Tetrahydrobenzothiophene Derivatives: Conformationally Restricted Inhibitors of TypeII Dehydroquinase

ChemMedChem

Volumn 6, Issue 2, 2011, Pages 266-272

  Paz, Sonia ^a   Tizón, Lorena ^a   Otero, José M ^a,b   Llamas Saiz, Antonio L ^a   Fox, Gavin C ^b   Van Raaij, Mark J ^c   Lamb, Heather ^d   Hawkins, Alastair R ^d   Lapthorn, Adrian J ^e   Castedo, Luis ^a   González Bello, Concepción ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^c CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^d NEWCASTLE UNIVERSITY   (United Kingdom)

^e UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Competitive inhibitors; Helicobacter pylori; Mycobacterium tuberculosis; Restricted conformation; Stable ozonides

Indexed keywords

3 DEHYDROQUINATE DEHYDRATASE; ALKENYL GROUP; AROMATIC AMINO ACID; DICARBOXYLIC ACID; FOLIC ACID; METHYLTHIOPHENE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; SHIKIMIC ACID; THIOPHENE; THIOPHENE DERIVATIVE; UBIQUINONE; UNCLASSIFIED DRUG; VITAMIN;

ARTICLE; BACTERIAL METABOLISM; BIOSYNTHESIS; COMPETITIVE INHIBITION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; HELICOBACTER PYLORI; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

ANTI-BACTERIAL AGENTS; ENZYME INHIBITORS; HYDRO-LYASES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PROTEIN CONFORMATION; THIOPHENES;

EID: 79251572960     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000343     Document Type: Article

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