EGR1 is a target for cooperative interactions between cholecystokinin and leptin, and inhibition by ghrelin, in vagal afferent neurons

Endocrinology

Volumn 151, Issue 8, 2010, Pages 3589-3599

  De Lartigue, Guillaume ^a,b   Lur, Gyorgy ^a   Dimaline, Rod ^a   Varro, Andrea ^a   Raybould, Helen ^b   Dockray, Graham J ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLECYSTOKININ; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; EARLY GROWTH RESPONSE FACTOR 1; GHRELIN; LEPTIN;

ANIMAL EXPERIMENT; ARTICLE; CELLULAR DISTRIBUTION; FOOD INTAKE; GENE EXPRESSION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN SYNTHESIS; PROTEIN TARGETING; RAT; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; VAGUS NERVE NUCLEUS;

ANIMALS; APPETITE REGULATION; CELL NUCLEUS; CELLS, CULTURED; CHOLECYSTOKININ; DOWN-REGULATION; DRUG ANTAGONISM; DRUG SYNERGISM; EARLY GROWTH RESPONSE PROTEIN 1; GHRELIN; LEPTIN; MALE; NEURONS, AFFERENT; PROTEIN TRANSPORT; RATS; RATS, WISTAR; TRANSCRIPTIONAL ACTIVATION; VAGUS NERVE;

EID: 77954934605     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-0106     Document Type: Article

References (39)

1. Murphy KG, Bloom SR 2006 Gut hormones and the regulation of energy homeostasis. Nature 444:854-859 (Pubitemid 46024992)
2. Dockray GJ 2004 Gut endocrine secretions and their relevance to satiety. Curr Opin Pharmacol 4:557-560
3. Cummings DE, Overduin J 2007 Gastrointestinal regulation of food intake. J Clin Invest 117:13-23
4. Schwartz GJ, McHugh PR, Moran TH 1993 Gastric loads and cholecystokinin synergistically stimulate rat gastric vagal afferents. Am J Physiol 265:R872-R876
5. Peters JH, Karpiel AB, Ritter RC, Simasko SM 2004 Cooperative activation of cultured vagal afferent neurons by leptin and cholecystokinin. Endocrinology 145:3652-3657
6. Barrachina MD, Martínez V, Wang L, Wei JY, Taché Y 1997 Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice. Proc Natl Acad Sci USA 94: 10455-10460 (Pubitemid 27407063)
7. Burdyga G, Lal S, Spiller D, Jiang W, Thompson D, Attwood S, Saeed S, Grundy D, Varro A, Dimaline R, Dockray GJ 2003 Localization of orexin-1 receptors to vagal afferent neurons in the rat and humans. Gastroenterology 124:129-139 (Pubitemid 36055346)
8. Date Y, Toshinai K, Koda S, Miyazato M, Shimbara T, Tsuruta T, Niijima A, Kangawa K, Nakazato M 2005 Peripheral interaction of ghrelin with cholecystokinin on feeding regulation. Endocrinology 146:3518-3525
9. Arnold M, Mura A, Langhans W, Geary N 2006 Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected ghrelin in the rat. J Neurosci 26:11052-11060 (Pubitemid 44772195)
10. Burdyga G, Lal S, Varro A, Dimaline R, Thompson DG, Dockray GJ 2004 Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin. J Neurosci 24:2708-2715 (Pubitemid 38380947)
11. Burdyga G, Varro A, Dimaline R, Thompson DG, Dockray GJ 2006 Feeding-dependent depression of melanin-concentrating hormone and melanin-concentrating hormone receptor-1 expression in vagal afferent neurones. Neuroscience 137:1405-1415 (Pubitemid 43133164)
12. de Lartigue G, Dimaline R, Varro A, Dockray GJ 2007 Cocaine- and amphetamine-regulated transcript: stimulation of expression in rat vagal afferent neurons by cholecystokinin and suppression by ghrelin. J Neurosci 27:2876-2882 (Pubitemid 46438967)
13. Burdyga G, de Lartigue G, Raybould HE, Morris R, Dimaline R, Varro A, Thompson DG, Dockray GJ 2008 Cholecystokinin regulates expression of Y2 receptors in vagal afferent neurons serving the stomach. J Neurosci 28:11583-11592
14. Burdyga G, Varro A, Dimaline R, Thompson DG, Dockray GJ 2006 Ghrelin receptors in rat and human nodose ganglia: putative role in regulating CB-1 and MCH receptor abundance. Am J Physiol Gastrointest Liver Physiol 290:G1289-G1297
15. Sukhatme VP, Cao XM, Chang LC, Tsai-Morris CH, Stamenkovich D, Ferreira PC, Cohen DR, Edwards SA, Shows TB, Curran T 1988 A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell 53:37-43
16. Cole AJ, Saffen DW, Baraban JM, Worley PF 1989 Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation. Nature 340:474-476
17. Beckmann AM, Wilce PA 1997 Egr transcription factors in the nervous system. Neurochem Int 31:477-510 (Pubitemid 27375859)
18. Thiel G, Schoch S, Petersohn D 1994 Regulation of synapsin I gene expression by the zinc finger transcription factor zif268/egr-1. J Biol Chem 269:15294-15301 (Pubitemid 24198380)
19. Cohen DM, Gullans SR, Chin WW 1996 Urea inducibility of egr-1 in murine inner medullary collecting duct cells is mediated by the serum response element and adjacent Ets motifs. J Biol Chem 271:12903-12908
20. Dominguez G, Lakatos A, Kuhar MJ 2002 Characterization of the cocaine- and amphetamine-regulated transcript (CART) peptide gene promoter and its activation by a cyclic AMP-dependent signaling pathway in GH3 cells. J Neurochem 80:885-893 (Pubitemid 34809241)
21. De Lartigue G, Dimaline R, Varro A, Raybould H, De la Serre CB, Dockray GJ 2010 Cocaine and amphetamine regulated transcript mediates the actions of cholecystokinin on rat vagal afferent neurons. Gastroenterology 138:1479-1490
22. Sharkey KA, Williams RG, Dockray GJ 1984 Sensory substance P innervation of the stomach and pancreas. Demonstration of capsaicin-sensitive sensory neurons in the rat by combined immunohistochemistry and retrograde tracing. Gastroenterology 87:914-921
23. Buyse M, Ovesjö ML, Goïot H, Guilmeau S, Péranzi G, Moizo L, Walker F, Lewin MJ, Meister B, Bado A 2001 Expression and regulation of leptin receptor proteins in afferent and efferent neurons of the vagus nerve. Eur J Neurosci 14:64-72 (Pubitemid 32738475)
24. Forster ER, Dockray GJ 1992 The role of cholecystokinin in inhibition of gastric emptying by peptone in the rat. Exp Physiol 77:693-699
25. Moran TH, Kinzig KP 2004 Gastrointestinal satiety signals. II. Cholecystokinin. Am J Physiol Gastrointest Liver Physiol 286:G183-G188
26. Morton GJ, Cummings DE, Baskin DG, Barsh GS, Schwartz MW 2006 Central nervous system control of food intake and body weight. Nature 443:289-295 (Pubitemid 44435142)
27. Morton GJ, Blevins JE, Williams DL, Niswender KD, Gelling RW, Rhodes CJ, Baskin DG, Schwartz MW 2005 Leptin action in the forebrain regulates the hindbrain response to satiety signals. J Clin Invest 115:703-710
28. Williams DL, Baskin DG, Schwartz MW 2009 Hindbrain leptin receptor stimulation enhances the anorexic response to cholecystokinin. Am J Physiol Regul Integr Comp Physiol 297:R1238-R1246
29. Hayes MR, Skibicka KP, Leichner TM, Guarnieri DJ, DiLeone RJ, Bence KK, Grill HJ 2010 Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation. Cell Metab 11:77-83
30. Wang YH, Taché Y, Sheibel AB, Go VL, Wei JY 1997 Two types of leptin-responsive gastric vagal afferent terminals: an in vitro single-unit study in rats. Am J Physiol 273:R833-R837
31. Saffen DW, Cole AJ, Worley PF, Christy BA, Ryder K, Baraban JM 1988 Convulsant-induced increase in transcription factor messenger RNAs in rat brain. Proc Natl Acad Sci USA 85:7795-7799
32. Gashler AL, Swaminathan S, Sukhatme VP 1993 A novel repression module, an extensive activation domain, and a bipartite nuclear localization signal defined in the immediate-early transcription factor Egr-1. Mol Cell Biol 13:4556-4571
33. Matheny C, Day ML, Milbrandt J 1994 The nuclear localization signal of NGFI-A is located within the zinc finger DNA binding domain. J Biol Chem 269:8176-8181
34. Mora GR, Olivier KR, Cheville JC, Mitchell Jr RF, Lingle WL, Tindall DJ 2004 The cytoskeleton differentially localizes the early growth response gene-1 protein in cancer and benign cells of the prostate. Mol Cancer Res 2:115-128
35. Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, Moizo L, Lehy T, Guerre-Millo M, Le Marchand-Brustel Y, Lewin MJ 1998 The stomach is a source of leptin. Nature 394:790-793
36. Burdyga G, Spiller D, Morris R, Lal S, Thompson DG, Saeed S, Dimaline R, Varro A, Dockray GJ 2002 Expression of the leptin receptor in rat and human nodose ganglion neurones. Neuroscience 109:339-347
37. Bjørbaek C, Buchholz RM, Davis SM, Bates SH, Pierroz DD, Gu H, Neel BG, Myers Jr MG, Flier JS 2001 Divergent roles of SHP-2 in ERK activation by leptin receptors. J Biol Chem 276:4747-4755
38. Sakamoto KM, Fraser JK, Lee HJ, Lehman E, Gasson JC 1994 Granulocyte-macrophage colony-stimulating factor and interleukin-3 signaling pathways converge on the CREB-binding site in the human egr-1 promoter. Mol Cell Biol 14:5975-5985 (Pubitemid 24264426)
39. Hao F, Tan M, Xu X, Cui MZ 2008 Histamine induces Egr-1 expression in human aortic endothelial cells via the H1 receptor-mediated protein kinase Cδ-dependent ERK activation pathway. J Biol Chem 283:26928-26936