through a neuronal network. Cell Metab 2009; 10: 99-109.
    • (2009) Cell Metab , vol.10 , pp. 99-109
    • Cheung, G.W.1    Kokorovic, A.2    Lam, C.K.3    Chari, M.4    Lam, T.K.5
  • 45
    • 0030459212 scopus 로고    scopus 로고
    • Anatomical relationship between vagal afferent fibers and CCK-immunoreactive entero-endocrine cells in the rat small intestinal mucosa
    • Berthoud HR, Patterson LM. Anatomical relationship between vagal afferent fibers and CCK-immunoreactive entero-endocrine cells in the rat small intestinal mucosa. Acta Anat (Basel) 1996; 156: 123-131.
    • (1996) Acta Anat (Basel) , vol.156 , pp. 123-131
    • Berthoud, H.R.1    Patterson, L.M.2
  • 46
    • 0023194939 scopus 로고
    • Transport of cholecystokinin (CCK) binding sites in subdiaphragmatic vagal branches
    • Moran TH, Smith GP, Hostetler AM, McHugh PR. Transport of cholecystokinin (CCK) binding sites in subdiaphragmatic vagal branches. Brain Res 1987; 415: 149-152.
    • (1987) Brain Res , vol.415 , pp. 149-152
    • Moran, T.H.1    Smith, G.P.2    Hostetler, A.M.3    McHugh, P.R.4
  • 47
    • 0025036101 scopus 로고
    • Central and peripheral vagal transport of cholecystokinin binding sites occurs in afferent fibers
    • Moran TH, Norgren R, Crosby RJ, McHugh PR. Central and peripheral vagal transport of cholecystokinin binding sites occurs in afferent fibers. Brain Res 1990; 526: 95-102.
    • (1990) Brain Res , vol.526 , pp. 95-102
    • Moran, T.H.1    Norgren, R.2    Crosby, R.J.3    McHugh, P.R.4
  • 48
    • 0037308812 scopus 로고    scopus 로고
    • Selective effects of vagal deafferentation and celiac-superior mesenteric ganglionectomy on the reinforcing and satiating action of intestinal nutrients
    • Sclafani A, Ackroff K, Schwartz GJ. Selective effects of vagal deafferentation and celiac-superior mesenteric ganglionectomy on the reinforcing and satiating action of intestinal nutrients. Physiol Behav 2003; 78: 285-294.
    • (2003) Physiol Behav , vol.78 , pp. 285-294
    • Sclafani, A.1    Ackroff, K.2    Schwartz, G.J.3
  • 49
    • 77949857843 scopus 로고    scopus 로고
    • Defining the role of cholecystokinin in the lipid-induced human brain activation matrix
    • Lassman DJ, McKie S, Gregory LJ, et al. Defining the role of cholecystokinin in the lipid-induced human brain activation matrix. Gastroenterology 2010; 138: 1514-1524.
    • (2010) Gastroenterology , vol.138 , pp. 1514-1524
    • Lassman, D.J.1    McKie, S.2    Gregory, L.J.3
  • 50
    • 17044441490 scopus 로고    scopus 로고
    • Peripheral administration of cholecystokinin activates c-fos expression in the locus coeruleus/subcoeruleus nucleus, dorsal vagal complex and paraventricular nucleus via capsaicin-sensitive vagal afferents and CCK-A receptors in the rat
    • Monnikes H, Lauer G, Arnold R. Peripheral administration of cholecystokinin activates c-fos expression in the locus coeruleus/subcoeruleus nucleus, dorsal vagal complex and paraventricular nucleus via capsaicin-sensitive vagal afferents and CCK-A receptors in the rat. Brain Res 1997; 770: 277-288.
    • (1997) Brain Res , vol.770 , pp. 277-288
    • Monnikes, H.1    Lauer, G.2    Arnold, R.3
  • 51
    • 0027511257 scopus 로고
    • The induction and suppression of c-fos expression in the rat brain by cholecystokinin and its antagonist L364,718
    • Chen DY, Deutsch JA, Gonzalez MF, Gu Y. The induction and suppression of c-fos expression in the rat brain by cholecystokinin and its antagonist L364, 718. Neurosci Lett 1993; 149: 91-94.
    • (1993) Neurosci Lett , vol.149 , pp. 91-94
    • Chen, D.Y.1    Deutsch, J.A.2    Gonzalez, M.F.3    Gu, Y.4
  • 52
    • 0027279526 scopus 로고
    • Meal-induced c-fos expression in brain stem is not dependent on cholecystokinin release
    • Fraser KA, Davison JS. Meal-induced c-fos expression in brain stem is not dependent on cholecystokinin release. Am J Physiol 1993; 265: R235-R239.
    • (1993) Am J Physiol , vol.265
    • Fraser, K.A.1    Davison, J.S.2
  • 54
    • 77954612376 scopus 로고    scopus 로고
    • Activation of N-methyl-D-aspartate (NMDA) receptors in the dorsal vagal complex lowers glucose production
    • Lam CK, Chari M, Su BB, et al. Activation of N-methyl-D-aspartate (NMDA) receptors in the dorsal vagal complex lowers glucose production. J Biol Chem 2010; 285: 21913-21921.
    • (2010) J Biol Chem , vol.285 , pp. 21913-21921
    • Lam, C.K.1    Chari, M.2    Su, B.B.3
  • 55
    • 15544362925 scopus 로고    scopus 로고
    • The gut and energy balance: visceral allies in the obesity wars
    • Badman MK, Flier JS. The gut and energy balance: visceral allies in the obesity wars. Science 2005; 307: 1909-1914.
    • (2005) Science , vol.307 , pp. 1909-1914
    • Badman, M.K.1    Flier, J.S.2
  • 56
    • 34147119799 scopus 로고    scopus 로고
    • The hormonal control of food intake
    • Coll AP, Farooqi IS, O'Rahilly S. The hormonal control of food intake. Cell 2007; 129: 251-262.
    • (2007) Cell , vol.129 , pp. 251-262
    • Coll, A.P.1    Farooqi, I.S.2    O'Rahilly, S.3
  • 57
    • 33845875966 scopus 로고    scopus 로고
    • Gut hormones and the regulation of energy homeostasis
    • Murphy KG, Bloom SR. Gut hormones and the regulation of energy homeostasis. Nature 2006; 444: 854-859.
    • (2006) Nature , vol.444 , pp. 854-859
    • Murphy, K.G.1    Bloom, S.R.2
  • 58
    • 0032802624 scopus 로고    scopus 로고
    • Reduced sensitivity to the satiation effect of intestinal oleate in rats adapted to high-fat diet
    • Covasa M, Ritter RC. Reduced sensitivity to the satiation effect of intestinal oleate in rats adapted to high-fat diet. Am J Physiol 1999; 277: R279-R285.
    • (1999) Am J Physiol , vol.277
    • Covasa, M.1    Ritter, R.C.2
  • 59
    • 0034735740 scopus 로고    scopus 로고
    • Reduced hindbrain and enteric neuronal response to intestinal oleate in rats maintained on high-fat diet
    • Covasa M, Grahn J, Ritter RC. Reduced hindbrain and enteric neuronal response to intestinal oleate in rats maintained on high-fat diet. Auton Neurosci 2000; 84: 8-18.
    • (2000) Auton Neurosci , vol.84 , pp. 8-18
    • Covasa, M.1    Grahn, J.2    Ritter, R.C.3
  • 60
    • 64149083743 scopus 로고    scopus 로고
    • Deficiency of the intestinal enzyme acyl CoA monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding
    • Yen CL, Cheong ML, Grueter C, et al. Deficiency of the intestinal enzyme acyl CoA monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding. Nat Med 2009; 15: 442-446.
    • (2009) Nat Med , vol.15 , pp. 442-446
    • Yen, C.L.1    Cheong, M.L.2    Grueter, C.3
  • 61
    • 33751164646 scopus 로고    scopus 로고
    • Differential regulation of intestinal lipid metabolism-related genes in obesity-resistant A/J vs. obesity-prone C57BL/6J mice
    • Kondo H, Minegishi Y, Komine Y, et al. Differential regulation of intestinal lipid metabolism-related genes in obesity-resistant A/J vs. obesity-prone C57BL/6J mice. Am J Physiol Endocrinol Metab 2006; 291: E1092-E1099.
    • (2006) Am J Physiol Endocrinol Metab , vol.291
    • Kondo, H.1    Minegishi, Y.2    Komine, Y.3
  • 62
    • 77950524984 scopus 로고    scopus 로고
    • Neuronal regulation of homeostasis by nutrient sensing
    • Lam TK. Neuronal regulation of homeostasis by nutrient sensing. Nat Med 2010; 16: 392-395.
    • (2010) Nat Med , vol.16 , pp. 392-395
    • Lam, T.K.1
  • 63
    • 0035709033 scopus 로고    scopus 로고
    • Glucosensing neurons do more than just sense glucose
    • Levin BE. Glucosensing neurons do more than just sense glucose. Int J Obes Relat Metab Disord 2001; 25(Suppl 5): S68-S72.
    • (2001) Int J Obes Relat Metab Disord , vol.25 , Issue.SUPPL. 5
    • Levin, B.E.1
  • 64
    • 12344277552 scopus 로고    scopus 로고
    • Diabetes, obesity, and the brain
    • Schwartz MW, Porte D, Jr. Diabetes, obesity, and the brain. Science 2005; 307: 375-379.
    • (2005) Science , vol.307 , pp. 375-379
    • Schwartz, M.W.1    Porte Jr, D.2
  • 65
    • 23244458439 scopus 로고    scopus 로고
    • Regulation of blood glucose by hypothalamic pyruvate metabolism
    • Lam TK, Gutierrez-Juarez R, Pocai A, Rossetti L. Regulation of blood glucose by hypothalamic pyruvate metabolism. Science 2005; 309: 943-947.
    • (2005) Science , vol.309 , pp. 943-947
    • Lam, T.K.1    Gutierrez-Juarez, R.2    Pocai, A.3    Rossetti, L.4
  • 66
    • 1842484296 scopus 로고    scopus 로고
    • AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
    • Minokoshi Y, Alquier T, Furukawa N, et al. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 2004; 428: 569-574.
    • (2004) Nature , vol.428 , pp. 569-574
    • Minokoshi, Y.1    Alquier, T.2    Furukawa, N.3
  • 67
    • 34548604499 scopus 로고    scopus 로고
    • Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
    • Parton LE, Ye CP, Coppari R, et al. Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature 2007; 449: 228-232.
    • (2007) Nature , vol.449 , pp. 228-232
    • Parton, L.E.1    Ye, C.P.2    Coppari, R.3
  • 69
    • 0024315871 scopus 로고
    • Fatty acid synthase, a proficient multifunctional enzyme
    • Wakil SJ. Fatty acid synthase, a proficient multifunctional enzyme. Biochemistry 1989; 28: 4523-4530.
    • (1989) Biochemistry , vol.28 , pp. 4523-4530
    • Wakil, S.J.1
  • 70
    • 0034733730 scopus 로고    scopus 로고
    • Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors
    • Loftus TM, Jaworsky DE, Frehywot GL, et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 2000; 288: 2379-2381.
    • (2000) Science , vol.288 , pp. 2379-2381
    • Loftus, T.M.1    Jaworsky, D.E.2    Frehywot, G.L.3
  • 71
    • 0036065628 scopus 로고    scopus 로고
    • Central administration of oleic acid inhibits glucose production and food intake
    • Obici S, Feng Z, Morgan K, Stein D, Karkanias G, Rossetti L. Central administration of oleic acid inhibits glucose production and food intake. Diabetes 2002; 51: 271-275.
    • (2002) Diabetes , vol.51 , pp. 271-275
    • Obici, S.1    Feng, Z.2    Morgan, K.3    Stein, D.4    Karkanias, G.5    Rossetti, L.6
  • 72
    • 0023636723 scopus 로고
    • Utilization of plasma fatty acid in rat brain: distribution of [14C]palmitate between oxidative and synthetic pathways
    • Miller JC, Gnaedinger JM, Rapoport SI. Utilization of plasma fatty acid in rat brain: distribution of [14C]palmitate between oxidative and synthetic pathways. J Neurochem 1987; 49: 1507-1514.
    • (1987) J Neurochem , vol.49 , pp. 1507-1514
    • Miller, J.C.1    Gnaedinger, J.M.2    Rapoport, S.I.3
  • 73
    • 16244388931 scopus 로고    scopus 로고
    • Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis
    • Lam TK, Pocai A, Gutierrez-Juarez R, et al. Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. Nat Med 2005; 11: 320-327.
    • (2005) Nat Med , vol.11 , pp. 320-327
    • Lam, T.K.1    Pocai, A.2    Gutierrez-Juarez, R.3
  • 74
    • 50949132040 scopus 로고    scopus 로고
    • Hypothalamic protein kinase C regulates glucose production
    • Ross R, Wang PY, Chari M, et al. Hypothalamic protein kinase C regulates glucose production. Diabetes 2008; 57: 2061-2065.
    • (2008) Diabetes , vol.57 , pp. 2061-2065
    • Ross, R.1    Wang, P.Y.2    Chari, M.3
  • 75
    • 20844451123 scopus 로고    scopus 로고
    • AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism
    • Kahn BB, Alquier T, Carling D, Hardie DG. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 2005; 1: 15-25.
    • (2005) Cell Metab , vol.1 , pp. 15-25
    • Kahn, B.B.1    Alquier, T.2    Carling, D.3    Hardie, D.G.4
  • 76
    • 3142677140 scopus 로고    scopus 로고
    • Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase
    • Kim MS, Park JY, Namkoong C, et al. Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med 2004; 10: 727-733.
    • (2004) Nat Med , vol.10 , pp. 727-733
    • Kim, M.S.1    Park, J.Y.2    Namkoong, C.3
  • 77
    • 34347255023 scopus 로고    scopus 로고
    • Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake
    • Kubota N, Yano W, Kubota T, et al. Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metab 2007; 6: 55-68.
    • (2007) Cell Metab , vol.6 , pp. 55-68
    • Kubota, N.1    Yano, W.2    Kubota, T.3
  • 78
    • 21644453934 scopus 로고    scopus 로고
    • Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase
    • Kola B, Hubina E, Tucci SA, et al. Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase. J Biol Chem 2005; 280: 25196-25201.
    • (2005) J Biol Chem , vol.280 , pp. 25196-25201
    • Kola, B.1    Hubina, E.2    Tucci, S.A.3
  • 79
    • 1842582870 scopus 로고    scopus 로고
    • AMP-activated protein kinase plays a role in the control of food intake
    • Andersson U, Filipsson K, Abbott CR, et al. AMP-activated protein kinase plays a role in the control of food intake. J Biol Chem 2004; 279: 12005-12008.
    • (2004) J Biol Chem , vol.279 , pp. 12005-12008
    • Andersson, U.1    Filipsson, K.2    Abbott, C.R.3
  • 80
    • 77957554805 scopus 로고    scopus 로고
    • Hypothalamic AMP-activated protein kinase regulates glucose production
    • Yang CS, Lam CK, Chari M, et al. Hypothalamic AMP-activated protein kinase regulates glucose production. Diabetes 2010; 59: 2435-2443.
    • (2010) Diabetes , vol.59 , pp. 2435-2443
    • Yang, C.S.1    Lam, C.K.2    Chari, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.