Identification of isomerization and racemization of aspartate in the Asp-Asp motifs of a therapeutic protein

Analytical Biochemistry

Volumn 410, Issue 2, 2011, Pages 234-243

  Zhang, Jennifer ^a   Yip, Holly ^a   Katta, Viswanatham ^a  

^a GENENTECH INC   (United States)

Author keywords

Asp Asp motifs; Isomerization; Racemization; Succinimide

Indexed keywords

ELECTROPHORESIS; ISOMERS; PEPTIDES; THERMAL STRESS;

ASP-ASP MOTIFS; CAPILLARY ISOELECTRIC FOCUSING; COMPLEMENTARITY-DETERMINING REGIONS; PROTEIN CONFORMATION; RACEMIZATION; SUCCINIMIDE; SYNTHETIC PEPTIDE; THERAPEUTIC PROTEIN;

ISOMERIZATION;

ASPARTIC ACID; SUCCINIMIDE;

AMINO ACID SEQUENCE; ARTICLE; COMPLEMENTARITY DETERMINING REGION; HEAVY CHAIN; HYDROLYSIS; ISOMERIZATION; LIGHT CHAIN; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN MOTIF; RACEMIZATION; TEMPERATURE STRESS;

EID: 79551550805     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2010.11.040     Document Type: Article

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