Multivariate QSAR study of 4,5-dihydroxypyrimidine carboxamides as HIV-1 integrase inhibitors

European Journal of Medicinal Chemistry

Volumn 44, Issue 9, 2009, Pages 3577-3583

  de Melo, Eduardo Borges ^a,b   Ferreira, Márcia Miguel Castro ^b  

^a UNIVERSIDADE ESTADUAL DO OESTE DO PARANÁ   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

4,5 Dihydroxypyrimidine carboxamides; HIV 1 integrase; OPS; PLS; QSAR

Indexed keywords

4,5 DIHYDROXYPYRIMIDINE CARBOXAMIDE DERIVATIVE; AMIDE; HYDROXYL GROUP; INTEGRASE; INTEGRASE INHIBITOR; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALGORITHM; ARTICLE; DRUG MECHANISM; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; MODEL; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; TECHNIQUE;

HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; MODELS, MOLECULAR; MULTIVARIATE ANALYSIS; PYRIMIDINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67650462278     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.03.001     Document Type: Article

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