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Volumn 9, Issue SUPPL. 1, 2010, Pages

R5X4 HIV-1 coreceptor use in primary target cells: Implications for coreceptor entry blocking strategies

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; CHEMOKINE RECEPTOR CXCR4;

EID: 79251564792     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-9-S1-S3     Document Type: Article
Times cited : (12)

References (68)
  • 2
    • 33750485035 scopus 로고    scopus 로고
    • HIV-1 coreceptor preference is distinct from target cell tropism: a dual-parameter nomenclature to define viral phenotypes.
    • 10.1189/jlb.0306148, 16923919
    • Goodenow MM, Collman RG. HIV-1 coreceptor preference is distinct from target cell tropism: a dual-parameter nomenclature to define viral phenotypes. J Leukoc Biol 2006, 80:965-972. 10.1189/jlb.0306148, 16923919.
    • (2006) J Leukoc Biol , vol.80 , pp. 965-972
    • Goodenow, M.M.1    Collman, R.G.2
  • 3
    • 0026070668 scopus 로고
    • Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture.
    • 240525, 1985204
    • Schuitemaker H, Kootstra NA, de Goede RE, de Wolf F, Miedema F, Tersmette M. Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture. J Virol 1991, 65:356-363. 240525, 1985204.
    • (1991) J Virol , vol.65 , pp. 356-363
    • Schuitemaker, H.1    Kootstra, N.A.2    de Goede, R.E.3    de Wolf, F.4    Miedema, F.5    Tersmette, M.6
  • 5
    • 0032929247 scopus 로고    scopus 로고
    • Conversion rate towards a syncytium-inducing (SI) phenotype during different stages of human immunodeficiency virus type 1 infection and prognostic value of SI phenotype for survival after AIDS diagnosis.
    • 10.1086/314539, 9841850
    • Koot M, van Leeuwen R, de Goede RE, Keet IP, Danner S, Eeftinck Schattenkerk JK, Reiss P, Tersmette M, Lange JM, Schuitemaker H. Conversion rate towards a syncytium-inducing (SI) phenotype during different stages of human immunodeficiency virus type 1 infection and prognostic value of SI phenotype for survival after AIDS diagnosis. J Infect Dis 1999, 179:254-258. 10.1086/314539, 9841850.
    • (1999) J Infect Dis , vol.179 , pp. 254-258
    • Koot, M.1    van Leeuwen, R.2    de Goede, R.E.3    Keet, I.P.4    Danner, S.5    Eeftinck Schattenkerk, J.K.6    Reiss, P.7    Tersmette, M.8    Lange, J.M.9    Schuitemaker, H.10
  • 6
    • 0033786824 scopus 로고    scopus 로고
    • Differential coreceptor expression allows for independent evolution of non-syncytium-inducing and syncytium-inducing HIV-1.
    • 10.1172/JCI7953, 314337, 11032864
    • van Rij RP, Blaak H, Visser JA, Brouwer M, Rientsma R, Broersen S, de Roda Husman AM, Schuitemaker H. Differential coreceptor expression allows for independent evolution of non-syncytium-inducing and syncytium-inducing HIV-1. J Clin Invest 2000, 106:1039-1052. 10.1172/JCI7953, 314337, 11032864.
    • (2000) J Clin Invest , vol.106 , pp. 1039-1052
    • van Rij, R.P.1    Blaak, H.2    Visser, J.A.3    Brouwer, M.4    Rientsma, R.5    Broersen, S.6    de Roda Husman, A.M.7    Schuitemaker, H.8
  • 7
    • 0031466811 scopus 로고    scopus 로고
    • Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: implications for HIV primary infection.
    • 10.1038/nm1297-1369, 9396607
    • Zaitseva M, Blauvelt A, Lee S, Lapham CK, Klaus-Kovtun V, Mostowski H, Manischewitz J, Golding H. Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: implications for HIV primary infection. Nat Med 1997, 3:1369-1375. 10.1038/nm1297-1369, 9396607.
    • (1997) Nat Med , vol.3 , pp. 1369-1375
    • Zaitseva, M.1    Blauvelt, A.2    Lee, S.3    Lapham, C.K.4    Klaus-Kovtun, V.5    Mostowski, H.6    Manischewitz, J.7    Golding, H.8
  • 9
    • 0030751948 scopus 로고    scopus 로고
    • Expression cloning of new receptors used by simian and human immunodeficiency viruses.
    • 10.1038/40894, 9230441
    • Deng HK, Unutmaz D, KewalRamani VN, Littman DR. Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature 1997, 388:296-300. 10.1038/40894, 9230441.
    • (1997) Nature , vol.388 , pp. 296-300
    • Deng, H.K.1    Unutmaz, D.2    KewalRamani, V.N.3    Littman, D.R.4
  • 10
    • 0034960174 scopus 로고    scopus 로고
    • Molecular basis for cell tropism of CXCR4-dependent human immunodeficiency virus type 1 isolates.
    • 10.1128/JVI.75.15.6776-6785.2001, 114404, 11435556
    • Tokunaga K, Greenberg ML, Morse MA, Cumming RI, Lyerly HK, Cullen BR. Molecular basis for cell tropism of CXCR4-dependent human immunodeficiency virus type 1 isolates. J Virol 2001, 75:6776-6785. 10.1128/JVI.75.15.6776-6785.2001, 114404, 11435556.
    • (2001) J Virol , vol.75 , pp. 6776-6785
    • Tokunaga, K.1    Greenberg, M.L.2    Morse, M.A.3    Cumming, R.I.4    Lyerly, H.K.5    Cullen, B.R.6
  • 11
    • 13744249284 scopus 로고    scopus 로고
    • Preferential use of CXCR4 by R5X4 human immunodeficiency virus type 1 isolates for infection of primary lymphocytes.
    • 10.1128/JVI.79.3.1480-1486.2005, 544090, 15650174
    • Yi Y, Shaheen F, Collman RG. Preferential use of CXCR4 by R5X4 human immunodeficiency virus type 1 isolates for infection of primary lymphocytes. J Virol 2005, 79:1480-1486. 10.1128/JVI.79.3.1480-1486.2005, 544090, 15650174.
    • (2005) J Virol , vol.79 , pp. 1480-1486
    • Yi, Y.1    Shaheen, F.2    Collman, R.G.3
  • 12
    • 0031042433 scopus 로고    scopus 로고
    • The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes.
    • 10.1073/pnas.94.5.1925, 20019, 9050881
    • Bleul CC, Wu L, Hoxie JA, Springer TA, Mackay CR. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc Natl Acad Sci USA 1997, 94:1925-1930. 10.1073/pnas.94.5.1925, 20019, 9050881.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 1925-1930
    • Bleul, C.C.1    Wu, L.2    Hoxie, J.A.3    Springer, T.A.4    Mackay, C.R.5
  • 14
    • 0005014748 scopus 로고    scopus 로고
    • The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.
    • 10.1016/S0092-8674(00)81313-6, 8674119
    • Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, et al. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 1996, 85(*):1135-1148. 10.1016/S0092-8674(00)81313-6, 8674119.
    • (1996) Cell , vol.85 , pp. 1135-1148
    • Choe, H.1    Farzan, M.2    Sun, Y.3    Sullivan, N.4    Rollins, B.5    Ponath, P.D.6    Wu, L.7    Mackay, C.R.8    LaRosa, G.9    Newman, W.10
  • 15
    • 0030604727 scopus 로고    scopus 로고
    • A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors.
    • 10.1016/S0092-8674(00)81314-8, 8674120
    • Doranz BJ, Rucker J, Yi Y, Smyth RJ, Samson M, Peiper SC, Parmentier M, Collman RG, Doms RW. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 1996, 85:1149-1158. 10.1016/S0092-8674(00)81314-8, 8674120.
    • (1996) Cell , vol.85 , pp. 1149-1158
    • Doranz, B.J.1    Rucker, J.2    Yi, Y.3    Smyth, R.J.4    Samson, M.5    Peiper, S.C.6    Parmentier, M.7    Collman, R.G.8    Doms, R.W.9
  • 16
    • 0029821869 scopus 로고    scopus 로고
    • A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains.
    • 190654, 8709256
    • Berson JF, Long D, Doranz BJ, Rucker J, Jirik FR, Doms RW. A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains. J Virol 1996, 70:6288-6295. 190654, 8709256.
    • (1996) J Virol , vol.70 , pp. 6288-6295
    • Berson, J.F.1    Long, D.2    Doranz, B.J.3    Rucker, J.4    Jirik, F.R.5    Doms, R.W.6
  • 17
    • 33745234283 scopus 로고    scopus 로고
    • Non-macrophage-tropic human immunodeficiency virus type 1 R5 envelopes predominate in blood, lymph nodes, and semen: implications for transmission and pathogenesis.
    • 10.1128/JVI.02328-05, 1488974, 16775320
    • Peters PJ, Sullivan WM, Duenas-Decamp MJ, Bhattacharya J, Ankghuambom C, Brown R, Luzuriaga K, Bell JE, Simmonds P, Ball J, Clapham PR. Non-macrophage-tropic human immunodeficiency virus type 1 R5 envelopes predominate in blood, lymph nodes, and semen: implications for transmission and pathogenesis. J Virol 2006, 80:6324-6332. 10.1128/JVI.02328-05, 1488974, 16775320.
    • (2006) J Virol , vol.80 , pp. 6324-6332
    • Peters, P.J.1    Sullivan, W.M.2    Duenas-Decamp, M.J.3    Bhattacharya, J.4    Ankghuambom, C.5    Brown, R.6    Luzuriaga, K.7    Bell, J.E.8    Simmonds, P.9    Ball, J.10    Clapham, P.R.11
  • 18
    • 2942687021 scopus 로고    scopus 로고
    • Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in the brain that confer an enhanced tropism and fusigenicity for macrophages.
    • 10.1128/JVI.78.13.6915-6926.2004, 421670, 15194768
    • Peters PJ, Bhattacharya J, Hibbitts S, Dittmar MT, Simmons G, Bell JE, Simmonds P, Clapham PR. Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in the brain that confer an enhanced tropism and fusigenicity for macrophages. J Virol 2004, 78:6915-6926. 10.1128/JVI.78.13.6915-6926.2004, 421670, 15194768.
    • (2004) J Virol , vol.78 , pp. 6915-6926
    • Peters, P.J.1    Bhattacharya, J.2    Hibbitts, S.3    Dittmar, M.T.4    Simmons, G.5    Bell, J.E.6    Simmonds, P.7    Clapham, P.R.8
  • 19
    • 0032546952 scopus 로고    scopus 로고
    • A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding.
    • 10.1126/science.280.5371.1949, 9632396
    • Rizzuto CD, Wyatt R, Hernandez-Ramos N, Sun Y, Kwong PD, Hendrickson WA, Sodroski J. A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding. Science 1998, 280:1949-1953. 10.1126/science.280.5371.1949, 9632396.
    • (1998) Science , vol.280 , pp. 1949-1953
    • Rizzuto, C.D.1    Wyatt, R.2    Hernandez-Ramos, N.3    Sun, Y.4    Kwong, P.D.5    Hendrickson, W.A.6    Sodroski, J.7
  • 20
    • 11244271607 scopus 로고    scopus 로고
    • The neuropathogenesis of AIDS.
    • 10.1038/nri1527, 15630430
    • Gonzalez-Scarano F, Martin-Garcia J. The neuropathogenesis of AIDS. Nat Rev Immunol 2005, 5:69-81. 10.1038/nri1527, 15630430.
    • (2005) Nat Rev Immunol , vol.5 , pp. 69-81
    • Gonzalez-Scarano, F.1    Martin-Garcia, J.2
  • 21
    • 0036114281 scopus 로고    scopus 로고
    • Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate.
    • 10.1128/JVI.76.12.6277-6292.2002, 136234, 12021361
    • Gorry PR, Taylor J, Holm GH, Mehle A, Morgan T, Cayabyab M, Farzan M, Wang H, Bell JE, Kunstman K, et al. Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate. J Virol 2002, 76:6277-6292. 10.1128/JVI.76.12.6277-6292.2002, 136234, 12021361.
    • (2002) J Virol , vol.76 , pp. 6277-6292
    • Gorry, P.R.1    Taylor, J.2    Holm, G.H.3    Mehle, A.4    Morgan, T.5    Cayabyab, M.6    Farzan, M.7    Wang, H.8    Bell, J.E.9    Kunstman, K.10
  • 22
    • 20444395434 scopus 로고    scopus 로고
    • Uncoupling coreceptor usage of human immunodeficiency virus type 1 (HIV-1) from macrophage tropism reveals biological properties of CCR5-restricted HIV-1 isolates from patients with acquired immunodeficiency syndrome.
    • 10.1016/j.virol.2005.04.034, 15916792
    • Gray L, Sterjovski J, Churchill MJ, Ellery P, Nasr N, Lewin SR, Crowe SM, Wesselingh SL, Cunningham AL, Gorry PR. Uncoupling coreceptor usage of human immunodeficiency virus type 1 (HIV-1) from macrophage tropism reveals biological properties of CCR5-restricted HIV-1 isolates from patients with acquired immunodeficiency syndrome. Virology 2005, 337:384-398. 10.1016/j.virol.2005.04.034, 15916792.
    • (2005) Virology , vol.337 , pp. 384-398
    • Gray, L.1    Sterjovski, J.2    Churchill, M.J.3    Ellery, P.4    Nasr, N.5    Lewin, S.R.6    Crowe, S.M.7    Wesselingh, S.L.8    Cunningham, A.L.9    Gorry, P.R.10
  • 23
    • 70349273723 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 V1-to-V5 envelope variants from the chronic phase of infection use CCR5 and fuse more efficiently than those from early after infection.
    • 10.1128/JVI.00925-09, 2748008, 19625411
    • Etemad B, Fellows A, Kwambana B, Kamat A, Feng Y, Lee S, Sagar M. Human immunodeficiency virus type 1 V1-to-V5 envelope variants from the chronic phase of infection use CCR5 and fuse more efficiently than those from early after infection. J Virol 2009, 83:9694-9708. 10.1128/JVI.00925-09, 2748008, 19625411.
    • (2009) J Virol , vol.83 , pp. 9694-9708
    • Etemad, B.1    Fellows, A.2    Kwambana, B.3    Kamat, A.4    Feng, Y.5    Lee, S.6    Sagar, M.7
  • 25
    • 0042029362 scopus 로고    scopus 로고
    • An unusual syncytia-inducing human immunodeficiency virus type 1 primary isolate from the central nervous system that is restricted to CXCR4, replicates efficiently in macrophages, and induces neuronal apoptosis.
    • Yi Y, Chen W, Frank I, Cutilli J, Singh A, Starr-Spires L, Sulcove J, Kolson DL, Collman RG. An unusual syncytia-inducing human immunodeficiency virus type 1 primary isolate from the central nervous system that is restricted to CXCR4, replicates efficiently in macrophages, and induces neuronal apoptosis. J Neurovirol 2003, 9:432-441.
    • (2003) J Neurovirol , vol.9 , pp. 432-441
    • Yi, Y.1    Chen, W.2    Frank, I.3    Cutilli, J.4    Singh, A.5    Starr-Spires, L.6    Sulcove, J.7    Kolson, D.L.8    Collman, R.G.9
  • 26
    • 0031985684 scopus 로고    scopus 로고
    • CXCR-4 is expressed by primary macrophages and supports CCR5-independent infection by dual-tropic but not T-tropic isolates of human immunodeficiency virus type 1.
    • 109434, 9420285
    • Yi Y, Rana S, Turner JD, Gaddis N, Collman RG. CXCR-4 is expressed by primary macrophages and supports CCR5-independent infection by dual-tropic but not T-tropic isolates of human immunodeficiency virus type 1. J Virol 1998, 72:772-777. 109434, 9420285.
    • (1998) J Virol , vol.72 , pp. 772-777
    • Yi, Y.1    Rana, S.2    Turner, J.D.3    Gaddis, N.4    Collman, R.G.5
  • 27
    • 0032837825 scopus 로고    scopus 로고
    • Role of CXCR4 in cell-cell fusion and infection of monocyte-derived macrophages by primary human immunodeficiency virus type 1 (HIV-1) strains: two distinct mechanisms of HIV-1 dual tropism.
    • 104231, 10438797
    • Yi Y, Isaacs SN, Williams DA, Frank I, Schols D, De Clercq E, Kolson DL, Collman RG. Role of CXCR4 in cell-cell fusion and infection of monocyte-derived macrophages by primary human immunodeficiency virus type 1 (HIV-1) strains: two distinct mechanisms of HIV-1 dual tropism. J Virol 1999, 73:7117-7125. 104231, 10438797.
    • (1999) J Virol , vol.73 , pp. 7117-7125
    • Yi, Y.1    Isaacs, S.N.2    Williams, D.A.3    Frank, I.4    Schols, D.5    De Clercq, E.6    Kolson, D.L.7    Collman, R.G.8
  • 28
    • 42449119376 scopus 로고    scopus 로고
    • Entry coreceptor use and fusion inhibitor T20 sensitivity of dual-tropic R5X4 HIV-1 in primary macrophage infection.
    • 10.1097/QAI.0b013e31816520f6, 2769518, 18197116
    • Yi Y, Loftin L, Wang L, Ratcliffe SJ, Isaacman-Beck J, Collman RG. Entry coreceptor use and fusion inhibitor T20 sensitivity of dual-tropic R5X4 HIV-1 in primary macrophage infection. J Acquir Immune Defic Syndr 2008, 47:285-292. 10.1097/QAI.0b013e31816520f6, 2769518, 18197116.
    • (2008) J Acquir Immune Defic Syndr , vol.47 , pp. 285-292
    • Yi, Y.1    Loftin, L.2    Wang, L.3    Ratcliffe, S.J.4    Isaacman-Beck, J.5    Collman, R.G.6
  • 29
    • 77952554637 scopus 로고    scopus 로고
    • Constrained use of CCR5 on CD4+ lymphocytes by R5X4 HIV-1: Efficiency of Env-CCR5 interactions and low CCR5 expression determine a range of restricted CCR5-mediated entry.
    • Loftin LM, Kienzle MF, Yi Y, Lee B, Lee F, Gray L, Gorry PR, Collman RG. Constrained use of CCR5 on CD4+ lymphocytes by R5X4 HIV-1: Efficiency of Env-CCR5 interactions and low CCR5 expression determine a range of restricted CCR5-mediated entry. Virology 2010,
    • (2010) Virology
    • Loftin, L.M.1    Kienzle, M.F.2    Yi, Y.3    Lee, B.4    Lee, F.5    Gray, L.6    Gorry, P.R.7    Collman, R.G.8
  • 31
    • 0034888099 scopus 로고    scopus 로고
    • A preponderance of CCR5(+) CXCR4(+) mononuclear cells enhances gastrointestinal mucosal susceptibility to human immunodeficiency virus type 1 infection.
    • 10.1128/JVI.75.18.8390-8399.2001, 115084, 11507184
    • Poles MA, Elliott J, Taing P, Anton PA, Chen IS. A preponderance of CCR5(+) CXCR4(+) mononuclear cells enhances gastrointestinal mucosal susceptibility to human immunodeficiency virus type 1 infection. J Virol 2001, 75:8390-8399. 10.1128/JVI.75.18.8390-8399.2001, 115084, 11507184.
    • (2001) J Virol , vol.75 , pp. 8390-8399
    • Poles, M.A.1    Elliott, J.2    Taing, P.3    Anton, P.A.4    Chen, I.S.5
  • 32
    • 27644510382 scopus 로고    scopus 로고
    • Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity.
    • 10.1128/AAC.49.11.4721-4732.2005, 1280117, 16251317
    • Dorr P, Westby M, Dobbs S, Griffin P, Irvine B, Macartney M, Mori J, Rickett G, Smith-Burchnell C, Napier C, et al. Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob Agents Chemother 2005, 49:4721-4732. 10.1128/AAC.49.11.4721-4732.2005, 1280117, 16251317.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 4721-4732
    • Dorr, P.1    Westby, M.2    Dobbs, S.3    Griffin, P.4    Irvine, B.5    Macartney, M.6    Mori, J.7    Rickett, G.8    Smith-Burchnell, C.9    Napier, C.10
  • 34
    • 0033609149 scopus 로고    scopus 로고
    • Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages.
    • 10.1073/pnas.96.9.5215, 21844, 10220446
    • Lee B, Sharron M, Montaner LJ, Weissman D, Doms RW. Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages. Proc Natl Acad Sci USA 1999, 96:5215-5220. 10.1073/pnas.96.9.5215, 21844, 10220446.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 5215-5220
    • Lee, B.1    Sharron, M.2    Montaner, L.J.3    Weissman, D.4    Doms, R.W.5
  • 37
    • 0037404511 scopus 로고    scopus 로고
    • Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry.
    • 10.1128/JVI.77.9.5201-5208.2003, 153966, 12692222
    • Tsamis F, Gavrilov S, Kajumo F, Seibert C, Kuhmann S, Ketas T, Trkola A, Palani A, Clader JW, Tagat JR, et al. Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry. J Virol 2003, 77:5201-5208. 10.1128/JVI.77.9.5201-5208.2003, 153966, 12692222.
    • (2003) J Virol , vol.77 , pp. 5201-5208
    • Tsamis, F.1    Gavrilov, S.2    Kajumo, F.3    Seibert, C.4    Kuhmann, S.5    Ketas, T.6    Trkola, A.7    Palani, A.8    Clader, J.W.9    Tagat, J.R.10
  • 38
    • 40849098660 scopus 로고    scopus 로고
    • Molecular interactions of CCR5 with major classes of small-molecule anti-HIV CCR5 antagonists.
    • 10.1124/mol.107.042101, 18096812
    • Kondru R, Zhang J, Ji C, Mirzadegan T, Rotstein D, Sankuratri S, Dioszegi M. Molecular interactions of CCR5 with major classes of small-molecule anti-HIV CCR5 antagonists. Mol Pharmacol 2008, 73:789-800. 10.1124/mol.107.042101, 18096812.
    • (2008) Mol Pharmacol , vol.73 , pp. 789-800
    • Kondru, R.1    Zhang, J.2    Ji, C.3    Mirzadegan, T.4    Rotstein, D.5    Sankuratri, S.6    Dioszegi, M.7
  • 39
    • 0025783669 scopus 로고
    • Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1.
    • 10.1126/science.1905842, 1905842
    • Hwang SS, Boyle TJ, Lyerly HK, Cullen BR. Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1. Science 1991, 253:71-74. 10.1126/science.1905842, 1905842.
    • (1991) Science , vol.253 , pp. 71-74
    • Hwang, S.S.1    Boyle, T.J.2    Lyerly, H.K.3    Cullen, B.R.4
  • 40
    • 0029955497 scopus 로고    scopus 로고
    • The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection.
    • 10.1038/nm1196-1244, 8898753
    • Cocchi F, DeVico AL, Garzino-Demo A, Cara A, Gallo RC, Lusso P. The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection. Nat Med 1996, 2:1244-1247. 10.1038/nm1196-1244, 8898753.
    • (1996) Nat Med , vol.2 , pp. 1244-1247
    • Cocchi, F.1    DeVico, A.L.2    Garzino-Demo, A.3    Cara, A.4    Gallo, R.C.5    Lusso, P.6
  • 43
    • 66249094578 scopus 로고    scopus 로고
    • Quantitative deep sequencing reveals dynamic HIV-1 escape and large population shifts during CCR5 antagonist therapy in vivo.
    • 10.1371/journal.pone.0005683, 2682648, 19479085
    • Tsibris AM, Korber B, Arnaout R, Russ C, Lo CC, Leitner T, Gaschen B, Theiler J, Paredes R, Su Z, et al. Quantitative deep sequencing reveals dynamic HIV-1 escape and large population shifts during CCR5 antagonist therapy in vivo. PLoS One 2009, 4:e5683. 10.1371/journal.pone.0005683, 2682648, 19479085.
    • (2009) PLoS One , vol.4
    • Tsibris, A.M.1    Korber, B.2    Arnaout, R.3    Russ, C.4    Lo, C.C.5    Leitner, T.6    Gaschen, B.7    Theiler, J.8    Paredes, R.9    Su, Z.10
  • 44
    • 33646443202 scopus 로고    scopus 로고
    • Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir.
    • 10.1128/JVI.80.10.4909-4920.2006, 1472081, 16641282
    • Westby M, Lewis M, Whitcomb J, Youle M, Pozniak AL, James IT, Jenkins TM, Perros M, van der Ryst E. Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir. J Virol 2006, 80:4909-4920. 10.1128/JVI.80.10.4909-4920.2006, 1472081, 16641282.
    • (2006) J Virol , vol.80 , pp. 4909-4920
    • Westby, M.1    Lewis, M.2    Whitcomb, J.3    Youle, M.4    Pozniak, A.L.5    James, I.T.6    Jenkins, T.M.7    Perros, M.8    van der Ryst, E.9
  • 45
    • 51849122551 scopus 로고    scopus 로고
    • Bioinformatic prediction programs underestimate the frequency of CXCR4 usage by R5X4 HIV type 1 in brain and other tissues.
    • 10.1089/aid.2008.0009, 2801411, 18788913
    • Mefford ME, Gorry PR, Kunstman K, Wolinsky SM, Gabuzda D. Bioinformatic prediction programs underestimate the frequency of CXCR4 usage by R5X4 HIV type 1 in brain and other tissues. AIDS Res Hum Retroviruses 2008, 24:1215-1220. 10.1089/aid.2008.0009, 2801411, 18788913.
    • (2008) AIDS Res Hum Retroviruses , vol.24 , pp. 1215-1220
    • Mefford, M.E.1    Gorry, P.R.2    Kunstman, K.3    Wolinsky, S.M.4    Gabuzda, D.5
  • 46
    • 10744231634 scopus 로고    scopus 로고
    • Improved coreceptor usage prediction and genotypic monitoring of R5-to-X4 transition by motif analysis of human immunodeficiency virus type 1 env V3 loop sequences.
    • 10.1128/JVI.77.24.13376-13388.2003, 296044, 14645592
    • Jensen MA, Li FS, van't Wout AB, Nickle DC, Shriner D, He HX, McLaughlin S, Shankarappa R, Margolick JB, Mullins JI. Improved coreceptor usage prediction and genotypic monitoring of R5-to-X4 transition by motif analysis of human immunodeficiency virus type 1 env V3 loop sequences. J Virol 2003, 77:13376-13388. 10.1128/JVI.77.24.13376-13388.2003, 296044, 14645592.
    • (2003) J Virol , vol.77 , pp. 13376-13388
    • Jensen, M.A.1    Li, F.S.2    van't Wout, A.B.3    Nickle, D.C.4    Shriner, D.5    He, H.X.6    McLaughlin, S.7    Shankarappa, R.8    Margolick, J.B.9    Mullins, J.I.10
  • 47
    • 67650694310 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial of maraviroc in treatment-experienced patients infected with non-R5 HIV-1.
    • 10.1086/598965, 19432546
    • Saag M, Goodrich J, Fatkenheuer G, Clotet B, Clumeck N, Sullivan J, Westby M, van der Ryst E, Mayer H. A double-blind, placebo-controlled trial of maraviroc in treatment-experienced patients infected with non-R5 HIV-1. J Infect Dis 2009, 199:1638-1647. 10.1086/598965, 19432546.
    • (2009) J Infect Dis , vol.199 , pp. 1638-1647
    • Saag, M.1    Goodrich, J.2    Fatkenheuer, G.3    Clotet, B.4    Clumeck, N.5    Sullivan, J.6    Westby, M.7    van der Ryst, E.8    Mayer, H.9
  • 49
    • 75749126915 scopus 로고    scopus 로고
    • Vicriviroc in combination therapy with an optimized regimen for treatment-experienced subjects: 48-week results of the VICTOR-E1 phase 2 trial.
    • 10.1086/650342, 20064072
    • Suleiman J, Zingman BS, Diaz RS, Madruga JV, DeJesus E, Slim J, Mak C, Lee E, McCarthy MC, Dunkle LM, Walmsley S. Vicriviroc in combination therapy with an optimized regimen for treatment-experienced subjects: 48-week results of the VICTOR-E1 phase 2 trial. J Infect Dis 2010, 201:590-599. 10.1086/650342, 20064072.
    • (2010) J Infect Dis , vol.201 , pp. 590-599
    • Suleiman, J.1    Zingman, B.S.2    Diaz, R.S.3    Madruga, J.V.4    DeJesus, E.5    Slim, J.6    Mak, C.7    Lee, E.8    McCarthy, M.C.9    Dunkle, L.M.10    Walmsley, S.11
  • 50
    • 0030952479 scopus 로고    scopus 로고
    • Decay characteristics of HIV-1-infected compartments during combination therapy.
    • 10.1038/387188a0, 9144290
    • Perelson AS, Essunger P, Cao Y, Vesanen M, Hurley A, Saksela K, Markowitz M, Ho DD. Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 1997, 387:188-191. 10.1038/387188a0, 9144290.
    • (1997) Nature , vol.387 , pp. 188-191
    • Perelson, A.S.1    Essunger, P.2    Cao, Y.3    Vesanen, M.4    Hurley, A.5    Saksela, K.6    Markowitz, M.7    Ho, D.D.8
  • 52
    • 0028874048 scopus 로고
    • Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection.
    • 10.1038/373123a0, 7816094
    • Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995, 373:123-126. 10.1038/373123a0, 7816094.
    • (1995) Nature , vol.373 , pp. 123-126
    • Ho, D.D.1    Neumann, A.U.2    Perelson, A.S.3    Chen, W.4    Leonard, J.M.5    Markowitz, M.6
  • 54
    • 0032947858 scopus 로고    scopus 로고
    • Human intestinal lamina propria lymphocytes are naturally permissive to HIV-1 infection.
    • 10.1002/(SICI)1521-4141(199904)29:04<1202::AID-IMMU1202>3.0.CO;2-O , 10229087
    • Lapenta C, Boirivant M, Marini M, Santini SM, Logozzi M, Viora M, Belardelli F, Fais S. Human intestinal lamina propria lymphocytes are naturally permissive to HIV-1 infection. Eur J Immunol 1999, 29:1202-1208. 10.1002/(SICI)1521-4141(199904)29:04<1202::AID-IMMU1202>3.0.CO;2-O , 10229087.
    • (1999) Eur J Immunol , vol.29 , pp. 1202-1208
    • Lapenta, C.1    Boirivant, M.2    Marini, M.3    Santini, S.M.4    Logozzi, M.5    Viora, M.6    Belardelli, F.7    Fais, S.8
  • 55
    • 0142092389 scopus 로고    scopus 로고
    • Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy.
    • 10.1128/JVI.77.21.11708-11717.2003, 229357, 14557656
    • Guadalupe M, Reay E, Sankaran S, Prindiville T, Flamm J, McNeil A, Dandekar S. Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy. J Virol 2003, 77:11708-11717. 10.1128/JVI.77.21.11708-11717.2003, 229357, 14557656.
    • (2003) J Virol , vol.77 , pp. 11708-11717
    • Guadalupe, M.1    Reay, E.2    Sankaran, S.3    Prindiville, T.4    Flamm, J.5    McNeil, A.6    Dandekar, S.7
  • 56
    • 1542287574 scopus 로고    scopus 로고
    • In vivo evolution of X4 human immunodeficiency virus type 1 variants in the natural course of infection coincides with decreasing sensitivity to CXCR4 antagonists.
    • 10.1128/JVI.78.6.2722-2728.2004, 353738, 14990692
    • Stalmeijer EH, van Rij RP, Boeser-Nunnink BD, Visser JA, Naarding MA, Schols D, Schuitemaker H. In vivo evolution of X4 human immunodeficiency virus type 1 variants in the natural course of infection coincides with decreasing sensitivity to CXCR4 antagonists. J Virol 2004, 78:2722-2728. 10.1128/JVI.78.6.2722-2728.2004, 353738, 14990692.
    • (2004) J Virol , vol.78 , pp. 2722-2728
    • Stalmeijer, E.H.1    van Rij, R.P.2    Boeser-Nunnink, B.D.3    Visser, J.A.4    Naarding, M.A.5    Schols, D.6    Schuitemaker, H.7
  • 58
    • 0033529303 scopus 로고    scopus 로고
    • Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis.
    • 10.1073/pnas.96.14.8212, 22214, 10393974
    • Kaul M, Lipton SA. Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis. Proc Natl Acad Sci U S A 1999, 96:8212-8216. 10.1073/pnas.96.14.8212, 22214, 10393974.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 8212-8216
    • Kaul, M.1    Lipton, S.A.2
  • 59
    • 0034796289 scopus 로고    scopus 로고
    • Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity.
    • 10.1128/JVI.75.21.10073-10089.2001, 114582, 11581376
    • Gorry PR, Bristol G, Zack JA, Ritola K, Swanstrom R, Birch CJ, Bell JE, Bannert N, Crawford K, Wang H, et al. Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity. J Virol 2001, 75:10073-10089. 10.1128/JVI.75.21.10073-10089.2001, 114582, 11581376.
    • (2001) J Virol , vol.75 , pp. 10073-10089
    • Gorry, P.R.1    Bristol, G.2    Zack, J.A.3    Ritola, K.4    Swanstrom, R.5    Birch, C.J.6    Bell, J.E.7    Bannert, N.8    Crawford, K.9    Wang, H.10
  • 60
    • 53849094834 scopus 로고    scopus 로고
    • Preclinical assessment of the distribution of maraviroc to potential human immunodeficiency virus (HIV) sanctuary sites in the central nervous system (CNS) and gut-associated lymphoid tissue (GALT).
    • 10.1080/00498250802447409, 18853388
    • Walker DK, Bowers SJ, Mitchell RJ, Potchoiba MJ, Schroeder CM, Small HF. Preclinical assessment of the distribution of maraviroc to potential human immunodeficiency virus (HIV) sanctuary sites in the central nervous system (CNS) and gut-associated lymphoid tissue (GALT). Xenobiotica 2008, 38:1330-1339. 10.1080/00498250802447409, 18853388.
    • (2008) Xenobiotica , vol.38 , pp. 1330-1339
    • Walker, D.K.1    Bowers, S.J.2    Mitchell, R.J.3    Potchoiba, M.J.4    Schroeder, C.M.5    Small, H.F.6
  • 61
    • 0027516822 scopus 로고
    • Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS.
    • 10.1038/362359a0, 8096068
    • Embretson J, Zupancic M, Ribas JL, Burke A, Racz P, Tenner-Racz K, Haase AT. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 1993, 362:359-362. 10.1038/362359a0, 8096068.
    • (1993) Nature , vol.362 , pp. 359-362
    • Embretson, J.1    Zupancic, M.2    Ribas, J.L.3    Burke, A.4    Racz, P.5    Tenner-Racz, K.6    Haase, A.T.7
  • 62
    • 0029993722 scopus 로고    scopus 로고
    • Low infection frequency of macrophages in the spleens of HIV+ patients.
    • 10.1016/0923-2516(96)80225-1, 8901430
    • McIlroy D, Autran B, Cheynier R, Clauvel JP, Oksenhendler E, Debre P, Hosmalin A. Low infection frequency of macrophages in the spleens of HIV+ patients. Res Virol 1996, 147:115-121. 10.1016/0923-2516(96)80225-1, 8901430.
    • (1996) Res Virol , vol.147 , pp. 115-121
    • McIlroy, D.1    Autran, B.2    Cheynier, R.3    Clauvel, J.P.4    Oksenhendler, E.5    Debre, P.6    Hosmalin, A.7
  • 63
    • 0026442236 scopus 로고
    • An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1.
    • 240461, 1433527
    • Collman R, Balliet JW, Gregory SA, Friedman H, Kolson DL, Nathanson N, Srinivasan A. An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1. J Virol 1992, 66:7517-7521. 240461, 1433527.
    • (1992) J Virol , vol.66 , pp. 7517-7521
    • Collman, R.1    Balliet, J.W.2    Gregory, S.A.3    Friedman, H.4    Kolson, D.L.5    Nathanson, N.6    Srinivasan, A.7
  • 64
    • 33947417638 scopus 로고    scopus 로고
    • Clinical resistance to enfuvirtide does not affect susceptibility of human immunodeficiency virus type 1 to other classes of entry inhibitors.
    • 10.1128/JVI.02413-06, 1866075, 17251281
    • Ray N, Harrison JE, Blackburn LA, Martin JN, Deeks SG, Doms RW. Clinical resistance to enfuvirtide does not affect susceptibility of human immunodeficiency virus type 1 to other classes of entry inhibitors. J Virol 2007, 81:3240-3250. 10.1128/JVI.02413-06, 1866075, 17251281.
    • (2007) J Virol , vol.81 , pp. 3240-3250
    • Ray, N.1    Harrison, J.E.2    Blackburn, L.A.3    Martin, J.N.4    Deeks, S.G.5    Doms, R.W.6
  • 65
    • 0029018332 scopus 로고
    • Isolation and characterization of a syncytium-inducing, macrophage/T-cell line-tropic human immunodeficiency virus type 1 isolate that readily infects chimpanzee cells in vitro and in vivo.
    • 189187, 7769705
    • Shibata R, Hoggan MD, Broscius C, Englund G, Theodore TS, Buckler-White A, Arthur LO, Israel Z, Schultz A, Lane HC. Isolation and characterization of a syncytium-inducing, macrophage/T-cell line-tropic human immunodeficiency virus type 1 isolate that readily infects chimpanzee cells in vitro and in vivo. J Virol 1995, 69:4453-4462. 189187, 7769705.
    • (1995) J Virol , vol.69 , pp. 4453-4462
    • Shibata, R.1    Hoggan, M.D.2    Broscius, C.3    Englund, G.4    Theodore, T.S.5    Buckler-White, A.6    Arthur, L.O.7    Israel, Z.8    Schultz, A.9    Lane, H.C.10
  • 66
    • 33645217128 scopus 로고    scopus 로고
    • Genetic and functional analysis of R5X4 human immunodeficiency virus type 1 envelope glycoproteins derived from two individuals homozygous for the CCR5delta32 allele.
    • 10.1128/JVI.80.7.3684-3691.2006, 1440368, 16537640
    • Gray L, Churchill MJ, Keane N, Sterjovski J, Ellett AM, Purcell DF, Poumbourios P, Kol C, Wang B, Saksena NK, et al. Genetic and functional analysis of R5X4 human immunodeficiency virus type 1 envelope glycoproteins derived from two individuals homozygous for the CCR5delta32 allele. J Virol 2006, 80:3684-3691. 10.1128/JVI.80.7.3684-3691.2006, 1440368, 16537640.
    • (2006) J Virol , vol.80 , pp. 3684-3691
    • Gray, L.1    Churchill, M.J.2    Keane, N.3    Sterjovski, J.4    Ellett, A.M.5    Purcell, D.F.6    Poumbourios, P.7    Kol, C.8    Wang, B.9    Saksena, N.K.10
  • 67
    • 0022480641 scopus 로고
    • The role of mononuclear phagocytes in HTLV-III/LAV infection.
    • 10.1126/science.3014648, 3014648
    • Gartner S, Markovits P, Markovitz DM, Kaplan MH, Gallo RC, Popovic M. The role of mononuclear phagocytes in HTLV-III/LAV infection. Science 1986, 233:215-219. 10.1126/science.3014648, 3014648.
    • (1986) Science , vol.233 , pp. 215-219
    • Gartner, S.1    Markovits, P.2    Markovitz, D.M.3    Kaplan, M.H.4    Gallo, R.C.5    Popovic, M.6
  • 68
    • 0031873026 scopus 로고    scopus 로고
    • Infection with dual-tropic human immunodeficiency virus type 1 variants associated with rapid total T cell decline and disease progression in injection drug users.
    • Yu XF, Wang Z, Vlahov D, Markham RB, Farzadegan H, Margolick JB. Infection with dual-tropic human immunodeficiency virus type 1 variants associated with rapid total T cell decline and disease progression in injection drug users. J Infect Dis 1998, 178:388-396.
    • (1998) J Infect Dis , vol.178 , pp. 388-396
    • Yu, X.F.1    Wang, Z.2    Vlahov, D.3    Markham, R.B.4    Farzadegan, H.5    Margolick, J.B.6


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