Turnover of BRCA1 involves in radiation-induced apoptosis

PLoS ONE

Volumn 5, Issue 12, 2010, Pages

  Liu, Weijun ^a   Zong, Wenjun ^a   Wu, George ^a   Fujita, Takeo ^a   Li, Wenqi ^a   Wu, Judy ^a   Wan, Yong ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; PROTEASOME; UBIQUITIN; BRCA1 PROTEIN, HUMAN; ION;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; FIBROBLAST; GAMMA IRRADIATION; GENOTOXICITY; HELA CELL; HUMAN; IONIZING RADIATION; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN STABILITY; RADIATION EXPOSURE; RADIATION RESPONSE; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; ANIMAL; BIOSYNTHESIS; CELL CYCLE; GAMMA RADIATION; GENE EXPRESSION REGULATION; GENOME; METABOLISM; PHOSPHORYLATION; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; BRCA1 PROTEIN; CELL CYCLE; FIBROBLASTS; GAMMA RAYS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, BRCA1; GENOME; HELA CELLS; HUMANS; IONS; MICE; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; UBIQUITIN;

EID: 79251496438     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014484     Document Type: Article

References (57)

1. Futreal PA, Liu Q, Shattuck-Eidens D, Cochran C, Harshman K, et al. (1994) BRCA1 mutations in primary breast and ovarian carcinomas. Science 266: 120-122.
2. Narod SA, Foulkes WD (2004) BRCA1 and BRCA2: 1994 and beyond. Nat Rev Cancer 4: 665-676.
3. Cable PL, Wilson CA, Calzone FJ, Rauscher FJ, 3rd, Scully R, et al. (2003) Novel consensus DNA-binding sequence for BRCA1 protein complexes. Mol Carcinog 38: 85-96.
4. Deng CX, Brodie SG (2000) Roles of BRCA1 and its interacting proteins. Bioessays 22: 728-737.
5. Gudmundsdottir K, Ashworth A (2006) The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability. Oncogene 25: 5864-5874.
6. Scully R (2001) Interactions between BRCA proteins and DNA structure. Exp Cell Res 264: 67-73.
7. Wu LC, Wang ZW, Tsan JT, Spillman MA, Phung A, et al. (1996) Identification of a RING protein that can interact in vivo with the BRCA1 gene product. Nat Genet 14: 430-440.
8. Baer R, Ludwig T (2002) The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity. Curr Opin Genet Dev 12: 86-91.
9. Lorick KL, Jensen JP, Fang S, Ong AM, Hatakeyama S, et al. (1999) RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc Natl Acad Sci U S A 96: 11364-11369.
10. Ruffner H, Joazeiro CA, Hemmati D, Hunter T, Verma IM (2001) ancerpredisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity. Proc Natl Acad Sci U S A 98: 5134-5139.
11. Hashizume R, Fukuda M, Maeda I, Nishikawa H, Oyake D, et al. (2001) The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation. J Biol Chem 276: 14537-14540.
12. Chen Y, Farmer AA, Chen CF, Jones DC, Chen PL, et al. (1996) BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner. Cancer Res 56: 3168-3172.
13. Scully R, Chen J, Ochs RL, Keegan K, Hoekstra M, et al. (1997) Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell 90: 425-435.
14. Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, et al. (2000) Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev 14: 2989-3002.
15. Cortez D, Wang Y, Qin J, Elledge SJ (1999) Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science 286: 1162-1166.
16. Wang Q, Zhang H, Fishel R, Greene MI (2000) BRCA1 and cell signaling. Oncogene 19: 6152-6158.
17. Choi YH (2001) Proteasome-mediated degradation of BRCA1 protein in MCF- 7 human breast cancer cells. Int J Oncol 19: 687-693.
18. Rodriguez JA, Au WW, Henderson BR (2004) Cytoplasmic mislocalization of BRCA1 caused by cancer-associated mutations in the BRCT domain. Exp Cell Res 293: 14-21.
19. Choudhury AD, Xu H, Baer R (2004) Ubiquitination and proteasomal degradation of the BRCA1 tumor suppressor is regulated during cell cycle progression. J Biol Chem 279: 33909-33918.
20. Mueller CR, Roskelley CD (2003) Regulation of BRCA1 expression and its relationship to sporadic breast cancer. Breast Cancer Res 5: 45-52.
21. Turner N, Tutt A, Ashworth A (2004) Hallmarks of 'BRCAness' in sporadic cancers. Nat Rev Cancer 4: 814-819.
22. Boulton SJ, Martin JS, Polanowska J, Hill DE, Gartner A, et al. (2004) BRC A1/ BARD1 orthologs required for DNA repair in Caenorhabditis elegans. Curr Biol 14: 33-39.
23. Polanowska J, Martin JS, Garcia-Muse T, Pet-aletal/et-alcorin MI, Boulton SJ (2006) A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites. Embo J 25: 2178-2188.
24. Zhang HG, Wang J, Yang X, Hsu HC, Mountz JD (2004) Regulation of apoptosis proteins in cancer cells by ubiquitin. Oncogene 23: 2009-2015.
25. Chen A, Kleiman FE, Manley JL, Ouchi T, Pan ZQ (2002) Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase. J Biol Chem 277: 22085-22092.
26. Zhang YW, Otterness DM, Chiang GG, Xie W, Liu YC, et al. (2005) Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway. Mol Cell 19: 607-618.
27. Mailand N, Podtelejnikov AV, Groth A, Mann M, Bartek J, et al. (2002) Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability. Embo J 21: 5911-5920.
28. Busino L, Donzelli M, Chiesa M, Guardavaccaro D, Ganoth D, et al. (2003) Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. Nature 426: 87-91.
29. Jacquemont C, Taniguchi T (2007) The Fanconi anemia pathway and ubiquitin. BMC Biochem 8(Suppl 1): S10.
30. Morris JR, Solomon E (2004) BRCA1: BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair. Hum Mol Genet 13: 807-817.
31. Boulton SJ (2006) BRCA1-mediated ubiquitylation. Cell Cycle 5: 1481-1486.
32. Mallery DL, Vandenberg CJ, Hiom K (2002) Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains. Embo J 21: 6755-6762.
33. Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, et al. (2003) Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. Mol Cell 12: 1087-1099.
34. Wan Y, Liu X, Kirschner MW (2001) The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction. Mol Cell 8: 1027-1039.
35. Esteller M, Silva JM, Dominguez G, Bonilla F, Matias-Guiu X, et al. (2000) Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. J Natl Cancer Inst 92: 564-569.
36. Liu W, Wu G, Li W, Lobur D, Wan Y (2007) Cdh1-anaphase-promoting complex targets Skp2 for destruction in transforming growth factor beta-induced growth inhibition. Mol Cell Biol 27: 2967-2979.
37. Ayad NG, Rankin S, Ooi D, Rape M, Kirschner MW (2005) Identification of ubiquitin ligase substrates by in vitro expression cloning. Methods Enzymol 399: 404-414.
38. Zhan Q, Jin S, Ng B, Plisket J, Shangary S, et al. (2002) Caspase-3 mediated cleavage of BRCA1 during UV-induced apoptosis. Oncogene 21: 5335-5345.
39. Koberle B, Roginskaya V, Wood RD (2006) XPA protein as a limiting factor for nucleotide excision repair and UV sensitivity in human cells. DNA Repair (Amst) 5: 641-648.
40. Wang W (2007) Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins. Nat Rev Genet 8: 735-748.
41. Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, et al. (2000) BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev 14: 927-939.
42. Scully R, Chen J, Plug A, Xiao Y, Weaver D, et al. (1997) Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88: 265-275.
43. Zhong Q, Chen CF, Li S, Chen Y, Wang CC, et al. (1999) Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response. Science 285: 747-750.
44. Gowen LC, Avrutskaya AV, Latour AM, Koller BH, Leadon SA (1998) BRCA1 required for transcription-coupled repair of oxidative DNA damage. Science 281: 1009-1012.
45. Hartman AR, Ford JM (2002) BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair. Nat Genet 32: 180-184.
46. Setlow RB (2002) Shedding light on proteins, nucleic acids, cells, humans and fish. Mutat Res 511: 1-14.
47. MacLachlan TK, Takimoto R, El-Deiry WS (2002) BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targets. Mol Cell Biol 22: 4280-4292.
48. Lafarge S, Sylvain V, Ferrara M, Bignon YJ (2001) Inhibition of BRCA1 leads to increased chemoresistance to microtubule-interfering agents, an effect that involves the JNK pathway. Oncogene 20: 6597-6606.
49. Sylvain V, Lafarge S, Bignon YJ (2002) Dominant-negative activity of a Brca1 truncation mutant: effects on proliferation, tumorigenicity in vivo, and chemosensitivity in a mouse ovarian cancer cell line. Int J Oncol 20: 845-853.
50. Quinn JE, Kennedy RD, Mullan PB, Gilmore PM, Carty M, et al. (2003) BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis. Cancer Res 63: 6221-6228.
51. DelloRusso C, Welcsh PL, Wang W, Garcia RL, King MC, et al. (2007) Functional characterization of a novel BRCA1-null ovarian cancer cell line in response to ionizing radiation. Mol Cancer Res 5: 35-45.
52. Schimmer AD, Dalili S, Batey RA, Riedl SJ (2006) Targeting XIAP for the treatment of malignancy. Cell Death Differ 13: 179-188.
53. Martin SJ (2002) Destabilizing influences in apoptosis: sowing the seeds of IAP destruction. Cell 109: 793-796.
54. MacFarlane M, Merrison W, Bratton SB, Cohen GM (2002) Proteasomemediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro. J Biol Chem 277: 36611-36616.
55. Chen ZJ (2005) Ubiquitin signalling in the NF-kappaB pathway. Nat Cell Biol 7: 758-765.
56. Kovalenko A, Chable-Bessia C, Cantarella G, Israel A, Wallach D, et al. (2003) The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. Nature 424: 801-805.
57. Jesenberger V, Jentsch S (2002) Deadly encounter: ubiquitin meets apoptosis. Nat Rev Mol Cell Biol 3: 112-121.