Functions of ICC-like cells in the urinary tract and male genital organs

Journal of Cellular and Molecular Medicine

Volumn 14, Issue 6 A, 2010, Pages 1199-1211

  Hashitani, Hikaru ^a   Lang, Richard J ^b  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Bladder; Corpus cavernosum; Interstitial cells of Cajal like cells; Prostate; Renal pelvis; Urethra; Urogenital tract

Indexed keywords

ANIMAL; ANTIBODY SPECIFICITY; CYTOLOGY; HUMAN; INTERSTITIAL CELL OF CAJAL; MALE; MALE GENITAL SYSTEM; METABOLISM; REVIEW; URINARY TRACT;

ANIMALS; GENITALIA, MALE; HUMANS; INTERSTITIAL CELLS OF CAJAL; MALE; ORGAN SPECIFICITY; URINARY TRACT;

EID: 77953945883     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2010.01043.x     Document Type: Review

References (83)

1. Sanders KM, Koh SD, Ward SM. Interstitial cells of Cajal as pacemakers in the gastrointestinal tract. Annu Rev Physiol. 2006, 68:307-43.
2. Brading AF, McCloskey KD. Mechanisms of disease: specialized interstitial cells of the urinary tract-an assessment of current knowledge. Nat Clin Pract Urol. 2005, 2:546-54.
3. McCloskey KD, Anderson UA, Davidson RA. Comparison of mechanical and electrical activity and interstitial cells of Cajal in urinary bladders from wild-type and W/Wv mice. Br J Pharmacol. 2009, 156:273-83.
4. Johnston L, Sergeant GP, Hollywood MA. Calcium oscillations in interstitial cells of the rabbit urethra. J Physiol. 2005, 565:449-61.
5. Hashitani H, Suzuki H. Properties of spontaneous Ca2+ transients recorded from interstitial cells of Cajal-like cells of the rabbit urethra in situ. J Physiol. 2007, 583:505-19.
6. Lang RJ, Hashitani H, Tonta MA. Spontaneous electrical and Ca2+ signals in typical and atypical smooth muscle cells and interstitial cell of Cajal-like cells of mouse renal pelvis. J Physiol. 2007, 583:1049-68.
7. Hashitani H, Yanai Y, Suzuki H. Role of interstitial cells and gap junctions in the transmission of spontaneous Ca2+ signals in detrusor smooth muscles of the guinea-pig urinary bladder. J Physiol. 2004, 559:567-81.
8. Hashitani H, Brading AF, Suzuki H. Correlation between spontaneous electrical, calcium and mechanical activity in detrusor smooth muscle of the guinea-pig bladder. Br J Pharmacol. 2004, 141:183-93.
9. Lang RJ, Hashitani H, Tonta MA. Role of Ca2+ entry and Ca2+ stores in atypical smooth muscle cell autorhythmicity in the mouse renal pelvis. Br J Pharmacol. 2007, 152:1248-59.
10. Montgomery BS, Fry CH. The action potential and net membrane currents in isolated human detrusor smooth muscle cells. J Urol. 1992, 147:176-84.
11. Karkanis T, DeYoung L, Brock GB. Ca2+-activated Cl- channels in corpus cavernosum smooth muscle: a novel mechanism for control of penile erection. J Appl Physiol. 2003, 94:301-13.
12. Craven M, Sergeant GP, Hollywood MA. Modulation of spontaneous Ca2+-activated Cl- currents in the rabbit corpus cavernosum by the nitric oxide-cGMP pathway. J Physiol. 2004, 556:495-506.
13. Wu C, Sui GP, Fry CH. Purinergic regulation of guinea pig suburothelial myofibroblasts. J Physiol. 2004, 559:231-43.
14. Lang RJ, Hashitani H, Tonta MA. Spontaneous electrical and Ca signals in the mouse renal pelvis that drive pyeloureteric peristalsis. Clin Exp Pharmacol Physiol. 2010, 37:509-15.
15. Davidson RA, McCloskey KD. Morphology and localization of interstitial cells in the guinea pig bladder: structural relationships with smooth muscle and neurons. J Urol. 2005, 173:1385-90.
16. Lyons AD, Gardiner TA, McCloskey KD. Kit-positive interstitial cells in the rabbit urethra: structural relationships with nerves and smooth muscle. BJU Int. 2007, 99:687-94.
17. Kubota Y, Hashitani H, Shirasawa N. Altered distribution of interstitial cells in the guinea pig bladder following bladder outlet obstruction. Neurourol Urodyn. 2008, 27:330-40.
18. Sergeant GP, Thornbury KD, McHale NG. Characterization of norepinephrine-evoked inward currents in interstitial cells isolated from the rabbit urethra. Am J Physiol Cell Physiol. 2002, 283:C885-94.
19. Johnston L, Carson C, Lyons AD. Cholinergic-induced Ca2+ signaling in interstitial cells of Cajal from the guinea pig bladder. Am J Physiol Renal Physiol. 2008, 294:F645-55.
20. Smet PJ, Jonavicius J, Marshall VR. Distribution of nitric oxide synthase-immunoreactive nerves and identification of the cellular targets of nitric oxide in guinea-pig and human urinary bladder by cGMP immunohistochemistry. Neuroscience. 1996, 71:337-48.
21. Gosling JA, Dixon JS. The structure and innervation of smooth muscle in the wall of the bladder neck and proximal urethra. Br J Urol. 1975, 47:549-8.
22. Exintaris B, Lang RJ. Effects of nerve stimulation on spontaneously active preparations of the guinea pig ureter. Urol Res. 1999, 27:328-35.
23. Lang RJ, Exintaris B, Teele ME. Electrical basis of peristalsis in the mammalian upper urinary tract. Clin Exp Pharmacol Physiol. 1998, 25:310-21.
24. Sui G, Fry CH, Malone-Lee J. Aberrant Ca2+ oscillations in smooth muscle cells from overactive human bladders. Cell Calcium. 2009, 45:456-64.
25. Biers SM, Reynard JM, Doore T. The functional effects of a c-kit tyrosine inhibitor on guinea-pig and human detrusor. BJU Int. 2006, 97:612-6.
26. Hashitani H, Hayase M, Suzuki H. Effects of imatinib mesylate on spontaneous electrical and mechanical activity in smooth muscle of the guinea-pig stomach. Br J Pharmacol. 2008, 154:451-9.
27. Chang IY, Glasgow NJ, Takayama I. Loss of interstitial cells of Cajal and development of electrical dysfunction in murine small bowel obstruction. J Physiol. 2001, 536:555-68.
28. Solari V, Piotrowska AP, Puri P. Altered expression of interstitial cells of Cajal in congenital ureteropelvic junction obstruction. J Urol. 2003, 170:2420-2.
29. Sanders KM, Ward SM. Kit mutants and gastrointestinal physiology. J Physiol. 2007, 578:33-42.
30. Rasmussen H, Hansen A, Smedts F. CD34-positive interstitial cells of the human detrusor. APMIS. 2007, 115:1260-6.
31. Yanai Y, Hashitani H, Hayase M. Role of nitric oxide/cyclic GMP pathway in regulating spontaneous excitations in detrusor smooth muscle of the guinea-pig bladder. Neurourol Urodyn. 2008, 27:446-53.
32. Sui GP, Wu C, Fry CH. Electrical characteristics of suburothelial cells isolated from the human bladder. J Urol. 2004, 171:938-43.
33. Wiseman OJ, Fowler CJ, Landon DN. The role of the human bladder lamina propria myofibroblast. BJU Int. 2003, 91:89-93.
34. Hashitani H, Van Helden DF, Suzuki H. Properties of spontaneous depolarizations in circular smooth muscle cells of rabbit urethra. Br J Pharmacol. 1996, 118:1627-32.
35. Hashitani H, Edwards FR. Spontaneous and neurally activated depolarizations in smooth muscle cells of the guinea-pig urethra. J Physiol. 1999, 514:459-70.
36. Sergeant GP, Hollywood MA, McCloskey KD. Specialised pacemaking cells in the rabbit urethra. J Physiol. 2000, 526:359-66.
37. Johnston L, Sergeant GP, Hollywood MA. Calcium oscillations in interstitial cells of the rabbit urethra. J Physiol. 2005, 565:449-61.
38. Sergeant GP, Bradley E, Thornbury KD. Role of mitochondria in modulation of spontaneous Ca2+ waves in freshly dispersed interstitial cells of Cajal from the rabbit urethra. J Physiol. 2008, 586:4631-42.
39. Hashitani H. Interaction between interstitial cells and smooth muscles in the lower urinary tract and penis. J Physiol. 2006, 576:707-14.
40. Hashitani H, Yanai Y, Kohri K. Heterogeneous CPA sensitivity of spontaneous excitation in smooth muscle of the rabbit urethra. Br J Pharmacol. 2006, 148:340-9.
41. Sergeant GP, Johnston L, McHale NG. Activation of the cGMP/PKG pathway inhibits electrical activity in rabbit urethral interstitial cells of Cajal by reducing the spatial spread of Ca2+ waves. J Physiol. 2006, 574:167-81.
42. Garcia-Pascual A, Sancho M, Costa G. Interstitial cells of Cajal in the urethra are cGMP-mediated targets of nitrergic neurotransmission. Am J Physiol Renal Physiol. 2008, 295:F971-83.
43. Hashitani H, Fukuta H, Dickens EJ. Cellular mechanisms of nitric oxide-induced relaxation of corporeal smooth muscle in the guinea-pig. J Physiol. 2002, 538:573-81.
44. Hashitani H, Suzuki H. Identification of interstitial cells of Cajal in corporal tissues of the guinea-pig penis. Br J Pharmacol. 2004, 141:199-204.
45. Hashitani H, Yanai Y, Shirasawa N. Interaction between spontaneous and neurally mediated regulation of smooth muscle tone in the rabbit corpus cavernosum. J Physiol. 2005, 569:723-35.
46. Pezzone MA, Watkins SC, Alber SM. Identification of c-kit-positive cells in the mouse ureter: the interstitial cells of Cajal of the urinary tract. Am J Physiol-Renal Physiol. 2003, 284:F925-9.
47. Lang RJ, Klemm MF. Interstitial cell of Cajal-like cells in the upper urinary tract. J Cell Mol Med. 2005, 9:543-56.
48. David SG, Cebrian C, Vaughan ED. C-kit and ureteral peristalsis. J Urol. 2005, 173:292-5.
49. Metzger R, Schuster T, Till H. Cajal-like cells in the upper urinary tract: comparative study in various species. Pediatr Surg Int. 2005, 21:169-74.
50. Metzger R, Neugebauer A, Rolle U. C-Kit receptor (CD117) in the porcine urinary tract. Pediatr Surg Int. 2008, 24:67-76.
51. Metzger R, Schuster T, Till H. Cajal-like cells in the human upper urinary tract. J Urol. 2004, 172:769-72.
52. van der Aa F, Roskams T, Blyweert W. Identification of kit positive cells in the human urinary tract. J Urol. 2004, 171:2492-6.
53. Zhang SC, Fedoroff S. Cellular localization of stem cell factor and c-kit receptor in the mouse nervous system. J Neurosci Res. 1997, 47:1-15.
54. Lang RJ, Tonta MA, Zoltkowski BZ. Pyeloureteric peristalsis: role of atypical smooth muscle cells and interstitial cells of Cajal-like cells as pacemakers. J Physiol. 2006, 576:695.
55. Lang RJ, Takano H, Davidson ME. Characterization of the spontaneous electrical and contractile activity of smooth muscle cells in the rat upper urinary tract. J Urol. 2001, 166:329-34.
56. Klemm MF, Exintaris B, Lang RJ. Identification of the cells underlying pacemaker activity in the guinea- pig upper urinary tract. J Physiol. 1999, 519:867-84.
57. Lang RJ, Hashitani H, Keller S. Modulators of internal Ca2+ stores and the spontaneous electrical and contractile activity of the guinea-pig renal pelvis. Br J Pharmacol. 2002, 135:1363-74.
58. Exintaris B, Nguyen DT, Lam M. Inositol trisphosphate-dependent Ca stores and mitochondria modulate slow wave activity arising from the smooth muscle cells of the guinea pig prostate gland. Br J Pharmacol. 2009, 56:1098-106.
59. Nguyen DT, Lang RJ, Exintaris B. alpha(1)-adrenoceptor modulation of spontaneous electrical waveforms in the guinea-pig prostate. Eur J Pharmacol. 2009, 608:62-70.
60. Davidson ME, Lang RJ. Effects of selective inhibitors of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) on the spontaneous myogenic contractions in the upper urinary tract of the guinea-pig and rat. Br J Pharmacol. 2000, 129:661-70.
61. Zhang Y, Lang RJ. Effects of intrinsic prostaglandins on the spontaneous contractile and electrical activity of the proximal renal pelvis of the guinea-pig. Br J Pharmacol. 1994, 113:431-8.
62. Exintaris B, Klemm MF, Lang RJ. Spontaneous slow wave and contractile activity of the guinea pig prostate. J Urol. 2002, 168:315-22.
63. Exintaris B, Nguyen DT, Dey A. Spontaneous electrical activity in the prostate gland. Auton Neurosci. 2006, 126:371-9.
64. Leong KG, Wang BE, Johnson L. Generation of a prostate from a single adult stem cell. Nature. 2008, 456:804-8.
65. Van der Aa F, Roskams T, Blyweert W. Interstitial cells in the human prostate: a new therapeutic target. Prostate. 2003, 56:250-5.
66. Shafik A, Shafik I, el-Sibai O. Identification of c-kit-positive cells in the human prostate: the interstitial cells of Cajal. Arch Androl. 2005, 51:345-51.
67. Aumuller G, Habenicht UF, el Etreby MF. Pharmacologically induced ultrastructural and immunohistochemical changes in the prostate of the castrated dog. Prostate. 1987, 11:211-8.
68. Lang RJ, Nguyen DTT, Matsuyama H. Characterization of spontaneous depolarizations in smooth muscle cells of the guinea pig prostate. J Urol. 2006, 175:370-80.
69. Oh SJ, Kim KM, Chung YS. Ion-channel currents of smooth muscle cells isolated from the prostate of guinea-pig. BJU Int. 2003, 92:1022-30.
70. Lang RJ, Mulholland E, Exintaris B. Characterization of the ion channel currents in single myocytes of the guinea pig prostate. J Urol. 2004, 172:1179-87.
71. Huizinga JD, Faussone-Pellegrini MS. About the presence of interstitial cells of Cajal outside the musculature of the gastrointestinal tract. J Cell Mol Med. 2005, 9:468-73.
72. Komuro T. Comparative morphology of interstitial cells of Cajal: ultrastructural characterization. Microsc Res Tech. 1999, 47:267-85.
73. Komuro T, Seki K, Horiguchi K. Ultrastructural characterization of the interstitial cells of Cajal. Arch Histol Cytol. 1999, 62:295-316.
74. Rasmussen H, Rumessen JJ, Hansen A. Ultrastructure of Cajal-like interstitial cells in the human detrusor. Cell Tissue Res. 2009, 335:517-27.
75. Kang HJ, Lee HY, Jin MH. Decreased interstitial cells of Cajal-like cells, possible cause of congenital refluxing megaureters: histopathologic differences in refluxing and obstructive megaureters. Urol. 2009, 74:318-23.
76. Arena E, Nicotina PA, Arena S. Interstitial cells of Cajal network in primary obstructive megaureter. Pediatr Med Chir. 2007, 29:28-31.
77. Arena F, Nicotina PA, Arena S. C-kit positive interstitial cells of Cajal network in primary obstructive megaureter. Minerva Pediatr. 2007, 59:7-11.
78. Kuzgunbay B, Doran F, Bayazit Y. The effects of ureteral obstruction on Cajal-like cells in rats. J Pediatr Urol. 2009, 5:269-73.
79. Oberritter Z, Rolle U, Juhasz Z. Altered expression of c-kit-positive cells in the ureterovesical junction after surgically created vesicoureteral reflux. Pediatr Surg Int. 2009, 25:1103-7.
80. Arena S, Fazzari C, Arena F. Altered 'active' antireflux mechanism in primary vesico-ureteric reflux: a morphological and manometric study. BJU Int. 2007, 100:407-12.
81. Gibbons SJ, De Giorgio R, Pellegrini MS. Apoptotic cell death of human interstitial cells of Cajal. Neurogastroenterol Motil. 2009, 21:85-93.
82. Hashitani H, Lang RJ, Mitsui R. Distinct effects of CGRP on typical and atypical smooth muscle cells involved in generating spontaneous contractions in the mouse renal pelvis. Br J Pharmacol. 2009, 158:2030-45.
83. Hashitani H, Yanai Y, Shirasawa N. Interaction between spontaneous and neurally mediated regulation of smooth muscle tone in the rabbit corpus cavernosum. J Physiol. 2005, 569:723-35.