Physiological effects of manipulating the level of insulin-degrading enzyme in insulin-producing cells of Drosophila

Fly

Volumn 5, Issue 1, 2011, Pages 1-5

  Hyun, Joogyung ^a   Hashimoto, Carl ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Beta cell; Drosophila; Insulin proteolysis; Lifespan; Signaling pathway

Indexed keywords

EID: 79551518866     PISSN: 19336934     EISSN: 19336942     Source Type: Journal    
DOI: 10.4161/fly.5.1.14459     Document Type: Article

References (28)

1. Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001; 414:799-806.
2. Taguchi A, White MF. Insulin-like signaling, nutrient homeostasis and life span. Annu Rev Physiol 2008; 70:191-212.
3. Duckworth WC, Bennett RG, Hamel FG. Insulin degradation: progress and potential. Endocr Rev 1998; 19:608-24.
4. Hulse RE, Ralat LA, Wei-Jen T. Structure, function and regulation of insulin-degrading enzyme. Vitam Horm 2009; 80:635-48.
5. Qiu WQ, Folstein MF. Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis. Neurobiol Aging 2006; 27:190-8.
6. Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, et al. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci USA 2003; 100:4162-7.
7. Miller BC, Eckman EA, Sambamurti K, Dobbs N, Chow KM, Eckman CB, et al. Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo. Proc Natl Acad Sci USA 2003; 100:6221-6.
8. Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell T, Holmans P, et al. Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme. Am J Med Genet B Neuropsychiatr Genet 2005; 136:62-8.
9. Vepsalainen S, Parkinson M, Helisalmi S, Mannermaa A, Soininen H, Tanzi RE, et al. Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population. J Med Genet 2007; 44:606-8.
10. Hersh LB. The insulysin (insulin degrading enzyme) enigma. Cell Mol Life Sci 2006; 63:2432-4.
11. Duckworth WC, Garcia JV, Liepnieks JJ, Hamel FG, Hermodson MA, Frank BH, et al. Drosophila insulin degrading enzyme and rat skeletal muscle insulin protease cleave insulin at similar sites. Biochemistry 1989; 28:2471-7.
12. Kuo WL, Gehm BD, Rosner MR. Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme. Mol Endocrinol 1990; 4:1580-91.
13. Tsuda M, Kobayashi T, Matsuo T, Aigaki T. Insulindegrading enzyme antagonizes insulin-dependent tissue growth and Abeta-induced neurotoxicity in Drosophila. FEBS Lett 2010; 584:2916-20.
14. Brogiolo W, Stocker H, Ikeya T, Rintelen F, Fernandez R, Hafen E. An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr Biol 2001; 11:213-21.
15. Ikeya T, Galic M, Belawat P, Nairz K, Hafen E. Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila. Curr Biol 2002; 12:1293-300.
16. Wu Q, Brown MR. Signaling and function of insulinlike peptides in insects. Annu Rev Entomol 2006; 51:1-24.
17. Rulifson EJ, Kim SK, Nusse R. Ablation of insulinproducing neurons in flies: growth and diabetic phenotypes. Science 2002; 296:1118-20.
18. Broughton SJ, Piper MD, Ikeya T, Bass TM, Jacobson J, Driege Y, et al. Longer lifespan, altered metabolism and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc Natl Acad Sci USA 2005; 102:3105-10.
19. Broughton S, Alic N, Slack C, Bass T, Ikeya T, Vinti G, et al. Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs. PLoS One 2008; 3:3721.
20. Zhang H, Liu J, Li CR, Momen B, Kohanski RA, Pick L. Deletion of Drosophila insulin-like peptides causes growth defects and metabolic abnormalities. Proc Natl Acad Sci USA 2009; 106:19617-22.
21. Kennerdell JR, Carthew RW. Heritable gene silencing in Drosophila using double-stranded RNA. Nat Biotechnol 2000; 18:896-8.
22. Duffy JB. GAL4 system in Drosophila: a fly geneticist's Swiss army knife. Genesis 2002; 34:1-15.
23. Flockhart I, Booker M, Kiger A, Boutros M, Armknecht S, Ramadan N, et al. FlyRNAi: the Drosophila RNAi screening center database. Nucleic Acids Res 2006; 34:489-94.
24. Hrdlicka L, Gibson M, Kiger A, Micchelli C, Schober M, Schock F, et al. Analysis of twenty-four Gal4 lines in Drosophila melanogaster. Genesis 2002; 34:51-7.
25. Gronke S, Clarke DF, Broughton S, Andrews TD, Partridge L. Molecular evolution and functional characterization of Drosophila insulin-like peptides. PLoS Genet 2010; 6:1000857.
26. Leibiger IB, Leibiger B, Berggren PO. Insulin signaling in the pancreatic beta-cell. Annu Rev Nutr 2008; 28:233-51.
27. Spradling AC, Rubin GM. Transposition of cloned P elements into Drosophila germ line chromosomes. Science 1982; 218:341-7.
28. Lung O, Wolfner MF. Drosophila seminal fluid proteins enter the circulatory system of the mated female fly by crossing the posterior vaginal wall. Insect Biochem Mol Biol 1999; 29:1043-52.