Muscarinic receptor subtypes in human bladder detrusor and mucosa, studied by radioligand binding and quantitative competitive RT-PCR: Changes in ageing

British Journal of Pharmacology

Volumn 144, Issue 8, 2005, Pages 1089-1099

  Mansfield, Kylie J ^a   Liu, Lu ^a   Mitchelson, Frederick J ^b   Moore, Kate H ^a   Millard, Richard J ^a   Burcher, Elizabeth ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

3H QNB; Detrusor; Human; M 3; Muscarinic receptors; QCRT PCR; Smooth muscle; Urinary bladder; Urothelium

Indexed keywords

11 [[4 [4 (DIETHYLAMINO)BUTYL] 1 PIPERIDYL]ACETYL] 5,11 DIHYDRO 6H PYRIDO[2,3 B][1,4]BENZODIAZEPIN 6 ONE; 4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; ATROPINE; DARIFENACIN; MESSENGER RNA; METHOCTRAMINE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M5 RECEPTOR; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; OTENZEPAD; PIRENZEPINE; QUINUCLIDINYL BENZILATE; RADIOLIGAND; RECEPTOR SUBTYPE; TROSPIUM CHLORIDE;

ADULT; AGED; AGING; ARTICLE; BINDING COMPETITION; BLADDER MUCOSA; CONTROLLED STUDY; CORRELATION ANALYSIS; CYSTOSCOPY; DETRUSOR MUSCLE; FEMALE; HUMAN; HUMAN TISSUE; LIGAND BINDING; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RECEPTOR AFFINITY; RECEPTOR DENSITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX DIFFERENCE; SMOOTH MUSCLE CONTRACTILITY;

ADULT; AGED; AGING; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; MIDDLE AGED; MUCOUS MEMBRANE; PROTEIN BINDING; PROTEIN ISOFORMS; QUINUCLIDINYL BENZILATE; RADIOLIGAND ASSAY; RECEPTORS, MUSCARINIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; URINARY BLADDER;

EID: 17844376219     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706147     Document Type: Article

References (40)

1. ANDERSSON, K.E. & YOSHIDA, M. (2003). Antimuscarinics and the overactive detrusor - Which is the main mechanism of action? Eur. Urol., 43, 1-5.
2. BIRDER, L.A., NAKAMURA, Y., KISS, S., NEALEN, M.L.M., BARRICK, S., KANAI, A.J., WANG, E., RUIZ, G., DE GROAT, W.C., APODACA, G., WATKINS, S. & CATERINA, M.J. (2002). Altered urinary bladder function in mice lacking the vanilloid receptor. Nat. Neurosci., 5, 856-860.
3. 2. Am. J. Physiol., 285, R701-R708.
4. CHAIYAPRASITHI, B., MANG, C.F., KILBINGER, H. & HOHENFELLNER, M. (2003). Inhibition of human detrusor contraction by a urothelium derived factor. J. Urol., 170, 1897-1900.
5. CHESS-WILLIAMS, R. (2002). Muscarinic receptors of the urinary bladder: detrusor, urothelial and prejunctional. Auton. Autocoid. Pharmacol., 22, 133-145.
6. 3-receptors mediate contraction of human detrusor muscle in vitro. J. Auton. Pharmacol., 21, 243-248.
7. 4 receptor subtype. Br. J. Pharmacol., 129, 493-500.
8. DASH, S., SAXENA, R., MYUNG, J., REGE, T., TSUJI, H., GAGLIO, P., GARRY, R.F., THUNG, S.N. & GERBER, M.A. (2000). HCV RNA levels in hepatocellular carcinomas and adjacent non-tumorous livers. J. Virol. Meth., 90, 15-23.
9. EGLEN, R.M., HEGDE, S.S. & WATSON, N. (1996). Muscarinic receptor subtypes and smooth muscle function. Pharmacol. Rev., 48, 531-565.
10. EGLEN, R.M. & NAHORSKI, S.R. (2000). The muscarinic M(5) receptor: a silent or emerging subtype? Br. J. Pharmacol., 130, 13-21.
11. 3 muscarinic receptors in gastrointestinal, airway and urinary bladder smooth muscle. Life Sci., 74, 355-366.
12. ELBADAWI, A., DIOKNO, A.C. & MILLARD, R.J. (1998). The aging bladder - morphology and urodynamics. World J. Urol., 16, S10-S34.
13. FERGUSON, D.R., KENNEDY, I. & BURTON, T.J. (1997). ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes - a possible sensory mechanism? J. Physiol., 505, 503-511.
14. 3 muscarinic receptors mediate contraction of human urinary bladder. Br. J. Pharmacol., 136, 641-644.
15. FRASER, C.M & LEE, N.H. (1995). Regulation of muscarinic receptor expression by changes in mRNA stability. Life Sci., 56, 899-906.
16. FRY, C.H., IKEDA, Y., HARVEY, R., WU, C. & SUI, G.P. (2004). Control of bladder function by peripheral nerves: avenues for novel drug targets. Urology, 63 (Suppl 1), 24-31.
17. GOEPEL, M., GRONEWALD, A., KREGE, S. & MICHEL, M.C. (1998). Muscarinic receptor subtypes in porcine detrusor: comparison with humans and regulation by bladder augmentation. Urol. Res., 26, 149-154.
18. HAWTHORN, M.H., CHAPPLE, C.R., COCK, M. & CHESS-WILLIAMS, R. (2000). Urothelium-derived inhibitory factor(s) influences on detrusor muscle contractility in vitro. Br. J. Pharmacol., 129, 416-419.
19. HOLSINGER, R.M.D., SCHNARR, J., HENRY, P., CASTELO, V.T. & FAHNESTOCK, M. (2000). Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction. Mol. Brain Res., 76, 347-354.
20. LATIFPOUR, J., KONDO, S., O'HOLLAREN, B., MORITA, T. & WEISS, R.M. (1990). Autonomic receptors in urinary tract: sex and age differences. J. Pharmacol. Exp. Ther., 253, 661-667.
21. LEPOR, H., GUP, D., SHAPIRO, E. & BAUMANN, M. (1989). Muscarinic cholinergic receptors in the normal and neurogenic human bladder. J. Urol., 142, 869-874.
22. MADERSBACHER, H.S. (2003). Trospium chloride. Focusing on the Science of OAB Management. ICS Symposium, Florence, Italy.
23. MADERSBACHER, S., PYCHA, A., SCHATZI, G., MIAN C KLINGLER, C.H. & MARBERGER, M. (1998). The ageing lower urinary tract: a comparative urodynamics study of men and women. Urology, 51, 206-212.
24. MANSFIELD, K.J., MITCHELSON, F.J., MOORE, K.H. & BURCHER, E. (2003). Muscarinic receptor subtypes in the human colon: lack of evidence for atypical subtypes. Eur. J. Pharmacol., 182, 101-109.
25. MATSUI, M., MOTOMURA, D., FUJIKAWA, T., JIANG, J., TAKAHASHI, S., MANABE, T. & TAKETO, M. (2002). Mice lacking M2 and M3 muscarinic acetylcholine receptors are devoid of cholinergic smooth muscle contractions but still viable. J. Neurosci., 22, 10627-10632.
26. MATSUI, M., MOTOMURA, D., KARASAWA, H., FUJIKAWA, T., JIANG, J., KOMIYA, Y., TAKAHASHI, S. & TAKETO, M. (2000). Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype. Proc. Natl. Acad. Sci. U.S.A., 97, 9579-9584.
27. MICHEL, M.C., SCHNEIDER, T., KREGE, S. & GOEPEL, M. (2002). Does gender or age affect the efficacy and safety of Tolterodine? J. Urol., 168, 102-1032.
28. MILSOM, I., ABRAMS, P., CARDOZO, L., ROBERTS, R.G., THUROFF, J. & WEIN, A.J. (2001). How widespread are the symptoms of an overactive bladder and how are they managed? A population-based prevalence study. BJU Int., 87, 760-766.
29. NILVEBRANT, L., ANDERSSON, K.E. & MATTIASSON, A. (1985). Characterization of the muscarinic cholinoceptors in the human detrusor. J. Urol., 134, 418-423.
30. ORDWAY, G.A., ESBENSHADE, T.A., KOLTA, M.G., GERALD, M.C. & WALLACE, L.J. (1986). Effect of age on cholinergic muscarinic responsiveness and receptors in the rat urinary bladder. J. Urol., 136, 492-496.
31. PAGALA, M.K., TETSOTI, L., NAGPAL, D. & WISE, G.J. (2001). Ageing effects on contractility of longitudinal and circular detrusor and trigone of rat bladder. J. Urol., 166, 721-725.
32. 2 muscarinic receptor mediates in vitro bladder contractions from patients with neurogenic bladder dysfunction. Am. J. Physiol., 268, R874-R880.
33. PREIKSAITIS, H.G., KRYSIAK, P.S., CHRONES, T., RAJGOPAL, V. & LAURIER, L.G. (2000). Pharmacological and molecular characterisation of muscarinic receptor subtypes in human oesophageal smooth muscle. J. Pharmacol. Exp. Ther., 295, 879-888.
34. SIGALA, S., MIRABELLA, G., PERONI, A., PEZZOTTI, G., SIMEONE, C., SPANO, P. & CUNINO, S.C. (2002). Differential gene expression of cholinergic muscarinic receptor subtypes in male and female normal human urinary bladder. J. Urol., 60, 719-725.
35. SOMOGYI, G.T. & De GROAT, W.C. (1999). Function, signal transduction mechanisms and plasticity of presynaptic muscarinic receptors in the urinary bladder. Life Sci., 64, 411-418.
36. TEMPLEMAN, L., CHAPPLE, C.R. & CHESS-WILLIAMS, R. (2002). Urothelium derived inhibitory factor and cross-talk among receptors in the trigone of the bladder of the pig. J. Urol., 167, 742-745.
37. WANG, P., LUTHIN, G.R. & RUGGIERI, M.R. (1995). Muscarinic acetylcholine receptor subtypes mediating urinary bladder contractility and coupling to GTP binding proteins. J. Pharmacol. Exp. Ther., 273, 959-966.
38. YOSHIDA, M., HOMMA, Y., INADOME, A., YONO, M., SESHITA, H., MIYAMOTO, Y., MURAKAMI, S., KAWABE, K. & UEDA, S. (2001). Age-related changes in cholinergic and purinergic neurotransmission in human isolated bladder smooth muscle. Exp. Geront., 36, 99-109.
39. YOSHIDA, M., MIYAMAE, K., IWASHITA, H., OTANI, M. & INADOME, A. (2004). Management of detrusor dysfunction in the elderly: changes in acetylcholine and adenosine triphosphate release during aging. Urology, 63, 17-23.
40. ZENG, X.P., MOORE, K.H. & BURCHER, E. (1995). Characterization of tachykinin NK2 receptors in human urinary bladder. J. Urol., 153, 1688-1692.