-
1
-
-
0344994511
-
Novel antitumor agents from higher plants
-
Lee, K. H. Novel antitumor agents from higher plants. Med. Res. Rev., 1999, 19(6), 569-96.
-
(1999)
Med. Res. Rev.
, vol.19
, Issue.6
, pp. 569-596
-
-
Lee, K.H.1
-
2
-
-
77950400139
-
Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach
-
Lee, K. H. Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach. J. Nat. Prod., 2010, 73(3), 500-16.
-
(2010)
J. Nat. Prod.
, vol.73
, Issue.3
, pp. 500-516
-
-
Lee, K.H.1
-
3
-
-
0035433799
-
Natural products in anticancer therapy
-
da Rocha, A. B.; Lopes, R. M.; Schwartsmann, G. Natural products in anticancer therapy. Curr. Opin. Pharmacol., 2001, 1(4), 364-9.
-
(2001)
Curr. Opin. Pharmacol.
, vol.1
, Issue.4
, pp. 364-369
-
-
Da Rocha, A.B.1
Lopes, R.M.2
Schwartsmann, G.3
-
5
-
-
67349190115
-
Bruceine D induces apoptosis in pancreatic adenocarcinoma cell line PANC-1 through the activation of p38-mitogen activated protein kinase
-
Lau, S. T.; Lin, Z. X.; Liao, Y.; Zhao, M.; Cheng, C. H.; Leung, P. S. Bruceine D induces apoptosis in pancreatic adenocarcinoma cell line PANC-1 through the activation of p38-mitogen activated protein kinase. Cancer Lett., 2009, 281(1), 42-52.
-
(2009)
Cancer Lett.
, vol.281
, Issue.1
, pp. 42-52
-
-
Lau, S.T.1
Lin, Z.X.2
Liao, Y.3
Zhao, M.4
Cheng, C.H.5
Leung, P.S.6
-
6
-
-
0021783508
-
Quassinoid bitter principles. II
-
Polonsky, J. Quassinoid bitter principles. II. Fortschr. Chem. Org. Naturst., 1985, 47, 221-64.
-
(1985)
Fortschr. Chem. Org. Naturst.
, vol.47
, pp. 221-264
-
-
Polonsky, J.1
-
7
-
-
0037044569
-
Cancer chemopreventive effect of quassinoid derivatives. Introduction of sidechain to shinjulactone C for enhancement of inhibitory effect on Epstein-Barr virus activation
-
Tamura, S.; Fukamiya, N.; Okano, M.; Tokuda, H.; Aoi, W.; Mukainaka, T.; Nishino, H.; Tagahara, K.; Koike, K. Cancer chemopreventive effect of quassinoid derivatives. Introduction of sidechain to shinjulactone C for enhancement of inhibitory effect on Epstein-Barr virus activation. Cancer Lett., 2002, 185(1), 47-51.
-
(2002)
Cancer Lett.
, vol.185
, Issue.1
, pp. 47-51
-
-
Tamura, S.1
Fukamiya, N.2
Okano, M.3
Tokuda, H.4
Aoi, W.5
Mukainaka, T.6
Nishino, H.7
Tagahara, K.8
Koike, K.9
-
8
-
-
33846908139
-
Anti-proliferative activity of the quassinoid NBT-272 in childhood medulloblastoma cells
-
von Bueren, A. O.; Shalaby, T.; Rajtarova, J.; Stearns, D.; Eberhart, C. G.; Helson, L.; Arcaro, A.; Grotzer, M. A. Anti-proliferative activity of the quassinoid NBT-272 in childhood medulloblastoma cells. BMC Cancer, 2007, 7, 19.
-
(2007)
BMC Cancer
, vol.7
, pp. 19
-
-
Von Bueren, A.O.1
Shalaby, T.2
Rajtarova, J.3
Stearns, D.4
Eberhart, C.G.5
Helson, L.6
Arcaro, A.7
Grotzer, M.A.8
-
9
-
-
0018230762
-
Plant antitumor agents. XVI. 6alpha-Senecioyloxy-chaparrinone, a new antileukemic quassinoid from Simaba multiflora
-
Wani, M. C.; Taylor, H. L.; Thompson, J. B.; Wall, M. E. Plant antitumor agents. XVI. 6alpha-Senecioyloxy-chaparrinone, a new antileukemic quassinoid from Simaba multiflora. Lloydia, 1978, 41(6), 578-83.
-
(1978)
Lloydia
, vol.41
, Issue.6
, pp. 578-583
-
-
Wani, M.C.1
Taylor, H.L.2
Thompson, J.B.3
Wall, M.E.4
-
10
-
-
11844255707
-
Biologically active quassinoids and their chemistry: Potential leads for drug design
-
Guo, Z.; Vangapandu, S.; Sindelar, R. W.; Walker, L. A.; Sindelar, R. D. Biologically active quassinoids and their chemistry: Potential leads for drug design. Curr. Med. Chem., 2005, 12(2), 173-90.
-
(2005)
Curr. Med. Chem.
, vol.12
, Issue.2
, pp. 173-190
-
-
Guo, Z.1
Vangapandu, S.2
Sindelar, R.W.3
Walker, L.A.4
Sindelar, R.D.5
-
11
-
-
63049119349
-
Chemical constituents of plants from the genus Brucea
-
Liu, J. H.; Jin, H. Z.; Zhang, W. D.; Yan, S. K.; Shen, Y. H. Chemical constituents of plants from the genus Brucea. Chem. Biodivers., 2009, 6(1), 57-70.
-
(2009)
Chem. Biodivers.
, vol.6
, Issue.1
, pp. 57-70
-
-
Liu, J.H.1
Jin, H.Z.2
Zhang, W.D.3
Yan, S.K.4
Shen, Y.H.5
-
12
-
-
65249093662
-
Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition
-
Beutler, J. A.; Kang, M. I.; Robert, F.; Clement, J. A.; Pelletier, J.; Colburn, N. H.; McKee, T. C.; Goncharova, E.; McMahon, J. B.; Henrich, C. J. Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition. J. Nat. Prod., 2009, 72(3), 503-6.
-
(2009)
J. Nat. Prod.
, vol.72
, Issue.3
, pp. 503-506
-
-
Beutler, J.A.1
Kang, M.I.2
Robert, F.3
Clement, J.A.4
Pelletier, J.5
Colburn, N.H.6
McKee, T.C.7
Goncharova, E.8
McMahon, J.B.9
Henrich, C.J.10
-
13
-
-
14644401085
-
Structure-activity relationships of quassinoids for eukaryotic protein synthesis
-
Fukamiya, N.; Lee, K. H.; Muhammad, I.; Murakami, C.; Okano, M.; Harvey, I.; Pelletier, J. Structure-activity relationships of quassinoids for eukaryotic protein synthesis. Cancer Lett., 2005, 220(1), 37-48.
-
(2005)
Cancer Lett.
, vol.220
, Issue.1
, pp. 37-48
-
-
Fukamiya, N.1
Lee, K.H.2
Muhammad, I.3
Murakami, C.4
Okano, M.5
Harvey, I.6
Pelletier, J.7
-
14
-
-
49749115202
-
A quassinoid 6alpha-tigloyloxychaparrinone inhibits hypoxiainducible factor-1 pathway by inhibition of eukaryotic translation initiation factor 4E phosphorylation
-
Jin, X.; Jin, H. R.; Lee, D.; Lee, J. H.; Kim, S. K.; Lee, J. J. A quassinoid 6alpha-tigloyloxychaparrinone inhibits hypoxiainducible factor-1 pathway by inhibition of eukaryotic translation initiation factor 4E phosphorylation. Eur. J. Pharmacol., 2008, 592(1-3), 41-7.
-
(2008)
Eur. J. Pharmacol.
, vol.592
, Issue.1-3
, pp. 41-47
-
-
Jin, X.1
Jin, H.R.2
Lee, D.3
Lee, J.H.4
Kim, S.K.5
Lee, J.J.6
-
15
-
-
1442285458
-
Antitumor activity of bruceantin: An old drug with new promise
-
Cuendet, M.; Pezzuto, J. M. Antitumor activity of bruceantin: An old drug with new promise. J. Nat. Prod., 2004, 67(2), 269-72.
-
(2004)
J. Nat. Prod.
, vol.67
, Issue.2
, pp. 269-272
-
-
Cuendet, M.1
Pezzuto, J.M.2
-
16
-
-
1042266695
-
Multiple myeloma regression mediated by bruceantin
-
Cuendet, M.; Christov, K.; Lantvit, D. D.; Deng, Y.; Hedayat, S.; Helson, L.; McChesney, J. D.; Pezzuto, J. M. Multiple myeloma regression mediated by bruceantin. Clin. Cancer Res., 2004, 10(3), 1170-9.
-
(2004)
Clin. Cancer Res.
, vol.10
, Issue.3
, pp. 1170-1179
-
-
Cuendet, M.1
Christov, K.2
Lantvit, D.D.3
Deng, Y.4
Hedayat, S.5
Helson, L.6
McChesney, J.D.7
Pezzuto, J.M.8
-
17
-
-
0016845068
-
The isolation and structural elucidation of bruceantin and bruceantinol, new potent antileukemic quassinoids from Brucea antidysenterica
-
Kupchan, S. M.; Britton, R. W.; Lacadie, J. A.; Ziegler, M. F.; Sigel, C. W. The isolation and structural elucidation of bruceantin and bruceantinol, new potent antileukemic quassinoids from Brucea antidysenterica. J. Org. Chem., 1975, 40(5), 648-54.
-
(1975)
J. Org. Chem.
, vol.40
, Issue.5
, pp. 648-654
-
-
Kupchan, S.M.1
Britton, R.W.2
Lacadie, J.A.3
Ziegler, M.F.4
Sigel, C.W.5
-
18
-
-
0032555437
-
Synthetic Studies on Quassinoids: Total Synthesis and Biological Evaluation of (+)-Des-Dchaparrinone
-
Grieco, P. A.; Speake, J. D. Synthetic Studies on Quassinoids: Total Synthesis and Biological Evaluation of (+)-Des-Dchaparrinone. J. Org. Chem., 1998, 63(17), 5929-5936.
-
(1998)
J. Org. Chem.
, vol.63
, Issue.17
, pp. 5929-5936
-
-
Grieco, P.A.1
Speake, J.D.2
-
20
-
-
67349260439
-
U2504 determines the species specificity of the A-site cleft antibiotics: The structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome
-
Gurel, G.; Blaha, G.; Moore, P. B.; Steitz, T. A. U2504 determines the species specificity of the A-site cleft antibiotics: The structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome. J. Mol. Biol., 2009, 389(1), 146-56.
-
(2009)
J. Mol. Biol.
, vol.389
, Issue.1
, pp. 146-156
-
-
Gurel, G.1
Blaha, G.2
Moore, P.B.3
Steitz, T.A.4
-
21
-
-
0020324821
-
Phase II trial of bruceantin in metastatic breast carcinoma
-
Wiseman, C. L.; Yap, H. Y.; Bedikian, A. Y.; Bodey, G. P.; Blumenschein, G. R. Phase II trial of bruceantin in metastatic breast carcinoma. Am. J. Clin. Oncol., 1982, 5(4), 389-91.
-
(1982)
Am. J. Clin. Oncol.
, vol.5
, Issue.4
, pp. 389-391
-
-
Wiseman, C.L.1
Yap, H.Y.2
Bedikian, A.Y.3
Bodey, G.P.4
Blumenschein, G.R.5
-
22
-
-
0020958892
-
A Phase II study of Bruceantin (NSC-165, 563) in advanced malignant melanoma
-
Arseneau, J. C.; Wolter, J. M.; Kuperminc, M.; Ruckdeschel, J. C. A Phase II study of Bruceantin (NSC-165, 563) in advanced malignant melanoma. Invest. New Drugs, 1983, 1(3), 239-42.
-
(1983)
Invest. New Drugs
, vol.1
, Issue.3
, pp. 239-242
-
-
Arseneau, J.C.1
Wolter, J.M.2
Kuperminc, M.3
Ruckdeschel, J.C.4
-
23
-
-
0029807585
-
BID: A novel BH3 domain-only death agonist
-
Wang, K.; Yin, X. M.; Chao, D. T.; Milliman, C. L.; Korsmeyer, S. J. BID: A novel BH3 domain-only death agonist. Genes Dev., 1996, 10(22), 2859-69.
-
(1996)
Genes Dev.
, vol.10
, Issue.22
, pp. 2859-2869
-
-
Wang, K.1
Yin, X.M.2
Chao, D.T.3
Milliman, C.L.4
Korsmeyer, S.J.5
-
24
-
-
0037879052
-
The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update
-
Ly, J. D.; Grubb, D. R.; Lawen, A. The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update. Apoptosis, 2003, 8(2), 115-28.
-
(2003)
Apoptosis
, vol.8
, Issue.2
, pp. 115-128
-
-
Ly, J.D.1
Grubb, D.R.2
Lawen, A.3
-
25
-
-
1442335376
-
Brusatol-induced HL-60 cell differentiation involves NF-kappaB activation
-
Cuendet, M.; Gills, J. J.; Pezzuto, J. M. Brusatol-induced HL-60 cell differentiation involves NF-kappaB activation. Cancer Lett., 2004, 206(1), 43-50.
-
(2004)
Cancer Lett.
, vol.206
, Issue.1
, pp. 43-50
-
-
Cuendet, M.1
Gills, J.J.2
Pezzuto, J.M.3
-
26
-
-
33144466315
-
C-Myc, genome instability, and tumorigenesis: The devil is in the details
-
Wade, M.; Wahl, G. M. c-Myc, genome instability, and tumorigenesis: The devil is in the details. Curr. Top. Microbiol. Immunol., 2006, 302, 169-203.
-
(2006)
Curr. Top. Microbiol. Immunol.
, vol.302
, pp. 169-203
-
-
Wade, M.1
Wahl, G.M.2
-
27
-
-
0036849687
-
Brusatol-mediated induction of leukemic cell differentiation and G(1) arrest is associated with down-regulation of c-myc
-
Mata-Greenwood, E.; Cuendet, M.; Sher, D.; Gustin, D.; Stock, W.; Pezzuto, J. M. Brusatol-mediated induction of leukemic cell differentiation and G(1) arrest is associated with down-regulation of c-myc. Leukemia, 2002, 16(11), 2275-84.
-
(2002)
Leukemia
, vol.16
, Issue.11
, pp. 2275-2284
-
-
Mata-Greenwood, E.1
Cuendet, M.2
Sher, D.3
Gustin, D.4
Stock, W.5
Pezzuto, J.M.6
-
28
-
-
42949125901
-
Brucea javanica fruit induces cytotoxicity and apoptosis in pancreatic adenocarcinoma cell lines
-
Lau, S. T.; Lin, Z. X.; Zhao, M.; Leung, P. S. Brucea javanica fruit induces cytotoxicity and apoptosis in pancreatic adenocarcinoma cell lines. Phytother. Res., 2008, 22(4), 477-86.
-
(2008)
Phytother. Res.
, vol.22
, Issue.4
, pp. 477-486
-
-
Lau, S.T.1
Lin, Z.X.2
Zhao, M.3
Leung, P.S.4
-
29
-
-
0242635945
-
Three novel quassinoids, javanicolides A and B, and javanicoside A, from seeds of Brucea javanica
-
Kim, I. H.; R., S.; Y., H.; K, T. Three novel quassinoids, javanicolides A and B, and javanicoside A, from seeds of Brucea javanica. Tetrahedron, 2003, 59 (50), 9985-9989.
-
(2003)
Tetrahedron
, vol.59
, Issue.50
, pp. 9985-9989
-
-
Kim I.H.R.S.Y.H.K, T.1
-
30
-
-
76349122924
-
Role of reactive oxygen species in brucein D-mediated p38-mitogen-activated protein kinase and nuclear factor-kappaB signalling pathways in human pancreatic adenocarcinoma cells
-
Lau, S. T.; Lin, Z. X.; Leung, P. S. Role of reactive oxygen species in brucein D-mediated p38-mitogen-activated protein kinase and nuclear factor-kappaB signalling pathways in human pancreatic adenocarcinoma cells. Br. J. Cancer., 2010, 102(3), 583-93.
-
(2010)
Br. J. Cancer.
, vol.102
, Issue.3
, pp. 583-593
-
-
Lau, S.T.1
Lin, Z.X.2
Leung, P.S.3
-
31
-
-
76749088358
-
Pathological roles of MAPK signaling pathways in human diseases
-
Kim, E. K.; Choi, E. J. Pathological roles of MAPK signaling pathways in human diseases. Biochim. Biophys. Acta, 2010, 1802(4), 396-405.
-
(2010)
Biochim. Biophys. Acta
, vol.1802
, Issue.4
, pp. 396-405
-
-
Kim, E.K.1
Choi, E.J.2
-
32
-
-
33645999706
-
NF-kappaB and IKK as therapeutic targets in cancer
-
Kim, H. J.; Hawke, N.; Baldwin, A. S. NF-kappaB and IKK as therapeutic targets in cancer. Cell Death Differ., 2006, 13(5), 738-47.
-
(2006)
Cell Death Differ.
, vol.13
, Issue.5
, pp. 738-747
-
-
Kim, H.J.1
Hawke, N.2
Baldwin, A.S.3
-
33
-
-
1442274808
-
P38 MAP kinase: A convergence point in cancer therapy
-
Olson, J. M.; Hallahan, A. R. p38 MAP kinase: A convergence point in cancer therapy. Trends Mol. Med., 2004, 10(3), 125-9.
-
(2004)
Trends Mol. Med.
, vol.10
, Issue.3
, pp. 125-129
-
-
Olson, J.M.1
Hallahan, A.R.2
-
34
-
-
26444605834
-
IKK/NF-kappaB signaling: Balancing life and death-A new approach to cancer therapy
-
Luo, J. L.; Kamata, H.; Karin, M. IKK/NF-kappaB signaling: Balancing life and death-a new approach to cancer therapy. J. Clin. Invest., 2005, 115(10), 2625-32.
-
(2005)
J. Clin. Invest.
, vol.115
, Issue.10
, pp. 2625-2632
-
-
Luo, J.L.1
Kamata, H.2
Karin, M.3
-
35
-
-
33846570444
-
The transcription factor nuclear factorkappa B and cancer
-
Escarcega, R. O.; Fuentes-Alexandro, S.; Garcia-Carrasco, M.; Gatica, A.; Zamora, A. The transcription factor nuclear factorkappa B and cancer. Clin. Oncol. (R. Coll. Radiol.), 2007, 19(2), 154-61.
-
(2007)
Clin. Oncol. (R. Coll. Radiol.)
, vol.19
, Issue.2
, pp. 154-161
-
-
Escarcega, R.O.1
Fuentes-Alexandro, S.2
Garcia-Carrasco, M.3
Gatica, A.4
Zamora, A.5
-
36
-
-
58149202128
-
Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls
-
Baud, V.; Karin, M. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat. Rev. Drug Discov., 2009, 8(1), 33-40.
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, Issue.1
, pp. 33-40
-
-
Baud, V.1
Karin, M.2
-
37
-
-
0035688049
-
Novel esters of glaucarubolone as inducers of terminal differentiation of promyelocytic HL-60 cells and inhibitors of 7,12- dimethylbenz [a]anthracene-induced preneoplastic lesion formation in mouse mammary organ culture
-
Mata-Greenwood, E.; Daeuble, J. F.; Grieco, P. A.; Dou, J.; McChesney, J. D.; Mehta, R. G.; Kinghorn, A. D.; Pezzuto, J. M. Novel esters of glaucarubolone as inducers of terminal differentiation of promyelocytic HL-60 cells and inhibitors of 7,12- dimethylbenz [a]anthracene-induced preneoplastic lesion formation in mouse mammary organ culture. J. Nat. Prod., 2001, 64(12), 1509-13.
-
(2001)
J. Nat. Prod.
, vol.64
, Issue.12
, pp. 1509-1513
-
-
Mata-Greenwood, E.1
Daeuble, J.F.2
Grieco, P.A.3
Dou, J.4
McChesney, J.D.5
Mehta, R.G.6
Kinghorn, A.D.7
Pezzuto, J.M.8
-
38
-
-
0030738677
-
Multidrug resistance: Molecular mechanisms and clinical relevance
-
Ling, V. Multidrug resistance: Molecular mechanisms and clinical relevance. Cancer Chemother. Pharmacol., 1997, 40(Suppl), S3-8.
-
(1997)
Cancer Chemother. Pharmacol.
, vol.40
, Issue.SUPPL.
-
-
Ling, V.1
-
39
-
-
4444322833
-
Multidrugresistant cancer cell susceptibility to cytotoxic quassinoids, and cancer chemopreventive effects of quassinoids and canthin alkaloids
-
Murakami, C.; Fukamiya, N.; Tamura, S.; Okano, M.; Bastow, K. F.; Tokuda, H.; Mukainaka, T.; Nishino, H.; Lee, K. H. Multidrugresistant cancer cell susceptibility to cytotoxic quassinoids, and cancer chemopreventive effects of quassinoids and canthin alkaloids. Bioorg. Med. Chem., 2004, 12(18), 4963-8.
-
(2004)
Bioorg. Med. Chem.
, vol.12
, Issue.18
, pp. 4963-4968
-
-
Murakami, C.1
Fukamiya, N.2
Tamura, S.3
Okano, M.4
Bastow, K.F.5
Tokuda, H.6
Mukainaka, T.7
Nishino, H.8
Lee, K.H.9
-
40
-
-
0347761416
-
Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia
-
Kuo, P. C.; Damu, A. G.; Lee, K. H.; Wu, T. S. Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia. Bioorg. Med. Chem., 2004, 12(3), 537-44.
-
(2004)
Bioorg. Med. Chem.
, vol.12
, Issue.3
, pp. 537-544
-
-
Kuo, P.C.1
Damu, A.G.2
Lee, K.H.3
Wu, T.S.4
-
41
-
-
0022588168
-
Plants as sources of antimalarial drugs. Part 31 eurycoma longifolia
-
Chan, K. L.; O'Neill M, J.; Phillipson, J. D.; Warhurst, D. C. Plants as Sources of Antimalarial Drugs. Part 31 Eurycoma longifolia. Planta Med., 1986, 52(2), 105-7.
-
(1986)
Planta Med.
, vol.52
, Issue.2
, pp. 105-107
-
-
Chan, K.L.1
O'Neill M, J.2
Phillipson, J.D.3
Warhurst, D.C.4
-
42
-
-
74049147889
-
Quassinoids from Eurycoma longifolia
-
Miyake, K.; Tezuka, Y.; Awale, S.; Li, F.; Kadota, S. Quassinoids from Eurycoma longifolia. J. Nat. Prod., 2009, 72(12), 2135-40.
-
(2009)
J. Nat. Prod.
, vol.72
, Issue.12
, pp. 2135-2140
-
-
Miyake, K.1
Tezuka, Y.2
Awale, S.3
Li, F.4
Kadota, S.5
-
43
-
-
12744274771
-
Quassinoids can induce mitochondrial membrane depolarisation and caspase 3 activation in human cells
-
Rosati, A.; Quaranta, E.; Ammirante, M.; Turco, M. C.; Leone, A.; De Feo, V. Quassinoids can induce mitochondrial membrane depolarisation and caspase 3 activation in human cells. Cell Death Differ., 2004, 11 Suppl 2, S216-8.
-
(2004)
Cell Death Differ.
, vol.11
, Issue.2 SUPPL.
-
-
Rosati, A.1
Quaranta, E.2
Ammirante, M.3
Turco, M.C.4
Leone, A.5
De Feo, V.6
-
44
-
-
77955667668
-
Ailanthus excelsa roxb. is really a plant of heaven
-
Kumar, D.; Bhat, Z. A.; Singh, P.; Shah, M. Y.; Bhujbal, S. S. Ailanthus excelsa roxb. is really a plant of heaven. Int. J. Pharmacol., 2010, 6, 535-550.
-
(2010)
Int. J. Pharmacol.
, vol.6
, pp. 535-550
-
-
Kumar, D.1
Bhat, Z.A.2
Singh, P.3
Shah, M.Y.4
Bhujbal, S.S.5
-
45
-
-
65449183737
-
A novel triterpenoid isolated from the root bark of Ailanthus excelsa Roxb (Tree of Heaven), AECHL-1 as a potential anti-cancer agent
-
Lavhale, M. S.; Kumar, S.; Mishra, S. H.; Sitasawad, S. L. A novel triterpenoid isolated from the root bark of Ailanthus excelsa Roxb (Tree of Heaven), AECHL-1 as a potential anti-cancer agent. PLoS One, 2009, 4(4), e5365.
-
(2009)
PLoS One
, vol.4
, Issue.4
-
-
Lavhale, M.S.1
Kumar, S.2
Mishra, S.H.3
Sitasawad, S.L.4
-
46
-
-
0037467088
-
Isolation of phytotoxic compounds from tree-of-heaven (Ailanthus altissima swingle)
-
De Feo, V.; De Martino, L.; Quaranta, E.; Pizza, C. Isolation of phytotoxic compounds from tree-of-heaven (Ailanthus altissima swingle). J. Agric. Food Chem., 2003, 51(5), 1177-80.
-
(2003)
J. Agric. Food Chem.
, vol.51
, Issue.5
, pp. 1177-1180
-
-
De Feo, V.1
De Martino, L.2
Quaranta, E.3
Pizza, C.4
-
47
-
-
34248591612
-
Targeting the Raf-MEK-ERK mitogenactivated protein kinase cascade for the treatment of cancer
-
Roberts, P. J.; Der, C. J. Targeting the Raf-MEK-ERK mitogenactivated protein kinase cascade for the treatment of cancer. Oncogene, 2007, 26(22), 3291-310.
-
(2007)
Oncogene
, vol.26
, Issue.22
, pp. 3291-3310
-
-
Roberts, P.J.1
Der, C.J.2
-
48
-
-
3843052715
-
HIF-1: A target for cancer, ischemia and inflammation-too good to be true?
-
Melillo, G. HIF-1: A target for cancer, ischemia and inflammation-too good to be true? Cell Cycle, 2004, 3(2), 154-5.
-
(2004)
Cell Cycle
, vol.3
, Issue.2
, pp. 154-155
-
-
Melillo, G.1
-
49
-
-
0242331755
-
HIF-1 as a target for drug development
-
Giaccia, A.; Siim, B. G.; Johnson, R. S. HIF-1 as a target for drug development. Nat. Rev. Drug Discov., 2003, 2(10), 803-11.
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, Issue.10
, pp. 803-811
-
-
Giaccia, A.1
Siim, B.G.2
Johnson, R.S.3
-
50
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza, G. L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer, 2003, 3(10), 721-32.
-
(2003)
Nat. Rev. Cancer
, vol.3
, Issue.10
, pp. 721-732
-
-
Semenza, G.L.1
-
51
-
-
0037530130
-
Hypoxia-induced angiogenesis during carcinogenesis
-
Choi, K. S.; Bae, M. K.; Jeong, J. W.; Moon, H. E.; Kim, K. W. Hypoxia-induced angiogenesis during carcinogenesis. J. Biochem. Mol. Biol., 2003, 36(1), 120-7.
-
(2003)
J. Biochem. Mol. Biol.
, vol.36
, Issue.1
, pp. 120-127
-
-
Choi, K.S.1
Bae, M.K.2
Jeong, J.W.3
Moon, H.E.4
Kim, K.W.5
-
52
-
-
0027138356
-
The role of p21ras in receptor tyrosine kinase signaling
-
Medema, R. H.; Bos, J. L. The role of p21ras in receptor tyrosine kinase signaling. Crit. Rev. Oncog., 1993, 4(6), 615-61.
-
(1993)
Crit. Rev. Oncog.
, vol.4
, Issue.6
, pp. 615-661
-
-
Medema, R.H.1
Bos, J.L.2
-
53
-
-
2342489456
-
EIF-4E expression and its role in malignancies and metastases
-
De Benedetti, A.; Graff, J. R. eIF-4E expression and its role in malignancies and metastases. Oncogene, 2004, 23(18), 3189-99.
-
(2004)
Oncogene
, vol.23
, Issue.18
, pp. 3189-3199
-
-
De Benedetti, A.1
Graff, J.R.2
-
54
-
-
85047696004
-
Translation initiation and its deregulation during tumorigenesis
-
Watkins, S. J.; Norbury, C. J. Translation initiation and its deregulation during tumorigenesis. Br. J. Cancer., 2002, 86(7), 1023-7.
-
(2002)
Br. J. Cancer.
, vol.86
, Issue.7
, pp. 1023-1027
-
-
Watkins, S.J.1
Norbury, C.J.2
-
55
-
-
38849180436
-
Targeting the eukaryotic translation initiation factor 4E for cancer therapy
-
Graff, J. R.; Konicek, B. W.; Carter, J. H.; Marcusson, E. G. Targeting the eukaryotic translation initiation factor 4E for cancer therapy. Cancer Res., 2008, 68(3), 631-4.
-
(2008)
Cancer Res.
, vol.68
, Issue.3
, pp. 631-634
-
-
Graff, J.R.1
Konicek, B.W.2
Carter, J.H.3
Marcusson, E.G.4
-
56
-
-
77955014467
-
Natural products as chemical probes
-
Carlson, E. E. Natural products as chemical probes. ACS Chem. Biol., 2010, 5(7), 639-53.
-
(2010)
ACS Chem. Biol.
, vol.5
, Issue.7
, pp. 639-653
-
-
Carlson, E.E.1
-
57
-
-
0020327082
-
Antitumor agents XLV: Bisbrusatolyl and brusatolyl esters and related compounds as novel potent antileukemic agents
-
Lee, K. H.; Okano, M.; Hall, I. H.; Brent, D. A.; Soltmann, B. Antitumor agents XLV: Bisbrusatolyl and brusatolyl esters and related compounds as novel potent antileukemic agents. J. Pharm. Sci., 1982, 71(3), 338-45.
-
(1982)
J. Pharm. Sci.
, vol.71
, Issue.3
, pp. 338-345
-
-
Lee, K.H.1
Okano, M.2
Hall, I.H.3
Brent, D.A.4
Soltmann, B.5
-
58
-
-
0030862913
-
Synthesis of cytotoxic fluorinated quassinoids
-
Ohno, N.; Fukamiya, N.; Okano, M.; Tagahara, K.; Lee, K. H. Synthesis of cytotoxic fluorinated quassinoids. Bioorg. Med. Chem., 1997, 5(8), 1489-95.
-
(1997)
Bioorg. Med. Chem.
, vol.5
, Issue.8
, pp. 1489-1495
-
-
Ohno, N.1
Fukamiya, N.2
Okano, M.3
Tagahara, K.4
Lee, K.H.5
-
59
-
-
33846905472
-
-
Geneva
-
Helson, L., McChesney, J., Bartyzel, P. In: In vitro cytotoxic activity of NBT-272, a novel quassinoid analog, Geneva, 2004; p. 171.
-
(2004)
Vitro Cytotoxic Activity of NBT-272, a Novel Quassinoid Analog
, pp. 171
-
-
Helson, L.1
McChesney, J.2
Bartyzel, P.3
-
60
-
-
31544466779
-
C-myc overexpression causes anaplasia in medulloblastoma
-
Stearns, D.; Chaudhry, A.; Abel, T. W.; Burger, P. C.; Dang, C. V.; Eberhart, C. G. c-myc overexpression causes anaplasia in medulloblastoma. Cancer Res., 2006, 66(2), 673-81.
-
(2006)
Cancer Res.
, vol.66
, Issue.2
, pp. 673-681
-
-
Stearns, D.1
Chaudhry, A.2
Abel, T.W.3
Burger, P.C.4
Dang, C.V.5
Eberhart, C.G.6
-
61
-
-
0025871006
-
Immunohistochemical analysis of N-myc protein expression in neuroblastoma: Correlation with prognosis of patients
-
Hiyama, E.; Hiyama, K.; Yokoyama, T.; Ishii, T. Immunohistochemical analysis of N-myc protein expression in neuroblastoma: Correlation with prognosis of patients. J. Pediatr. Surg., 1991, 26(7), 838-43.
-
(1991)
J. Pediatr. Surg.
, vol.26
, Issue.7
, pp. 838-843
-
-
Hiyama, E.1
Hiyama, K.2
Yokoyama, T.3
Ishii, T.4
-
62
-
-
59049091416
-
Low-level copy gain versus amplification of myc oncogenes in medulloblastoma: Utility in predicting prognosis and survival. Laboratory investigation
-
Takei, H.; Nguyen, Y.; Mehta, V.; Chintagumpala, M.; Dauser, R. C.; Adesina, A. M. Low-level copy gain versus amplification of myc oncogenes in medulloblastoma: Utility in predicting prognosis and survival. Laboratory investigation. J. Neurosurg. Pediatr., 2009, 3(1), 61-5.
-
(2009)
J. Neurosurg. Pediatr.
, vol.3
, Issue.1
, pp. 61-65
-
-
Takei, H.1
Nguyen, Y.2
Mehta, V.3
Chintagumpala, M.4
Dauser, R.C.5
Adesina, A.M.6
-
63
-
-
78650496926
-
The quassinoid derivative NBT-272 targets both the AKT and ERK signaling pathways in embryonal tumors
-
Epub ahead of print
-
Castelletti, D.; Fiaschetti, G.; Di Dato, V.; Ziegler, U.; Kumps, C.; De Preter, K.; Zollo, M.; Speleman, F.; Shalaby, T.; De Martino, D.; Berg, T.; Eggert, A.; Arcaro, A.; Grotzer, M. A. The quassinoid derivative NBT-272 targets both the AKT and ERK signaling pathways in embryonal tumors. Mol. Cancer Ther.; 2010; [Epub ahead of print].
-
(2010)
Mol. Cancer Ther.
-
-
Castelletti, D.1
Fiaschetti, G.2
Di Dato, V.3
Ziegler, U.4
Kumps, C.5
De Preter, K.6
Zollo, M.7
Speleman, F.8
Shalaby, T.9
De Martino, D.10
Berg, T.11
Eggert, A.12
Arcaro, A.13
Grotzer, M.A.14
-
64
-
-
0033551387
-
Mechanisms of apoptosis by c-Myc
-
Prendergast, G. C. Mechanisms of apoptosis by c-Myc. Oncogene, 1999, 18(19), 2967-87.
-
(1999)
Oncogene
, vol.18
, Issue.19
, pp. 2967-2987
-
-
Prendergast, G.C.1
-
65
-
-
0033611644
-
Control of cell proliferation by Myc family genes
-
Eilers, M. Control of cell proliferation by Myc family genes. Mol. Cells, 1999, 9(1), 1-6.
-
(1999)
Mol. Cells
, vol.9
, Issue.1
, pp. 1-6
-
-
Eilers, M.1
-
66
-
-
37549032776
-
The interplay between MYC and HIF in cancer
-
Dang, C. V.; Kim, J. W.; Gao, P.; Yustein, J. The interplay between MYC and HIF in cancer. Nat. Rev. Cancer, 2008, 8(1), 51-6.
-
(2008)
Nat. Rev. Cancer
, vol.8
, Issue.1
, pp. 51-56
-
-
Dang, C.V.1
Kim, J.W.2
Gao, P.3
Yustein, J.4
-
67
-
-
0842309106
-
MYCN in neuronal tumours
-
Schwab, M. MYCN in neuronal tumours. Cancer Lett., 2004, 204(2), 179-87.
-
(2004)
Cancer Lett.
, vol.204
, Issue.2
, pp. 179-187
-
-
Schwab, M.1
-
68
-
-
77649262185
-
MYC regulation of a "poorprognosis" metastatic cancer cell state
-
Wolfer, A.; Wittner, B. S.; Irimia, D.; Flavin, R. J.; Lupien, M.; Gunawardane, R. N.; Meyer, C. A.; Lightcap, E. S.; Tamayo, P.; Mesirov, J. P.; Liu, X. S.; Shioda, T.; Toner, M.; Loda, M.; Brown, M.; Brugge, J. S.; Ramaswamy, S. MYC regulation of a "poorprognosis" metastatic cancer cell state. Proc. Natl. Acad. Sci. USA, 2010, 107(8), 3698-703.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, Issue.8
, pp. 3698-3703
-
-
Wolfer, A.1
Wittner, B.S.2
Irimia, D.3
Flavin, R.J.4
Lupien, M.5
Gunawardane, R.N.6
Meyer, C.A.7
Lightcap, E.S.8
Tamayo, P.9
Mesirov, J.P.10
Liu, X.S.11
Shioda, T.12
Toner, M.13
Loda, M.14
Brown, M.15
Brugge, J.S.16
Ramaswamy, S.17
-
69
-
-
53349103292
-
Modelling Myc inhibition as a cancer therapy
-
Soucek, L.; Whitfield, J.; Martins, C. P.; Finch, A. J.; Murphy, D. J.; Sodir, N. M.; Karnezis, A. N.; Swigart, L. B.; Nasi, S.; Evan, G. I. Modelling Myc inhibition as a cancer therapy. Nature, 2008, 455(7213), 679-83.
-
(2008)
Nature
, vol.455
, Issue.7213
, pp. 679-683
-
-
Soucek, L.1
Whitfield, J.2
Martins, C.P.3
Finch, A.J.4
Murphy, D.J.5
Sodir, N.M.6
Karnezis, A.N.7
Swigart, L.B.8
Nasi, S.9
Evan, G.I.10
-
70
-
-
0038107350
-
Genomically complex lymphomas undergo sustained tumor regression upon MYC inactivation unless they acquire novel chromosomal translocations
-
Karlsson, A.; Giuriato, S.; Tang, F.; Fung-Weier, J.; Levan, G.; Felsher, D. W. Genomically complex lymphomas undergo sustained tumor regression upon MYC inactivation unless they acquire novel chromosomal translocations. Blood, 2003, 101(7), 2797-803.
-
(2003)
Blood
, vol.101
, Issue.7
, pp. 2797-2803
-
-
Karlsson, A.1
Giuriato, S.2
Tang, F.3
Fung-Weier, J.4
Levan, G.5
Felsher, D.W.6
-
71
-
-
62549126478
-
Targeting Myc in pediatric malignancies of the central and peripheral nervous system
-
Grotzer, M. A.; Castelletti, D.; Fiaschetti, G.; Shalaby, T.; Arcaro, A. Targeting Myc in pediatric malignancies of the central and peripheral nervous system. Curr. Cancer Drug Targets, 2009, 9(2), 176-88.
-
(2009)
Curr. Cancer Drug Targets
, vol.9
, Issue.2
, pp. 176-188
-
-
Grotzer, M.A.1
Castelletti, D.2
Fiaschetti, G.3
Shalaby, T.4
Arcaro, A.5
-
72
-
-
69049087664
-
Cellular signaling perturbation by natural products
-
Sarkar, F. H.; Li, Y.; Wang, Z.; Kong, D. Cellular signaling perturbation by natural products. Cell. Signal., 2009, 21(11), 1541-7.
-
(2009)
Cell. Signal.
, vol.21
, Issue.11
, pp. 1541-1547
-
-
Sarkar, F.H.1
Li, Y.2
Wang, Z.3
Kong, D.4
|