Quantitative structure activity relationship analysis of dicationic diphenylisoxazole as potent anti-trypanosomal agents

QSAR and Combinatorial Science

Volumn 28, Issue 11-12, 2009, Pages 1367-1375

  Paliwal, Sarvesh ^a   Narayan, Ankita ^a   Paliwal, Shailendra ^b  

^a BANASTHALI UNIVERSITY   (India)

^b LLRM MEDICAL COLLEGE   (India)

Author keywords

Drug design; Human african trypanosomiasis; Kinetoplast DNA; Medicinal chemistry; Multiple linear regressions; Partial least squares analysis; Quantitative structure activity relationship; Tools for structure activity relationship

Indexed keywords

3,5 DIPHENYLISOXAZOLE DERIVATIVE; ANTITRYPANOSOMAL AGENT; CATION; ISOXAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

AFRICAN TRYPANOSOMIASIS; ANTIMICROBIAL ACTIVITY; ARTICLE; COMPUTER PROGRAM; DRUG DESIGN; DRUG STRUCTURE; LINEAR REGRESSION ANALYSIS; PARTIAL LEAST SQUARES REGRESSION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STATISTICAL ANALYSIS; TRYPANOSOMA RHODESIENSE;

EID: 76049119726     PISSN: 1611020X     EISSN: 16110218     Source Type: Journal    
DOI: 10.1002/qsar.200860206     Document Type: Article

References (31)

1. African trypanosomiasis, Fact Sheet Number 259, World Health Organization Publications, Geneva 2001.
2. M. P. Barrett, Lancet 1999, 353, 1113-1114.
3. S. C. Welburn, I. Maudlin, Parasitol. Today 1999, 15, 399-403.
4. I. O. Donkor, T. L. Huang, B. Tao, D. Rattendi, S. Lane, M. Vargas, B. Goldberg, C. Bacchi, J. Med. Chem. 2003, 46, 1041-1048.
5. D. A. Patrick, S. A. Bakunov, S. M. Bakunova, E. V. K. S. Kumar, R. J. Lombardy, S. K. Jones, A. S. Bridges, O. Zhir-nov, J. E. Hall, T. Wenzler, R. Brun, R. R. Tidwell, J. Med. Chem. 2007, 50, 2468-2485.
6. J. Pepin, N. Khonde, Trans. Roy. Soc. Trop. Med. Hyg. 1996, 90, 183-186.
7. J. Pepin, F. Milord, A. N. Khonde, T. Niyonsenga, L. Loko, B. Mypia, P. De Wals, Trans. Roy. Soc. Trop. Med. Hyg. 1995, 89, 92-97.
8. D. Legros, G. Ollivier, M. Gasteullu-Etchegorry, C. Paquet, C. Burri, J. Jannin, P. Buscher, Lancet Infect. Dis. 2002, 2, 437-440.
9. M. P. Barrett, R. J. S. Burchmore, A. Stich, J. O. Lazzari, A. C. Frasch, J. J. Cazzulo, S. Krishna, Lancet 2003, 362, 1469-1480.
10. http://www.who.int/mediacentre/factsheets/fs259/en/ (accessed October 2006).
11. R. R. Tidwell, D.W. Boyken, M. In Demeunynck, C. Baelly, Small molecule DNA and RNA binders: From synthesis to nucleic acid complexes, Wiley-VCH, Weinheim, Germany 2003, p. 414-460.
12. A. H. Faerlamb, Trends Parasitol. 2003, 19, 488.
13. B. Bouteille, O. Oukem, S. Bisser, M. B. Dumas, Fundam. Clin. Pharmacol. 2003, 17, 171.
14. H. Singh, R. J. Sivakumar, Infect. Chemother. 2004, 10, 307.
15. J. Jannin, P. Cattand, Curr. Opin. Infect. Dis. 2004, 17, 565.
16. D.W. Wilson, B. Nguyen, F. Taneous, A. Mathis, J. E. Hall, L. E. Stephans, D.W. Boykin, Curr. Med. Chem. 2005, 5, in press.
17. T. A. Shapiro, P. T. Englund, Proc. Natl. Acad. Sci. USA 1990, 87, 950.
18. T. A. Shapiro, P. T. Englund, Annu. Rev. Microbiol. 1995, 49, 117.
19. C. Yeates, DB-289 Immtech International: IDrugs 2003, 6, 1086-1093.
20. A. Afantitis, G. Melaqraki, H. Sarimveis, P. A. Koutentis, J. Markopoulos, O. Iqqlessi-Markopoulou, Mol. Divers. 2006, 10, 405-414.
21. P. Athri, T. Wenzler, P. Ruiz, R. Brun, D.W. Boykin, R. Tidwell, W. D. Wilson, Bioorg. Med. Chem. 2006, 14, 3144-3152.
22. J. Sadowski, J. Gasteiger, Chem. Rev. 1993, 93, 2567-2581.
23. H. Z. Si, T. Wang, K. J. Zhang, Z. D. Hu, B. T. Fan, Bioorg. Med. Chem. 2006, 14, 4834-4841.
24. N. Rameshwar, K. Krishna, K. B. Ashok, T. Parthasarathy, Bioorg. Med. Chem. 2006, 14, 319-325.
25. C. D. Selassie, in Bruger's Medicinal Chemistry and Drug Discovery, Vol. 1 (Ed: D. J. Abraham), Wiley, New York 2003, pp. 1-37.
26. H. Kubinyi, Evolutionary J Chemometr. 1996, 10, 119-133.
27. F .Lindgren, P. Geladi, S. Rannar, S. Wold, J. Chemometr. 1994, 8, 349-363.
28. D. Kim, Suk-In. Hong, Dae-Sil. Lee, Int. J. Mol. Sci. 2006, 7, 485-496.
29. R. D. Cramer, Perspect. Drug Discov. Des .1993, 1, 269-278.
30. S. W. Yao, V. H. C. Lopes, F .Fernández, X. García-Mera, M. Morales, J. E. Rodríguez-Borges, M. N. D. S .Cordeiroa, Bioor. Med. Chem. 2003, 11, 4999-5006.
31. R. R. Tidwell, D.W. Boykin, in Interaction of Small Molecules with DNA and RNA: From Synthesis to Nucleic Acid Complexes (Eds: M.Demeunynck, C. Bailly, W. D. Wilson), Wiley-VCH, Hoboken, NJ 2002.