The role of caspase 3 in producing cytokeratin 19 fragment (CYFRA21-1) in human lung cancer cell lines

International Journal of Cancer

Volumn 91, Issue 4, 2001, Pages 468-473

  Dohmoto, Kazutaka ^a,b   Hojo, Satoko ^a,c   Fujita, Jiro ^a   Yang, Yu ^a,b   Ueda, Yutaka ^a   Bandoh, Shuji ^a   Yamaji, Yasufumi ^a   Ohtsuki, Yuji ^a   Dobashi, Naomi ^a   Ishida, Toshihiko ^a   Takahara, Jiro ^a  

^a KAGAWA UNIVERSITY   (Japan)

^b Mitoyo General Hospital   (Japan)

^c KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

Caspase 3; CYFRA 21 1; Cytokeratin 19; Lung cancer; Quantitative RT PCR

Indexed keywords

CASPASE 3; CYTOKERATIN 19; CYTOKERATIN 19 FRAGMENT; MESSENGER RNA; TUMOR MARKER;

APOPTOSIS; ARTICLE; CANCER DIAGNOSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNORADIOMETRIC ASSAY; LUNG CARCINOMA; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUPERNATANT; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, NEOPLASM; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASE 6; CASPASES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINS; LUNG NEOPLASMS; MICE; MODELS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 0035866040     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(200002)9999:9999<::AID-IJC1082>3.0.CO;2-T     Document Type: Article

References (25)

1. The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells
2. Genetic skin diseases caused by mutations in keratin intermediate filaments
3. Serum fragment of cytokeratin subunit 19 measured by CYFRA 21-1 immunoradiometric assay as a marker of lung cancer
4. Production of cytokeratin 19 fragment by human squamous lung cancer cell lines
5. Identification of keratins 18, 19 and heat-shock protein 90β as candidate substrates of proteolysis during ionizing radiation-induced apoptosis of estrogen-receptor negative breast tumor cells
6. Simple quantitative reverse transcribed-polymerase chain reaction (RT-PCR) method involving recombinant RNA generated by a false-priming PCR product
7. Quantitation by competitive PCR assay of vascular endothelial growth factor in non-small cell lung carcinomas
8. Embryonic expression of the human 40-kD keratin: Evidence from a processed pseudogene sequence
9. Identification of a novel cytokeratin 19 pseudogene that may interfere with reverse transcriptase-polymerase chain reaction assays used to detect micrometastatic tumor cells
10. Sensitive detection of occult breast cancer by the reverse-transcriptase polymerase chain reaction
11. Limitations of specific reverse-transcriptase polymerase chain reaction markers in the detection of metastases in the lymph nodes and blood of breast cancer patients
12. Cleavage of structural proteins during the assembly of the head of Bacteriophage T4
13. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
14. Alteration of caspase-3 (CPP32/Yama/apopain) in wild-type MCF-7, breast cancer cells
15. Identification of gene family of caspases in rat kidney and altered expression in ischemia-reperfusion injury
16. Function of caspases in regulating apoptosis caused by erythropoietin deprivation in erythroid progenitors
17. Caspase inhibition selectively reduces the apoptotic component of oxygen-glucose deprivation-induced cortical neuronal cell death
18. Lung cancer-associated keratin 19 fragments: Development and biochemical characterization of the new serum assay Enzymun-Test CYFRA 21-1
19. Cytokeratins as serum markers in lung cancer: A comparison of CYFRA 21-1 and TPS
20. Epitope specificity of 30 monoclonal antibodies against cytokeratin antigens: The ISOBM TD5-1 workshop
21. Epitope mapping of monoclonal antibodies to keratin 19 using keratin fragments, synthetic peptides and phage peptide libraries
22. Expression of cytokeratin 19 mRNA in human lung cancer cell lines
23. Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis
24. Alterations in cytoskeletal and nuclear matrix-associated proteins during apoptosis
25. Apoptosis generates stable fragments of human type I keratins