메뉴 건너뛰기




Volumn 123, Issue 3, 2010, Pages 613-625

Relevance of circulating tumor cells, extracellular nucleic acids, and exosomes in breast cancer

Author keywords

Breast cancer; Cancer stem cells; Circulating tumor cells; Exosomes; Extracellular nucleic acids

Indexed keywords

BIOLOGICAL MARKER; BMI1 PROTEIN; CA 15-3 ANTIGEN; CA 27-29 ANTIGEN; CARCINOEMBRYONIC ANTIGEN; CYCLIN D1; CYTOKERATIN 19; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; EXTRACELLULAR DNA; EXTRACELLULAR NUCLEIC ACID; EXTRACELLULAR RNA; MAMMAGLOBIN; MICRORNA; NUCLEIC ACID; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROGESTERONE RECEPTOR; TELOMERASE REVERSE TRANSCRIPTASE; TRASTUZUMAB; UNCLASSIFIED DRUG; UROKINASE; MESSENGER RNA; TUMOR MARKER;

EID: 78951475136     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-010-0980-2     Document Type: Review
Times cited : (62)

References (157)
  • 2
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou C et al (2000) Molecular portraits of human breast tumours. Nature 406(6797):747-752
    • (2000) Nature , vol.406 , Issue.6797 , pp. 747-752
    • Perou, C.1
  • 3
    • 60849097255 scopus 로고    scopus 로고
    • Gene-expression signatures in breast cancer
    • Sotiriou C, Pusztai L (2009) Gene-expression signatures in breast cancer. N Engl J Med 360(8):790-800
    • (2009) N Engl J Med , vol.360 , Issue.8 , pp. 790-800
    • Sotiriou, C.1    Pusztai, L.2
  • 4
    • 0036298299 scopus 로고    scopus 로고
    • Molecular detection of micro-metastasis in breast cancer
    • DOI 10.1016/S1040-8428(01)00181-0, PII S1040842801001810
    • Jiang WG et al (2002) Molecular detection of micro-metastasis in breast cancer. Crit Rev Oncol Hematol 43(1):13-31 (Pubitemid 34722785)
    • (2002) Critical Reviews in Oncology/Hematology , vol.43 , Issue.1 , pp. 13-31
    • Jiang, W.G.1    Martin, T.A.2    Mansel, R.E.3
  • 6
    • 2942538264 scopus 로고    scopus 로고
    • Dissecting the metastatic cascade
    • Pantel K, Brakenhoff R (2004) Dissecting the metastatic cascade. Nat Rev Cancer 4(6):448-456 (Pubitemid 38745530)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.6 , pp. 448-456
    • Pantel, K.1    Brakenhoff, R.H.2
  • 8
    • 49249091523 scopus 로고    scopus 로고
    • Identification and characterization of ovarian cancer-initiating cells from primary human tumors
    • Zhang S et al (2008) Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res 68(11):4311-4320
    • (2008) Cancer Res , vol.68 , Issue.11 , pp. 4311-4320
    • Zhang, S.1
  • 9
    • 58249095085 scopus 로고    scopus 로고
    • Epigenetic regulation of cd133 and tumorigenicity of cd133? Ovarian cancer cells
    • Baba T et al (2009) Epigenetic regulation of CD133 and tumorigenicity of CD133? ovarian cancer cells. Oncogene 28(2):209-218
    • (2009) Oncogene , vol.28 , Issue.2 , pp. 209-218
    • Baba, T.1
  • 10
    • 73349125059 scopus 로고    scopus 로고
    • Cd133 expression defines a tumor initiating cell population in primary human ovarian cancer
    • Curley M et al (2009) CD133 Expression defines a tumor initiating cell population in primary human ovarian cancer. Stem Cells 27(12):2875-2883
    • (2009) Stem Cells , vol.27 , Issue.12 , pp. 2875-2883
    • Curley, M.1
  • 11
    • 67650561888 scopus 로고    scopus 로고
    • Cells with characteristics of cancer stem/progenitor cells express the cd133 antigen in human endometrial tumors
    • Rutella S et al (2009) Cells with characteristics of cancer stem/progenitor cells express the CD133 antigen in human endometrial tumors. Clin Cancer Res 15(13):4299-4311
    • (2009) Clin Cancer Res , vol.15 , Issue.13 , pp. 4299-4311
    • Rutella, S.1
  • 12
    • 0000110505 scopus 로고
    • A case of cancer in which cells similar to those in the tumours were seen in the blood after death
    • Ashworth T (1869) A case of cancer in which cells similar to those in the tumours were seen in the blood after death. Aust Med J 14:146-147
    • (1869) Aust Med J , vol.14 , pp. 146-147
    • Ashworth, T.1
  • 13
    • 84907163633 scopus 로고    scopus 로고
    • Circulating tumor cell analysis: Technical and statistical considerations for application to the clinic
    • Allan AL, Keeney M (2010) Circulating tumor cell analysis: technical and statistical considerations for application to the clinic. J Oncol 2010:426218
    • (2010) J Oncol , vol.2010 , pp. 426218
    • Allan, A.L.1    Keeney, M.2
  • 14
    • 70449713638 scopus 로고    scopus 로고
    • Circulating tumor cells: A useful predictor of treatment efficacy in metastatic breast cancer
    • Liu M et al (2009) Circulating tumor cells: A useful predictor of treatment efficacy in metastatic breast cancer. J Clin Oncol 27(31):5153-5159
    • (2009) J Clin Oncol , vol.27 , Issue.31 , pp. 5153-5159
    • Liu, M.1
  • 17
    • 33846814619 scopus 로고    scopus 로고
    • Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progression-free and overall survival
    • Hayes D et al (2006) Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progression-free and overall survival. Clin Cancer Res 12(141):4218-4224
    • (2006) Clin Cancer Res , vol.12 , Issue.141 , pp. 4218-4224
    • Hayes, D.1
  • 18
    • 57049162148 scopus 로고    scopus 로고
    • Circulating tumor cell detection predicts early metastatic relapse after neoadjuvant chemotherapy in large operable and locally advanced breast cancer in a phase ii randomized trial
    • Pierga J et al (2008) Circulating tumor cell detection predicts early metastatic relapse after neoadjuvant chemotherapy in large operable and locally advanced breast cancer in a phase II randomized trial. Clin Cancer Res 14(21):7004-7010
    • (2008) Clin Cancer Res , vol.14 , Issue.21 , pp. 7004-7010
    • Pierga, J.1
  • 20
    • 37549002543 scopus 로고    scopus 로고
    • Isolation of rare circulating tumour cells in cancer patients by microchip technology
    • Nagrath S et al (2007) Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature 450(7173): 1235-1239
    • (2007) Nature , vol.450 , Issue.7173 , pp. 1235-1239
    • Nagrath, S.1
  • 21
    • 67349253810 scopus 로고    scopus 로고
    • Molecular profiling and predictive value of circulating tumor cells in patients with metastatic breast cancer: An option for monitoring response to breast cancer related therapies
    • Tewes M et al (2009) Molecular profiling and predictive value of circulating tumor cells in patients with metastatic breast cancer: An option for monitoring response to breast cancer related therapies. Breast Cancer Res Treat 115(3):581-590
    • (2009) Breast Cancer Res Treat , vol.115 , Issue.3 , pp. 581-590
    • Tewes, M.1
  • 24
    • 77449088191 scopus 로고    scopus 로고
    • Detection and characterization of circulating tumor cells in blood of primary breast cancer patients by rt-pcr and comparison to status of bone marrow disseminated cells
    • Fehm T et al (2009) Detection and characterization of circulating tumor cells in blood of primary breast cancer patients by RT-PCR and comparison to status of bone marrow disseminated cells. Breast Cancer Res 11(4):R59
    • (2009) Breast Cancer Res , vol.11 , Issue.4
    • Fehm, T.1
  • 25
    • 40449098857 scopus 로고    scopus 로고
    • Determination of her2 status using both serum her2 levels and circulating tumor cells in patients with recurrent breast cancer whose primary tumor was her2 negative or of unknown her2 status
    • Fehm T et al (2007) Determination of HER2 status using both serum HER2 levels and circulating tumor cells in patients with recurrent breast cancer whose primary tumor was HER2 negative or of unknown HER2 status. Breast Cancer Res 9(5):R74
    • (2007) Breast Cancer Res , vol.9 , Issue.5
    • Fehm, T.1
  • 26
    • 77649237594 scopus 로고    scopus 로고
    • Circulating tumour cells in clinical practice: Methods of detection and possible characterization
    • Alunni-Fabbroni M, Sandri M (2010) Circulating tumour cells in clinical practice: methods of detection and possible characterization. Methods 50(4):289-297
    • (2010) Methods , vol.50 , Issue.4 , pp. 289-297
    • Alunni-Fabbroni, M.1    Sandri, M.2
  • 28
    • 0041780998 scopus 로고    scopus 로고
    • Detection of circulating tumor cells in blood using an optimized density gradient centrifugation
    • Gertler R et al (2003) Detection of circulating tumor cells in blood using an optimized density gradient centrifugation. Recent Results Cancer Res 162:149-155
    • (2003) Recent Results Cancer Res , vol.162 , pp. 149-155
    • Gertler, R.1
  • 29
    • 18844450688 scopus 로고    scopus 로고
    • Circulating tumor cells in breast cancer: Correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity
    • DOI 10.1158/1078-0432.CCR-04-2469
    • Müller V et al (2005) Circulating tumor cells in breast cancer: correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity. Clin Cancer Res 11(10):3678-3685 (Pubitemid 40685584)
    • (2005) Clinical Cancer Research , vol.11 , Issue.10 , pp. 3678-3685
    • Muller, V.1    Stahmann, N.2    Riethdorf, S.3    Rau, T.4    Zabel, T.5    Goetz, A.6    Janicke, F.7    Pantel, K.8
  • 30
    • 3042849126 scopus 로고    scopus 로고
    • Detection of isolated tumor cells in peripheral blood and in BM: Evaluation of a new enrichment method
    • DOI 10.1080/14653240410006086
    • Naume B et al (2004) Detection of isolated tumor cells in peripheral blood and in BM: evaluation of a new enrichment method. Cytotherapy 6(3):244-252 (Pubitemid 38868097)
    • (2004) Cytotherapy , vol.6 , Issue.3 , pp. 244-252
    • Naume, B.1    Borgen, E.2    Tossvik, S.3    Pavlak, N.4    Oates, D.5    Nesland, J.M.6
  • 31
    • 77952090367 scopus 로고    scopus 로고
    • Isolation of malignant b cells from patients with chronic lymphocytic leukemia (cll) for analysis of cell proliferation: Validation of a simplified method suitable for multi-center clinical studies
    • Hayes G et al (2010) Isolation of malignant B cells from patients with chronic lymphocytic leukemia (CLL) for analysis of cell proliferation: validation of a simplified method suitable for multi-center clinical studies. Leuk Res 34(6):809-815
    • (2010) Leuk Res , vol.34 , Issue.6 , pp. 809-815
    • Hayes, G.1
  • 32
    • 67849124183 scopus 로고    scopus 로고
    • Circulating tumor cells (ctcs): Detection methods and their clinical relevance in breast cancer
    • Mostert B et al (2009) Circulating tumor cells (CTCs): detection methods and their clinical relevance in breast cancer. Cancer Treat Rev 35(5):463-474
    • (2009) Cancer Treat Rev , vol.35 , Issue.5 , pp. 463-474
    • Mostert, B.1
  • 33
    • 77949523595 scopus 로고    scopus 로고
    • Circulating tumor cells revisited
    • Cristofanilli M, Braun S (2010) Circulating tumor cells revisited. JAMA 303(11):1092-1093
    • (2010) JAMA , vol.303 , Issue.11 , pp. 1092-1093
    • Cristofanilli, M.1    Braun, S.2
  • 34
    • 21044458905 scopus 로고    scopus 로고
    • Methods for isolating circulating epithelial cells and criteria for their classification as carcinoma cells
    • DOI 10.1080/14653240510027082
    • Fehm T et al (2005) Methods for isolating circulating epithelial cells and criteria for their classification as carcinoma cells. Cytotherapy 7(2):171-185 (Pubitemid 40872753)
    • (2005) Cytotherapy , vol.7 , Issue.2 , pp. 171-185
    • Fehm, T.1    Solomayer, E.F.2    Meng, S.3    Tucker, T.4    Lane, N.5    Wang, J.6    Gebauer, G.7
  • 39
    • 42649100970 scopus 로고    scopus 로고
    • Detection, clinical relevance and specific biological properties of disseminating tumour cells
    • DOI 10.1038/nrc2375, PII NRC2375
    • Pantel K et al (2008) Detection, clinical relevance and specific biological properties of disseminating tumour cells. Nat Rev Cancer 8(5):329-340 (Pubitemid 351596394)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.5 , pp. 329-340
    • Pantel, K.1    Brakenhoff, R.H.2    Brandt, B.3
  • 40
    • 67649973938 scopus 로고    scopus 로고
    • The prognostic impact of bone marrow micrometastases in women with breast cancer
    • Braun S et al (2009) The prognostic impact of bone marrow micrometastases in women with breast cancer. Cancer Invest 27(6):598-603
    • (2009) Cancer Invest , vol.27 , Issue.6 , pp. 598-603
    • Braun, S.1
  • 43
    • 71949125229 scopus 로고    scopus 로고
    • Her2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial her2 status on primary tumor
    • Krawczyk N et al (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res 29(10):4019-4024
    • (2009) Anticancer Res , vol.29 , Issue.10 , pp. 4019-4024
    • Krawczyk, N.1
  • 44
    • 84957852098 scopus 로고
    • Les acides nucleiques du plasma sanguine chez l'homme (in french)
    • Mandel P, Metais P (1948) Les acides nucleiques du plasma sanguine chez l'homme (in French). C R Seances Soc Biol Fil 142(3-4):241-243
    • (1948) C R Seances Soc Biol Fil , vol.142 , Issue.3-4 , pp. 241-243
    • Mandel, P.1    Metais, P.2
  • 45
    • 0013964845 scopus 로고
    • Deoxybonucleic acid (dna) and antibodies to dna in the serum of patients with systemic lupus erythematosus
    • Tan EM et al (1966) Deoxybonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosus. J Clin Invest 45(11):1732-1740
    • (1966) J Clin Invest , vol.45 , Issue.11 , pp. 1732-1740
    • Tan, E.M.1
  • 46
    • 0015535196 scopus 로고
    • The occurrence of single-stranded dna in the serum of patients with systemic lupus erythematosus and other diseases
    • Koffler D et al (1973) The occurrence of single-stranded DNA in the serum of patients with systemic lupus erythematosus and other diseases. J Clin Invest 52(1):198-204
    • (1973) J Clin Invest , vol.52 , Issue.1 , pp. 198-204
    • Koffler, D.1
  • 47
    • 0017499407 scopus 로고
    • Free dna in the serum of rheumatoid arthritis patients
    • Leon S et al (1977) Free DNA in the serum of rheumatoid arthritis patients. J Rheumatol 4(2):139-143
    • (1977) J Rheumatol , vol.4 , Issue.2 , pp. 139-143
    • Leon, S.1
  • 48
    • 0017360626 scopus 로고
    • Free DNA in the serum of cancer patients and the effect of therapy
    • Leon S et al (1977) Free DNA in the serum of cancer patients and the effect of therapy. Cancer Res 37(3):646-650 (Pubitemid 8051621)
    • (1977) Cancer Research , vol.37 , Issue.3 , pp. 646-650
    • Leon, S.A.1    Shapiro, B.2    Sklaroff, D.M.3    Yaros, M.J.4
  • 50
    • 0028225017 scopus 로고
    • Soluble normal and mutated dna sequences from single-copy genes in human blood
    • Sorenson G et al (1994) Soluble normal and mutated DNA sequences from single-copy genes in human blood. Cancer Epidemiol Biomarkers Prev 3(1):67-71
    • (1994) Cancer Epidemiol Biomarkers Prev , vol.3 , Issue.1 , pp. 67-71
    • Sorenson, G.1
  • 51
    • 0028241030 scopus 로고
    • Point mutations of the N-ras gene in the blood plasma DNA of patients with myelodysplastic syndrome or acute myelogenous leukaemia
    • Vasioukhin V et al (1994) Point mutations of the N-ras gene in the blood plasma DNA of patients with myelodysplastic syndrome or acute myelogenous leukaemia. Br J Haematol 86(4):774-779 (Pubitemid 24194434)
    • (1994) British Journal of Haematology , vol.86 , Issue.4 , pp. 774-779
    • Vasioukhin, V.1    Anker, P.2    Maurice, P.3    Lyautey, J.4    Lederrey, C.5    Stroun, M.6
  • 52
    • 71049146803 scopus 로고    scopus 로고
    • Levels of plasma circulating cell free nuclear and mitochondrial dna as potential biomarkers for breast tumors
    • Kohler C et al (2009) Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumors. Mol Cancer 8:105
    • (2009) Mol Cancer , vol.8 , pp. 105
    • Kohler, C.1
  • 53
    • 69249194732 scopus 로고    scopus 로고
    • Circulating htert dna in early breast cancer
    • Divella R et al (2009) Circulating hTERT DNA in early breast cancer. Anticancer Res 29(7):2845-2849
    • (2009) Anticancer Res , vol.29 , Issue.7 , pp. 2845-2849
    • Divella, R.1
  • 54
    • 64949112189 scopus 로고    scopus 로고
    • The presence of circulating total dna and methylated genes is associated with circulating tumour cells in blood from breast cancer patients
    • Van der Auwera I et al (2009) The presence of circulating total DNA and methylated genes is associated with circulating tumour cells in blood from breast cancer patients. Br J Cancer 100(8):1277-1286
    • (2009) Br J Cancer , vol.100 , Issue.8 , pp. 1277-1286
    • Van Der Auwera, I.1
  • 55
    • 77950459166 scopus 로고    scopus 로고
    • Circulating dna is a non-invasive prognostic factor for survival in non-small cell lung cancer
    • van der Drift M et al (2010) Circulating DNA is a non-invasive prognostic factor for survival in non-small cell lung cancer. Lung Cancer 68(2):283-287
    • (2010) Lung Cancer , vol.68 , Issue.2 , pp. 283-287
    • Van Der Drift, M.1
  • 56
    • 67149087399 scopus 로고    scopus 로고
    • Comparison of circulating plasma dna levels between lung cancer patients and healthy controls
    • Yoon K et al (2009) Comparison of circulating plasma DNA levels between lung cancer patients and healthy controls. J Mol Diagn 11(3):182-185
    • (2009) J Mol Diagn , vol.11 , Issue.3 , pp. 182-185
    • Yoon, K.1
  • 57
    • 67650366758 scopus 로고    scopus 로고
    • Detection of kras oncogene in peripheral blood as a predictor of the response to cetuximab plus chemotherapy in patients with metastatic colorectal cancer
    • Yen L et al (2009) Detection of KRAS oncogene in peripheral blood as a predictor of the response to cetuximab plus chemotherapy in patients with metastatic colorectal cancer. Clin Cancer Res 15(13):4508-4513
    • (2009) Clin Cancer Res , vol.15 , Issue.13 , pp. 4508-4513
    • Yen, L.1
  • 58
    • 66749190952 scopus 로고    scopus 로고
    • Cpg island hypermethylation of cell-free circulating serum dna in patients with testicular cancer
    • Ellinger J et al (2009) CpG island hypermethylation of cell-free circulating serum DNA in patients with testicular cancer. J Urol 182(1):324-329
    • (2009) J Urol , vol.182 , Issue.1 , pp. 324-329
    • Ellinger, J.1
  • 59
    • 70449535638 scopus 로고    scopus 로고
    • Detection of braf mutations in the tumour and serum of patients enrolled in the azd6244 (arry-142886) advanced melanoma phase ii study
    • Board R et al (2009) Detection of BRAF mutations in the tumour and serum of patients enrolled in the AZD6244 (ARRY-142886) advanced melanoma phase II study. Br J Cancer 101(10):1724-1730
    • (2009) Br J Cancer , vol.101 , Issue.10 , pp. 1724-1730
    • Board, R.1
  • 60
    • 74749092632 scopus 로고    scopus 로고
    • Detectable braf mutation in serum dna samples from patients with papillary thyroid carcinomas
    • Chuang T et al (2010) Detectable BRAF mutation in serum DNA samples from patients with papillary thyroid carcinomas. Head Neck 32(2):229-234
    • (2010) Head Neck , vol.32 , Issue.2 , pp. 229-234
    • Chuang, T.1
  • 61
    • 77449135297 scopus 로고    scopus 로고
    • Comparative evaluation of cellfree tumor dna in blood and disseminated tumor cells in bone marrow of patients with primary breast cancer
    • Schwarzenbach H et al (2009) Comparative evaluation of cellfree tumor DNA in blood and disseminated tumor cells in bone marrow of patients with primary breast cancer. Breast Cancer Res 11(5):R71
    • (2009) Breast Cancer Res , vol.11 , Issue.5
    • Schwarzenbach, H.1
  • 62
    • 65349154656 scopus 로고    scopus 로고
    • Detection of cytokeratin 19 mrna and cyfra 21-1 (cytokeratin 19 fragments) in blood of tunisian women with breast cancer
    • Marrakchi R et al (2008) Detection of cytokeratin 19 mRNA and CYFRA 21-1 (cytokeratin 19 fragments) in blood of Tunisian women with breast cancer. Int J Biol Markers 23(4):238-243
    • (2008) Int J Biol Markers , vol.23 , Issue.4 , pp. 238-243
    • Marrakchi, R.1
  • 63
    • 41649115577 scopus 로고    scopus 로고
    • Free circulating mrna in plasma from breast cancer patients and clinical outcome
    • García V et al (2008) Free circulating mRNA in plasma from breast cancer patients and clinical outcome. Cancer Lett 263(2):312-320
    • (2008) Cancer Lett , vol.263 , Issue.2 , pp. 312-320
    • García, V.1
  • 64
    • 43149116331 scopus 로고    scopus 로고
    • Feasibility and relevance of global expression profiling of gene transcripts in serum from breast cancer patients using whole genome microarrays and quantitative rt-pcr
    • O'Driscoll L et al (2008) Feasibility and relevance of global expression profiling of gene transcripts in serum from breast cancer patients using whole genome microarrays and quantitative RT-PCR. Cancer Genomics Proteomics 5(2):94-104
    • (2008) Cancer Genomics Proteomics , vol.5 , Issue.2 , pp. 94-104
    • O'Driscoll, L.1
  • 65
    • 58149352913 scopus 로고    scopus 로고
    • Relationship between tumor and plasma levels of htert mrna in patients with colorectal cancer: Implications for monitoring of neoplastic disease
    • Terrin L et al (2008) Relationship between tumor and plasma levels of hTERT mRNA in patients with colorectal cancer: implications for monitoring of neoplastic disease. Clin Cancer Res 14(22):7444-7451
    • (2008) Clin Cancer Res , vol.14 , Issue.22 , pp. 7444-7451
    • Terrin, L.1
  • 66
    • 61649088607 scopus 로고    scopus 로고
    • Expression of insulin-like growth factor system components in colorectal tissue and its relation with serum igf levels
    • Vrieling A et al (2009) Expression of insulin-like growth factor system components in colorectal tissue and its relation with serum IGF levels. Growth Horm IGF Res 19(2):126-135
    • (2009) Growth Horm IGF Res , vol.19 , Issue.2 , pp. 126-135
    • Vrieling, A.1
  • 67
  • 68
    • 0016376113 scopus 로고
    • An ''external'' rna removable from mammalian cells by mild proteolysis
    • Rieber M, Bacalao J (1974) An ''external'' RNA removable from mammalian cells by mild proteolysis. Proc Natl Acad Sci USA 71(12):4960-4964
    • (1974) Proc Natl Acad Sci USA , vol.71 , Issue.12 , pp. 4960-4964
    • Rieber, M.1    Bacalao, J.2
  • 71
    • 0024454157 scopus 로고
    • EIN GENSONDENTEST FUR RNA-PROTEOLIPID IN SERUMPROBEN BEI NEOPLASIE
    • Wieczorek AJ, Rhyner K (1989) A gene probe test for serum RNA proteolipid in neoplasia. Schweiz Med Wochenschr 119(39):1342-1343 (Pubitemid 19240958)
    • (1989) Schweizerische Medizinische Wochenschrift , vol.119 , Issue.39 , pp. 1342-1343
    • Wieczorek, A.J.1    Rhyner, K.2
  • 73
    • 0034926031 scopus 로고    scopus 로고
    • Extracellular tyrosinase mRNA within apoptotic bodies is protected from degradation in human serum
    • Hasselmann DO et al (2001) Extracellular tyrosinase mRNA within apoptotic bodies is protected from degradation in human serum. Clin Chem 47(8):1488-1489 (Pubitemid 32678837)
    • (2001) Clinical Chemistry , vol.47 , Issue.8 , pp. 1488-1489
    • Hasselmann, D.O.1    Rappl, G.2    Tilgen, W.3    Reinhold, U.4
  • 74
    • 0018081012 scopus 로고
    • Presence of RNA in the nucleoprotein complex spontaneously released by human lymphocytes and frog auricles in culture
    • Stroun M et al (1978) Presence of RNA in the nucleoprotein complex spontaneously released by human lymphocytes and frog auricles in culture. Cancer Res 38(10):3546-3554 (Pubitemid 9043248)
    • (1978) Cancer Research , vol.38 , Issue.10 , pp. 3546-3554
    • Stroun, M.1    Anker, P.2    Beljanski, M.3
  • 75
    • 0018701257 scopus 로고
    • Information carried by the DNA released by antigen-stimulated lymphocytes
    • Jachertz D et al (1979) Information carried by the DNA released by antigen-stimulated lymphocytes. Immunology 37(4):753-763 (Pubitemid 10220695)
    • (1979) Immunology , vol.37 , Issue.4 , pp. 753-763
    • Jachertz, D.1    Anker, P.2    Maurice, P.A.3    Stroun, M.4
  • 76
    • 0002832039 scopus 로고    scopus 로고
    • Detection of circulating tumour DNA in the blood (plasma/serum) of cancer patients
    • DOI 10.1023/A:1006260319913
    • Anker P et al (1999) Detection of circulating tumour DNA in the blood (plasma/serum) of cancer patients. Cancer Metastasis Rev 18(1):65-73 (Pubitemid 29411092)
    • (1999) Cancer and Metastasis Reviews , vol.18 , Issue.1 , pp. 65-73
    • Anker, P.1    Mulcahy, H.2    Chen, X.Q.3    Stroun, M.4
  • 78
    • 57049103401 scopus 로고    scopus 로고
    • Glioblastoma microvesicles transport rna and proteins that promote tumour growth and provide diagnostic biomarkers
    • Skog J et al (2008) Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 10(12):1470-1476
    • (2008) Nat Cell Biol , vol.10 , Issue.12 , pp. 1470-1476
    • Skog, J.1
  • 79
    • 0022512728 scopus 로고
    • A proteolipid in cancer cells is the origin of their high-resolution NMR spectrum
    • DOI 10.1016/0014-5793(86)80735-9
    • Wright LC et al (1986) A proteolipid in cancer cells is the origin of their high-resolution NMR spectrum. FEBS Lett 203(2): 164-168 (Pubitemid 16046792)
    • (1986) FEBS Letters , vol.203 , Issue.2 , pp. 164-168
    • Wright, L.C.1    May, G.L.2    Dyne, M.3    Mountford, C.E.4
  • 80
    • 0023927585 scopus 로고
    • Rna-lipid complexes released from the plasma membrane of human colon carcinoma cells
    • Rosi A et al (1988) RNA-lipid complexes released from the plasma membrane of human colon carcinoma cells. Cancer Lett 39(2):153-160
    • (1988) Cancer Lett , vol.39 , Issue.2 , pp. 153-160
    • Rosi, A.1
  • 81
    • 0024464266 scopus 로고
    • Biochemical and NMR studies on structure and release conditions of RNA-containing vesicles shed by human colon adenocarcinoma cells
    • Ceccarini M et al (1989) Biochemical and NMR studies on structure and release conditions of RNA-containing vesicles shed by human colon adenocarcinoma cells. Int J Cancer 44(4):714-721 (Pubitemid 19258750)
    • (1989) International Journal of Cancer , vol.44 , Issue.4 , pp. 714-721
    • Ceccarini, M.1    Guidoni, L.2    Luciani, A.M.3    Mariutti, G.4    Rosi, A.5    Viti, V.6
  • 82
    • 33747616431 scopus 로고    scopus 로고
    • Membrane-derived microvesicles: Important and underappreciated mediators of cell-to-cell communication
    • DOI 10.1038/sj.leu.2404296, PII 2404296
    • Ratajczak J et al (2006) Membrane-derived microvesicles: important and underappreciated mediators of cell-To-cell communication. Leukemia 20(9):1487-1495 (Pubitemid 44264090)
    • (2006) Leukemia , vol.20 , Issue.9 , pp. 1487-1495
    • Ratajczak, J.1    Wysoczynski, M.2    Hayek, F.3    Janowska-Wieczorek, A.4    Ratajczak, M.Z.5
  • 83
    • 70349316341 scopus 로고    scopus 로고
    • Proteomic and immunologic analyses of brain tumor exosomes
    • Graner MW et al (2009) Proteomic and immunologic analyses of brain tumor exosomes. FASEB J 23(5):1541-1557
    • (2009) FASEB J , vol.23 , Issue.5 , pp. 1541-1557
    • Graner, M.W.1
  • 85
    • 33751199883 scopus 로고    scopus 로고
    • Exosomes: From biogenesis and secretion to biological function
    • DOI 10.1016/j.imlet.2006.09.005, PII S0165247806002288
    • Keller S et al (2006) Exosomes: from biogenesis and secretion to biological function. Immunol Lett 107(2):102-108 (Pubitemid 44779821)
    • (2006) Immunology Letters , vol.107 , Issue.2 , pp. 102-108
    • Keller, S.1    Sanderson, M.P.2    Stoeck, A.3    Altevogt, P.4
  • 87
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • DOI 10.1038/ncb1596, PII NCB1596
    • Valadi H et al (2007) Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9(6):654-659 (Pubitemid 47214727)
    • (2007) Nature Cell Biology , vol.9 , Issue.6 , pp. 654-659
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3    Sjostrand, M.4    Lee, J.J.5    Lotvall, J.O.6
  • 91
    • 0031760355 scopus 로고    scopus 로고
    • The amount and proteolytic content of vesicles shed by human cancer cell lines correlates with their in vitro invasiveness
    • Ginestra A et al (1998) The amount and proteolytic content of vesicles shed by human cancer cell lines correlates with their in vitro invasiveness. Anticancer Res 18(5A):3433-3437 (Pubitemid 28546471)
    • (1998) Anticancer Research , vol.18 , Issue.5 A , pp. 3433-3437
    • Ginestra, A.1    La Placa, M.D.2    Saladino, F.3    Cassara, D.4    Nagase, H.5    Vittorelli, M.L.6
  • 92
    • 34547686145 scopus 로고    scopus 로고
    • Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2
    • DOI 10.1158/0008-5472.CAN-06-3456
    • Clayton A et al (2007) Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2. Cancer Res 67(15):7458-7466 (Pubitemid 47214451)
    • (2007) Cancer Research , vol.67 , Issue.15 , pp. 7458-7466
    • Clayton, A.1    Mitchell, J.P.2    Court, J.3    Mason, M.D.4    Tabi, Z.5
  • 94
    • 34249335372 scopus 로고    scopus 로고
    • Extracellular nucleic acids and their potential as diagnostic, prognostic and predictive biomarkers
    • O'Driscoll L (2007) Extracellular nucleic acids and their potential as diagnostic, prognostic and predictive biomarkers. Anticancer Res 27(3):1257-1265 (Pubitemid 46807271)
    • (2007) Anticancer Research , vol.27 , Issue.3 A , pp. 1257-1265
    • O'Driscoll, L.1
  • 95
    • 62549125455 scopus 로고    scopus 로고
    • Exosomal microrna: A diagnostic marker for lung cancer
    • Rabinowits G et al (2009) Exosomal microRNA: A diagnostic marker for lung cancer. Clin Lung Cancer 10(1):42-46
    • (2009) Clin Lung Cancer , vol.10 , Issue.1 , pp. 42-46
    • Rabinowits, G.1
  • 97
    • 0033760396 scopus 로고    scopus 로고
    • Telomerase rna as a detection marker in the serum of breast cancer patients
    • Chen X et al (2000) Telomerase RNA as a detection marker in the serum of breast cancer patients. Clin Cancer Res 6(10):3823-3826
    • (2000) Clin Cancer Res , vol.6 , Issue.10 , pp. 3823-3826
    • Chen, X.1
  • 98
    • 36549060556 scopus 로고    scopus 로고
    • Circulating bmi-1 mrna as a possible prognostic factor for advanced breast cancer patients
    • Silva J et al (2007) Circulating Bmi-1 mRNA as a possible prognostic factor for advanced breast cancer patients. Breast Cancer Res 9(4):R55
    • (2007) Breast Cancer Res , vol.9 , Issue.4
    • Silva, J.1
  • 99
    • 0028283501 scopus 로고
    • Intermediate filaments: Structure, dynamics, function, and disease
    • Fuchs E, Weber K (1994) Intermediate filaments: structure, dynamics, function, and disease. Annu Rev Biochem 63:345-382
    • (1994) Annu Rev Biochem , vol.63 , pp. 345-382
    • Fuchs, E.1    Weber, K.2
  • 101
    • 0027530418 scopus 로고
    • Serum fragment of cytokeratin subunit 19 measured by cyfra 21-1 immunoradiometric assay as a marker of lung cancer
    • Pujol JL et al (1993) Serum fragment of cytokeratin subunit 19 measured by CYFRA 21-1 immunoradiometric assay as a marker of lung cancer. Cancer Res 53(1):61-66
    • (1993) Cancer Res , vol.53 , Issue.1 , pp. 61-66
    • Pujol, J.L.1
  • 103
    • 0037102125 scopus 로고    scopus 로고
    • Molecular detection of cytokeratin-19-positive cells in the peripheral blood of patients with operable breast cancer: Evaluation of their prognostic significance
    • Stathopoulou A et al (2002) Molecular detection of cytokeratin-19- positive cells in the peripheral blood of patients with operable breast cancer: evaluation of their prognostic significance. J Clin Oncol 20(16):3404-3412
    • (2002) J Clin Oncol , vol.20 , Issue.16 , pp. 3404-3412
    • Stathopoulou, A.1
  • 105
    • 68749113691 scopus 로고    scopus 로고
    • Detection of cytokeratin-19 mrnapositive cells in the peripheral blood and bone marrow of patients with operable breast cancer
    • Daskalaki A et al (2009) Detection of cytokeratin-19 mRNApositive cells in the peripheral blood and bone marrow of patients with operable breast cancer. Br J Cancer 101(4):589-597
    • (2009) Br J Cancer , vol.101 , Issue.4 , pp. 589-597
    • Daskalaki, A.1
  • 107
    • 33747079859 scopus 로고    scopus 로고
    • Breast cancer-specific mRNA transcripts presence in peripheral blood after adjuvant chemotherapy predicts poor survival among high-risk breast cancer patients treated with high-dose chemotherapy with peripheral blood stem cell support
    • DOI 10.1200/JCO.2005.04.0576
    • Quintela-Fandino M et al (2006) Breast cancer-specific mRNA transcripts presence in peripheral blood after adjuvant chemotherapy predicts poor survival among high-risk breast cancer patients treated with high-dose chemotherapy with peripheral blood stem cell support. J Clin Oncol 24(22):3611-3618 (Pubitemid 46630534)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.22 , pp. 3611-3618
    • Quintela-Fandino, M.1    Lopez, J.M.2    Hitt, R.3    Gamarra, S.4    Jimeno, A.5    Ayala, R.6    Hornedo, J.7    Guzman, C.8    Gilsanz, F.9    Cortes-Funes, H.10
  • 108
    • 4143134311 scopus 로고    scopus 로고
    • Isolated tumor cells in bone marrow three years after diagnosis in disease-free breast cancer patients predict unfavorable clinical outcome
    • DOI 10.1158/1078-0432.CCR-04-0245
    • Wiedswang G et al (2004) Isolated tumor cells in bone marrow three years after diagnosis in disease-free breast cancer patients predict unfavorable clinical outcome. Clin Cancer Res 10(16): 5342-5348 (Pubitemid 39100469)
    • (2004) Clinical Cancer Research , vol.10 , Issue.16 , pp. 5342-5348
    • Wiedswang, G.1    Borgen, E.2    Karesen, R.3    Qvist, H.4    Janbu, J.5    Kvalheim, G.6    Nesland, J.M.7    Naume, B.8
  • 109
    • 38149037275 scopus 로고    scopus 로고
    • Circulating tumor cells in breast cancer
    • Ignatiadis M et al (2008) Circulating tumor cells in breast cancer. Curr Opin Obstet Gynecol 20(1):55-60
    • (2008) Curr Opin Obstet Gynecol , vol.20 , Issue.1 , pp. 55-60
    • Ignatiadis, M.1
  • 110
    • 74049140862 scopus 로고    scopus 로고
    • Full-length cytokeratin-19 is released by human tumor cells: A potential role in metastatic progression of breast cancer
    • Alix-Panabieres C et al (2009) Full-length cytokeratin-19 is released by human tumor cells: A potential role in metastatic progression of breast cancer. Breast Cancer Res 11(3):R39
    • (2009) Breast Cancer Res , vol.11 , Issue.3
    • Alix-Panabieres, C.1
  • 111
    • 0034626769 scopus 로고    scopus 로고
    • The age of cancer
    • DePinho R (2000) The age of cancer. Nature 408(6809): 248-254
    • (2000) Nature , vol.408 , Issue.6809 , pp. 248-254
    • DePinho, R.1
  • 113
    • 72849147702 scopus 로고    scopus 로고
    • Relationship between the expression of htert and eya4 mrna in peripheral blood mononuclear cells with the progressive stages of carcinogenesis of the esophagus
    • Li H et al (2009) Relationship between the expression of hTERT and EYA4 mRNA in peripheral blood mononuclear cells with the progressive stages of carcinogenesis of the esophagus. J Exp Clin Cancer Res 28:145
    • (2009) J Exp Clin Cancer Res , vol.28 , pp. 145
    • Li, H.1
  • 114
    • 0037341420 scopus 로고    scopus 로고
    • KI-67 and hTERT expression can aid in the distinction between malignant and benign pheochromocytoma and paraganglioma
    • DOI 10.1097/01.MP.0000056982.07160.E3
    • Elder E et al (2003) KI-67 and hTERT expression can aid in the distinction between malignant and benign pheochromocytoma and paraganglioma. Mod Pathol 16(3):246-255 (Pubitemid 36337431)
    • (2003) Modern Pathology , vol.16 , Issue.3 , pp. 246-255
    • Elder, E.E.1    Xu, D.2    Hoog, A.3    Enberg, U.4    Hou, M.5    Pisa, P.6    Gruber, A.7    Larsson, C.8    Backdahl, M.9
  • 115
    • 58349097930 scopus 로고    scopus 로고
    • The detection of circulating tumor cells of breast cancer patients by using multimarker (survivin, htert and hmam) quantitative real-Time pcr
    • Shen C et al (2009) The detection of circulating tumor cells of breast cancer patients by using multimarker (Survivin, hTERT and hMAM) quantitative real-Time PCR. Clin Biochem 42(3): 194-200
    • (2009) Clin Biochem , vol.42 , Issue.3 , pp. 194-200
    • Shen, C.1
  • 116
    • 0037150730 scopus 로고    scopus 로고
    • Polycomb repression: From cellular memory to cellular proliferation and cancer
    • DOI 10.1016/S0304-419X(02)00052-5, PII S0304419X02000525
    • Jacobs JJ, van Lohuizen M (2002) Polycomb repression: from cellular memory to cellular proliferation and cancer. Biochim Biophys Acta 1602(2):151-161 (Pubitemid 34521793)
    • (2002) Biochimica et Biophysica Acta - Reviews on Cancer , vol.1602 , Issue.2 , pp. 151-161
    • Jacobs, J.J.L.1    Van Lohuizen, M.2
  • 117
    • 17444379015 scopus 로고    scopus 로고
    • Deregulated expression of Polycomb-group oncogenes in human malignant lymphomas and epithelial tumors
    • DOI 10.1093/hmg/ddi111
    • Raaphorst FM (2005) Deregulated expression of Polycombgroup oncogenes in human malignant lymphomas and epithelial tumors. Hum Mol Genet 14 Spec No 1, R93-R100 (Pubitemid 40542625)
    • (2005) Human Molecular Genetics , vol.14 , Issue.SPEC. ISS. 1
    • Raaphorst, F.M.1
  • 118
    • 72849130207 scopus 로고    scopus 로고
    • The polycomb group protein bmi-1 represses the tumor suppressor pten and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells
    • Song LB et al (2009) The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest 119(12):3626-3636
    • (2009) J Clin Invest , vol.119 , Issue.12 , pp. 3626-3636
    • Song, L.B.1
  • 122
    • 33745728170 scopus 로고    scopus 로고
    • Hedgehog signaling and bmi-1 regulate selfrenewal of normal and malignant human mammary stem cells
    • Liu S et al (2006) Hedgehog signaling and Bmi-1 regulate selfrenewal of normal and malignant human mammary stem cells. Cancer Res 66(12):6063-6071
    • (2006) Cancer Res , vol.66 , Issue.12 , pp. 6063-6071
    • Liu, S.1
  • 123
    • 9244248707 scopus 로고    scopus 로고
    • Overexpression of Bmi-1 oncoprotein correlates with axillary lymph node metastases in invasive ductal breast cancer
    • DOI 10.1016/j.breast.2004.02.010, PII S0960977604000372
    • Kim JH et al (2004) Overexpression of Bmi-1 oncoprotein correlates with axillary lymph node metastases in invasive ductal breast cancer. Breast 13(5):383-388 (Pubitemid 39549787)
    • (2004) Breast , vol.13 , Issue.5 , pp. 383-388
    • Kim, J.H.1    Yoon, S.Y.2    Jeong, S.-H.3    Kim, S.Y.4    Moon, S.K.5    Joo, J.H.6    Lee, Y.7    Choe, I.S.8    Kim, J.W.9
  • 125
    • 0346094301 scopus 로고    scopus 로고
    • The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins
    • DOI 10.1016/j.canlet.2003.07.009
    • Kim JH et al (2004) The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins. Cancer Lett 203(2):217-224 (Pubitemid 38058689)
    • (2004) Cancer Letters , vol.203 , Issue.2 , pp. 217-224
    • Kim, J.H.1    Yoon, S.Y.2    Kim, C.-N.3    Joo, J.H.4    Moon, S.K.5    Choe, I.S.6    Choe, Y.-K.7    Kim, J.W.8
  • 128
    • 0028074616 scopus 로고
    • Isolation of differentially expressed sequence tags from human breast cancer
    • Watson MA, Fleming TP (1994) Isolation of differentially expressed sequence tags from human breast cancer. Cancer Res 54(17):4598-4602 (Pubitemid 24276479)
    • (1994) Cancer Research , vol.54 , Issue.17 , pp. 4598-4602
    • Watson, M.A.1    Fleming, T.P.2
  • 129
    • 0032510111 scopus 로고    scopus 로고
    • Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to Chromosome 11q13
    • Watson MA et al (1998) Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to chromosome 11q13. Oncogene 16(6):817-824 (Pubitemid 28076094)
    • (1998) Oncogene , vol.16 , Issue.6 , pp. 817-824
    • Watson, M.A.1    Darrow, C.2    Zimonjic, D.B.3    Popescu, N.C.4    Fleming, T.P.5
  • 130
    • 51749099388 scopus 로고    scopus 로고
    • Mammaglobin b expression in human endometrial cancer
    • Tassi RA et al (2008) Mammaglobin B expression in human endometrial cancer. Int J Gynecol Cancer 18(5):1090-1096
    • (2008) Int J Gynecol Cancer , vol.18 , Issue.5 , pp. 1090-1096
    • Tassi, R.A.1
  • 131
    • 0030056285 scopus 로고    scopus 로고
    • Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer
    • Watson MA, Fleming TP (1996) Mammaglobin, a mammaryspecific member of the uteroglobin gene family, is overexpressed in human breast cancer. Cancer Res 56(4):860-865 (Pubitemid 26055478)
    • (1996) Cancer Research , vol.56 , Issue.4 , pp. 860-865
    • Watson, M.A.1    Fleming, T.P.2
  • 132
    • 33745998578 scopus 로고    scopus 로고
    • Expression analysis of mammaglobin a (scgb2a2) and lipophilin b (scgb1d2) in more than 300 human tumors and matching normal tissues reveals their coexpression in gynecologic malignancies
    • Zafrakas M et al (2006) Expression analysis of mammaglobin A (SCGB2A2) and lipophilin B (SCGB1D2) in more than 300 human tumors and matching normal tissues reveals their coexpression in gynecologic malignancies. BMC Cancer 6:88
    • (2006) BMC Cancer , vol.6 , pp. 88
    • Zafrakas, M.1
  • 133
    • 1542324603 scopus 로고    scopus 로고
    • Elevated mammaglobin (h-mam) expression in breast cancer is associated with clinical and biological features defining a less aggressive tumour phenotype
    • Nunez-Villar MJ et al (2003) Elevated mammaglobin (h-MAM) expression in breast cancer is associated with clinical and biological features defining a less aggressive tumour phenotype. Breast Cancer Res 5(3):R65-R70
    • (2003) Breast Cancer Res , vol.5 , Issue.3
    • Nunez-Villar, M.J.1
  • 134
    • 0034503089 scopus 로고    scopus 로고
    • Mammaglobin, a breast-specific gene, and its utility as a marker for breast cancer
    • Fleming TP, Watson MA (2000) Mammaglobin, a breast-specific gene, and its utility as a marker for breast cancer. Ann NY Acad Sci 923:78-89 (Pubitemid 32050207)
    • (2000) Annals of the New York Academy of Sciences , vol.923 , pp. 78-89
    • Fleming, T.P.1    Watson, M.A.2
  • 136
    • 0032983945 scopus 로고    scopus 로고
    • Detection of circulating mammary carcinoma cells in the peripheral blood of breast cancer patients via a nested reverse transcriptase polymerase chain reaction assay for mammaglobin mRNA
    • Zach O et al (1999) Detection of circulating mammary carcinoma cells in the peripheral blood of breast cancer patients via a nested reverse transcriptase polymerase chain reaction assay for mammaglobin mRNA. J Clin Oncol 17(7):2015-2019 (Pubitemid 29318829)
    • (1999) Journal of Clinical Oncology , vol.17 , Issue.7 , pp. 2015-2019
    • Zach, O.1    Kasparu, H.2    Krieger, O.3    Hehenwarter, W.4    Girschikofsky, M.5    Lutz, D.6
  • 138
    • 59449107997 scopus 로고    scopus 로고
    • Detection of human mammaglobin mrna in serial peripheral blood samples from patients with non-metastatic breast cancer is not predictive of disease recurrence
    • Marques AR et al (2009) Detection of human mammaglobin mRNA in serial peripheral blood samples from patients with non-metastatic breast cancer is not predictive of disease recurrence. Breast Cancer Res Treat 114(2):223-232
    • (2009) Breast Cancer Res Treat , vol.114 , Issue.2 , pp. 223-232
    • Marques, A.R.1
  • 139
    • 42249100865 scopus 로고    scopus 로고
    • Detection of mammaglobin mrna in peripheral blood is associated with high grade breast cancer: Interim results of a prospective cohort study
    • Mikhitarian K et al (2008) Detection of mammaglobin mRNA in peripheral blood is associated with high grade breast cancer: interim results of a prospective cohort study. BMC Cancer 8:55
    • (2008) BMC Cancer , vol.8 , pp. 55
    • Mikhitarian, K.1
  • 140
    • 9444236895 scopus 로고    scopus 로고
    • Minireview: Cyclin D1: Normal and abnormal functions
    • DOI 10.1210/en.2004-0959
    • Fu M et al (2004) Minireview: Cyclin D1: normal and abnormal functions. Endocrinology 145(12):5439-5447 (Pubitemid 39564581)
    • (2004) Endocrinology , vol.145 , Issue.12 , pp. 5439-5447
    • Fu, M.1    Wang, C.2    Li, Z.3    Sakamaki, T.4    Pestell, R.G.5
  • 141
    • 25844515780 scopus 로고    scopus 로고
    • Downstream targets of growth factor and oestrogen signalling and endocrine resistance: The potential roles of c-Myc, cyclin D1 and cyclin E
    • DOI 10.1677/erc.1.00993, Growth Factor Signalling snd Therapeutic Resistance in Breast Cancer
    • Butt AJ et al (2005) Downstream targets of growth factor and oestrogen signalling and endocrine resistance: the potential roles of c-Myc, cyclin D1 and cyclin E. Endocr Relat Cancer 12(Suppl 1): S47-S59 (Pubitemid 41395413)
    • (2005) Endocrine-Related Cancer , vol.12 , Issue.SUPPL. 1
    • Butt, A.J.1    McNeil, C.M.2    Musgrove, E.A.3    Sutherland, R.L.4
  • 143
    • 70349578779 scopus 로고    scopus 로고
    • Detection of occult her2 mrnapositive tumor cells in the peripheral blood of patients with operable breast cancer: Evaluation of their prognostic relevance
    • Apostolaki S et al (2009) Detection of occult HER2 mRNApositive tumor cells in the peripheral blood of patients with operable breast cancer: evaluation of their prognostic relevance. Breast Cancer Res Treat 117(3):525-534
    • (2009) Breast Cancer Res Treat , vol.117 , Issue.3 , pp. 525-534
    • Apostolaki, S.1
  • 144
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • DOI 10.1038/nature02871
    • Ambros V (2004) The functions of animal microRNAs. Nature 431(7006):350-355 (Pubitemid 39265675)
    • (2004) Nature , vol.431 , Issue.7006 , pp. 350-355
    • Ambros, V.1
  • 145
    • 50249172898 scopus 로고    scopus 로고
    • Molecular medicine of micrornas: Structure, function and implications for diabetes
    • Hennessy E, O'Driscoll L (2008) Molecular medicine of microRNAs: structure, function and implications for diabetes. Expert Rev Mol Med 10:e24
    • (2008) Expert Rev Mol Med , vol.10
    • Hennessy, E.1    O'Driscoll, L.2
  • 146
    • 40449134399 scopus 로고    scopus 로고
    • Mirnas: Little known mediators of oncogenesis
    • Gartel A, Kandel E (2008) miRNAs: Little known mediators of oncogenesis. Semin Cancer Biol 18(2):103-110
    • (2008) Semin Cancer Biol , vol.18 , Issue.2 , pp. 103-110
    • Gartel, A.1    Kandel, E.2
  • 148
    • 48749122914 scopus 로고    scopus 로고
    • Circulating micrornas as stable bloodbased markers for cancer detection
    • Mitchell P et al (2008) Circulating microRNAs as stable bloodbased markers for cancer detection. Proc Natl Acad Sci USA 105(30):10513-10518
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.30 , pp. 10513-10518
    • Mitchell, P.1
  • 149
    • 53349177819 scopus 로고    scopus 로고
    • Characterization of micrornas in serum: A novel class of biomarkers for diagnosis of cancer and other diseases
    • Chen X et al (2008) Characterization of microRNAs in serum: A novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 18(10):997-1006
    • (2008) Cell Res , vol.18 , Issue.10 , pp. 997-1006
    • Chen, X.1
  • 150
    • 45449093192 scopus 로고    scopus 로고
    • MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
    • DOI 10.1016/j.ygyno.2008.04.033, PII S0090825808003430
    • Taylor D, Gercel-Taylor C (2008) MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol Oncol 110(1):13-21 (Pubitemid 351853251)
    • (2008) Gynecologic Oncology , vol.110 , Issue.1 , pp. 13-21
    • Taylor, D.D.1    Gercel-Taylor, C.2
  • 151
    • 77649138141 scopus 로고    scopus 로고
    • Circulating micrornas as novel minimally invasive biomarkers for breast cancer
    • Heneghan H et al (2010) Circulating microRNAs as novel minimally invasive biomarkers for breast cancer. Ann Surg 251(3):499-505
    • (2010) Ann Surg , vol.251 , Issue.3 , pp. 499-505
    • Heneghan, H.1
  • 152
    • 14544270950 scopus 로고    scopus 로고
    • Predictive markers in breast and other cancers: A review
    • DOI 10.1373/clinchem.2004.046227
    • Duffy M (2005) Predictive markers in breast and other cancers: A review. Clin Chem 51(3):494-503 (Pubitemid 40300223)
    • (2005) Clinical Chemistry , vol.51 , Issue.3 , pp. 494-503
    • Duffy, M.J.1
  • 154
    • 15544372843 scopus 로고    scopus 로고
    • Prognostic and predictive factors for breast cancer: Translating technology to oncology
    • DOI 10.1200/JCO.2005.10.074
    • Hayes D (2005) Prognostic and predictive factors for breast cancer: translating technology to oncology. J Clin Oncol 23(8):1596-1597 (Pubitemid 46211406)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.8 , pp. 1596-1597
    • Hayes, D.F.1
  • 155
    • 33644830699 scopus 로고    scopus 로고
    • Reporting recommendations for tumor marker prognostic studies
    • McShane L et al (2005) Reporting recommendations for tumor marker prognostic studies. J Clin Oncol 23(36):9067-9072
    • (2005) J Clin Oncol , vol.23 , Issue.36 , pp. 9067-9072
    • McShane, L.1
  • 156
    • 67650652432 scopus 로고    scopus 로고
    • I-spy 2: An adaptive breast cancer trial design in the setting of neoadjuvant chemotherapy
    • Barker AD et al (2009) I-SPY 2: An adaptive breast cancer trial design in the setting of neoadjuvant chemotherapy. Clin Pharmacol Ther 86(1):97-100
    • (2009) Clin Pharmacol Ther , vol.86 , Issue.1 , pp. 97-100
    • Barker, A.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.