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Volumn 10, Issue , 2009, Pages

Hypoxia regulates human lung fibroblast proliferation via p53-dependent and -independent pathways

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; DEFEROXAMINE; OXYGEN; PROTEIN P21; PROTEIN P27; PROTEIN P53; CDKN1A PROTEIN, HUMAN; CDKN1B PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; IRON CHELATING AGENT; SIGNAL PEPTIDE; SMALL INTERFERING RNA; TP53 PROTEIN, HUMAN;

EID: 65649117863     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-10-17     Document Type: Article
Times cited : (39)

References (54)
  • 1
    • 0842321774 scopus 로고    scopus 로고
    • Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expression
    • Olman MA, White KE, Ware LB, Simmons WL, Benveniste EN, Zhu S, Pugin J, Matthay MA. Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expression. J Immunol 2004, 172(4):2668-2677.
    • (2004) J Immunol , vol.172 , Issue.4 , pp. 2668-2677
    • Olman, M.A.1    White, K.E.2    Ware, L.B.3    Simmons, W.L.4    Benveniste, E.N.5    Zhu, S.6    Pugin, J.7    Matthay, M.A.8
  • 2
    • 0032825924 scopus 로고    scopus 로고
    • Effect of endothelin-1 on alpha-smooth muscle actin expression and on alveolar fibroblasts proliferation in interstitial lung diseases
    • 10.1016/S0192-0561(99)00056-9, 10576621
    • Shahar I, Fireman E, Topilsky M, Grief J, Schwarz Y, Kivity S, Ben-Efraim S, Spirer Z. Effect of endothelin-1 on alpha-smooth muscle actin expression and on alveolar fibroblasts proliferation in interstitial lung diseases. Int J Immunopharmacol 1999, 21(11):759-775. 10.1016/S0192-0561(99)00056-9, 10576621.
    • (1999) Int J Immunopharmacol , vol.21 , Issue.11 , pp. 759-775
    • Shahar, I.1    Fireman, E.2    Topilsky, M.3    Grief, J.4    Schwarz, Y.5    Kivity, S.6    Ben-Efraim, S.7    Spirer, Z.8
  • 4
    • 0027245754 scopus 로고
    • Gene expression in low oxygen tension
    • 10.1097/00000441-199307000-00010, 8328508
    • Helfman T, Falanga V. Gene expression in low oxygen tension. Am J Med Sci 1993, 306(1):37-41. 10.1097/00000441-199307000-00010, 8328508.
    • (1993) Am J Med Sci , vol.306 , Issue.1 , pp. 37-41
    • Helfman, T.1    Falanga, V.2
  • 7
    • 0037111104 scopus 로고    scopus 로고
    • Prolonged hypoxia accelerates the posttranscriptional process of collagen synthesis in cultured fibroblasts
    • 10.1016/S0024-3205(02)02142-2, 12408871
    • Horino Y, Takahashi S, Miura T, Takahashi Y. Prolonged hypoxia accelerates the posttranscriptional process of collagen synthesis in cultured fibroblasts. Life Sci 2002, 71(26):3031-3045. 10.1016/S0024-3205(02)02142-2, 12408871.
    • (2002) Life Sci , vol.71 , Issue.26 , pp. 3031-3045
    • Horino, Y.1    Takahashi, S.2    Miura, T.3    Takahashi, Y.4
  • 8
    • 20144373102 scopus 로고    scopus 로고
    • Collagenase expression and activity is modulated by the interaction of collagen types, hypoxia, and nutrition in human lung cells
    • 10.1002/jcp.20289, 15672417
    • Leufgen H, Bihl MP, Rüdiger JJ, Gambazzi J, Perruchoud AP, Tamm M, Roth M. Collagenase expression and activity is modulated by the interaction of collagen types, hypoxia, and nutrition in human lung cells. J Cell Physiol 2005, 204(1):146-154. 10.1002/jcp.20289, 15672417.
    • (2005) J Cell Physiol , vol.204 , Issue.1 , pp. 146-154
    • Leufgen, H.1    Bihl, M.P.2    Rüdiger, J.J.3    Gambazzi, J.4    Perruchoud, A.P.5    Tamm, M.6    Roth, M.7
  • 9
    • 33847361673 scopus 로고    scopus 로고
    • Cell type-specific effect of hypoxia and platelet-derived growth factor-BB on extracellular matrix turnover and its consequences for lung remodeling
    • 10.1074/jbc.M602178200, 17099219
    • Karakiulakis G, Papakonstantinou E, Aletras AJ, Tamm M, Roth M. Cell type-specific effect of hypoxia and platelet-derived growth factor-BB on extracellular matrix turnover and its consequences for lung remodeling. J Biol Chem 2007, 282(2):908-915. 10.1074/jbc.M602178200, 17099219.
    • (2007) J Biol Chem , vol.282 , Issue.2 , pp. 908-915
    • Karakiulakis, G.1    Papakonstantinou, E.2    Aletras, A.J.3    Tamm, M.4    Roth, M.5
  • 11
    • 34548667496 scopus 로고    scopus 로고
    • Cardiovascular adjustments for life at high altitude
    • 10.1016/j.resp.2007.05.006, 17597013
    • Hainsworth R, Drinkhill MJ. Cardiovascular adjustments for life at high altitude. Respir Physiol Neurobiol 2007, 158(2-3):204-211. 10.1016/j.resp.2007.05.006, 17597013.
    • (2007) Respir Physiol Neurobiol , vol.158 , Issue.2-3 , pp. 204-211
    • Hainsworth, R.1    Drinkhill, M.J.2
  • 12
    • 0024240198 scopus 로고
    • Pulmonary hypertension and right ventricular function in patients with COPD
    • 10.1378/chest.94.6.1169, 3191757
    • Biernacki W, Flenley DC, Muir AL, MacNee W. Pulmonary hypertension and right ventricular function in patients with COPD. Chest 1988, 94(6):1169-75. 10.1378/chest.94.6.1169, 3191757.
    • (1988) Chest , vol.94 , Issue.6 , pp. 1169-1175
    • Biernacki, W.1    Flenley, D.C.2    Muir, A.L.3    MacNee, W.4
  • 13
    • 0027930046 scopus 로고
    • Pathophysiology of cor pulmonale in chronic obstructive pulmonary disease
    • Part One
    • MacNee W. Part One Pathophysiology of cor pulmonale in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1994, 150(3):833-852. Part One.
    • (1994) Am J Respir Crit Care Med , vol.150 , Issue.3 , pp. 833-852
    • MacNee, W.1
  • 14
    • 0016256179 scopus 로고
    • Pulmonary arterial muscularity and right ventricular hypertrophy in chronic bronchitis and emphysema
    • Semmens M, Reid L. Pulmonary arterial muscularity and right ventricular hypertrophy in chronic bronchitis and emphysema. Br J Dis Chest 1974, 68:253-263.
    • (1974) Br J Dis Chest , vol.68 , pp. 253-263
    • Semmens, M.1    Reid, L.2
  • 16
    • 0030873298 scopus 로고    scopus 로고
    • G1 accumulation caused by iron deprivation with deferoxamine does not accompany change of pRB status in ML-1 cells
    • 10.1016/S0167-4889(97)00040-2, 9268054
    • Fukuchi K, Tomoyasu S, Watanabe H, Tsuruoka N, Gomi K. G1 accumulation caused by iron deprivation with deferoxamine does not accompany change of pRB status in ML-1 cells. Biochim Biophys Acta 1997, 1357(3):297-305. 10.1016/S0167-4889(97)00040-2, 9268054.
    • (1997) Biochim Biophys Acta , vol.1357 , Issue.3 , pp. 297-305
    • Fukuchi, K.1    Tomoyasu, S.2    Watanabe, H.3    Tsuruoka, N.4    Gomi, K.5
  • 17
    • 0035896558 scopus 로고    scopus 로고
    • Hypoxia inhibits G1/S transition through regulation of p27 expression
    • 10.1074/jbc.M010189200, 11112789
    • Gardner LB, Li Q, Park MS, Flanagan WM, Semenza GL, Dang CV. Hypoxia inhibits G1/S transition through regulation of p27 expression. J Biol Chem 2001, 276(11):7919-7926. 10.1074/jbc.M010189200, 11112789.
    • (2001) J Biol Chem , vol.276 , Issue.11 , pp. 7919-7926
    • Gardner, L.B.1    Li, Q.2    Park, M.S.3    Flanagan, W.M.4    Semenza, G.L.5    Dang, C.V.6
  • 18
    • 0033662026 scopus 로고    scopus 로고
    • Hypoxia promotes fibrogenesis in human renal fibroblasts
    • 10.1046/j.1523-1755.2000.00419.x, 11115069
    • Norman JT, Clark IM, Garcia PL. Hypoxia promotes fibrogenesis in human renal fibroblasts. Kidney Int 2000, 58(6):2351-2366. 10.1046/j.1523-1755.2000.00419.x, 11115069.
    • (2000) Kidney Int , vol.58 , Issue.6 , pp. 2351-2366
    • Norman, J.T.1    Clark, I.M.2    Garcia, P.L.3
  • 19
    • 0031427459 scopus 로고    scopus 로고
    • Chronic hypoxia induces proliferation of cultured mesangial cells: role of calcium and protein kinase C
    • Sahai A, Mei C, Pattison TA, Tannen RL. Chronic hypoxia induces proliferation of cultured mesangial cells: role of calcium and protein kinase C. Am J Physiol 1997, 273(6 Pt 2):F954-960.
    • (1997) Am J Physiol , vol.273 , Issue.6 PART 2
    • Sahai, A.1    Mei, C.2    Pattison, T.A.3    Tannen, R.L.4
  • 22
    • 21344459451 scopus 로고    scopus 로고
    • The role of p27 in controlling the oxygen-dependent checkpoint of mammalian cells in late G1
    • Graff P, Amellem O, Seim J, Stokke T, Pettersen EO. The role of p27 in controlling the oxygen-dependent checkpoint of mammalian cells in late G1. Anticancer Res 2005, 25(3B):2259-2267.
    • (2005) Anticancer Res , vol.25 , Issue.3 B , pp. 2259-2267
    • Graff, P.1    Amellem, O.2    Seim, J.3    Stokke, T.4    Pettersen, E.O.5
  • 23
    • 0141988842 scopus 로고    scopus 로고
    • Cyclin dependent kinase inhibitor p27Kip1 is upregulated by hypoxia via an ARNT dependent pathway
    • 10.1002/jcb.10621, 14523989
    • Wang G, Reisdorph R, Clark RE, Miskimins R, Lindahl R, Miskimins WK. Cyclin dependent kinase inhibitor p27Kip1 is upregulated by hypoxia via an ARNT dependent pathway. J Cell Biochem 2003, 90(3):548-560. 10.1002/jcb.10621, 14523989.
    • (2003) J Cell Biochem , vol.90 , Issue.3 , pp. 548-560
    • Wang, G.1    Reisdorph, R.2    Clark, R.E.3    Miskimins, R.4    Lindahl, R.5    Miskimins, W.K.6
  • 24
    • 27644564685 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitor p27Kip1, but not p21WAF1/Cip1, is required for inhibition of hypoxia-induced pulmonary hypertension and remodeling by heparin in mice
    • Yu L, Quinn DA, Garg HG, Hales CA. Cyclin-dependent kinase inhibitor p27Kip1, but not p21WAF1/Cip1, is required for inhibition of hypoxia-induced pulmonary hypertension and remodeling by heparin in mice. Cir Res 2005, 97(9):937-945.
    • (2005) Cir Res , vol.97 , Issue.9 , pp. 937-945
    • Yu, L.1    Quinn, D.A.2    Garg, H.G.3    Hales, C.A.4
  • 25
    • 33744510570 scopus 로고    scopus 로고
    • Gene expression of cyclin-dependent kinase inhibitors and effect of heparin on their expression in mice with hypoxia-induced pulmonary hypertension
    • 10.1016/j.bbrc.2006.05.060, 16729969
    • Yu L, Quinn DA, Garg HG, Hales CA. Gene expression of cyclin-dependent kinase inhibitors and effect of heparin on their expression in mice with hypoxia-induced pulmonary hypertension. Biochem Biophys Res Commun 2006, 345(4):1565-1572. 10.1016/j.bbrc.2006.05.060, 16729969.
    • (2006) Biochem Biophys Res Commun , vol.345 , Issue.4 , pp. 1565-1572
    • Yu, L.1    Quinn, D.A.2    Garg, H.G.3    Hales, C.A.4
  • 26
    • 4143129889 scopus 로고    scopus 로고
    • P42/44 Mitogen-activated protein kinase regulated by p53 and nitric oxide in human pulmonary arterial smooth muscle cells
    • 10.1165/rcmb.2003-0397OC, 15016620
    • Mizuno S, Kadowaki M, Demura Y, Ameshima S, Miyamori I, Ishizaki T. p42/44 Mitogen-activated protein kinase regulated by p53 and nitric oxide in human pulmonary arterial smooth muscle cells. Am J Respir Cell Mol Biol 2004, 31(2):184-192. 10.1165/rcmb.2003-0397OC, 15016620.
    • (2004) Am J Respir Cell Mol Biol , vol.31 , Issue.2 , pp. 184-192
    • Mizuno, S.1    Kadowaki, M.2    Demura, Y.3    Ameshima, S.4    Miyamori, I.5    Ishizaki, T.6
  • 28
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
    • 10.1038/379088a0, 8538748
    • Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW, Giaccia AJ. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 1996, 379(6560):88-91. 10.1038/379088a0, 8538748.
    • (1996) Nature , vol.379 , Issue.6560 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3    Housman, D.E.4    Koch, C.J.5    Lowe, S.W.6    Giaccia, A.J.7
  • 29
    • 0037452759 scopus 로고    scopus 로고
    • PUMA mediates the apoptotic response to p53 in colorectal cancer cells
    • 149936, 12574499, 10.1073/pnas.2627984100
    • Yu J, Wang Z, Kinzler KW, Vogelstein B, Zhang L. PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proc Natl Acad Sci USA 2003, 100(4):1931-1936. 149936, 12574499, 10.1073/pnas.2627984100.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.4 , pp. 1931-1936
    • Yu, J.1    Wang, Z.2    Kinzler, K.W.3    Vogelstein, B.4    Zhang, L.5
  • 30
    • 0032568448 scopus 로고    scopus 로고
    • Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
    • 10.1038/32925, 9537326
    • An WG, Kanekal M, Simon MC, Maltepe E, Blagosklonny MV, Neckers LM. Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha. Nature 1998, 392(6674):405-408. 10.1038/32925, 9537326.
    • (1998) Nature , vol.392 , Issue.6674 , pp. 405-408
    • An, W.G.1    Kanekal, M.2    Simon, M.C.3    Maltepe, E.4    Blagosklonny, M.V.5    Neckers, L.M.6
  • 31
    • 0032524285 scopus 로고    scopus 로고
    • P53 inhibits hypoxia-inducible factor-stimulated transcription
    • 10.1074/jbc.273.20.11995, 9575138
    • Blagosklonny MV, An WG, Romanova LY, Trepel J, Fojo T, Neckers L. p53 inhibits hypoxia-inducible factor-stimulated transcription. J Biol Chem 1998, 273(20):11995-11998. 10.1074/jbc.273.20.11995, 9575138.
    • (1998) J Biol Chem , vol.273 , Issue.20 , pp. 11995-11998
    • Blagosklonny, M.V.1    An, W.G.2    Romanova, L.Y.3    Trepel, J.4    Fojo, T.5    Neckers, L.6
  • 32
    • 0034003005 scopus 로고    scopus 로고
    • Stress signals utilize multiple pathways to stabilize p53
    • 85616, 10757806, 10.1128/MCB.20.9.3224-3233.2000
    • Ashcroft M, Taya Y, Vousden KH. Stress signals utilize multiple pathways to stabilize p53. Mol Cell Biol 2000, 20(9):3224-3233. 85616, 10757806, 10.1128/MCB.20.9.3224-3233.2000.
    • (2000) Mol Cell Biol , vol.20 , Issue.9 , pp. 3224-3233
    • Ashcroft, M.1    Taya, Y.2    Vousden, K.H.3
  • 33
    • 0035140981 scopus 로고    scopus 로고
    • Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation
    • 99582, 11158315, 10.1128/MCB.21.4.1297-1310.2001
    • Koumenis C, Alarcon R, Hammond E, Sutphin P, Hoffman W, Murphy M, Derr J, Taya Y, Lowe SW, Kastan M, Giaccia A. Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. Mol Cell Biol 2001, 21(4):1297-1310. 99582, 11158315, 10.1128/MCB.21.4.1297-1310.2001.
    • (2001) Mol Cell Biol , vol.21 , Issue.4 , pp. 1297-1310
    • Koumenis, C.1    Alarcon, R.2    Hammond, E.3    Sutphin, P.4    Hoffman, W.5    Murphy, M.6    Derr, J.7    Taya, Y.8    Lowe, S.W.9    Kastan, M.10    Giaccia, A.11
  • 34
    • 0038687772 scopus 로고    scopus 로고
    • Potent iron chelators increase the mRNA levels of the universal cyclin-dependent kinase inhibitor p21(CIP1/WAF1), but paradoxically inhibit its translation: a potential mechanism of cell cycle dysregulation
    • 10.1093/carcin/bgg042, 12807743
    • Le NT, Richardson DR. Potent iron chelators increase the mRNA levels of the universal cyclin-dependent kinase inhibitor p21(CIP1/WAF1), but paradoxically inhibit its translation: a potential mechanism of cell cycle dysregulation. Carcinogenesis 2003, 24(6):1045-1058. 10.1093/carcin/bgg042, 12807743.
    • (2003) Carcinogenesis , vol.24 , Issue.6 , pp. 1045-1058
    • Le, N.T.1    Richardson, D.R.2
  • 35
    • 0028110809 scopus 로고
    • Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status
    • 359153, 8065358
    • Graeber TG, Peterson JF, Tsai M, Monica K, Fornace AJ, Giaccia AJ. Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. Mol Cell Biol 1994, 14(9):6264-6277. 359153, 8065358.
    • (1994) Mol Cell Biol , vol.14 , Issue.9 , pp. 6264-6277
    • Graeber, T.G.1    Peterson, J.F.2    Tsai, M.3    Monica, K.4    Fornace, A.J.5    Giaccia, A.J.6
  • 38
    • 20944432353 scopus 로고    scopus 로고
    • Hypoxia-driven proliferation of human pulmonary artery fibroblasts: cross-talk between HIF-1alpha and an autocrine angiotensin system
    • Krick S, Hanze J, Eul B, Savai R, Seay U, Grimminger F, Lohmeyer J, Klepetko W, Seeger W, Rose F. Hypoxia-driven proliferation of human pulmonary artery fibroblasts: cross-talk between HIF-1alpha and an autocrine angiotensin system. FASEB J 2005, 19(7):857-859.
    • (2005) FASEB J , vol.19 , Issue.7 , pp. 857-859
    • Krick, S.1    Hanze, J.2    Eul, B.3    Savai, R.4    Seay, U.5    Grimminger, F.6    Lohmeyer, J.7    Klepetko, W.8    Seeger, W.9    Rose, F.10
  • 41
    • 0032429520 scopus 로고    scopus 로고
    • Hypoxia enhances cellular proliferation and inositol 1,4, 5-triphosphate generation in fibroblasts from bovine pulmonary artery but not from mesenteric artery
    • Welsh DJ, Scott P, Plevin R, Wadsworth R, Peacock AJ. Hypoxia enhances cellular proliferation and inositol 1,4, 5-triphosphate generation in fibroblasts from bovine pulmonary artery but not from mesenteric artery. Am J Respir Crit Care Med 1998, 158(6):1757-1762.
    • (1998) Am J Respir Crit Care Med , vol.158 , Issue.6 , pp. 1757-1762
    • Welsh, D.J.1    Scott, P.2    Plevin, R.3    Wadsworth, R.4    Peacock, A.J.5
  • 42
    • 0027407995 scopus 로고
    • Low oxygen stimulates proliferation of fibroblasts seeded as single cells
    • 10.1002/jcp.1041540308, 8436599
    • Falanga V, Kirsner RS. Low oxygen stimulates proliferation of fibroblasts seeded as single cells. J Cell Physiol 1993, 154(3):506-510. 10.1002/jcp.1041540308, 8436599.
    • (1993) J Cell Physiol , vol.154 , Issue.3 , pp. 506-510
    • Falanga, V.1    Kirsner, R.S.2
  • 43
    • 0035858987 scopus 로고    scopus 로고
    • Human fibroblast replicative senescence can occur in the absence of extensive cell division and short telomeres
    • 10.1038/sj.onc.1204460, 11429701
    • Munro J, Steeghs K, Morrison V, Ireland H, Parkinson EK. Human fibroblast replicative senescence can occur in the absence of extensive cell division and short telomeres. Oncogene 2001, 20(27):3541-3552. 10.1038/sj.onc.1204460, 11429701.
    • (2001) Oncogene , vol.20 , Issue.27 , pp. 3541-3552
    • Munro, J.1    Steeghs, K.2    Morrison, V.3    Ireland, H.4    Parkinson, E.K.5
  • 45
    • 38449101675 scopus 로고    scopus 로고
    • Effect of hypoxia and Beraprost sodium on human pulmonary arterial smooth muscle cell proliferation: the role of p27kip1
    • 2164950, 17974037
    • Kadowaki M, Mizuno S, Demura Y, Ameshima S, Miyamori I, Ishizaki T. Effect of hypoxia and Beraprost sodium on human pulmonary arterial smooth muscle cell proliferation: the role of p27kip1. Respir Res 2007, 8(77). 2164950, 17974037.
    • (2007) Respir Res , vol.8 , Issue.77
    • Kadowaki, M.1    Mizuno, S.2    Demura, Y.3    Ameshima, S.4    Miyamori, I.5    Ishizaki, T.6
  • 46
    • 0030609861 scopus 로고    scopus 로고
    • Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts
    • 10.1126/science.277.5327.831, 9242615
    • Brown JP, Wei W, Sedivy JM. Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. Science 1997, 277(5327):831-834. 10.1126/science.277.5327.831, 9242615.
    • (1997) Science , vol.277 , Issue.5327 , pp. 831-834
    • Brown, J.P.1    Wei, W.2    Sedivy, J.M.3
  • 47
    • 0029073142 scopus 로고
    • Transforming growth factor β induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism
    • 41732, 7777546, 10.1073/pnas.92.12.5545
    • Datto MB, Li Y, Panus JF, Howe DJ, Xiong Y, Wang XF. Transforming growth factor β induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc Natl Acad Sci USA 1995, 92(12):5545-5549. 41732, 7777546, 10.1073/pnas.92.12.5545.
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.12 , pp. 5545-5549
    • Datto, M.B.1    Li, Y.2    Panus, J.F.3    Howe, D.J.4    Xiong, Y.5    Wang, X.F.6
  • 48
    • 0031597420 scopus 로고    scopus 로고
    • A new p21waf1/cip1 isoform is an early event of cell response to oxidative stress
    • 10.1038/sj.cdd.4400427, 9846180
    • Esposito F, Cuccovillo F, Russo L, Casella F, Russo T, Cimino F. A new p21waf1/cip1 isoform is an early event of cell response to oxidative stress. Cell Death Differ 1998, 5(11):940-945. 10.1038/sj.cdd.4400427, 9846180.
    • (1998) Cell Death Differ , vol.5 , Issue.11 , pp. 940-945
    • Esposito, F.1    Cuccovillo, F.2    Russo, L.3    Casella, F.4    Russo, T.5    Cimino, F.6
  • 49
    • 0030997927 scopus 로고    scopus 로고
    • Redox-mediated regulation of p21waf1/cip1 expression involves a post-transcriptional mechanism and activation of the mitogen-activated protein kinase pathway
    • 10.1111/j.1432-1033.1997.00730.x, 9183012
    • Esposito F, Cuccovillo F, Vanoni M, Cimino F, Anderson CW, Appella E, Russo T. Redox-mediated regulation of p21waf1/cip1 expression involves a post-transcriptional mechanism and activation of the mitogen-activated protein kinase pathway. Eur J Biochem 1997, 245(3):730-737. 10.1111/j.1432-1033.1997.00730.x, 9183012.
    • (1997) Eur J Biochem , vol.245 , Issue.3 , pp. 730-737
    • Esposito, F.1    Cuccovillo, F.2    Vanoni, M.3    Cimino, F.4    Anderson, C.W.5    Appella, E.6    Russo, T.7
  • 50
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • 10.1038/387296a0, 9153395
    • Haupt Y, Maya R, Kazaz A, Oren M. Mdm2 promotes the rapid degradation of p53. Nature 1997, 387(6630):296-299. 10.1038/387296a0, 9153395.
    • (1997) Nature , vol.387 , Issue.6630 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 51
    • 0032511848 scopus 로고    scopus 로고
    • The murine gene p27Kip1 is haplo-insufficient for tumour suppression
    • 10.1038/24179, 9823898
    • Fero ML, Randel E, Gurley KE, Roberts JM, Kemp CJ. The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature 1998, 396(6707):177-180. 10.1038/24179, 9823898.
    • (1998) Nature , vol.396 , Issue.6707 , pp. 177-180
    • Fero, M.L.1    Randel, E.2    Gurley, K.E.3    Roberts, J.M.4    Kemp, C.J.5
  • 52
    • 1342280369 scopus 로고    scopus 로고
    • Distinct roles for p53, p27Kip1, and p21Cip1 during tumor development
    • 10.1038/sj.onc.1207220, 14647411
    • Philipp-Staheli J, Kim KH, Liggitt D, Gurley KE, Longton G, Kemp CJ. Distinct roles for p53, p27Kip1, and p21Cip1 during tumor development. Oncogene 2004, 23(4):905-913. 10.1038/sj.onc.1207220, 14647411.
    • (2004) Oncogene , vol.23 , Issue.4 , pp. 905-913
    • Philipp-Staheli, J.1    Kim, K.H.2    Liggitt, D.3    Gurley, K.E.4    Longton, G.5    Kemp, C.J.6
  • 53
    • 0036559462 scopus 로고    scopus 로고
    • Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice
    • 10.1016/S1535-6108(02)00054-5, 12086850
    • Philipp-Staheli J, Kim KH, Payne SR, Gurley KE, Liggitt D, Longton G, Kemp CJ. Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice. Cancer Cell 2002, 1(4):355-368. 10.1016/S1535-6108(02)00054-5, 12086850.
    • (2002) Cancer Cell , vol.1 , Issue.4 , pp. 355-368
    • Philipp-Staheli, J.1    Kim, K.H.2    Payne, S.R.3    Gurley, K.E.4    Liggitt, D.5    Longton, G.6    Kemp, C.J.7
  • 54
    • 0030613633 scopus 로고    scopus 로고
    • Activation of p53-p21waf1 pathway in response to disruption of cell-matrix interactions
    • 10.1074/jbc.272.46.29091, 9360984
    • Wu RC, Schönthal AH. Activation of p53-p21waf1 pathway in response to disruption of cell-matrix interactions. J Biol Chem 1997, 272(46):29091-29098. 10.1074/jbc.272.46.29091, 9360984.
    • (1997) J Biol Chem , vol.272 , Issue.46 , pp. 29091-29098
    • Wu, R.C.1    Schönthal, A.H.2


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