Requirements of the engineered leader peptide of nisin for inducing modification, export, and cleavage

Applied and Environmental Microbiology

Volumn 77, Issue 2, 2011, Pages 604-611

  Plat, Annechien ^a   Kluskens, Leon D ^a,b   Kuipers, Anneke ^a   Rink, Rick ^a   Moll, Gert N ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY OF MINHO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOCLEAVAGE; FACTOR XA; HIS-TAG; LACTOCOCCUS LACTIS; PEPTIDE ANTIBIOTICS; POST-TRANSLATIONAL MODIFICATIONS; PROPEPTIDES; REDUCED PRODUCTION; TRANSPORT EFFICIENCY;

AMINO ACIDS; ANTIBIOTICS;

PEPTIDES;

ANTIINFECTIVE AGENT; NISIN; SIGNAL PEPTIDE;

AMINO ACID; ANTIBIOTICS; BACTERIUM; MUTAGENICITY; PEPTIDE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CHEMICAL STRUCTURE; GENETIC RECOMBINATION; GENETICS; LACTOCOCCUS LACTIS; METABOLISM; MICROBIOLOGICAL EXAMINATION; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN ENGINEERING; PROTEIN PROCESSING; PROTEIN TRANSPORT;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; DNA MUTATIONAL ANALYSIS; LACTOCOCCUS LACTIS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NISIN; PROTEIN ENGINEERING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN SORTING SIGNALS; PROTEIN TRANSPORT; RECOMBINATION, GENETIC;

LACTOCOCCUS LACTIS;

EID: 79551491572     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.01503-10     Document Type: Article

References (54)

1. Chatterjee, C., G. C. Patton, L. Cooper, M. Paul, and W. A. van der Donk. 2006. Engineering dehydro amino acids and thioethers into peptides using lacticin 481 synthetase. Chem. Biol. 13:1109-1117.
2. Chatterjee, C., M. Paul, L. Xie, and W. A. van der Donk. 2005. Biosynthesis and mode of action of lantibiotics. Chem. Rev. 105:633-684.
3. Chen, P., F. X. Qi, J. Novak, R. E. Krull, and P. W. Caufield. 2001. Effect of amino acid substitutions in conserved residues in the leader peptide on biosynthesis of the lantibiotic mutacin II. FEMS Microbiol. Lett. 195:139-144.
4. De Kwaadsteniet, M., K. ten Doeschate, and L. M. T. Dicks. 2008. Characterization of the structural gene encoding nisin F, a new lantibiotic produced by Lactococcus lactis subsp. lactis isolated from freshwater catfish (Clarias gariepinus). Appl. Environ. Microbiol. 74:547-549.
5. De Vries, L., et al. 2010. Oral and pulmonary delivery of thioether-bridged angiotensin-(1-7). Peptides 31:893-898.
6. Furgerson Ihnken, L. A., C. Chatterjee, and W. A. van der Donk. 2008. In vitro reconstitution and substrate specificity of a lantibiotic protease. Biochemistry 47:7352-7363.
7. Furmanek, B., et al. 1999. Identification, characterization and purification of the lantibiotic staphylococcin T, a natural gallidermin variant. J. Appl. Microbiol. 87:856-866.
8. Gilmore, M. S., et al. 1994. Genetic structure of the Enterococcus faecalis plasmid pAD1-encoded cytolytic toxin system and its relation to lantibiotic determinants. J. Bacteriol. 176:7335-7344.
9. Gross, E., and J. L. Morrell. 1971. The structure of nisin. J. Am. Chem. Soc. 93:4634-4635.
10. Gross, E., H. H. Klitz, and E. Nebelin. 1973. Die Struktur des Subtilins. Hoppe-Seylers Z. Physiol. Chem. 354:810-812.
11. Heidrich, C., et al. 1998. Isolation, characterization, and heterologous expression of the novel lantibiotic epicidin 280 and analysis of its biosynthetic gene cluster. Appl. Environ. Microbiol. 64:3140-3146.
12. Holo, H., and I. F. Nes. 1995. Transformation of Lactococcus by electroporation. Methods Mol. Biol. 47:195-199.
13. Holo, H., Z. Jeknic, M. Daeschel, S. Stevanovic, and I. F. Nes. 2001. Plantaricin W from Lactobacillus plantarum belongs to a new family of twopeptide lantibiotics. Microbiology 147:643-651.
14. Huot, E., J. Meghrous, C. Barrena-Gonzalez, and H. Petitdemange. 1996. Bacteriocin J46, a new bacteriocin produced by Lactococcus lactis subsp. cremoris J46: Isolation and characterization of the protein and its gene. Anaerobe 2:137-145.
15. Jensen, P. R., and K. Hammer. 1993. Minimal requirements for exponential growth of Lactococcus lactis. Appl. Environ. Microbiol. 59:4363-4366.
16. Kellner, R., G. Jung, C. Kaletta, K.-D. Entian, and H.-G. Sahl. 1989. Pep5: Structure elucidation of a large lantibiotic. Angew. Chem. Int. Ed. Engl. 28:616-619.
17. Kessler, H., et al. 1988. The structure of the polycyclic nonadecapeptide Ro 09-0198. Helv. Chim. Acta 71:1924-1929.
18. Kluskens, L. D., et al. 2005. Post-translational modification of therapeutic peptides by NisB, the dehydratase of the lantibiotic nisin. Biochemistry 44:12827-12834.
19. Kluskens, L. D., et al. 2009. Angiotensin-(1-7) with thioether bridge: An angiotensin-converting enzyme-resistant, potent angiotensin-(1-7) analog. J. Pharmacol. Exp. Ther. 328:849-854.
20. Kuipers, A., et al. 2004. NisT, the transporter of the lantibiotic nisin, can transport fully modified, dehydrated, and unmodified prenisin and fusions of the leader peptide with non-lantibiotic peptides. J. Biol. Chem. 279:22176-22182.
21. Kuipers, A., et al. 2006. Sec-mediated transport of posttranslationally dehydrated peptides in Lactococcus lactis. Appl. Environ. Microbiol. 72:7626-7633.
22. Kuipers, A., R. Rink, and G. N. Moll. Genetics, biosynthesis, structure and mode of action of lantibiotics. In D. Drider and S. Rebuffat (ed.), Prokaryotic antimicrobial peptides: From genes to applications, in press. Springer- Verlag, Berlin, Germany.
23. Kuipers, O. P., P. G. de Ruyter, M. Kleerebezem, and W. M. de Vos. 1997. Controlled overproduction of proteins by lactic acid bacteria. Trends Biotechnol. 15:135-140.
24. Leenhouts, K., A. Bolhuis, G. Venema, and J. Kok. 1998. Construction of a food-grade multi-copy integration system for Lactococcus lactis. Appl. Microbiol. Biotechnol. 49:249-256.
25. Li, B., et al. 2010. Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria. Proc. Natl. Acad. Sci. U. S. A. 107:10430-10435.
26. Li, B., J. P. Yu, J. S. Brunzelle, G. N. Moll, W. A. van der Donk, and S. K. Nair. 2006. Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis. Science 311:1464-1467.
27. Lubelski, J., R. Rink, R. Khusainov, G. N. Moll, and O. P. Kuipers. 2008. Biosynthesis, immunity, regulation, mode of action and engineering of the model lantibiotic nisin. Cell. Mol. Life Sci. 65:455-476.
28. McClerren, A. L., et al. 2006. Discovery and in vitro biosynthesis of haloduracin, a new two-component lantibiotic. Proc. Natl. Acad. Sci. U. S. A. 103:17243-17248.
29. Mulders, J. W. M., I. J. Boerrigter, H. S. Rollema, R. J. Siezen, and W. M. de Vos. 1991. Identification and characterization of the lantibiotic nisin Z, a natural nisin variant. Eur. J. Biochem. 301:581-584.
30. Nagao, J., et al. 2009. Mapping and identification of the region and secondary structure required for the maturation of the nukacin ISK-1 prepeptide. Peptides 30:1412-1420.
31. Neis, S., et al. 1997. Effect of leader peptide mutations on biosynthesis of the lantibiotic Pep5. FEMS Microbiol. Lett. 149:249-255.
32. Patton, G. C., M. Paul, L. E. Cooper, C. Chatterjee, and W. A. van der Donk. 2008. The importance of the leader sequence for directing lanthionine formation in lacticin 481. Biochemistry 47:7342-7351.
33. Petersen, J., et al. 2009. Identification and characterization of a bioactive lantibiotic produced by Staphylococcus warneri. Biol. Chem. 390:437-444.
34. Piard, J. C., O. P. Kuipers, H. S. Rollema, M. J. Desmaazeaud, and W. M. de Vos. 1993. Structure, organization, and expression of the lct gene for lacticin 481, a novel lantibiotic produced by Lactococcus lactis. J. Biol. Chem. 268:16361-16368.
35. Rajagopalan, P. T. R., A. Dattta, and D. Pei. 1997. Purification, characterization, and inhibition of peptide deformylase from Escherichia coli. Biochemistry 36:13910-13918.
36. Rink, R., et al. 2005. Lantibiotic structures as guidelines for the design of peptides that can be modified by lantibiotic enzymes. Biochemistry 44:8873-8882.
37. Rink, R., et al. 2007. Production of dehydroamino acid-containing peptides by Lactococcus lactis. Appl. Environ. Microbiol. 73:1792-1796.
38. Rink, R., et al. 2007. Dissection and modulation of the four distinct activities of nisin by mutagenesis of rings A and B and by C-terminal truncation. Appl. Environ. Microbiol. 73:5809-5816.
39. Rink, R., et al. 2007. NisC, the cyclase of the lantibiotic nisin, can catalyze cyclization of designed nonlantibiotic peptides. Biochemistry 46:13179-13189.
40. Sambrook, J., E. F. Fritsch, and A. Maniatis. 1989. Molecular cloning: A laboratory manual, 2nd ed. Cold Spring Laboratory Press, Cold Spring Harbor, NY.
41. Schägger, H., and G. von Jagow. 1987. Tricine-sodium dodecyl sulfatepolyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal. Biochem. 166:368-379.
42. Schnell, N., et al. 1989. Structural gene isolation and prepeptide sequence of gallidermin, a new lanthionine containing antibiotic. FEMS Microbiol. Lett. 58:263-268.
43. Schnell, N., et al. 1988. Prepeptide sequence of epidermin, a ribosomally synthesized antibiotic with four sulphide-rings. Nature 333:276-278.
44. Siezen, R. J., H. S. Rollema, O. P. Kuipers, and W. M. de Vos. 1995. Homology modelling of the Lactococcus lactis leader peptidase NisP and its interaction with the precursor of the lantibiotic nisin. Protein Eng. 8:117-125.
45. Simon, D., and A. Chopin. 1988. Construction of a vector plasmid family and its use for molecular cloning in Streptococcus lactis. Biochimie 70:559-566.
46. Stein, T., et al. 2002. Two different lantibiotic-like peptides originate from the ericin gene cluster of Bacillus subtilis A1/3. J. Bacteriol. 184:1703-1711.
47. Terzaghi, B. E., and W. E. Sandine. 1975. Improved medium for lactic streptococci and their bacteriophages. Appl. Microbiol. 29:807-813.
48. Van de Kamp, M., et al. 1995. Elucidation of the primary structure of the lantibiotic epilancin K7 from Staphylococcus epidermis K7-cloning of the epilancin-K7-encoding gene and NMR analysis of mature epilancin K7. Eur. J. Biochem. 230:587-600.
49. Van der Meer, J. R., et al. 1994. Influence of amino acid substitutions in the nisin leader peptide on biosynthesis and secretion of nisin by Lactococcus lactis. J. Biol. Chem. 269:3555-3562.
50. Wescombe, P. A., N. C. K. Heng, J. P. Burton, and J. R. Tagg. 2010. Something old and something new: An update on the amazing repertoire of bacteriocins produced by Streptococcus salivarius. Probiotics Antimicrob. Proteins 2:37-45.
51. Widdick, D. A., et al. 2003. Cloning and engineering of the cinnamycin biosynthetic gene cluster from Streptomyces cinnamoneus cinnamoneus DSM 40005. Proc. Natl. Acad. Sci. U. S. A. 100:4316-4321.
52. Willey, J. M., and W. A. van der Donk. 2007. Lantibiotics: Peptides of diverse structure and function. Annu. Rev. Microbiol. 61:477-501.
53. Wirawan, R. E., N. A. Klesse, R. W. Jack, and J. R. Tagg. 2006. Molecular and genetic characterization of a novel nisin variant produced by Streptococcus uberis. Appl. Environ. Microbiol. 72:1148-1156.
54. Zendo, T., et al. 2003. Identification of the lantibiotic nisin Q, a new natural nisin variant produced by Lactococcus lactis 61-14 isolated from a river in Japan. Biosci. Biotechnol. Biochem. 67:1616-1619.