Conversion rate towards a syncytium-inducing (SI) phenotype during different stages of human immunodeficiency virus type 1 infection and prognostic value of SI phenotype for survival after AIDS diagnosis

Journal of Infectious Diseases

Volumn 179, Issue 1, 1999, Pages 254-258

  Koot, M ^a   Van Leeuwen, R ^b   De Goede, R E Y ^b   Keet, I P M ^b   Danner, S ^b   Schattenkerk, J K M Eeftinck ^b   Reiss, P ^b   Tersmette, M ^b   Lange, J M A ^b   Schuitemaker, H ^b  

^a CENTRAL LABORATORY   (Netherlands)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; PHENOTYPE; PREDICTION; PRIORITY JOURNAL; SURVIVAL TIME; SYNCYTIUM; VIRUS TRANSFORMATION;

ACQUIRED IMMUNODEFICIENCY SYNDROME; CD4 LYMPHOCYTE COUNT; CYTOPATHOGENIC EFFECT, VIRAL; HIV INFECTIONS; HIV-1; HUMANS; NETHERLANDS; PHENOTYPE; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; SURVIVAL RATE; VARIATION (GENETICS);

EID: 0032929247     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/314539     Document Type: Article

References (15)

1. Polk BF, Fox R, Brookmeyer R, et al. Predictors of the acquired immunodeficiency syndrome developing in a cohort of seropositive homosexual men. N Engl J Med 1987;316:61-6.
2. Fahey JL, Taylor JMG, Detels R, et al. The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1. N Engl J Med 1990;322:166-72.
3. 6/l but free of AIDS-defining clinical disease. AIDS 1994;8:1577-83.
4. Dean M, Carrington M, Winkler C, et al. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 1996;273:1856-62.
5. De Roda Husman AM, Koot M, Cornelissen M, et al. Association between CCR5 genotype and the clinical course of HIV-1 infection. Ann Intern Med 1997;127:882-90.
6. Tersmette M, Miedema F. Interactions between HIV-1 and the host immune system in the pathogenesis of AIDS. AIDS 1990;5:S57-66.
7. 4 cell depletion and progression to AIDS. Ann Intern Med 1993;118:681-8.
8. Bozzette SA, McCutchan JA, Spector SA, Wright B, Richman DD. A cross-sectional comparison of persons with syncytium- and non-syncytium inducing human immunodeficiency virus. J Infect Dis 1993;168:1374-9.
9. Koot M, Van 't Wout AB, Kootstra NA, De Goede REY, Tersmette M, Schuitemaker H. Relation between changes in cellular load, evolution of viral phenotype, and the clonal composition of virus populations in the course of human immunodeficiency virus type 1 infection. J Infect Dis 1996;173:349-54.
10. Centers for Disease Control. Revision of the CDC surveillance case definition of AIDS. MMWR 1987;36:3-15.
11. Tersmette M, Gruters RA, De Wolf F, et al. Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates. J Virol 1989;63:2118-25.
12. Richman DD, Bozzette SA. The impact of the syncytium-inducing phenotype of human immunodeficiency virus on disease progression. J Infect Dis 1994;169:968-74.
13. Oberlin E, Amara A, Bachelerie F, et al. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line adapted HIV-1. Nature 1996;382:833-5.
14. Bleul CC, Farzan M, Choe H, et al. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 1996;382: 829-32.
15. Amara A, Le Gall S, Schwartz O, et al. HIV coreceptor downregulation as antiviral principle: SDF-1α-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication. J Exp Med 1997;186:139-46.