Antimuscarinic mechanisms and the overactive detrusor: An update

European Urology

Volumn 59, Issue 3, 2011, Pages 377-386

  Andersson, Karl Erik ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Acetylcholine release; Muscarinic receptors; Overactive bladder (OAB) syndrome; Urine storage; Urothelium

Indexed keywords

ADENOSINE TRIPHOSPHATE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT;

ACETYLCHOLINE RELEASE; AGING; BLADDER FUNCTION; BLADDER NECK STENOSIS; CHOLINERGIC ACTIVITY; CHOLINERGIC TRANSMISSION; DIABETES MELLITUS; EFFERENT NERVE; HUMAN; IMMUNOHISTOCHEMISTRY; INTERSTITIAL CELL OF CAJAL; INTERSTITIAL CYSTITIS; LAMINA PROPRIA; MEDLINE; NONHUMAN; OUTCOME ASSESSMENT; OVERACTIVE BLADDER; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SENSORY NERVE; SIGNAL TRANSDUCTION;

ANIMALS; HUMANS; MUSCARINIC ANTAGONISTS; URINARY BLADDER, OVERACTIVE; UROLOGY;

EID: 79551485468     PISSN: 03022838     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eururo.2010.11.040     Document Type: Review

References (117)

1. K.E. Andersson, C.R. Chapple, and L. Cardozo Pharmacological treatment of overactive bladder: report from the International Consultation on Incontinence Curr Opin Urol 19 2009 380 394
2. K.-E. Andersson, and M. Yoshida Antimuscarinics and the overactive detrusor - which is the main mechanism of action? Eur Urol 43 2003 1 5
3. K.E. Andersson, and A. Arner Urinary bladder contraction and relaxation: physiology and pathophysiology Physiol Rev 84 2004 935 986
4. K.E. Andersson Antimuscarinics for treatment of overactive bladder Lancet Neurol 3 2004 46 53
5. P. Abrams, S. Kaplan, H.J. De Koning Gans, and R. Millard Safety and tolerability of tolterodine for the treatment of overactive bladder in men with bladder outlet obstruction J Urol 175 2006 999 1004
6. P. Abrams, and K.E. Andersson Muscarinic receptor antagonists for overactive bladder BJU Int 100 2007 987 1006
7. D. Giglio, and G. Tobin Muscarinic receptor subtypes in the lower urinary tract Pharmacology 83 2009 259 269
8. K.S. Lips, J. Wunsch, and S. Zarghooni Acetylcholine and molecular components of its synthesis and release machinery in the urothelium Eur Urol 51 2007 1042 1053
9. A.T. Hanna-Mitchell, J.M. Beckel, S. Barbadora, A.J. Kanai, W.C. de Groat, and L.A. Birder Non-neuronal acetylcholine and urinary bladder urothelium Life Sci 80 2007 2298 2302
10. S. Sigala, G. Mirabella, and A. Peroni Differential gene expression of cholinergic muscarinic receptor subtypes in male and female normal human urinary bladder Urology 60 2002 719 725
11. T. Bschleipfer, K. Schukowski, and W. Weidner Expression and distribution of cholinergic receptors in the human urothelium Life Sci 80 2007 2303 2307
12. R.M. Eglen, S.S. Hegde, and N. Watson Muscarinic receptor subtypes and smooth muscle function Pharmacol Rev 48 1996 531 565
13. K.E. Andersson, F. Holmquist, M. Fovaeus, H. Hedlund, and R. Sundler Muscarinic receptor stimulation of phosphoinositide hydrolysis in the human isolated urinary bladder J Urol 146 1991 1156 1159
14. D.R. Harriss, K.A. Marsh, A.T. Birmingham, and S.J. Hill Expression of muscarinic M3-receptors coupled to inositol phospholipid hydrolysis in human detrusor cultured smooth muscle cells J Urol 154 1995 1241 1245
15. T. Schneider, C. Fetscher, S. Krege, and M.C. Michel Signal transduction underlying carbachol-induced contraction of human urinary bladder J Pharmacol Exp Ther 309 2004 1148 1153
16. K.-E. Andersson Detrusor contraction - focus on muscarinic receptors Scand J Urol Nephrol Suppl 2004 54 57
17. S.S. Hegde, A. Choppin, and D. Bonhaus Functional role of M-2 and M-3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo Br J Pharmacol 120 1997 1409 1418
18. A.D. Bonev, and M.T. Nelson Muscarinic inhibition of ATP-sensitive K+ channels by protein kinase C in urinary bladder smooth muscle Am J Physiol 265 1993 C1623 C1628
19. T. Nakamura, J. Kimura, and O. Yamaguchi Muscarinic M2 receptors inhibit Ca2+-activated K+ channels in rat bladder smooth muscle Int J Urol 9 2002 689 696
20. M.E. Werner, A.M. Knorn, A.L. Meredith, R.W. Aldrich, and M.T. Nelson Frequency encoding of cholinergic- and purinergic-mediated signaling to mouse urinary bladder smooth muscle: modulation by BK channels Am J Physiol Regul Integr Comp Physiol 292 2007 R616 R624
21. M.I. Kotlikoff, P. Dhulipala, and Y.X. Wang M2 signaling in smooth muscle cells Life Sci 64 1999 437 442
22. M. Yamamoto, T. Unno, and H. Matsuyama Two types of cation channel activated by stimulation of muscarinic receptors in guinea-pig urinary bladder smooth muscle J Pharmacol Sci 108 2008 248 257
23. N. Yoshimura, Y. Kaiho, and M. Miyazato Therapeutic receptor targets for lower urinary tract dysfunction Naunyn Schmiedebergs Arch Pharmacol 377 2008 437 448
24. S. Tyagi, P. Tyagi, S. Van-le, N. Yoshimura, M.B. Chancellor, and F. de Miguel Qualitative and quantitative expression profile of muscarinic receptors in human urothelium and detrusor J Urol 176 2006 1673 1678
25. K.J. Mansfield, L. Liu, F.J. Mitchelson, K.H. Moore, R.J. Millard, and E. Burcher Muscarinic receptor subtypes in human bladder detrusor and mucosa, studied by radioligand binding and quantitative competitive RT-PCR: changes in ageing Br J Pharmacol 144 2005 1089 1099
26. G. Mukerji, Y. Yiangou, and J. Grogono Localization of M2 and M3 muscarinic receptors in human bladder disorders and their clinical correlations J Urol 176 2006 367 373
27. S. Grol, P.B. Essers, G.A. van Koeveringe, P. Martinez-Martinez, J. de Vente, and J.I. Gillespie M(3) muscarinic receptor expression on suburothelial interstitial cells BJU Int 104 2009 398 405
28. G. Jositsch, T. Papadakis, R.V. Haberberger, M. Wolff, J. Wess, and W. Kummer Suitability of muscarinic acetylcholine receptor antibodies for immunohistochemistry evaluated on tissue sections of receptor gene-deficient mice Naunyn Schmiedebergs Arch Pharmacol 379 2009 389 395
29. G.P. Sui, S. Rothery, E. Dupont, C.H. Fry, and N.J. Severs Gap junctions and connexin expression in human suburothelial interstitial cells BJU Int 90 2002 118 129
30. G.P. Sui, C. Wu, and C.H. Fry Electrical characteristics of suburothelial cells isolated from the human bladder J Urol 171 2004 938 943
31. K.D. McCloskey Interstitial cells in the urinary bladder - localization and function Neurourol Urodyn 29 2010 82 87
32. P. Wang, G.R. Luthin, and M.R. Ruggieri Muscarinic acetylcholine receptor subtypes mediating urinary bladder contractility and coupling to GTP binding proteins J Pharmacol Exp Ther 273 1995 959 966
33. T. Yamanishi, C.R. Chapple, K. Yasuda, and R. Chess-Williams The role of M2-muscarinic receptors in mediating contraction of the pig urinary bladder in vitro Br J Pharmacol 131 2000 1482 1488
34. A.F. Brading, and K.D. McCloskey Mechanisms of disease: specialized interstitial cells of the urinary tract - an assessment of current knowledge Nat Clin Pract Urol 2 2005 546 554
35. H. Hashitani, and R.J. Lang Functions of ICC-like cells in the urinary tract and male genital organs J Cell Mol Med 14 2010 1199 1211
36. L. Johnston, S. Woolsey, and R.M. Cunningham Morphological expression of KIT positive interstitial cells of Cajal in human bladder J Urol 184 2010 370 377
37. R. Nandigama, M. Bonitz, T. Papadakis, U. Schwantes, T. Bschleipfer, and W. Kummer Muscarinic acetylcholine receptor subtypes expressed by mouse bladder afferent neurons Neuroscience 168 2010 842 850
38. G. D'Agostino, M.L. Bolognesi, and A. Lucchelli Prejunctional muscarinic inhibitory control of acetylcholine release in the human isolated detrusor: involvement of the M4 receptor subtype Br J Pharmacol 129 2000 493 500
39. G.T. Somogyi, and W.C. de Groat Function, signal transduction mechanisms and plasticity of presynaptic muscarinic receptors in the urinary bladder Life Sci 64 1999 411 418
40. S.M. Finney, K.E. Andersson, J.I. Gillespie, and L.H. Stewart Antimuscarinic drugs in detrusor overactivity and the overactive bladder syndrome: motor or sensory actions? BJU Int 98 2006 503 507
41. K.E. Andersson Detrusor myocyte activity and afferent signaling Neurourol Urodyn 29 2010 97 106
42. M.J. Drake, I.J. Harvey, J.I. Gillespie, and W.A. Van Duyl Localized contractions in the normal human bladder and in urinary urgency BJU Int 95 2005 1002 1005
43. W.C. de Groat, A.M. Booth, and N. Yoshimura Neurophysiology of micturition and its modification in animal models of human disease C.A. Maggi, Nervous control of the urogenital system 1993 Harwood Academic London, UK 227 290
44. J.I. Gillespie The autonomous bladder: a view of the origin of bladder overactivity and sensory urge BJU Int 93 2004 478 483
45. J.I. Gillespie A developing view of the origins of urgency: the importance of animal models BJU Int 96 Suppl 1 2005 22 28
46. J.I. Gillespie, G.A. van Koeveringe, S.G. de Wachter, and J. de Vente On the origins of the sensory output from the bladder: the concept of afferent noise BJU Int. 103 2009 1324 1333
47. A. Avelino, C. Cruz, I. Nagy, and F. Cruz Vanilloid receptor 1 expression in the rat urinary tract Neuroscience 109 2002 787 798
48. O. Yokoyama, A. Yusup, Y. Miwa, N. Oyama, Y. Aoki, and H. Akino Effects of tolterodine on an overactive bladder depend on suppression of C-fiber bladder afferent activity in rats J Urol 174 2005 2032 2036
49. P. Hedlund, T. Streng, T. Lee, and K.E. Andersson Effects of tolterodine on afferent neurotransmission in normal and resiniferatoxin treated conscious rats J Urol 178 2007 326 331
50. S. De Wachter, and J.J. Wyndaele Intravesical oxybutynin: a local anesthetic effect on bladder C afferents J Urol 169 2003 1892 1895
51. K. De Laet, S. De Wachter, and J.J. Wyndaele Systemic oxybutynin decreases afferent activity of the pelvic nerve of the rat: new insights into the working mechanism of antimuscarinics Neurourol Urodyn 25 2006 156 161
52. K. Iijima, S. De Wachter, and J.-J. Wyndaele Effects of the M3 receptor selective muscarinic antagonist darifenacin on bladder afferent activity of the rat pelvic nerve Eur Urol 52 2007 842 849
53. K.E. Andersson Bladder activation: afferent mechanisms Urology 59 Suppl 1 2002 43
54. L.A. Birder, and W.C. de Groat Mechanisms of disease: involvement of the urothelium in bladder dysfunction Nat Clin Pract Urol 4 2007 46 54
55. Yokoyama O, Tanaka I, Kusukawa N, et al. Antimuscarinics suppress ATP and prostaglandin E2 release from the urothelium, with resultant improvement of detrusor overactivity in rats with cerebral infarction. J Urol. In press.
56. Y. Yu, and W.C. de Groat Effects of stimulation of muscarinic receptors on bladder afferent nerves in the in vitro bladder-pelvic afferent nerve preparation of the rat Brain Res 1361 2010 43 53
57. Y. Kim, N. Yoshimura, and H. Masuda Intravesical instillation of human urine after oral administration of trospium, tolterodine and oxybutynin in a rat model of detrusor overactivity BJU Int 97 2006 400 403
58. Y. Kim, N. Yoshimura, and H. Masuda Antimuscarinic agents exhibit local inhibitory effects on muscarinic receptors in bladder-afferent pathways Urology 65 2005 238 242
59. P. Walter, J. Grosse, and A.M. Bihr Bioavailability of trospium chloride after intravesical instillation in patients with neurogenic lower urinary tract dysfunction: a pilot study Neurourol Urodyn 18 1999 447 453
60. G. Frohlich, S. Burmeister, A. Wiedemann, and M. Bulitta Intravesical instillation of trospium chloride, oxybutynin and verapamil for relaxation of the bladder detrusor muscle. A placebo controlled, randomized clinical test [in German] Arzneimittelforschung 48 1998 486 491
61. Y. Matsumoto, M. Miyazato, and A. Furuta Differential roles of M2 and M3 muscarinic receptor subtypes in modulation of bladder afferent activity in rats Urology 75 2010 862 867
62. P.H. Smith, J.B. Cook, and E.W.M. Prasad The effect of Ubretid on bladder function after recent complete spinal cord injury Br J Urol 46 1974 187 192
63. O. Yossepowitch, G. Gillon, J. Baniel, D. Engelstein, and P.M. Livne The effect of cholinergic enhancement during filling cystometry: can edrophonium chloride be used as a provocative test for overactive bladder? J Urol 165 2001 1441 1445
64. T.D. Van Meel, S. De Wachter, and J.J. Wyndaele The effect of intravesical oxybutynin on the ice water test and on electrical perception thresholds in patients with neurogenic detrusor overactivity Neurourol Urodyn 29 2010 391 394
65. S. Boy, B. Schurch, U. Mehnert, G. Mehring, G. Karsenty, and A. Reitz The effects of tolterodine on bladder-filling sensations and perception thresholds to intravesical electrical stimulation: method and initial results BJU Int 100 2007 574 578
66. U. Mehnert, A. Reitz, M. Ziegler, P.A. Knapp, and B. Schurch Does tolterodine extended release affect the bladder electrical perception threshold? A placebo controlled, double-blind study with 4 and 8 mg in healthy volunteers J Urol 178 2007 2495 2500
67. U. Mehnert, A. Reitz, S.A. Youssef, and B. Schurch Proof of principle: the effect of antimuscarinics on bladder filling sensations in healthy subjects - a placebo controlled double blind investigation using 4 and 8 mg tolterodine extended release Neurourol Urodyn 29 2010 464 469
68. M.R. Ruggieri Sr., and A.S. Braverman Regulation of bladder muscarinic receptor subtypes by experimental pathologies Auton Autacoid Pharmacol 26 2006 311 325
69. M. Wuest, B. Eichhorn, M. Braeter, G. Strugala, M.C. Michel, and U. Ravens Muscarinic receptor expression and receptor-mediated detrusor contraction: comparison of juvenile and adult porcine tissue Pflugers Arch 456 2008 349 358
70. M.G. Kolta, L.J. Wallace, and M.C. Gerald Age-related changes in sensitivity of rat urinary bladder to autonomic agents Mech Ageing Dev 27 1984 183 188
71. G.A. Ordway, T.A. Esbenshade, M.G. Kolta, M.C. Gerald, and L.J. Wallace Effect of age on cholinergic muscarinic responsiveness and receptors in the rat urinary bladder J Urol 136 1986 492 496
72. A.L. Chun, L.J. Wallace, M.C. Gerald, A.J. Wein, and R.M. Levin Effects of age on urinary bladder function in the male rat J Urol 141 1989 170 173
73. M.K. Pagala, L. Tetsoti, D. Nagpal, and G.J. Wise Aging effects on contractility of longitudinal and circular detrusor and trigone of rat bladder J Urol 166 2001 721 727
74. W. Zhao, T. Aboushwareb, and C. Turner Impaired bladder function in aging male rats J Urol 184 2010 378 385
75. P. Lluel, S. Palea, and M. Barras Functional and morphological modifications of the urinary bladder in aging female rats Am J Physiol Regul Integr Comp Physiol 278 2000 R964 R972
76. T. Schneider, P. Hein, M.B. Michel-Reher, and M.C. Michel Effects of ageing on muscarinic receptor subtypes and function in rat urinary bladder Naunyn Schmiedebergs Arch Pharmacol 372 2005 71 78
77. H.I. Yu, A.J. Wein, and R.M. Levin Contractile responses and calcium mobilization induced by muscarinic agonists in the rat urinary bladder: effects of age Gen Pharmacol 28 1997 623 628
78. S.S. Hegde, D.A. Mandel, M.R. Wilford, S. Briaud, A.P. Ford, and R.M. Eglen Evidence for purinergic neurotransmission in the urinary bladder of pithed rats Eur J Pharmacol 349 1998 75 82
79. P. Lluel, V. Deplanne, D. Heudes, P. Bruneval, and S. Palea Age-related changes in urethrovesical coordination in male rats: relationship with bladder instability? Am J Physiol Regul Integr Comp Physiol 284 2003 R1287 R1295
80. O.E. Brodde, U. Konschak, and K. Becker Cardiac muscarinic receptors decrease with age. In vitro and in vivo studies J Clin Invest 101 1998 471 478
81. M.C. Michel, T. Schneider, S. Krege, and M. Goepel Does gender or age affect the efficacy and safety of tolterodine? J Urol 168 2002 1027 1031
82. D.R. Staskin Overactive bladder in the elderly: a guide to pharmacological management Drugs Aging 22 2005 1013 1028
83. A.S. Wagg, L. Cardozo, and C. Chapple Overactive bladder syndrome in older people BJU Int 99 2007 502 509
84. 2 muscarinic receptors in contraction Eur Urol 52 2007 531 538
85. K.J. Mansfield, L. Liu, K.H. Moore, K.J. Vaux, R.J. Millard, and E. Burcher Molecular characterization of M2 and M3 muscarinic receptor expression in bladder from women with refractory idiopathic detrusor overactivity BJU Int 99 2007 1433 1438
86. J.M. Restorick, and A.R. Mundy The density of cholinergic and alpha and beta adrenergic receptors in the normal and hyper-reflexic human detrusor Br J Urol 63 1989 32 35
87. R.B. Kinder, and A.R. Mundy Pathophysiology of idiopathic detrusor instability and detrusor hyper-reflexia. An in vitro study of human detrusor muscle Br J Urol 60 1987 509 515
88. D.I. Gup, M. Baumann, H. Lepor, and E. Shapiro Muscarinic cholinergic receptors in normal pediatric and myelodysplastic bladders J Urol 142 1989 595 599 discussion 603-5
89. K. German, J. Bedwani, J. Davies, A.F. Brading, and T.P. Stephenson Physiological and morphometric studies into the pathophysiology of detrusor hyperreflexia in neuropathic patients J Urol 153 1995 1678 1683
90. B. Amend, J. Hennenlotter, T. Schäfer, M. Horstmann, A. Stenzl, and K.-D. Sievert Effective treatment of neurogenic detrusor dysfunction by combined high-dosed antimuscarinics without increased side-effects Eur Urol 53 2008 1021 1028
91. S. Bolduc, K. Moore, S. Lebel, P. Lamontagne, and M. Hamel Double anticholinergic therapy for refractory overactive bladder J Urol 182 Suppl 2009 2033 2038
92. J.A. Gosling, S.A. Gilpin, J.S. Dixon, and C.J. Gilpin Decrease in the autonomic innervation of human detrusor muscle in outflow obstruction J Urol 136 1986 501 504
93. G.N. Sibley The physiological response of the detrusor muscle to experimental bladder outflow obstruction in the pig Br J Urol 60 1987 332 336
94. M.J. Speakman, A.F. Brading, C.J. Gilpin, J.S. Dixon, S.A. Gilpin, and J.A. Gosling Bladder outflow obstruction - a cause of denervation supersensitivity J Urol 138 1987 1461 1466
95. R.K. Pandita, M. Fujiwara, P. Alm, and K.-E. Andersson Cystometric evaluation of bladder function in non-anesthetized mice with and without bladder outlet obstruction J Urol 164 2000 1385 1389
96. G.N. Sibley A comparison of spontaneous and nerve-mediated activity in bladder muscle from man, pig and rabbit J Physiol 354 1984 431 443
97. S.C.V. Harrison, G.R. Hunnam, P. Farman, and P.T. Doyle Bladder instability and denervation in patients with bladder outflow obstruction Br J Urol 60 1987 519 522
98. N. Takahashi, H. Shiomi, and N. Kushida Obstruction alters muscarinic receptor-coupled RhoA/Rho-kinase pathway in the urinary bladder of the rat Neurourol Urodyn 28 2009 257 262
99. O. Yokoyama, K. Nagano, K. Kawaguchi, and H. Hisazumi The response of the detrusor muscle to acetylcholine in patients with infravesical obstruction Urol Res 19 1991 117 121
100. C. Sjögren, K.E. Andersson, S. Husted, A. Mattiasson, and B. Moller-Madsen Atropine resistance of transmurally stimulated isolated human bladder muscle J Urol 128 1982 1368 1371
101. M. Bayliss, C. Wu, D. Newgreen, A.R. Mundy, and C.H. Fry A quantitative study of atropine-resistant contractile responses in human detrusor smooth muscle, from stable, unstable and obstructed bladders J Urol 162 1999 1833 1839
102. M. Tagliani, S.M. Candura, and A. Di Nucci A re-appraisal of the nature of the atropine-resistant contraction to electrical field stimulation in the human isolated detrusor muscle Naunyn Schmiedebergs Arch Pharmacol 356 1997 750 755
103. V.P. Krichevsky, M.K. Pagala, I. Vaydovsky, V. Damer, and G.J. Wise Function of M3 muscarinic receptors in the rat urinary bladder following partial outlet obstruction J Urol 161 1999 1644 1650
104. A.S. Braverman, and M.R. Ruggieri Sr. Hypertrophy changes the muscarinic receptor subtype mediating bladder contraction from M3 toward M2 Am J Physiol Regul Integr Comp Physiol 285 2003 R701 R708
105. S.A. Kaplan, C.G. Roehrborn, E.S. Rovner, M. Carlsson, T. Bavendam, and Z. Guan Tolterodine and tamsulosin for treatment of men with lower urinary tract symptoms and overactive bladder: a randomized controlled trial JAMA 296 2006 2319 2328
106. C. Chapple Antimuscarinics in men with lower urinary tract symptoms suggestive of bladder outlet obstruction due to benign prostatic hyperplasia Curr Opin Urol 20 2010 43 48
107. S.A. Kaplan, A.E. Te, and J.G. Blaivas Urodynamic findings in patients with diabetic cystopathy J Urol 153 1995 342 344
108. J. Latifpour, A. Gousse, S. Kondo, T. Morita, and R.M. Weiss Effects of experimental diabetes on biochemical and functional characteristics of bladder muscarinic receptors J Pharmacol Exp Ther 248 1989 81 88
109. H. Mimata, M.A. Wheeler, and Y. Fukomoto Enhancement of muscarinic receptor-coupled phosphatidyl inositol hydrolysis in diabetic bladder Mol Cell Biochem 152 1995 71 76
110. H. Hashitani, and H. Suzuki Altered electrical properties of bladder smooth muscle in streptozotocin-induced diabetic rats Br J Urol 77 1996 798 804
111. L.A. Stevens, D.J. Sellers, N.G. McKay, C.R. Chapple, and R. Chess-Williams Muscarinic receptor function, density and G-protein coupling in the overactive diabetic rat bladder Auton Autacoid Pharmacol 26 2006 303 309
112. Y.C. Tong, J.T. Cheng, and C.T. Hsu Alterations of M(2)-muscarinic receptor protein and mRNA expression in the urothelium and muscle layer of the streptozotocin-induced diabetic rat urinary bladder Neurosci Lett 406 2006 216 221
113. J.T. Cheng, B.C. Yu, and Y.C. Tong Changes of M3-muscarinic receptor protein and mRNA expressions in the bladder urothelium and muscle layer of streptozotocin-induced diabetic rats Neurosci Lett 423 2007 1 5
114. K.J. Pak, R.S. Ostrom, M. Matsui, and F.J. Ehlert The M2-muscarinic receptor inhibits the development of streptozotocin-induced neuropathy in mouse urinary bladder J Pharmacol Exp Ther 335 2010 239 248
115. K. Höfner, M. Burkart, G. Jacob, and U. Jonas Symptomatic and quality of life response to tolterodine in subgroups of men with overactive bladder symptoms and presumed non-obstructive benign prostatic hyperplasia World J Urol 28 2010 353 357
116. G.N. Gupta, S.G. Lu, M.S. Gold, and T.C. Chai Bladder urothelial cells from patients with interstitial cystitis have an increased sensitivity to carbachol Neurourol Urodyn 28 2009 1022 1027
117. Y. Ikeda, L. Birder, C. Buffington, J. Roppolo, and A. Kanai Mucosal muscarinic receptors enhance bladder activity in cats with feline interstitial cystitis J Urol 181 2009 1415 1422