Monocyte-Endothelial Cell Interactions in the Development of Atherosclerosis

Trends in Cardiovascular Medicine

Volumn 18, Issue 6, 2008, Pages 228-232

  Mestas, Javier ^a   Ley, Klaus ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; CHEMOKINE; CYTOKINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PADGEM PROTEIN; VASCULAR CELL ADHESION MOLECULE 1;

ATHEROSCLEROSIS; BLOOD VESSEL WALL; CELL INTERACTION; MONOCYTE; NONHUMAN; PHAGOCYTE; PRIORITY JOURNAL; REVIEW; THROMBOCYTE ACTIVATION;

ATHEROSCLEROSIS; CELL ADHESION MOLECULES; CHEMOKINES; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; INFLAMMATION; INTEGRINS; LIPOPROTEINS, LDL; MEMBRANE GLYCOPROTEINS; MONOCYTES; P-SELECTIN; VASCULAR CELL ADHESION MOLECULE-1;

EID: 58649100256     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tcm.2008.11.004     Document Type: Review

References (72)

1. Alon R., Kassner P.D., Carr M.W., et al. The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J Cell Biol 128 (1995) 1243-1253
2. An G., Wang H., Tang R., et al. P-selectin glycoprotein ligand-1 is highly expressed on Ly-6Chi monocytes and a major determinant for Ly-6Chi monocyte recruitment to sites of atherosclerosis in mice. Circulation 117 (2008) 3227-3237
3. Bernhagen J., Krohn R., Lue H., et al. MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med 13 (2007) 587-596
4. Boring L., Gosling J., Cleary M., and Charo I.F. Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 394 (1998) 894-897
5. Braunersreuther V., Zernecke A., Arnaud C., et al. Ccr5 but not Ccr1 deficiency reduces development of diet-induced atherosclerosis in mice. Arterioscler Thromb Vasc Biol 27 (2007) 373-379
6. Braunersreuther V., Steffens S., Arnaud C., et al. A novel RANTES antagonist prevents progression of established atherosclerotic lesions in mice. Arterioscler Thromb Vasc Biol 28 (2008) 1090-1096
7. Bullard D.C., Kunkel E.J., Kubo H., et al. Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J Exp Med 183 (1996) 2329-2336
8. Burger P.C., and Wagner D.D. Platelet P-selectin facilitates atherosclerotic lesion development. Blood 101 (2003) 2661-2666
9. Campbell J.J., Hedrick J., Zlotnik A., et al. Chemokines and the arrest of lymphocytes rolling under flow conditions. Science 279 (1998) 381-384
10. Chiu J.J., Usami S., and Chien S. Vascular endothelial responses to altered shear stress: Pathologic implications for atherosclerosis. Ann Med 18 (2008) 1-10
11. Collins R.G., Velji R., Guevara N.V., et al. P-Selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice. J Exp Med 191 (2000) 189-194
12. Combadiere C., Potteaux S., Gao J.L., et al. Decreased atherosclerotic lesion formation in CX3CR1/apolipoprotein E double knockout mice. Circulation 107 (2003) 1009-1016
13. Combadiere C., Potteaux S., Rodero M., et al. Combined inhibition of CCL2, CX3CR1, and CCR5 abrogates Ly6C(hi) and Ly6C(lo) monocytosis and almost abolishes atherosclerosis in hypercholesterolemic mice. Circulation 117 (2008) 1649-1657
14. Cybulsky M.I., and Gimbrone Jr. M.A. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 251 (1991) 788-791
15. Cybulsky M.I., Iiyama K., Li H., et al. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest 107 (2001) 1255-1262
16. Dong Z.M., Chapman S.M., Brown A.A., et al. The combined role of P- and E-selectins in atherosclerosis. J Clin Invest 102 (1998) 145-152
17. Elstad M.R., La Pine T.R., Cowley F.S., et al. P-selectin regulates platelet-activating factor synthesis and phagocytosis by monocytes. J Immunol 155 (1995) 2109-2122
18. Fong A.M., Robinson L.A., Steeber D.A., et al. Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow. J Exp Med 188 (1998) 1413-1419
19. Galkina E., and Ley K. Leukocyte influx in atherosclerosis. Curr Drug Targets 8 (2007) 1239-1248
20. Galkina E., and Ley K. Vascular adhesion molecules in atherosclerosis. Arterioscler Thromb Vasc Biol 27 (2007) 2292-2301
21. Gebuhrer V., Murphy J.F., Bordet J.C., et al. Oxidized low-density lipoprotein induces the expression of P-selectin (GMP140/PADGEM/CD62) on human endothelial cells. Biochem J 306 Pt 1 (1995) 293-298
22. Geissmann F., Jung S., and Littman D.R. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 19 (2003) 71-82
23. Gerrity R.G. The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. Am J Pathol 103 (1981) 181-190
24. Gerszten R.E., Lim Y.C., Ding H.T., et al. Adhesion of monocytes to vascular cell adhesion molecule-1-transduced human endothelial cells: implications for atherogenesis. Circ Res 82 (1998) 871-878
25. Gerszten R.E., Garcia-Zepeda E.A., Lim Y.C., et al. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature 398 (1999) 718-723
26. Gu L., Okada Y., Clinton S.K., et al. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Mol Cell 2 (1998) 275-281
27. Haskell C.A., Cleary M.D., and Charo I.F. Molecular uncoupling of fractalkine-mediated cell adhesion and signal transduction. Rapid flow arrest of CX3CR1-expressing cells is independent of G-protein activation. J Biol Chem 274 (1999) 10053-10058
28. Hermand P., Pincet F., Carvalho S., et al. Functional adhesiveness of the CX3CLl1 chemokine requires its aggregation: role of the transmembrane domain. J Biol Chem 283 (2008) 30225-30234
29. Huo Y., and Ley K. Adhesion molecules and atherogenesis. Acta Physiol Scand 173 (2001) 35-43
30. Huo Y., and Ley K.F. Role of platelets in the development of atherosclerosis. Trends Cardiovasc Med 14 (2004) 18-22
31. Huo Y., Hafezi-Moghadam A., and Ley K. Role of vascular cell adhesion molecule-1 and fibronectin connecting segment-1 in monocyte rolling and adhesion on early atherosclerotic lesions. Circ Res 87 (2000) 153-159
32. Huo Y., Weber C., Forlow S.B., et al. The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium. J Clin Invest 108 (2001) 1307-1314
33. Huo Y., Schober A., Forlow S.B., et al. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med 9 (2003) 61-67
34. Imhof B.A., and Aurrand-Lions M. Adhesion mechanisms regulating the migration of monocytes. Nat Rev Immunol 4 (2004) 432-444
35. Ishibashi S., Brown M.S., Goldstein J.L., et al. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest 92 (1993) 883-893
36. Jia T., Serbina N.V., Brandl K., et al. Additive roles for MCP-1 and MCP-3 in CCR2-mediated recruitment of inflammatory monocytes during Listeria monocytogenes infection. J Immunol 180 (2008) 6846-6853
37. Khan B.V., Parthasarathy S.S., Alexander R.W., and Medford R.M. Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells. J Clin Invest 95 (1995) 1262-1270
38. Lesnik P., Haskell C.A., and Charo I.F. Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis. J Clin Invest 111 (2003) 333-340
39. Ley K., and Kansas G.S. Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation. Nat Rev Immunol 4 (2004) 325-335
40. Lortat-Jacob H., Grosdidier A., and Imberty A. Structural diversity of heparan sulfate binding domains in chemokines. Proc Natl Acad Sci U S A 99 (2002) 1229-1234
41. Luo B.H., Carman C.V., and Springer T.A. Structural basis of integrin regulation and signaling. Annu Rev Immunol 25 (2007) 619-647
42. Luscinskas F.W., Kansas G.S., Ding H., et al. Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins. J Cell Biol 125 (1994) 1417-1427
43. Ma Y.Q., Plow E.F., and Geng J.G. P-selectin binding to P-selectin glycoprotein ligand-1 induces an intermediate state of alphaMbeta2 activation and acts cooperatively with extracellular stimuli to support maximal adhesion of human neutrophils. Blood 104 (2004) 2549-2556
44. McEver R.P., Moore K.L., and Cummings R.D. Leukocyte trafficking mediated by selectin-carbohydrate interactions. J Biol Chem 270 (1995) 11025-11028
45. Nageh M.F., Sandberg E.T., Marotti K.R., et al. Deficiency of inflammatory cell adhesion molecules protects against atherosclerosis in mice. Arterioscler Thromb Vasc Biol 17 (1997) 1517-1520
46. Poston R.N., Haskard D.O., Coucher J.R., et al. Expression of intercellular adhesion molecule-1 in atherosclerotic plaques. Am J Pathol 140 (1992) 665-673
47. Pruenster M., and Rot A. Throwing light on DARC. Biochem Soc Trans 34 (2006) 1005-1008
48. Qiao J.H., Tripathi J., Mishra N.K., et al. Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice. Am J Pathol 150 (1997) 1687-1699
49. Rajavashisth T., Qiao J.H., Tripathi S., et al. Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor-deficient mice. J Clin Invest 101 (1998) 2702-2710
50. Ramos C.L., Huo Y., Jung U., et al. Direct demonstration of P-selectin- and VCAM-1-dependent mononuclear cell rolling in early atherosclerotic lesions of apolipoprotein E-deficient mice. Circ Res 84 (1999) 1237-1244
51. Rivera-Nieves J., Burcin T.L., Olson T.S., et al. Critical role of endothelial P-selectin glycoprotein ligand 1 in chronic murine ileitis. J Exp Med 203 (2006) 907-917
52. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362 (1993) 801-809
53. Saederup N., Chan L., Lira S.A., and Charo I.F. Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesis. Circulation 117 (2008) 1642-1648
54. Schulz C., Schafer A., Stolla M., et al. Chemokine fractalkine mediates leukocyte recruitment to inflammatory endothelial cells in flowing whole blood: a critical role for P-selectin expressed on activated platelets. Circulation 116 (2007) 764-773
55. Shih P.T., Brennan M.L., Vora D.K., et al. Blocking very late antigen-4 integrin decreases leukocyte entry and fatty streak formation in mice fed an atherogenic diet. Circ Res 84 (1999) 345-351
56. Smith J.D., Trogan E., Ginsberg M., et al. Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E. Proc Natl Acad Sci U S A 92 (1995) 8264-8268
57. Smith M.L., Olson T.S., and Ley K. CXCR2- and E-selectin-induced neutrophil arrest during inflammation in vivo. J Exp Med 200 (2004) 935-939
58. Smith D.F., Galkina E., Ley K., and Huo Y. GRO family chemokines are specialized for monocyte arrest from flow. Am J Physiol Heart Circ Physiol 289 (2005) H1976-H1984
59. Subramaniam M., Frenette P.S., Saffaripour S., et al. Defects in hemostasis in P-selectin-deficient mice. Blood 87 (1996) 1238-1242
60. Sunderkotter C., Nikolic T., Dillon M.J., et al. Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J Immunol 172 (2004) 4410-4417
61. Swirski F.K., Libby P., Aikawa E., et al. Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J Clin Invest 117 (2007) 195-205
62. Tacke F., Alvarez D., Kaplan T.J., et al. Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J Clin Invest 117 (2007) 185-194
63. van der Wal A.C., Das P.K., Tigges A.J., and Becker A.E. Adhesion molecules on the endothelium and mononuclear cells in human atherosclerotic lesions. Am J Pathol 141 (1992) 1427-1433
64. Von Hundelshausen P., Weber K.S., Huo Y., et al. RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium. Circulation 103 (2001) 1772-1777
65. Von Hundelshausen P., Koenen R.R., Sack M., et al. Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium. Blood 105 (2005) 924-930
66. Weber C. Novel mechanistic concepts for the control of leukocyte transmigration: specialization of integrins, chemokines, and junctional molecules. J Mol Med 81 (2003) 4-19
67. Weber K.S., von Hundelshausen P., Clark-Lewis I., et al. Differential immobilization and hierarchical involvement of chemokines in monocyte arrest and transmigration on inflamed endothelium in shear flow. Eur J Immunol 29 (1999) 700-712
68. Weyrich A.S., McIntyre T.M., McEver R.P., et al. Monocyte tethering by P-selectin regulates monocyte chemotactic protein-1 and tumor necrosis factor-alpha secretion. Signal integration and NF-kappa B translocation. J Clin Invest 95 (1995) 2297-2303
69. World C.J., Garin G., and Berk B. Vascular shear stress and activation of inflammatory genes. Curr Atheroscler Rep 8 (2006) 240-244
70. Yang X.P., Mattagajasingh S., Su S., et al. Fractalkine upregulates intercellular adhesion molecule-1 in endothelial cells through CX3CR1 and the Jak Stat5 pathway. Circ Res 101 (2007) 1001-1008
71. Zand T., Hoffman A.H., Savilonis B.J., et al. Lipid deposition in rat aortas with intraluminal hemispherical plug stenosis. A morphological and biophysical study. Am J Pathol 155 (1999) 85-92
72. Zhang S.H., Reddick R.L., Piedrahita J.A., and Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 258 (1992) 468-471