메뉴 건너뛰기




Volumn 58, Issue 10, 2005, Pages 1033-1038

Proliferating fibroblasts at the invading tumour edge of colorectal adenocarcinomas are associated with endogenous markers of hypoxia, acidity, and oxidative stress

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; KI 67 ANTIGEN; LACTATE DEHYDROGENASE; THYMIDINE PHOSPHORYLASE;

EID: 26244432793     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.2005.026260     Document Type: Article
Times cited : (51)

References (47)
  • 2
    • 0347383870 scopus 로고    scopus 로고
    • Gene expression profiling of normal human pulmonary fibroblasts following coculture with non-small-cell lung cancer cells reveals alterations related to matrix degradation, angiogenesis, cell growth and survival
    • Fromigue O, Louis K, Dayem M, et al. Gene expression profiling of normal human pulmonary fibroblasts following coculture with non-small-cell lung cancer cells reveals alterations related to matrix degradation, angiogenesis, cell growth and survival. Oncogene 2003;22:8487-97.
    • (2003) Oncogene , vol.22 , pp. 8487-8497
    • Fromigue, O.1    Louis, K.2    Dayem, M.3
  • 3
    • 6044270514 scopus 로고    scopus 로고
    • Role of cancer-associated stromal fibroblasts in metastatic colon cancer to the liver and their expression profiles
    • Nakagawa H, Liyanarachchi S, Davuluri RV, et al. Role of cancer-associated stromal fibroblasts in metastatic colon cancer to the liver and their expression profiles. Oncogene 2004;23:7366-77.
    • (2004) Oncogene , vol.23 , pp. 7366-7377
    • Nakagawa, H.1    Liyanarachchi, S.2    Davuluri, R.V.3
  • 4
    • 9944246963 scopus 로고    scopus 로고
    • Tumour angiogenesis: Vascular growth and survival
    • Giatromanolaki A, Sivridis E, Koukourakis MI. Tumour angiogenesis: vascular growth and survival. APMIS 2004;112:431-40.
    • (2004) APMIS , vol.112 , pp. 431-440
    • Giatromanolaki, A.1    Sivridis, E.2    Koukourakis, M.I.3
  • 5
    • 0037899253 scopus 로고    scopus 로고
    • Role of tissue stroma in cancer cell invasion
    • De Wever O, Mareel M. Role of tissue stroma in cancer cell invasion. J Pathol 2003;200:429-47.
    • (2003) J Pathol , vol.200 , pp. 429-447
    • De Wever, O.1    Mareel, M.2
  • 7
    • 0036990102 scopus 로고    scopus 로고
    • Tumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells
    • Mueller MM, Fusenig NE. Tumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells. Differentiation 2002;70:486-97.
    • (2002) Differentiation , vol.70 , pp. 486-497
    • Mueller, M.M.1    Fusenig, N.E.2
  • 8
    • 0036993579 scopus 로고    scopus 로고
    • Role of stroma in carcinogenesis of the prostate
    • Cunha GR, Hayward SW, Wang YZ. Role of stroma in carcinogenesis of the prostate. Differentiation 2002;70:473-85.
    • (2002) Differentiation , vol.70 , pp. 473-485
    • Cunha, G.R.1    Hayward, S.W.2    Wang, Y.Z.3
  • 9
    • 0036163492 scopus 로고    scopus 로고
    • Melanoma-stroma interactions: Structural and functional aspects
    • Ruiter D, Bogenrieder T, Elder D, et al. Melanoma-stroma interactions: structural and functional aspects. Lancet Oncol 2002;3:35-43.
    • (2002) Lancet Oncol , vol.3 , pp. 35-43
    • Ruiter, D.1    Bogenrieder, T.2    Elder, D.3
  • 10
    • 0035720007 scopus 로고    scopus 로고
    • Phenotypic and genetic alterations in mammary stroma: Implications for tumour progression
    • Schor SL, Schor AM. Phenotypic and genetic alterations in mammary stroma: implications for tumour progression. Breast Cancer Res 2001;3:373-9.
    • (2001) Breast Cancer Res , vol.3 , pp. 373-379
    • Schor, S.L.1    Schor, A.M.2
  • 11
    • 0027173695 scopus 로고
    • Detection of the Ki-67 antigen in fixed and wax-embedded sections with the monoclonal antibody MIB1
    • McCormik D, Chong H, Hobbs C, et al. Detection of the Ki-67 antigen in fixed and wax-embedded sections with the monoclonal antibody MIB1. Histopathology 1993;22:355-60.
    • (1993) Histopathology , vol.22 , pp. 355-360
    • McCormik, D.1    Chong, H.2    Hobbs, C.3
  • 12
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIP-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages
    • Talks KL, Turley H, Gatter KC, et al. The expression and distribution of the hypoxia-inducible factors HIP-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 2000;157:411-21.
    • (2000) Am J Pathol , vol.157 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3
  • 13
    • 0031759488 scopus 로고    scopus 로고
    • Expression of VEGF in routinely fixed material using a new monoclonal antibody VG1
    • Turley H, Scott PA, Watts VM, et al. Expression of VEGF in routinely fixed material using a new monoclonal antibody VG1. J Pathol 1998;186:313-18.
    • (1998) J Pathol , vol.186 , pp. 313-318
    • Turley, H.1    Scott, P.A.2    Watts, V.M.3
  • 14
    • 0030027519 scopus 로고    scopus 로고
    • The angiogenic factor platelet-derived endothelial cell growth factor/thymidine phosphorylose is up-regulated in breast cancer epithelium and endothelium
    • Fox SB, Westwood M, Moghaddam A, et al. The angiogenic factor platelet-derived endothelial cell growth factor/thymidine phosphorylose is up-regulated in breast cancer epithelium and endothelium. Br J Cancer 1996;73:275-80.
    • (1996) Br J Cancer , vol.73 , pp. 275-280
    • Fox, S.B.1    Westwood, M.2    Moghaddam, A.3
  • 15
    • 0344197042 scopus 로고    scopus 로고
    • Lactate dehydrogenase isoenzymes 1 and 5: Differential expression by neoplastic and stromal cells in non-small cell lung cancer and other epithelial malignant tumors
    • Koukourakis MI, Giatromanolaki A, Sivridis E. Lactate dehydrogenase isoenzymes 1 and 5: differential expression by neoplastic and stromal cells in non-small cell lung cancer and other epithelial malignant tumors. Tumour Biol 2003;24:199-202.
    • (2003) Tumour Biol , vol.24 , pp. 199-202
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Sivridis, E.3
  • 16
    • 0026497186 scopus 로고
    • Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer
    • Horak ER, Leek R, Klenk N, et al. Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer. Lancet 1992;340:1120-4.
    • (1992) Lancet , vol.340 , pp. 1120-1124
    • Horak, E.R.1    Leek, R.2    Klenk, N.3
  • 17
    • 0033692793 scopus 로고    scopus 로고
    • Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors
    • Brown NS, Jones A, Fujiyama C, et al. Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors. Cancer Res 2000;60:6298-302.
    • (2000) Cancer Res , vol.60 , pp. 6298-6302
    • Brown, N.S.1    Jones, A.2    Fujiyama, C.3
  • 18
    • 0035860147 scopus 로고    scopus 로고
    • Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival
    • Giatromanolaki A, Koukourakis MI, Sivridis E, et al. Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival. Br J Cancer 2001;85:881-90.
    • (2001) Br J Cancer , vol.85 , pp. 881-890
    • Giatromanolaki, A.1    Koukourakis, M.I.2    Sivridis, E.3
  • 19
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1a7lpha in common human cancers and their metastases
    • Zhong H, De Marzo AM, Laughner E, et al. Overexpression of hypoxia-inducible factor 1a7lpha in common human cancers and their metastases. Cancer Res 1999;59:5830-5.
    • (1999) Cancer Res , vol.59 , pp. 5830-5835
    • Zhong, H.1    De Marzo, A.M.2    Laughner, E.3
  • 20
    • 0036721256 scopus 로고    scopus 로고
    • Association of hypoxia-inducible factors 1 alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma
    • Sivridis E, Giatromanolaki A, Gatter KC, Tumor and Angiogenesis Research Group, et al. Association of hypoxia-inducible factors 1 alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma. Cancer 2002;95:1055-63.
    • (2002) Cancer , vol.95 , pp. 1055-1063
    • Sivridis, E.1    Giatromanolaki, A.2    Gatter, K.C.3
  • 21
    • 0036680153 scopus 로고    scopus 로고
    • Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-ana-neck cancer
    • Koukourakis MI, Giatromanolaki A, Sivridis E, et al. Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-ana-neck cancer. Int J Radiat Oncol Biol Phys 2002;53:1192-202.
    • (2002) Int J Radiat Oncol Biol Phys , vol.53 , pp. 1192-1202
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Sivridis, E.3
  • 22
    • 0035266307 scopus 로고    scopus 로고
    • Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy
    • Koukourakis MI, Giatromanolaki A, Skarlatos J, et al. Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy. Cancer Res 2001;61:1830-2.
    • (2001) Cancer Res , vol.61 , pp. 1830-1832
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Skarlatos, J.3
  • 23
    • 0142120661 scopus 로고    scopus 로고
    • Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin
    • Giatromanolaki A, Sivridis E, Kouskoukis C, et al. Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. Melanoma Res 2003;13:493-501.
    • (2003) Melanoma Res , vol.13 , pp. 493-501
    • Giatromanolaki, A.1    Sivridis, E.2    Kouskoukis, C.3
  • 24
    • 0035144836 scopus 로고    scopus 로고
    • Fibroblast migratory factor derived from mouse colon carcinoma cells: Potential roles of fibronectin in tumor stroma formation
    • Morimoto M, Irimura T. Fibroblast migratory factor derived from mouse colon carcinoma cells: potential roles of fibronectin in tumor stroma formation. J Cell Biochem 2001;80:635-46.
    • (2001) J Cell Biochem , vol.80 , pp. 635-646
    • Morimoto, M.1    Irimura, T.2
  • 25
    • 0028132865 scopus 로고
    • Vitronectin in colorectal adenocarcinoma - Synthesis by stromal cells in culture
    • Tomasini-Johansson BR, Sundberg C, Lindmark G, et al. Vitronectin in colorectal adenocarcinoma - synthesis by stromal cells in culture. Exp Cell Res 1994;214:303-12.
    • (1994) Exp Cell Res , vol.214 , pp. 303-312
    • Tomasini-Johansson, B.R.1    Sundberg, C.2    Lindmark, G.3
  • 26
    • 0842288323 scopus 로고    scopus 로고
    • TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
    • Bhowmick NA, Chytil A, Plieth D, et al. TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science 2004;303:848-51.
    • (2004) Science , vol.303 , pp. 848-851
    • Bhowmick, N.A.1    Chytil, A.2    Plieth, D.3
  • 27
    • 0037261751 scopus 로고    scopus 로고
    • Regulation of cell growth and the expression of extracellular matrix proteins in colorectal adenocarcinoma: A fibroblast-tumor cell coculture model to study tumor-host interactions in vitro
    • Hauptmann S, Siegert A, Berger S, et al. Regulation of cell growth and the expression of extracellular matrix proteins in colorectal adenocarcinoma: a fibroblast-tumor cell coculture model to study tumor-host interactions in vitro. Eur J Cell Biol 2003;82:1-8.
    • (2003) Eur J Cell Biol , vol.82 , pp. 1-8
    • Hauptmann, S.1    Siegert, A.2    Berger, S.3
  • 28
    • 0025103317 scopus 로고
    • Fibroblast-mediated acceleration of human epithelial tumor growth in vivo
    • Camps JL, Chang SM, Hsu TC, et al. Fibroblast-mediated acceleration of human epithelial tumor growth in vivo. Proc Natl Acad Sci U S A 1990;87:75-9.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 75-79
    • Camps, J.L.1    Chang, S.M.2    Hsu, T.C.3
  • 29
    • 0033215242 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium
    • Olumi AF, Grossfeld GD, Hayward SW, et al. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res 1999;59:5002-11.
    • (1999) Cancer Res , vol.59 , pp. 5002-5011
    • Olumi, A.F.1    Grossfeld, G.D.2    Hayward, S.W.3
  • 30
    • 0035866363 scopus 로고    scopus 로고
    • Breast stroma plays a dominant regulatory role in breast epithelial growth and differentiation: Implications for tumor development and progression
    • Shekhar MP, Werdell J, Santner SJ, et al. Breast stroma plays a dominant regulatory role in breast epithelial growth and differentiation: implications for tumor development and progression. Cancer Res 2001;61:1320-6.
    • (2001) Cancer Res , vol.61 , pp. 1320-1326
    • Shekhar, M.P.1    Werdell, J.2    Santner, S.J.3
  • 31
    • 0037930620 scopus 로고    scopus 로고
    • Thymidine phosphorylase induces angiogenesis in vivo and in vitro: An evaluation of possible mechanisms
    • Sengupta S, Sellers LA, Matheson HB, et al. Thymidine phosphorylase induces angiogenesis in vivo and in vitro: an evaluation of possible mechanisms. Br J Pharmacol 2003;139:219-31.
    • (2003) Br J Pharmacol , vol.139 , pp. 219-231
    • Sengupta, S.1    Sellers, L.A.2    Matheson, H.B.3
  • 32
    • 0031982381 scopus 로고    scopus 로고
    • Different patterns of stromal and cancer cell thymidine phosphorylase reactivity in non-small-cell lung cancer: Impact on tumour neoangiogenesis and survival
    • Koukourakis MI, Giatromanolaki A, Kakolyris S, et al. Different patterns of stromal and cancer cell thymidine phosphorylase reactivity in non-small-cell lung cancer: impact on tumour neoangiogenesis and survival. Br J Cancer 1998;77:1696-703.
    • (1998) Br J Cancer , vol.77 , pp. 1696-1703
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Kakolyris, S.3
  • 34
    • 0037029708 scopus 로고    scopus 로고
    • Thymidine phosphorylase expression in normal, hyperplastic and neoplastic prostates: Correlation with tumour associated macrophages, infiltrating lymphocytes, and angiogenesis
    • Sivridis E, Giatromanolaki A, Papadopoulos I, et al. Thymidine phosphorylase expression in normal, hyperplastic and neoplastic prostates: correlation with tumour associated macrophages, infiltrating lymphocytes, and angiogenesis. Br J Cancer 2002;86:1465-71.
    • (2002) Br J Cancer , vol.86 , pp. 1465-1471
    • Sivridis, E.1    Giatromanolaki, A.2    Papadopoulos, I.3
  • 35
    • 0742307278 scopus 로고    scopus 로고
    • Tumor-stromal cell contact promotes invasion of human uterine cervical carcinoma cells by augmenting the expression and activation of stromal matrix metalloproteinases
    • Sato T, Sakai T, Noguchi Y, et al. Tumor-stromal cell contact promotes invasion of human uterine cervical carcinoma cells by augmenting the expression and activation of stromal matrix metalloproteinases. Gynecol Oncol 2004;92:47-56.
    • (2004) Gynecol Oncol , vol.92 , pp. 47-56
    • Sato, T.1    Sakai, T.2    Noguchi, Y.3
  • 36
    • 0034744375 scopus 로고    scopus 로고
    • The Ets-1 transcription factor is up-regulated together with MMP 1 and MMP 9 in the stroma of pre-invasive breast cancer
    • Behrens P, Rothe M, Wellmann A, et al. The Ets-1 transcription factor is up-regulated together with MMP 1 and MMP 9 in the stroma of pre-invasive breast cancer. J Pathol 2001;194:43-50.
    • (2001) J Pathol , vol.194 , pp. 43-50
    • Behrens, P.1    Rothe, M.2    Wellmann, A.3
  • 37
    • 0024601997 scopus 로고
    • Purification of the migration stimulating factor produced by fetal and breast cancer patient fibroblasts
    • Grey AM, Schor AM, Rushton G, et al. Purification of the migration stimulating factor produced by fetal and breast cancer patient fibroblasts. Proc Natl Acad Sci U S A J 1989;86:2438-42.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 2438-2442
    • Grey, A.M.1    Schor, A.M.2    Rushton, G.3
  • 38
    • 7044263046 scopus 로고    scopus 로고
    • The role of fibroblasts in the modulation of integrin-dependent interactions between the gastric cell line HGT-1 and fibronectin
    • Nejjari M, Anderson W, Pourreyron C, et al. The role of fibroblasts in the modulation of integrin-dependent interactions between the gastric cell line HGT-1 and fibronectin. Int J Cancer 2004;112:560-9.
    • (2004) Int J Cancer , vol.112 , pp. 560-569
    • Nejjari, M.1    Anderson, W.2    Pourreyron, C.3
  • 39
    • 8344237449 scopus 로고    scopus 로고
    • Hydroxylation of HIF-1: Oxygen sensing at the molecular level
    • Semenza GL. Hydroxylation of HIF-1: oxygen sensing at the molecular level. Physiology Bethesda 2004;19:176-82.
    • (2004) Physiology Bethesda , vol.19 , pp. 176-182
    • Semenza, G.L.1
  • 40
    • 0031748828 scopus 로고    scopus 로고
    • The contribution of lactic acid to acidification of tumours: Studies of variant cells lacking lactate dehydrogenase
    • Yamagata M, Hasuda K, Stamato T, et al. The contribution of lactic acid to acidification of tumours: studies of variant cells lacking lactate dehydrogenase. Br J Cancer 1998;77:1726-31.
    • (1998) Br J Cancer , vol.77 , pp. 1726-1731
    • Yamagata, M.1    Hasuda, K.2    Stamato, T.3
  • 41
    • 0344197968 scopus 로고    scopus 로고
    • Anoxic fibroblasts activate a replication checkpoint that is bypassed by E1a
    • Gardner LB, Li F, Yang X, et al. Anoxic fibroblasts activate a replication checkpoint that is bypassed by E1a. Mol Cell Biol 2003;23:9032-45.
    • (2003) Mol Cell Biol , vol.23 , pp. 9032-9045
    • Gardner, L.B.1    Li, F.2    Yang, X.3
  • 42
    • 12344288653 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase, Akt and mammalian target of rapamycin (mTOR) is necessary for hypoxia-induced pulmonary artery adventitial fibroblast proliferation
    • Gerasimovskaya EV, Tucker DA, Stenmark KR. Activation of phosphatidylinositol 3-kinase, Akt and mammalian target of rapamycin (mTOR) is necessary for hypoxia-induced pulmonary artery adventitial fibroblast proliferation. J Appl Physiol 2005;98:722-31.
    • (2005) J Appl Physiol , vol.98 , pp. 722-731
    • Gerasimovskaya, E.V.1    Tucker, D.A.2    Stenmark, K.R.3
  • 43
    • 12344254223 scopus 로고    scopus 로고
    • Egr-1 antisense oligonucleotides inhibit hypoxia-induced proliferation of pulmonary artery adventitial fibroblasts
    • Banks MF, Gerasimovskaya EV, Tucker DA, et al. Egr-1 antisense oligonucleotides inhibit hypoxia-induced proliferation of pulmonary artery adventitial fibroblasts. J Appl Physiol 2005;98:732-8.
    • (2005) J Appl Physiol , vol.98 , pp. 732-738
    • Banks, M.F.1    Gerasimovskaya, E.V.2    Tucker, D.A.3
  • 44
    • 0345829932 scopus 로고    scopus 로고
    • Extracellular ATP is an autocrine/paracrine regulator of hypoxia-induced adventitial fibroblast growth. Signaling through extracellular signal-regulated kinase-1/2 and the Egr-1 transcription factor
    • Gerasimovskaya EV, Ahmad S, White CW, et al. Extracellular ATP is an autocrine/paracrine regulator of hypoxia-induced adventitial fibroblast growth. Signaling through extracellular signal-regulated kinase-1/2 and the Egr-1 transcription factor. J Biol Chem 2002;277:44638-50.
    • (2002) J Biol Chem , vol.277 , pp. 44638-44650
    • Gerasimovskaya, E.V.1    Ahmad, S.2    White, C.W.3
  • 45
    • 0024428826 scopus 로고
    • Normal fibroblasts responding to anoxia exhibit features of the malignant phenotype
    • Anderson GR, Stoler DL, Scarcello LA. Normal fibroblasts responding to anoxia exhibit features of the malignant phenotype. J Biol Chem 1989;264:14885-92.
    • (1989) J Biol Chem , vol.264 , pp. 14885-14892
    • Anderson, G.R.1    Stoler, D.L.2    Scarcello, L.A.3
  • 46
    • 3042731572 scopus 로고    scopus 로고
    • Stimulation of fibroblast proliferation by lactate-mediated oxidants
    • Wagner S, Hussain MZ, Hunt TK, et al. Stimulation of fibroblast proliferation by lactate-mediated oxidants. Wound Repair Regen 2004;12:368-73.
    • (2004) Wound Repair Regen , vol.12 , pp. 368-373
    • Wagner, S.1    Hussain, M.Z.2    Hunt, T.K.3
  • 47
    • 0036427196 scopus 로고    scopus 로고
    • Fibroblast proliferation due to exposure to a platelet concentrate in vitro is pH dependent
    • Liu Y, Kalen A, Risto O, et al. Fibroblast proliferation due to exposure to a platelet concentrate in vitro is pH dependent. Wound Repair Regen 2002;10:336-40.
    • (2002) Wound Repair Regen , vol.10 , pp. 336-340
    • Liu, Y.1    Kalen, A.2    Risto, O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.