Disease risk of missense mutations using structural inference from predicted function

Current Protein and Peptide Science

Volumn 11, Issue 7, 2010, Pages 573-588

  Horst, Jeremy A ^a,b   Wang, Kai ^c   Horst, Orapin V ^a,b   Cunningham, Michael L ^a,b,d   Samudrala, Ram ^a,b  

^a Department of Oral Biology ^*  (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^d SEATTLE CHILDREN S HOSPITAL   (United States)

Author keywords

Computational biology; machine learning; missense mutation; nonsynonymous SNP; protein stability; sequence analysis

Indexed keywords

LAC REPRESSOR;

ALGORITHM; AMINO ACID SUBSTITUTION; ARTICLE; CRANIOFACIAL SYNOSTOSIS; GENERAL ASPECTS OF DISEASE; HUMAN; IN VITRO STUDY; MACHINE LEARNING; MISSENSE MUTATION; NONHUMAN; PATHOGENESIS; PREDICTIVE VALUE; PROTEIN FUNCTION; PROTEIN INTERACTION; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SEQUENCE ANALYSIS;

ALGORITHMS; AMINO ACID SUBSTITUTION; COMPUTER SIMULATION; DATABASES, GENETIC; DATABASES, PROTEIN; DISEASE; HUMANS; LAC REPRESSORS; MARKOV CHAINS; MODELS, MOLECULAR; MUTANT PROTEINS; MUTATION, MISSENSE; NEURAL NETWORKS (COMPUTER); POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; RISK ASSESSMENT; RISK FACTORS; SEQUENCE ALIGNMENT;

EID: 79251482424     PISSN: 13892037     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920310794109139     Document Type: Article

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