TGF-β1 increases invasiveness of SW1990 cells through Rac1/ROS/NF-κB/IL-6/MMP-2

Biochemical and Biophysical Research Communications

Volumn 405, Issue 1, 2011, Pages 140-145

  Binker, Marcelo G ^a,b   Binker Cosen, Andres A ^b   Gaisano, Herbert Y ^a   de Cosen, Rodica H ^b   Cosen Binker, Laura I ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b CBRHC Research Center   (Argentina)

Author keywords

Cancer invasion; Interleukin 6 (IL 6); Matrix metalloproteinase 2 (MMP 2); Nuclear factor kappa beta (NF B); Rac1; Reactive oxygen species (ROS); SW1990 cells; Transforming growth factor beta 1 (TGF 1)

Indexed keywords

GELATINASE A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CANCER CELL CULTURE; CANCER INVASION; CELL INVASION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME RELEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; PANCREAS CANCER; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

CELL LINE, TUMOR; HUMANS; INTERLEUKIN-6; MATRIX METALLOPROTEINASE 2; NEOPLASM INVASIVENESS; NF-KAPPA B; PANCREATIC NEOPLASMS; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; RAC1 GTP-BINDING PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 79551475611     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.01.023     Document Type: Article

References (27)

1. Raimondi S., Maisonneuve P., Lowenfels A.B. Epidemiology of pancreatic cancer: an overview. Nat. Rev. Gastroenterol. Hepatol. 2009, 6:699-708.
2. Collins A., Bloomston M. Diagnosis and management of pancreatic cancer. Minerva Gastroenterol. Dietol. 2009, 55:445-454.
3. Björklund M., Koivunen E. Gelatinase-mediated migration and invasion of cancer cells. Biochim. Biophys. Acta 2005, 1755:37-69.
4. Gress T.M., Muller-Pillasch F., Lerch M.M., Friess H., Büchler M., Adler G. Expression and in situ localization of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in pancreatic cancer. Int. J. Cancer 1995, 62:407-413.
5. Koshiba T., Hosotani R., Wada M., Miyamoto Y., Fujimoto K., Lee J.U., Doi R., Arii S., Imamura M. Involvement of matrix metalloproteinase-2 activity in invasion and metastasis of pancreatic carcinoma. Cancer 1998, 82:642-650.
6. Ellenrieder V., Alber B., Lacher U., Hendler S.F., Menke A., Boeck W., Wagner M., Wilda M., Friess H., Büchler M., Adler G., Gress T.M. Role of MT-MMPs and MMP-2 in pancreatic cancer progression. Int. J. Cancer 2000, 85:14-20.
7. Joshi A., Cao D. TGF-beta signaling, tumor microenvironment and tumor progression: the butterfly effect. Front Biosci. 2010, 15:180-194.
8. Ellenrieder V., Hendler S.F., Ruhland C., Boeck W., Adler G., Gress T.M. TGF-beta-induced invasiveness of pancreatic cancer cells is mediated by matrix metalloproteinase-2 and the urokinase plasminogen activator system. Int. J. Cancer 2001, 93:204-211.
9. Teraoka H., Sawada T., Yamashita Y., Nakata B., Ohira M., Ishikawa T., Nishino H., Hirakawa K. TGF-beta1 promotes liver metastasis of pancreatic cancer by modulating the capacity of cellular invasion. Int. J. Oncol. 2001, 19:709-715.
10. Etienne-Manneville S., Hall A. Rho GTPases in cell biology. Nature 2002, 420:629-635.
11. Zhuge Y., Xu J. Rac1 mediates type I collagen-dependent MMP-2 activation. Role in cell invasion across collagen barrier. J. Biol. Chem. 2001, 276:16248-16256.
12. Laeeq S., Faust R. Modeling the cholesteatoma microenvironment: coculture of HaCaT keratinocytes with WS1 fibroblasts induces MMP-2 activation, invasive phenotype, and proteolysis of the extracellular matrix. Laryngoscope 2007, 117:313-318.
13. Binker M.G., Binker-Cosen A.A., Richards D., Oliver B., Cosen-Binker L.I. EGF promotes invasion by PANC-1 cells through Rac1/ROS-dependent secretion and activation of MMP-2. Biochem. Biophys. Res. Commun. 2009, 379:445-450.
14. Wu W.S. The signaling mechanism of ROS in tumor progression. Cancer Metastasis Rev. 2006, 25:695-705.
15. Inoue N., Takeshita S., Gao D., Ishida T., Kawashima S., Akita H., Tawa R., Sakurai H., Yokoyama M. Lysophosphatidylcholine increases the secretion of matrix metalloproteinases 2 through the activation of NADH/NADPH oxidase in cultured aortic endothelial cells. Atherosclerosis 2001, 155:45-52.
16. Gloire G., Legrand-Poels S., Piette J. NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem. Pharmacol. 2006, 72:1493-1505.
17. Libermann T.A., Baltimore D. Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol. Cell Biol. 1990, 10:2327-2334.
18. Aggarwal B.B., Shishodia S., Sandur S.K., Pandey M.K., Sethi G. Inflammation and cancer: how hot is the link? Biochem. Pharmacol. 2006, 72:1605-1621.
19. Meisser A., Cameo P., Islami D., Campana A., Bischof P. Effects of interleukin-6 (IL-6) on cytotrophoblastic cells. Mol. Hum. Reprod. 1999, 5:1055-1058.
20. Li R., Li G., Deng L., Liu Q., Dai J., Shen J., Zhang J. IL-6 augments the invasiveness of U87MG human glioblastoma multiforme cells via up-regulation of MMP-2 and fascin-1. Oncol. Rep. 2010, 23:1553-1559.
21. Huang C., Yang G., Jiang T., Huang K., Cao J., Qiu Z. Effects of IL-6 and AG490 on regulation of Stat3 signaling pathway and invasion of human pancreatic cancer cells in vitro. J. Exp. Clin. Cancer Res. 2010, 29:51-58.
22. Itoh T., Tanioka M., Yoshida H., Yoshioka T., Nishimoto H., Itohara S. Reduced angiogenesis and tumor progression in gelatinase A-deficient mice. Cancer Res. 1998, 58:1048-1051.
23. Binker M.G., Binker-Cosen A.A., Richards D., Gaisano G.Y., de Cosen R.H., Cosen-Binker L.I. Hypoxia-reoxygenation increase invasiveness of PANC-1 cells through Rac1/MMP-2. Biochem. Biophys. Res. Commun. 2010, 393:371-376.
24. Baugher P.J., Krishnamoorthy L., Price J.E., Dharmawardhane S.F. Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells. Breast Cancer Res. 2005, 7:965-974.
25. Devine K.M., Smicun Y., Hope J.M., Fishman D.A. S1P induced changes in epithelial ovarian cancer proteolysis, invasion, and attachment are mediated by Gi and Rac. Gynecol. Oncol. 2008, 110:237-245.
26. Wang L., Kuang L., Pan X., Liu J., Wang Q., Du B., Li D., Luo J., Liu M., Hou A., Qian M. Isoalvaxanthone inhibits colon cancer cell proliferation, migration and invasion through inactivating Rac1 and AP-1. Int. J. Cancer 2010, 127:1220-1229.
27. Tobar N., Villar V., Santibanez J.F. ROS-NFkappaB mediates TGF-beta1-induced expression of urokinase-type plasminogen activator, matrix metalloproteinase-9 and cell invasion. Mol. Cell Biochem. 2010, 340:195-202.