Ligand - Based virtual screening procedure for the prediction and the identification of novel β-amyloid aggregation inhibitors using Kohonen maps and Counterpropagation Artificial Neural Networks

European Journal of Medicinal Chemistry

Volumn 46, Issue 2, 2011, Pages 497-508

  Afantitis, Antreas ^a   Melagraki, Georgia ^b   Koutentis, Panayiotis A ^b   Sarimveis, Haralambos ^c   Kollias, George ^d  

^a NOVAMECHANICS LTD   (Cyprus)

^b UNIVERSITY OF CYPRUS   (Cyprus)

^c NATIONAL TECHNICAL UNIVERSITY OF ATHENS   (Greece)

^d BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING   (Greece)

Author keywords

Amyloid inhibitors; Alzheimer's disease; CP ANN; In silico virtual screening; Kohonen map; QSAR

Indexed keywords

AMYLOID BETA PROTEIN; EFENAMIC ACID;

ARTICLE; ARTIFICIAL NEURAL NETWORK; BIOLOGICAL ACTIVITY; COMPUTER MODEL; DRUG IDENTIFICATION; DRUG SCREENING; PHARMACOPHORE; PREDICTION; PROTEIN AGGREGATION; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

AMYLOID BETA-PEPTIDES; CLUSTER ANALYSIS; FENAMATES; HIGH-THROUGHPUT SCREENING ASSAYS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEURAL NETWORKS (COMPUTER); PREDICTIVE VALUE OF TESTS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79151478389     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.11.029     Document Type: Article

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