Low infection frequency of macrophages in the spleens of HIV+ patients

Research in Virology

Volumn 147, Issue 2-3, 1996, Pages 115-121

  McIlroy, D ^a   Autran, B ^a   Cheynier, R ^b   Clauvel, J P ^c   Oksenhendler, E ^c   Debre P ^a   Hosmalin, A ^a  

^a Laboratoire d'Immunologie Cellulaire et Tissulaire CNRS URA 625   (France)

^b INSTITUT PASTEUR   (France)

^c SAINT LOUIS HOSPITAL   (France)

Author keywords

Dendritic cells; HIV; Infection frequency; Lymphoid organs; Macrophage; PCR; Spleen

Indexed keywords

CD14 ANTIGEN; CELL RECEPTOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; DENDRITIC CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MACROPHAGE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SPLEEN; T LYMPHOCYTE;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0029993722     PISSN: 09232516     EISSN: None     Source Type: Journal    
DOI: 10.1016/0923-2516(96)80225-1     Document Type: Conference Paper

References (32)

1. Armstrong, J.A. & Horne, R. (1984), Follicular dendritic cells and virus-like particles in AIDS-related lymphadenopathy. Lancet, ii, 370-372.
2. Buckley, P.J. (1991), Phenotypic subpopulations of macrophages and dendritic cells in human spleen. Scanning Microsc., 5, 147-158.
3. Chakrabarti, L., Isola, P., Cumont, M.C., Claessens-Maire, M.A., Hurtrel, M., Montagnier, L. & Hurtrel, B. (1994), Early stages of SIV infection in lymph nodes. Evidence for high viral load and successive populations of target cells. Am. J. Pathol., 144, 1-11.
4. Delassus, S., Cheynier, R. & Wain-Hobson, S. (1992), Nonhomogeneous distribution of human immunodeficiency virus type 1 proviruses in the spleen. J. Virol., 66, 5642-5645.
5. Delorme, P., Dezutter-Dambuyant, C., Ebersold, A., Desgranges, C., Thivolet, J. & Schmitt, D. (1993), In vitro infection of epidermal Langerhans cells with human immunodeficiency virus type 1 (HTLV-IIIB isolate). Res. Virol., 144, 53-58.
6. Embretson, J., Zupancic, M., Ribas, J.L., Burke, A., Racz, P., Tenner-Racz, K. & Haase, A.T. (1993), Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature (Lond.), 362, 359-362.
7. Fox, C.H., Tenner-Racz, K., Racz, P., Firpo, A., Pizzo, P.A. & Fauci, A.S. (1991), Lymphoid germinal centers are reservoirs of human immunodeficiency virus type-1 RNA. J. Infect. Dis., 164, 1051-1057.
8. Gartner, S., Markovits, P., Markovitz, D.M., Kaplan, M.H., Gallo, R.C. & Popovic, M. (1986), The role of mononuclear phagocytes in HTLV-III/LAV infection. Science, 233, 215-219.
9. Gyorkey, F., Melnick, J.L., Sinkovics, J.G. & Gyorkey, P. (1985), Retrovirus resembling HTLV in macrophages of patients with AIDS. Lancet, i, 106.
10. Ho, D.D., Rota, T.R. & Hirsch, M.S. (1986), Infection of monocyte/macrophages by HTLV type III. J. Clin. Invest, 77, 1712-1715.
11. Hsia, K., Tsai, V., Zvaifler, N.J. & Spector, S.A. (1995), Low prevalence of HIV-1 proviral DNA in peripheral blood monocytes and dendritic cells from HIV-1-infected individuals. AIDS, 9, 398-399.
12. Kaaya, E., Li, S.L., Feichtinger, H., Stahmer, I., Putkonen, P., Mandache, E., Mgaya, E., Biberfeld, G. & Biberfeld, P. (1993), Accessory cells and macrophages in the histopathology of SIVsm-infected cynomolgus monkeys. Res. Virol., 144, 81-92.
13. Koenig, S., Gendelman, H.E., Orenstein, J.M., Canto, M.C.D., Pezeshkpour, G.H., Yungbluth, M., Janotta, F., Aksamit, A., Martin, M.A. & Fauci, A.S. (1986), Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science, 233, 1089-1093.
14. Levy, J.A. (1993), Pathogenesis of human immunodeficiency virus infection. Microbiol. Rev., 57, 183-289.
15. McElrath, M.J., Steinman, R.M. & Cohn, Z.A. (1991), Latent HIV-1 infection in enriched populations of blood monocytes and T cells from seropositive patients. J. Clin. Invest., 87, 27-30.
16. + T lymphocyte infection frequency in spleens of HIV-positive patients. J. Virol., 69, 4737-4745.
17. Pantaleo, G., Graziosi, C., Butini, L., Pizzo, P.A., Schnittman, S.M., Kotler, D.P. & Fauci, A.S. (1991), Lymphoid organs function as major reservoirs for human immunodeficiency virus. Proc. Natl. Acad. Sci. USA, 88, 9838-9842.
18. Pope, M., Betjes, M.G.H., Romani, N., Hirmand, H., Cameron, P.U., Hoffman, L., Gezelter, S., Schuler, G. & Steinman, R.M. (1994), Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1. Cell, 78, 389-398.
19. Poznansky, M.C., Walker, B., Haseltine, W.A., Sodroski, J. & Langhoff, E. (1991), A rapid method for quantitating the frequency of peripheral blood cells containing HIV-1 DNA. J. Acquired Immune Defic. Syndr., 4, 368-373.
20. Salahuddin, S.Z., Rose, R.M. & Groopman, I.E. (1986), HTLV-III infection of human alveolar macrophages. Blood, 68, 281-284.
21. + T cells from patients with HIV infection reflects rapidly progressive immunosuppression and clinical disease. Ann. Intern. Med., 113, 438-443.
22. Schnittman, S.M., Psallidopoulos, M.C., Lane, H.C., Thompson, L., Baseler, M., Massari, F., Fox, C.H., Salzman, N.P. & Fauci, A.S. (1989), The reservoir for HIV-1 in human peripheral blood is a T cell that maintains expression of CD4. Science, 245, 305-308.
23. Spear, G.T., Ou, C.Y., Kessler, H.A., Moore, J.L., Schochetman, G. & Landay, A.L. (1990), Analysis of lymphocytes, monocytes and neutrophils from HIV-infected persons for HIV DNA. J. Infect. Dis., 162, 1239-1244.
24. + T-helper cells. Am. J. Pathol., 140, 15-22.
25. Steinman, R.M., Van Voorhis, W.C. & Spalding, D.M. (1986), "Dendritic cells" in "Handbook of experimental immunology" published by Blackwell, Oxford, UK, editor D.M. Weir.
26. Tenner-Racz, K., Stemm, A.M.v., Guhlk, B., Schmitz, J. & Racz, P. (1994), Are follicular dendritic cells, macrophages and interdigitating dendritic cells of the lymphoid tissue productively infected by HIV? Res. Virol., 145, 177-182.
27. Tschachler, E., Groh, V., Popovic, M., Mann, D.L., Konrad, K., Safai, B., Eron, L., Veronese, F., Wolff, K. & Stingl, G. (1987), Langerhans cells - a target for HTLVIII/LAV infection. J. Invest. Dermatol., 88, 233-237.
28. Ward, J.M., O'Leary, T.J., Baskin, G.B., Benveniste, R., Harris, C.A., Nara, P.L. & Rhodes, R.H. (1987), Immunohistochemical localization of human and simian immunodeficiency viral antigens in fixed tissue sections. Am. J. Pathol., 127, 199-205.
29. Wiley, C.A., Schrier, R.D., Nelson, J.A., Lampert, P.W. & Oldstone, M.B.A. (1986), Cellular localization of HIV infection within the brains of AIDS patients. Proc. Natl. Acad. Sci. USA, 83, 7089-7093.
30. Winkel, K., Sotzik, F., Vremec, D., Cameron, P.U. & Shortman, K. (1994), CD4 and CD8 expression by human and mouse thymic dendritic cells. Immunol. Lett., 40, 93-99.
31. Wood, G.S., Turner, R.R., Shiurba, R.A., Eng, L. & Warnke, R.A. (1985), Human dendritic cells and macrophages: in situ immunophenotypic definition of subsets that exhibit specific morphologic and microenvironmental characteristics. Am. J. Pathol., 119, 73-82.
32. + T cells. J. Acquired Immune Defic. Syndr., 6, 237-240.