Detrusor contraction: Focus on muscarinic receptors

Scandinavian Journal of Urology and Nephrology, Supplement

Volumn 38, Issue 215, 2004, Pages 54-57

  Andersson, Karl Erik ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Acetylcholine; Bladder; Calcium sensitivity; Contractile proteins; Signal transduction

Indexed keywords

ADENYLATE CYCLASE; CALCIUM; CALCIUM CHANNEL L TYPE; G PROTEIN COUPLED RECEPTOR; G Q 11 PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL TRISPHOSPHATE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; MUSCARINIC RECEPTOR; MYOSIN LIGHT CHAIN PHOSPHATASE; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITIDE; PROTEIN; RHO KINASE; UNCLASSIFIED DRUG;

CALCIUM MOBILIZATION; CONFERENCE PAPER; DETRUSOR MUSCLE; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; MICTURITION DISORDER; MUSCLE CONTRACTION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; ANIMAL; BLADDER; PHYSIOLOGY; REVIEW; SMOOTH MUSCLE;

ANIMALS; HUMANS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; RECEPTORS, MUSCARINIC; URINARY BLADDER;

EID: 9244260506     PISSN: 03008886     EISSN: None     Source Type: Journal    
DOI: 10.1080/03008880410015192     Document Type: Conference Paper

References (38)

1. Andersson KE. Pharmacology of lower urinary tract smooth muscles and penile erectile tissues. Pharmacol Rev 1993; 45: 253-308.
2. De Groat WC, Yoshimura N. Pharmacology of the lower urinary tract. Annu Rev Pharmacol Toxicol 2001; 41: 691-721.
3. Andersson K-E, Arner A. Detrusor smooth muscle-physiology and pathophysiology of contraction and relaxation. Physiol Rev 2004; 84: 935-86.
4. Andersson KE, Holmquist F, Fovaeus M, Hedlund H, Sundler R. Muscarinic receptor stimulation of phosphoinositide hydrolysis in the human isolated urinary bladder. J Urol 1991; 146: 1156-9.
5. 3-receptors coupled to inositol phospholipid hydrolysis in human detrusor cultured smooth muscle cells. J Urol 1995; 154: 1241-5.
6. Andersson K-E. Pathways for relaxation of detrusor smooth muscle. Adv Exp Med Biol 1999; 462: 241-52.
7. Andersson K-E, Wein AJ. Pharmacology of the lower urinary tract-basis for current treatment of urinary incontinence. Pharmacol Rev 2004; in press.
8. 3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol 1997; 120: 1409-18.
9. Sigala S, Mirabella G, Peroni A, Pezzotti G, Simeone C, Spano P, Cunico SC. Differential gene expression of cholinergic muscarinic receptor subtypes in male and female normal human urinary bladder. Urology 2002; 60: 719-25.
10. Yamaguchi O, Shishido K, Tamura K, Ogawa T, Fujimura T, Ohtsuka M. Evaluation of mRNAs encoding muscarinic receptor subtypes in human detrusor muscle. J Urol 1996; 156: 1208-13.
11. Hegde SS, Eglen RM. Muscarinic receptor subtypes modulating smooth muscle contractility in the urinary bladder. Life Sci 1999; 64: 419-28.
12. Chess-Williams R. Muscarinic receptors of the urinary bladder: detrusor, urothelial and prejunctional. Auton Autacoid Pharmacol 2002; 22: 133-45.
13. Gillespie JI, Harvey IJ, Drake MJ. Agonist- and nerve-induced phasic activity in the isolated whole bladder of the guinea pig: evidence for two types of bladder activity. Exp Physiol 2003; 88: 343-57.
14. 3 receptors? Naunyn-Schmiedebergs Arch Pharmacol 2003; 367: 524-31.
15. 3 subtype. Proc Natl Acad Sci USA 2000; 97: 9579-84.
16. 2 muscarinic receptor contributes to contraction of the denervated rat urinary bladder. Am J Physiol 1998; 275: R1654-60.
17. 2 receptors in genito-urinary smooth muscle pathology. Life Sci 1999; 64: 429-36.
18. Braverman AS, Tallarida RJ, Ruggieri MR Sr. Interaction between muscarinic receptor subtype signal transduction pathways mediating bladder contraction. Am J Physiol Regul Integr Comp Physiol 2002; 283: R663-8.
19. 2. Am J Physiol Regul Integr Comp Physiol 2003; 285: R701-8.
20. 2 muscarinic receptor mediates in vitro bladder contractions from patients with neurogenic bladder dysfunction. Am J Physiol Regul Integr Comp Physiol. 2004; 286: R874-80 (e-pub 2004; Jan 29).
21. Eglen RM, Hegde SS, Watson N. Muscarinic receptor subtypes and smooth muscle function. Pharmacol Rev 1996; 48: 531-65.
22. An JY, Yun HS, Lee YP, Yang SJ, Shim JO, Jeong JH, et al. The intracellular pathway of the acetylcholine-induced contraction in cat detrusor muscle cells. Br J Pharmacol 2002; 137: 1001-10.
23. Jezior JR, Brady JD, Rosenstein DI, McCammon KA, Miner AS, Ratz PH. Dependency of detrusor contractions on calcium sensitization and calcium entry through LOE-908-sensitive channels. Br J Pharmacol 2001; 134: 78-87.
24. Wibberley A, Chen Z, Hu E, Hieble JP, Westfall TD. Expression and functional role of Rho-kinase in rat urinary bladder smooth muscle. Br J Pharmacol 2003; 138: 757-66.
25. Fleischmann M, Schneider T, Fetscher C, Michel MC. Signal transduction underlying carbachol-induced contraction of rat urinary bladder. II. Protein kinases. J Pharmacol Exp Ther 2004; 308: 54-8.
26. Schneider T, Fetscher C, Krege S, Michel MC. Signal transduction underlying carbachol-induced contraction of human urinary bladder. J Pharmacol Exp Ther 2004; 308: 47-53.
27. Fovaeus M, Andersson KE, Batra S, Morgan E, Sjögren C. Effects of calcium, calcium channel blockers and Bay K 8644 on contractions induced by muscarinic receptor stimulation of isolated bladder muscle from rabbit and man. J Urol 1987; 137: 798-803.
28. Hashitani H, Bramich NJ, Hirst GD. Mechanisms of excitatory neuromuscular transmission in the guinea-pig urinary bladder. J Physiol 2000; 524: 565-79.
29. Mostwin JL. Receptor operated intracellular calcium stores in the smooth muscle of the guinea pig bladder. J Urol 1985; 133: 900-5.
30. Iacovou JW, Hill SJ, Birmingham AT. Agonist-induced contraction and accumulation of inositol phosphates in the guinea-pig detrusor: evidence that muscarinic and purinergic receptors raise intracellular calcium by different mechanisms. J Urol 1990; 144: 775-9.
31. 2 receptor knockout mice. J Pharmacol Exp Ther 2003; 305: 106-13.
32. 2 receptors in cholinergic and purinergic responses in the rat urinary bladder. Eur J Pharmacol 2001; 428: 357-64.
33. 2 signaling in smooth muscle cells. Life Sci 1999; 64: 437-442.
34. Bonev AD, Nelson MT. ATP-sensitive potassium channels in smooth muscle cells from guinea pig urinary bladder. Am J Physiol 1993; 264: C1190-200.
35. + channels in rat bladder smooth muscle. Int J Urol 2002; 9: 689-696.
36. Fovaeus M, Fujiwara M, Hogestatt ED, Persson K, Andersson KE. A non-nitrergic smooth muscle relaxant factor released from rat urinary bladder by muscarinic receptor stimulation. J Urol 1999; 161: 649-53.
37. Hawthorn MH, ChappLe CR, Cock M, Chess-Williams R. Urothelium-derived inhibitory factor(s) influences on detrusor muscle contractility in vitro. Br J Pharmacol 2000; 129: 416-9.
38. Chaiyaprasithi B, Mang CF, Kilbinger H, Hohenfellner M. Inhibition of human detrusor contraction by a urothelium derived factor. J Urol 2003; 170: 1897-900.