Modeling the cholesteatoma microenvironment: Coculture of HaCaT keratinocytes with WS1 fibroblasts induces MMP-2 activation, invasive phenotype, and proteolysis of the extracellular matrix

Laryngoscope

Volumn 117, Issue 2, 2007, Pages 313-318

  Laeeq, Sabahat ^b   Faust, Russell ^a  

^a CHILDREN'S HOSPITAL OF MICHIGAN   (United States)

^b NONE

Author keywords

Cell invasion; Cell line; Cell movement; Cholesteatoma; Coculture techniques; Collagen metabolism; Computer assisted; Fluorescence; Human; Image processing; In vitro; Matrix metalloproteinases; Microscopy; Rho GTP binding proteins; Stromal cells

Indexed keywords

COLLAGEN TYPE 4; GELATINASE A; GUANOSINE TRIPHOSPHATASE; HYDROLASE INHIBITOR; MATRIGEL;

ARTICLE; CELL ACTIVATION; CELL GROWTH; CELL INVASION; CELL MIGRATION; CHOLESTEATOMA; COCULTURE; COMPUTER PROGRAM; CONFOCAL MICROSCOPY; ENZYME ACTIVATION; ENZYME RELEASE; EXPERIMENTAL MODEL; EXTRACELLULAR MATRIX; FIBROBLAST; HUMAN; HUMAN CELL; KERATINOCYTE; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION;

CELL COMMUNICATION; CELL LINE; CELL MOVEMENT; CHOLESTEATOMA; COCULTURE TECHNIQUES; COLLAGEN; COLLAGEN TYPE IV; DRUG COMBINATIONS; ENZYME ACTIVATION; ENZYME INHIBITORS; EXTRACELLULAR MATRIX; FIBROBLASTS; FLUORESCENT DYES; HUMANS; KERATINOCYTES; LAMININ; MATRIX METALLOPROTEINASE 2; MICROSCOPY, CONFOCAL; PHENOTYPE; PROTEOGLYCANS; RAC1 GTP-BINDING PROTEIN; STROMAL CELLS;

EID: 33846809219     PISSN: 0023852X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mlg.0000251164.26405.1a     Document Type: Article

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